Autophagy Dysfunction In Alzheimer S Disease And Dementia

Author : Tadanori Hamano,Tatsuro Mutoh
Publisher : Academic Press
Page : 360 pages
File Size : 55,7 Mb
Release : 2022-08-20
Category : Medical
ISBN : 9780323899147

Get Book

Autophagy Dysfunction in Alzheimer's Disease and Dementia by Tadanori Hamano,Tatsuro Mutoh Pdf

Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases. Discusses the implication of autophagy dysfunction in neurodegenerative diseases Highlights the mechanisms involved in protein degradation Explores the possibilities of drug development through autophagy modulation

Author : José M. Fuentes
Publisher : Springer
Page : 268 pages
File Size : 42,8 Mb
Release : 2015-05-04
Category : Medical
ISBN : 9783319139395

Get Book

Toxicity and Autophagy in Neurodegenerative Disorders by José M. Fuentes Pdf

Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.

Author : Lawrence H. Lash,Dean P. Jones
Publisher : Elsevier
Page : 528 pages
File Size : 50,9 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483218618

Get Book

Mitochondrial Dysfunction by Lawrence H. Lash,Dean P. Jones Pdf

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Author : Zhenyu Yue
Publisher : World Scientific
Page : 441 pages
File Size : 45,6 Mb
Release : 2012
Category : Medical
ISBN : 9789814350457

Get Book

Autophagy of the Nervous System by Zhenyu Yue Pdf

What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.

Author : Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf
Publisher : Frontiers Media SA
Page : 501 pages
File Size : 44,5 Mb
Release : 2019-12-04
Category : Electronic
ISBN : 9782889631285

Get Book

The Alzheimer's Disease Challenge by Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf Pdf

Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.

Author : Heather M. Wilkins,Levi Wood,Jill K. Morris
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 44,6 Mb
Release : 2022-02-11
Category : Science
ISBN : 9782889743612

Get Book

Metabolism in Alzheimer’s Disease by Heather M. Wilkins,Levi Wood,Jill K. Morris Pdf

Author : S. Tariq Ahmad,Jin-A. Lee
Publisher : Elsevier Inc. Chapters
Page : 360 pages
File Size : 53,9 Mb
Release : 2013-07-29
Category : Medical
ISBN : 9780128069080

Get Book

Autophagy by S. Tariq Ahmad,Jin-A. Lee Pdf

Autophagy is a highly regulated process that promotes vital cellular homeostasis by allowing bulk non-specific degradation of the cytoplasmic contents, mainly damaged and/or surplus organelles and proteins. Autophagy is ubiquitous in eukaryotes, highly conserved from yeast to mammals, and occurs in all mammalian tissues. Historically, autophagy was characterized as the coping response to limited energy resources (starvation), to generate additional biomolecular raw materials. However, research in the past two decades has demonstrated the indispensible roles of autophagy in eukaryotic physiology and pathology with respect to wide-ranging processes such as development, differentiation, aging, immunity, cancer biology, and neurodegenerative disorders. In this chapter, we will provide an overview of the types of autophagy and mechanisms of the autophagy pathway followed by a discussion of the current understanding of the role of autophagy in neuronal physiology, pathology of neurodegenerative disorders, and potential therapeutic approaches.

Author : Davide Moretti
Publisher : BoD – Books on Demand
Page : 560 pages
File Size : 45,6 Mb
Release : 2016-09-28
Category : Medical
ISBN : 9789535126546

Get Book

Update on Dementia by Davide Moretti Pdf

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Author : Montasir Elahi
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 44,5 Mb
Release : 2022-11-02
Category : Medical
ISBN : 9781839693434

Get Book

Alzheimer's Disease by Montasir Elahi Pdf

This Edited Volume Alzheimer’s Disease is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field. The book comprises single chapters authored by various researchers and edited by an expert in the field, working on Alzheimer’s disease and dementia with cutting-edge technology. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors in this research area, and opening new possible research paths for further novel developments.

Author : Thimmaiah Govindaraju
Publisher : Royal Society of Chemistry
Page : 695 pages
File Size : 41,6 Mb
Release : 2022-01-04
Category : Medical
ISBN : 9781839162749

Get Book

Alzheimer's Disease by Thimmaiah Govindaraju Pdf

Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.

Author : Wilma Wasco,Rudolph Tanzi
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 51,7 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9781592594719

Get Book

Molecular Mechanisms of Dementia by Wilma Wasco,Rudolph Tanzi Pdf

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Author : Ghulam Md Ashraf,Md. Sahab Uddin
Publisher : Springer Nature
Page : 621 pages
File Size : 49,5 Mb
Release : 2022-07-06
Category : Medical
ISBN : 9789811676062

Get Book

Current Thoughts on Dementia by Ghulam Md Ashraf,Md. Sahab Uddin Pdf

This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies. The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.

Author : Vee Prasher
Publisher : CRC Press
Page : 249 pages
File Size : 51,9 Mb
Release : 2018-12-14
Category : Medical
ISBN : 9781315345383

Get Book

Down Syndrome and Alzheimer's Disease by Vee Prasher Pdf

This is the first book in the field to address the underlying biological abnormalities of Dementia in Alzheimer’s Disease (DAD) in people with Down syndrome. It brings together research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer’s disease in older adults with Down syndrome. Down Syndrome and Alzheimer’s Disease presents vital information to medical professionals who provide clinical care to people with Alzheimer’s disease and Down syndrome. It will also be of great benefit to researchers with an interest in Alzheimer’s disease and Down syndrome and academics researching ageing issues in people with Down Syndrome. It complements Alzheimer's Disease and Dementia in Down Syndrome and Intellectual Disabilities by the same author.

Author : Richard J. Wurtman
Publisher : Unknown
Page : 460 pages
File Size : 42,5 Mb
Release : 1996
Category : Medical
ISBN : UVA:X004080894

Get Book

The Neurobiology of Alzheimer's Disease by Richard J. Wurtman Pdf

The overall goal of the International Study Group on the Pharmacology of Memory Disorders Associated with Ageing is to point out discoveries that shed light on the potential causes of Alzheimer's disease, its pathogenesis, and the biological mechanisms that could underlie its cure. This eighth meeting in the series, aims to stimulate research in dementia and increase the transfer of information from the basic sciences to physicians and the pharmaceutical industry."

Author : Gen Sobue,Naruhiko Sahara
Publisher : Frontiers Media SA
Page : 237 pages
File Size : 53,5 Mb
Release : 2019-06-28
Category : Electronic
ISBN : 9782889458721

Get Book

Brain Protein Aging and Dementia Control by Gen Sobue,Naruhiko Sahara Pdf