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Author : Weili Fu,Yin Fang,Chao Zhao,Dong Jiang
Publisher : Frontiers Media SA
Page : 298 pages
File Size : 52,8 Mb
Release : 2022-10-06
Category : Science
ISBN : 9782832501740
Author : Dan Heller
Publisher : States Academic Press
Page : 0 pages
File Size : 47,5 Mb
Release : 2023-09-26
Category : Health & Fitness
ISBN : 1639897917
Bone diseases refer to a group of diseases or injuries that affect human bones, which lead to abnormalities of the human skeletal system. Abnormal stress on bone, metabolic bone diseases, deficient blood supply to bone, bone tumor, infectious diseases of bone and fractures are a few major types of bone diseases. Lack of physical activity has a profound impact on the bone tissue because of lower level of mechanical stimulus that aids in bone formation. Metabolic bone diseases are a result of inadequate supply of amino acids for the production of collagen, calcium and phosphate. There are several therapeutic and corrective measures to treat bone diseases. One such measure is anthroplasty that helps in restoration of normal joint motion in rheumatoid arthritis of the elbow or hip. Bone transplantation targets stimulation of bone formation that provides structural support until a defect gets bridged by new bone. This book includes contributions of experts and scientists which will provide innovative insights on the translational research and its clinical applications in the treatment of bone diseases. Coherent flow of topics, student-friendly language, and extensive use of examples make this book an invaluable source of knowledge.
Author : Beth A. Winkelstein
Publisher : CRC Press
Page : 637 pages
File Size : 53,6 Mb
Release : 2012-12-18
Category : Medical
ISBN : 9781439860946
Given the strong current attention of orthopaedic, biomechanical, and biomedical engineering research on translational capabilities for the diagnosis, prevention, and treatment of clinical disease states, the need for reviews of the state-of-art and current needs in orthopaedics is very timely. Orthopaedic Biomechanics provides an in-depth review o
Author : Jennifer J. Westendorf,Andre J. Van Wijnen
Publisher : Unknown
Page : 214 pages
File Size : 50,6 Mb
Release : 2014
Category : Biomedicine
ISBN : 149391619X
In Osteoporosis and Osteoarthritis expert investigators detail modern tools to enhance discovery in bone and cartilage biology and promote translational research in osteoporosis and osteoarthritis. New chapters describe methods to generate induced pluripotent stem cells, perform high-throughput chromatin analysis, assess loads on bone cells in vivo and in vitro, use state-of-the art imaging techniques to measure articular cartilage thickness and biochemical properties, and establish animal models of osteoarthritis and bone healing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Osteoporosis and Osteoarthritis shares successful techniques that can be applied to the study of either disease.
Author : Felix Bronner,Mary C. Farach-Carson,Antonios G. Mikos
Publisher : Springer Science & Business Media
Page : 191 pages
File Size : 46,9 Mb
Release : 2007-03-14
Category : Medical
ISBN : 9781846283666
This is the 3rd volume in a series of reviews centered on the single major topic of bone replacement, discussing the biology of stem cells and cell signals, the knowledge needed to make stem cell-engineered bone tissue a reality, and how to prevent bone allograft infection. Useful as a followup to its predecessors, and as a stand-alone reference, it will interest a broad audience from orthopedists and bioengineers to dentists.
Author : Mehdi Razavi
Publisher : Academic Press
Page : 290 pages
File Size : 48,6 Mb
Release : 2020-05-09
Category : Science
ISBN : 9780128202630
Nanoengineering in Musculoskeletal Regeneration provides the reader an updated summary of the therapeutic pipeline—from biomedical discovery to clinical implementation—aimed at improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus, and bone. Regenerative medicine focuses on using stem cell biology to advance medical therapies for devastating disorders. This text presents novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in musculoskeletal regeneration. Content includes basic, translational, and clinical research addressing musculoskeletal repair and regeneration for the treatment of diseases and injuries of the skeleton and its associated tissues. Musculoskeletal degeneration and complications from injuries have become more prevalent as people live longer and increasingly participate in rigorous athletic and recreational activities. Additionally, defects in skeletal tissues may immobilize people and cause inflammation and pain. Musculoskeletal regeneration research provides solutions to repair, restore, or replace skeletal elements and associated tissues that are affected by acute injury, chronic degeneration, genetic dysfunction, and cancer-related defects. The goal of musculoskeletal regeneration medicine research is to improve quality of life and outcomes for people with musculoskeletal injury or degradation. Provides broad coverage in all research areas focused on the applications of nanotechnology in musculoskeletal regeneration Offers useful guidance for physician-scientists with expertise in orthopedics, regenerative medicine, bioengineering, biomaterials, nanoengineering, stem cell biology, and chemistry Serves as a practical reference for many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, musculoskeletal regenerative medicine, and nanomedicine
Author : Beata Lecka-Czernik,John L. Fowlkes
Publisher : Springer
Page : 241 pages
File Size : 44,7 Mb
Release : 2015-10-12
Category : Medical
ISBN : 9783319164021
Providing the most up-to-date research and current clinical knowledge of diabetic bone disease and the challenges still facing the research and clinical care communities, this book unites insights from endocrinology and orthopedics to create a truly unique text. The first part covers clinical and pre-clinical applications and research. The first two chapters present the clinical and epidemiological data about diabetic bone disease, evaluated and reviewed for type 1 and type 2, respectively. This is followed by discussions of how the propensity to fracture in diabetic bone disease can impact fracture risk assessments and how it can be adjusted for using current clinically relevant fracture risk models. A comprehensive overview of orthopedic complications observed in diabetes is next, as well as a focus on the consequences of diabetes on periodontal disease. Other topics include the utility of skeletal biomarkers in assessing diabetic bone disease, how drugs used to treat diabetes may also have skeletal consequences, and the possibility that diabetes may fundamentally impact early progenitor cells of various bone lineages and thus globally impact bone. The second part covers biomechanics and bone quality in diabetes: how diabetes ultimately may impact the architecture, integrity, and quality of bone. Utilizing the expertise of top researcher and clinicians in diabetic bone disease in one comprehensive text, this volume will be a useful and thought-provoking resource for endocrinologists and orthopedic surgeons alike.
Author : Deming Jiang,Ahmed H.K. El-Hashash
Publisher : Elsevier
Page : 246 pages
File Size : 41,9 Mb
Release : 2023-01-27
Category : Science
ISBN : 9780323919388
Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside. Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases. Provides cutting-edge research needed to understand stem cell functions in joint and bone diseases Develops processes to bring stem cells from bench to bedside Includes up-to-date references on stem cell biology and function in the joint and bone
Author : Javaid Kassim,Paul Sponseller
Publisher : Academic Press
Page : 0 pages
File Size : 46,8 Mb
Release : 2013-09-11
Category : Medical
ISBN : 0123971659
Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI.
Author : Anna Lange-Consiglio,Charlotte Riviere,V. Prasad Shastri,Amiq Gazdhar
Publisher : Frontiers Media SA
Page : 151 pages
File Size : 42,9 Mb
Release : 2023-03-27
Category : Science
ISBN : 9782832518878
Author : Mark Gray,Abirami Kugadas,Stefano Guido
Publisher : Frontiers Media SA
Page : 161 pages
File Size : 43,8 Mb
Release : 2023-03-30
Category : Medical
ISBN : 9782832519325
Author : Frederick M Azar
Publisher : Elsevier Health Sciences
Page : 128 pages
File Size : 50,7 Mb
Release : 2019-05-15
Category : Medical
ISBN : 9780323682589
Guest edited by Drs. Jonathan Kay and Sergio Schwartzman, this issue of Rheumatic Disease Clinics will cover Controversies in Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman of Cedars-Sinai. Articles explore several questions, including, but not limited to: Is triple therapy or methotrexate plus a biologic the initial treatment of choice for RA patients; Is hypo or hyper-uricemia a risk requiring treatment for cardiac morbidity and mortality; Are there benefits and risks to biosimilars from a patient perspective; Should platelet-rich plasma be used to treat osteoarthritis; Is there a role for stem cell therapy to treat cartilage defects in osteoarthritis; Should any rheumatology patient, today, be treated with bone marrow ablation and stem cell transplantation; Is there effective prevention, prophylaxis, or treatment for CPPD arthritis; Is fibromyalgia a psychiatric disease or a pain syndrome; Should cyclophosphamide still be used to treat ANCA-associated vasculitis; Does methotrexate have a place in the treatment of psoriatic arthritis; Should hydroxychloroquine dosing be limited because of potential ocular toxicity; and Should generalized immunosuppression or targeted organ treatment be the best principle for overall management of SLE.
Author : Liqiang Wang,Lechun Xie,Daixiu Wei
Publisher : Frontiers Media SA
Page : 158 pages
File Size : 46,7 Mb
Release : 2022-11-14
Category : Science
ISBN : 9782832505502
Author : Jeffrey A. Bakal,Jack M. Haglin,Joseph Abboud,Joseph J. Crisco,Adam E.M. Eltorai
Publisher : Elsevier
Page : 580 pages
File Size : 50,9 Mb
Release : 2024-04-26
Category : Science
ISBN : 9780323885621
Translational Orthopedics: Designing and Conducting Translational Research covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control study, prospective cohort study, randomized trial, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in translational orthopedics, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in translational orthopedics, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every Medical Researcher or Orthopedist who has ever had a good clinical idea but not the knowledge of how to test it. Focuses on the principles of evidence-based medicine and applies these principles to the design of translational investigations within orthopedics Provides a practical, straightforward approach that helps investigators navigate challenging considerations in study design and implementation Details discussions of the critical appraisal of published studies in translational orthopedics, supporting evaluation with respect to measuring outcomes and making effective use of all types of evidence in patient care
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Committee on Temporomandibular Disorders (TMDs): From Research Discoveries to Clinical Treatment
Publisher : National Academies Press
Page : 427 pages
File Size : 49,6 Mb
Release : 2020-07-01
Category : Medical
ISBN : 9780309670487
Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.