Basic Statistics And Pharmaceutical Statistical Applications Third Edition

Author : James E. De Muth
Publisher : CRC Press
Page : 850 pages
File Size : 43,6 Mb
Release : 2014-04-28
Category : Mathematics
ISBN : 9781466596733

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Basic Statistics and Pharmaceutical Statistical Applications, Third Edition by James E. De Muth Pdf

Building on its best-selling predecessors, Basic Statistics and Pharmaceutical Statistical Applications, Third Edition covers statistical topics most relevant to those in the pharmaceutical industry and pharmacy practice. It focuses on the fundamentals required to understand descriptive and inferential statistics for problem solving. Incorporating new material in virtually every chapter, this third edition now provides information on software applications to assist with evaluating data. New to the Third Edition Use of Excel® and Minitab® for performing statistical analysis Discussions of nonprobability sampling procedures, determining if data is normally distributed, evaluation of covariances, and testing for precision equivalence Expanded sections on regression analysis, chi square tests, tests for trends with ordinal data, and tests related to survival statistics Additional nonparametric procedures, including the one-sided sign test, Wilcoxon signed-ranks test, and Mood’s median test With the help of flow charts and tables, the author dispels some of the anxiety associated with using basic statistical tests in the pharmacy profession and helps readers correctly interpret their results using statistical software. Through the text’s worked-out examples, readers better understand how the mathematics works, the logic behind many of the equations, and the tests’ outcomes.

Author : James E. De Muth
Publisher : CRC Press
Page : 624 pages
File Size : 49,5 Mb
Release : 1999-06-18
Category : Mathematics
ISBN : 0824719670

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Basic Statistics and Pharmaceutical Statistical Applications by James E. De Muth Pdf

This extremely pragmatic and accessible reference provides scientists with a basic knowledge of statistics-focusing on the practical applications of statistical methods to research, quality control, and data analysis. Basic Statistics and Pharmaceutical Statistical Applications explores types of variables, random sampling, probability, measures of central tendency, and hypothesis (or significance) testing, discusses regression analysis, nonparametric tests, and power determination, and examines study designs, confidence intervals, dissolution testing, and bioequivalence. The author also describes the interrelation of hypotheses, test statistics, decision rules, computations, and statistical decisions and addresses testing factors such as precision, accuracy, bias, sensitivity, and selectivity Featuring almost 500 equations, tables, drawings, and references, Basic Statistics and Pharmaceutical Statistical Applications is required reading for pharmacists, analytical chemists, clinical trial monitors, medical writers, and upper-level undergraduate and graduate students in these disciplines.

Author : James E. De Muth
Publisher : CRC Press
Page : 754 pages
File Size : 49,7 Mb
Release : 2006-05-10
Category : Mathematics
ISBN : 0849337992

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Basic Statistics and Pharmaceutical Statistical Applications, Second Edition by James E. De Muth Pdf

The first edition of Basic Statistics and Pharmaceutical Statistical Applications successfully provided a practical, easy-to-read, basic statistics book. This second edition not only updates the previous edition, but expands coverage in the area of biostatistics and how it relates to real-world professional practice. Taking you on a roller coaster ride through the world of statistics, Dr. De Muth clearly details the methodology necessary to summarize data and make informed decisions about observed outcomes. What's new or different in the Second Edition? New chapters cover: Measures of association primarily with nominal and ordinal data and and more than 15 tests Survival statistics including actuarial analysis and an introduction to multiple regression with survival data using proportional hazards regression An introduction to the topic of evidence-based practice with discussions of sensitivity and specificity, predictive values, and likelihood ratios Odds ratios and relative risk ratios that provide valuable information for dealing with probability, odds, and risk New sections address Power and sample size determination for two-sample Z-tests of proportions Clinical equivalence and noninferiority studies, process capability, and tolerance limits Methods for assessing repeatability and reproducibility Expanded information includes: Chi square, repeated measures designs, Latin Square designs, nine multiple comparison tests, and outlier testing Inverse prediction with linear regression, handling of multiple data points at different levels of independent variable, and assessment of parallelism of slopes for two samples Additional types of bivariate correlations and various assessments for independence and randomness More nonparametric tests including new information on post hoc comparisons for a significant Kruskal-Wallis test, the Kolmogorov-Smirnov goodness-of-fit test, and the Anderson-Darling test, as well as runs and range tests Eight new tables useful for the interpretation of some of the new inferential statistics De Muth provides concrete examples that enable you to effectively manage information in your day-to-day problem solving and reporting of findings. By avoiding heavy-duty mathematics and theory, even the mathematically challenged can benefit and increase their confidence in using statistics procedures.

Author : Bolton Sanford
Publisher : CRC Press
Page : 776 pages
File Size : 49,5 Mb
Release : 1997-01-17
Category : Business & Economics
ISBN : UOM:39015039921047

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Pharmaceutical Statistics Practical And Clinical Applications, Third Edition by Bolton Sanford Pdf

This edition offers new and expanded information on recent developments in stability data analysis, concepts of statistical outliners, bioequivalence studies, problems in sampling and devising limits for product release, covariance analysis and tolerance intervals, multiple endpoints and clinical data analysis, and more. student price which is available upon request from Marcel Dekker.

Author : Olive Jean Dunn,Virginia A. Clark
Publisher : John Wiley & Sons
Page : 271 pages
File Size : 50,6 Mb
Release : 2009-08-11
Category : Mathematics
ISBN : 9780470496855

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Basic Statistics by Olive Jean Dunn,Virginia A. Clark Pdf

New Edition of a Classic Guide to Statistical Applications in the Biomedical Sciences In the last decade, there have been significant changes in the way statistics is incorporated into biostatistical, medical, and public health research. Addressing the need for a modernized treatment of these statistical applications, Basic Statistics, Fourth Edition presents relevant, up-to-date coverage of research methodology using careful explanations of basic statistics and how they are used to address practical problems that arise in the medical and public health settings. Through concise and easy-to-follow presentations, readers will learn to interpret and examine data by applying common statistical tools, such as sampling, random assignment, and survival analysis. Continuing the tradition of its predecessor, this new edition outlines a thorough discussion of different kinds of studies and guides readers through the important, related decision-making processes such as determining what information is needed and planning the collections process. The book equips readers with the knowledge to carry out these practices by explaining the various types of studies that are commonly conducted in the fields of medical and public health, and how the level of evidence varies depending on the area of research. Data screening and data entry into statistical programs is explained and accompanied by illustrations of statistical analyses and graphs. Additional features of the Fourth Edition include: A new chapter on data collection that outlines the initial steps in planning biomedical and public health studies A new chapter on nonparametric statistics that includes a discussion and application of the Sign test, the Wilcoxon Signed Rank test, and the Wilcoxon Rank Sum test and its relationship to the Mann-Whitney U test An updated introduction to survival analysis that includes the Kaplan Meier method for graphing the survival function and a brief introduction to tests for comparing survival functions Incorporation of modern statistical software, such as SAS, Stata, SPSS, and Minitab into the presented discussion of data analysis Updated references at the end of each chapter Basic Statistics, Fourth Edition is an ideal book for courses on biostatistics, medicine, and public health at the upper-undergraduate and graduate levels. It is also appropriate as a reference for researchers and practitioners who would like to refresh their fundamental understanding of statistical techniques.

Author : Sanford Bolton,Charles Bon
Publisher : CRC Press
Page : 666 pages
File Size : 45,9 Mb
Release : 2009-12-23
Category : Mathematics
ISBN : 9781420074239

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Pharmaceutical Statistics by Sanford Bolton,Charles Bon Pdf

Through the use of practical examples and solutions, Pharmaceutical Statistics: Practical and Clinical Applications, Fifth Edition provides the most complete and comprehensive guide to the various statistical applications and research issues in the pharmaceutical industry, particularly in clinical trials and bioequivalence studies.

Author : David S. Jones
Publisher : Pharmaceutical Press
Page : 612 pages
File Size : 40,6 Mb
Release : 2002
Category : Medical
ISBN : 0853694257

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Pharmaceutical Statistics by David S. Jones Pdf

Pharmaceutical Statistics is a new publication on basic statistics, specifically written for pharmacy students. It contains chapters on basic concepts such as types of data, graphical representation of data, distribution and standard deviation. More advanced, frequently used, statistical techniques such as ANOVA and the chi-squared test are also discussed using pharmaceutical examples. Pharmaceutical Statistics is essential reading for all pharmacy students and will also be of interest to those working in the pharmaceutical industry.

Author : C. Ralph Buncher,Jia-Yeong Tsay
Publisher : CRC Press
Page : 497 pages
File Size : 49,9 Mb
Release : 2019-03-07
Category : Mathematics
ISBN : 9781420056457

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Statistics In the Pharmaceutical Industry by C. Ralph Buncher,Jia-Yeong Tsay Pdf

The growth of the pharmaceutical industry over the past decade is astounding, but the impact of this growth on statistics is somewhat confusing. While software has made analysis easier and more efficient, regulatory bodies now demand deeper and more complex analyses, and pharmacogenetic/genomic studies serve up an entirely new set of challenges. For more than two decades, Statistics in the Pharmaceutical Industry has been the definitive guide to sorting through the challenges in the industry, and this Third Edition continues that tradition. Updated and expanded to reflect the most recent trends and developments in the field, Statistics in the Pharmaceutical Industry, Third Edition presents chapters written by experts from both regulatory agencies and pharmaceutical companies who discuss everything from experimental design to post-marketing studies. This approach sheds light on what regulators consider acceptable methodologies and what methods have proven successful for industrial statisticians. Both new and revised chapters reflect the increasingly global nature of the industry as represented by authors from Japan and Europe, the increasing trend toward non-inferiority/equivalence testing, adaptive design in clinical trials, global harmonization of regulatory standards, and multiple comparison studies. The book also examines the latest considerations in anti-cancer studies. Statistics in the Pharmaceutical Industry, Third Edition demystifies the approval process by combining regulatory and industrial points of view, making it a must-read for anyone performing statistical analysis at any point in the drug approval process.

Author : Charles Ralph Buncher,Jia-Yeong Tsay
Publisher : CRC Press
Page : 606 pages
File Size : 54,6 Mb
Release : 1993-11-17
Category : Mathematics
ISBN : 0824790731

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Statistics In the Pharmaceutical Industry, 3rd Edition by Charles Ralph Buncher,Jia-Yeong Tsay Pdf

This rewritten and updated second edition provides comprehensive information on the wide-ranging applications of statistics in the pharmacological field. Focusing on practical aspects, it sets out to bridge the gap between industry and academia.;Reflecting the changes that have taken place since publication of the first edition, this volume covers new topics such as: cancer clinical trials, clinical trials of AIDS patients and animal tumorigenicity studies; the development of antiepileptic drugs; the role of epidemiology in postmarketing trials and adverse drug experience; computer-assisted new drug application (CANDA) submissions; contract research organizations; interim analysis in clinical trials; and room-temperature tests for the stability of drugs.;This work is intended as: a reference for statisticians, biostatisticians, pharmacologists, administrators, managers, and scientists in the pharmaceutical industry; and a text for graduate students taking courses in applied statistics or pharmaceutical statistics.

Author : Richard K. Burdick,David J. LeBlond,Lori B. Pfahler,Jorge Quiroz,Leslie Sidor,Kimberly Vukovinsky,Lanju Zhang
Publisher : Springer
Page : 379 pages
File Size : 41,6 Mb
Release : 2017-02-14
Category : Medical
ISBN : 9783319501864

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Statistical Applications for Chemistry, Manufacturing and Controls (CMC) in the Pharmaceutical Industry by Richard K. Burdick,David J. LeBlond,Lori B. Pfahler,Jorge Quiroz,Leslie Sidor,Kimberly Vukovinsky,Lanju Zhang Pdf

This book examines statistical techniques that are critically important to Chemistry, Manufacturing, and Control (CMC) activities. Statistical methods are presented with a focus on applications unique to the CMC in the pharmaceutical industry. The target audience consists of statisticians and other scientists who are responsible for performing statistical analyses within a CMC environment. Basic statistical concepts are addressed in Chapter 2 followed by applications to specific topics related to development and manufacturing. The mathematical level assumes an elementary understanding of statistical methods. The ability to use Excel or statistical packages such as Minitab, JMP, SAS, or R will provide more value to the reader. The motivation for this book came from an American Association of Pharmaceutical Scientists (AAPS) short course on statistical methods applied to CMC applications presented by four of the authors. One of the course participants asked us for a good reference book, and the only book recommended was written over 20 years ago by Chow and Liu (1995). We agreed that a more recent book would serve a need in our industry. Since we began this project, an edited book has been published on the same topic by Zhang (2016). The chapters in Zhang discuss statistical methods for CMC as well as drug discovery and nonclinical development. We believe our book complements Zhang by providing more detailed statistical analyses and examples.

Author : Philip Rowe
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 54,5 Mb
Release : 2015-07-20
Category : Medical
ISBN : 9781118913406

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Essential Statistics for the Pharmaceutical Sciences by Philip Rowe Pdf

Essential Statistics for the Pharmaceutical Sciences is targeted at all those involved in research in pharmacology, pharmacy or other areas of pharmaceutical science; everybody from undergraduate project students to experienced researchers should find the material they need. This book will guide all those who are not specialist statisticians in using sound statistical principles throughout the whole journey of a research project - designing the work, selecting appropriate statistical methodology and correctly interpreting the results. It deliberately avoids detailed calculation methodology. Its key features are friendliness and clarity. All methods are illustrated with realistic examples from within pharmaceutical science. This edition now includes expanded coverage of some of the topics included in the first edition and adds some new topics relevant to pharmaceutical research. a clear, accessible introduction to the key statistical techniques used within the pharmaceutical sciences all examples set in relevant pharmaceutical contexts. key points emphasised in summary boxes and warnings of potential abuses in ‘pirate boxes’. supplementary material - full data sets and detailed instructions for carrying out analyses using packages such as SPSS or Minitab – provided at www.ljmu.ac.uk/pbs/rowestats/ An invaluable introduction to statistics for any science student and an essential text for all those involved in pharmaceutical research at whatever level.

Author : Sanford Bolton
Publisher : Unknown
Page : 680 pages
File Size : 53,7 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015017972749

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Pharmaceutical Statistics by Sanford Bolton Pdf

Author : James E. De Muth
Publisher : Springer
Page : 245 pages
File Size : 51,6 Mb
Release : 2019-12-19
Category : Medical
ISBN : 3030339882

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Practical Statistics for Pharmaceutical Analysis by James E. De Muth Pdf

This is an introductory statistics book designed to provide scientists with practical information needed to apply the most common statistical tests to laboratory research data. The book is designed to be practical and applicable, so only minimal information is devoted to theory or equations. Emphasis is placed on the underlying principles for effective data analysis and survey the statistical tests. It is of special value for scientists who have access to Minitab software. Examples are provides for all the statistical tests and explanation of the interpretation of these results presented with Minitab (similar to results for any common software package). The book is specifically designed to contribute to the AAPS series on advances in the pharmaceutical sciences. It benefits professional scientists or graduate students who have not had a formal statistics class, who had bad experiences in such classes, or who just fear/don’t understand statistics. Chapter 1 focuses on terminology and essential elements of statistical testing. Statistics is often complicated by synonyms and this chapter established the terms used in the book and how rudiments interact to create statistical tests. Chapter 2 discussed descriptive statistics that are used to organize and summarize sample results. Chapter 3 discussed basic assumptions of probability, characteristics of a normal distribution, alternative approaches for non-normal distributions and introduces the topic of making inferences about a larger population based on a small sample from that population. Chapter 4 discussed hypothesis testing where computer output is interpreted and decisions are made regarding statistical significance. This chapter also deasl with the determination of appropriate sample sizes. The next three chapters focus on tests that make decisions about a population base on a small subset of information. Chapter 5 looks at statistical tests that evaluate where a significant difference exists. In Chapter 6 the tests try to determine the extent and importance of relationships. In contrast to fifth chapter, Chapter 7 presents tests that evaluate the equivalence, not the difference between levels being tested. The last chapter deals with potential outlier or aberrant values and how to statistically determine if they should be removed from the sample data. Each statistical test presented includes an example problem with the resultant software output and how to interpret the results. Minimal time is spent on the mathematical calculations or theory. For those interested in the associated equations, supplemental figures are presented for each test with respective formulas. In addition, Appendix D presents the equations and proof for every output result for the various examples. Examples and results from the appropriate statistical results are displayed using Minitab 18Ò. In addition to the results, the required steps to analyze data using Minitab are presented with the examples for those having access to this software. Numerous other software packages are available, including based data analysis with Excel.

Author : Antoine Al-Achi
Publisher : Cambridge Scholars Publishing
Page : 607 pages
File Size : 44,9 Mb
Release : 2022-10-13
Category : Mathematics
ISBN : 9781527588592

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A Review of Statistical Methods for Medical and Allied Health Professionals by Antoine Al-Achi Pdf

Statistics is a subject that benefits many other disciplines in its application and has contributed tremendously to the advancement of medicine. In recognition of the central role of statistics in the health fields, certification agencies have incorporated this science into their requirements for knowledge acquisition by their members. This recognition is also reflected in the board exams, particularly those taken for clinical board specialty certification tests. This book reinforces statistical principles for those who have taken a course in the subject during their years of education. It provides many examples and exercises to allow the reader to review the material discussed. Its concise presentation and the repetition of ideas throughout the text help solidify the reader’s learning and retention of knowledge of the various topics presented.

Author : Alex Dmitrienko,Ajit C. Tamhane,Frank Bretz
Publisher : CRC Press
Page : 323 pages
File Size : 53,6 Mb
Release : 2009-12-08
Category : Mathematics
ISBN : 9781584889854

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Multiple Testing Problems in Pharmaceutical Statistics by Alex Dmitrienko,Ajit C. Tamhane,Frank Bretz Pdf

Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c