Biofabrication And 3d Tissue Modeling

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Biofabrication and 3D Tissue Modeling

Dong-Woo Cho
Biofabrication and 3D Tissue Modeling Book PDF

Author : Dong-Woo Cho
Publisher : Royal Society of Chemistry
Page : 369 pages
File Size : 48,8 Mb
Release : 2019-01-02
Category : Technology & Engineering
ISBN : 9781788011983

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Biofabrication and 3D Tissue Modeling by Dong-Woo Cho Pdf

3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

3D Bioprinting

Dong-Woo Cho,Byoung Soo Kim,Jinah Jang,Ge Gao,Wonil Han,Narendra K. Singh
3D Bioprinting Book PDF

Author : Dong-Woo Cho,Byoung Soo Kim,Jinah Jang,Ge Gao,Wonil Han,Narendra K. Singh
Publisher : Springer Nature
Page : 124 pages
File Size : 42,9 Mb
Release : 2019-12-04
Category : Medical
ISBN : 9783030322229

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3D Bioprinting by Dong-Woo Cho,Byoung Soo Kim,Jinah Jang,Ge Gao,Wonil Han,Narendra K. Singh Pdf

This text advances fundamental knowledge in modeling in vitro tissues/organs as an alternative to 2D cell culture and animal testing. Prior to engineering in vitro tissues/organs,the descriptions of prerequisites (from pre-processing to post-processing) in modeling in vitro tissues/organs are discussed. The most prevalent technologies that have been widely used for establishing the in vitro tissue/organ models are also described, including transwell, cell spheroids/sheets, organoids, and microfluidic-based chips. In particular, the authors focus on 3D bioprinting in vitro tissue/organ models using tissue-specific bioinks. Several representative bioprinting methods and conventional bioinks are introduced. As a bioink source, decellularized extracellular matrix (dECM) are importantly covered, including decellularization methods, evaluation methods for demonstrating successful decellularization, and material safety. Taken together, the authors delineate various application examples of 3D bioprinted in vitro tissue/organ models especially using dECM bioinks.

Engineering 3D Tissue Test Systems

Karen J.L. Burg,Didier Dréau,Timothy Burg
Engineering 3D Tissue Test Systems Book PDF

Author : Karen J.L. Burg,Didier Dréau,Timothy Burg
Publisher : CRC Press
Page : 638 pages
File Size : 53,8 Mb
Release : 2017-07-28
Category : Medical
ISBN : 9781351644549

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Engineering 3D Tissue Test Systems by Karen J.L. Burg,Didier Dréau,Timothy Burg Pdf

Engineering 3D Tissue Test Systems provides an introduction to, and unique coverage of, a rapidly evolving area in biomaterials engineering. It reveals the current and future research responses, the current and future diagnostic applications, and provides a comprehensive overview to foster innovation. It offers insight into the importance of 3D systems and their use as benchtop models, spanning applications from basic scientific research to clinical diagnostics. Methods and limitations of building 3D tissue structures are evaluated, with attention given to the cellular, polymeric, and fabrication instrumentation components. The book covers the important aspects of polymeric tissue test systems, highlighting the needs and constraints of the industry, and includes a chapter on regulatory and pricing issues.

Biofabrication and 3D Tissue Modeling

Dong-Woo Cho
Biofabrication and 3D Tissue Modeling Book PDF

Author : Dong-Woo Cho
Publisher : Royal Society of Chemistry
Page : 369 pages
File Size : 45,7 Mb
Release : 2019-01-02
Category : Technology & Engineering
ISBN : 9781788016643

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Biofabrication and 3D Tissue Modeling by Dong-Woo Cho Pdf

3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

Essentials of 3D Biofabrication and Translation

Anthony Atala,James J Yoo
Essentials of 3D Biofabrication and Translation Book PDF

Author : Anthony Atala,James J Yoo
Publisher : Academic Press
Page : 440 pages
File Size : 49,7 Mb
Release : 2015-07-17
Category : Science
ISBN : 9780128010150

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Essentials of 3D Biofabrication and Translation by Anthony Atala,James J Yoo Pdf

Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

Biofabrication

Joydip Kundu,Falguni Pati,Young Hun Jeong,Dong-Woo Cho
Biofabrication Book PDF

Author : Joydip Kundu,Falguni Pati,Young Hun Jeong,Dong-Woo Cho
Publisher : Elsevier Inc. Chapters
Page : 288 pages
File Size : 47,9 Mb
Release : 2013-03-18
Category : Medical
ISBN : 9780128090497

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Biofabrication by Joydip Kundu,Falguni Pati,Young Hun Jeong,Dong-Woo Cho Pdf

Biomaterials have advanced from merely interacting with the body to controlling biological processes toward the goal of tissue regeneration. In order to reconstitute a new tissue or repair a damaged/diseased tissue, three components are critical for regenerative medicine or tissue engineering: cells, biomaterials as scaffold substrates, and growth factors. Thus, the design and selection of materials and the methods used for scaffold fabrication play a very important role in tissue engineering and regenerative medicine. Recent developments in biofabrication strategies have created enormous possibilities for the construction of biomimetic 3D scaffolds, where well-defined architectures can be generated with suitable surface chemistry using appropriate materials. This chapter summarizes the materials used for the fabrication of scaffolds, the different types of scaffold manufacturing processes, and the basics of the various tissue-specific scaffolds used in regenerative medicine.

3D Printing and Biofabrication

Aleksandr Ovsianikov,James Yoo,Vladimir Mironov
3D Printing and Biofabrication Book PDF

Author : Aleksandr Ovsianikov,James Yoo,Vladimir Mironov
Publisher : Springer
Page : 0 pages
File Size : 46,7 Mb
Release : 2018-06-08
Category : Science
ISBN : 3319454439

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3D Printing and Biofabrication by Aleksandr Ovsianikov,James Yoo,Vladimir Mironov Pdf

This volume provides an in-depth introduction to 3D printing and biofabrication and covers the recent advances in additive manufacturing for tissue engineering. The book is divided into two parts, the first part on 3D printing discusses conventional approaches in additive manufacturing aimed at fabrication of structures, which are seeded with cells in a subsequent step. The second part on biofabrication presents processes which integrate living cells into the fabrication process.

Tissue Engineering

Paulo Rui Fernandes,Paulo Jorge Bartolo
Tissue Engineering Book PDF

Author : Paulo Rui Fernandes,Paulo Jorge Bartolo
Publisher : Springer Science & Business Media
Page : 191 pages
File Size : 45,6 Mb
Release : 2013-07-31
Category : Technology & Engineering
ISBN : 9789400770737

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Tissue Engineering by Paulo Rui Fernandes,Paulo Jorge Bartolo Pdf

This book describes the state of the art on computational modeling and fabrication in Tissue Engineering. It is inspired by the ECCOMAS thematic conference, the European Committee on Computational Methods in Applied Sciences, on Tissue Engineering, held in Lisbon, Portugal, June 2-4, 2011. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. Emphasis is put on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.

Kenzan Method for Scaffold-Free Biofabrication

Koichi Nakayama
Kenzan Method for Scaffold Free Biofabrication Book PDF

Author : Koichi Nakayama
Publisher : Springer Nature
Page : 186 pages
File Size : 40,6 Mb
Release : 2021-01-22
Category : Technology & Engineering
ISBN : 9783030586881

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Kenzan Method for Scaffold-Free Biofabrication by Koichi Nakayama Pdf

This is the first book about the “Kenzan” method for scaffold-free biofabrication, which does not rely on biomaterials as scaffolds to ensure correct multicellular spheroid positioning for building three dimensional construct only made from cells. The book explains the basic principles and concepts of the microneedle-based (“Kenzan”) method of building surgically-implantable tissue constructs using robotic cell spheroid-based three-dimensional bioprinting, a novel technology that opens up unique opportunities for the bioengineering of tissues and organs. First book on the novel Kenzan method of tissue engineering; Explains basic concepts and applications for organ regeneration modeling; Introduces a unique robotic system for scaffold-free cell construction.

3D Bioprinting

Ibrahim Tarik Ozbolat
3D Bioprinting Book PDF

Author : Ibrahim Tarik Ozbolat
Publisher : Academic Press
Page : 356 pages
File Size : 47,6 Mb
Release : 2016-11-21
Category : Technology & Engineering
ISBN : 9780128030301

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3D Bioprinting by Ibrahim Tarik Ozbolat Pdf

3D Bioprinting: Fundamentals, Principles and Applications provides the latest information on the fundamentals, principles, physics, and applications of 3D bioprinting. It contains descriptions of the various bioprinting processes and technologies used in additive biomanufacturing of tissue constructs, tissues, and organs using living cells. The increasing availability and decreasing costs of 3D printing technologies are driving its use to meet medical needs, and this book provides an overview of these technologies and their integration. Each chapter discusses current limitations on the relevant technology, giving future perspectives. Professor Ozbolat has pulled together expertise from the fields of bioprinting, tissue engineering, tissue fabrication, and 3D printing in his inclusive table of contents. Topics covered include raw materials, processes, machine technology, products, applications, and limitations. The information in this book will help bioengineers, tissue and manufacturing engineers, and medical doctors understand the features of each bioprinting process, as well as bioink and bioprinter types. In addition, the book presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics. Describes all aspects of the bioprinting process, from bioink processing through design for bioprinting, bioprinting techniques, bioprinter technologies, organ printing, applications, and future trends Provides a detailed description of each bioprinting technique with an in-depth understanding of its process modeling, underlying physics and characteristics, suitable bioink and cell types printed, and major accomplishments achieved thus far Explains organ printing technology in detail with a step-by-step roadmap for the 3D bioprinting of organs from isolating stem cells to the post-transplantation of organs Presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics

3D Bioprinting in Medicine

Murat Guvendiren
3D Bioprinting in Medicine Book PDF

Author : Murat Guvendiren
Publisher : Springer
Page : 209 pages
File Size : 52,7 Mb
Release : 2019-08-02
Category : Medical
ISBN : 9783030239060

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3D Bioprinting in Medicine by Murat Guvendiren Pdf

This book provides current and emerging developments in bioprinting with respect to bioprinting technologies, bioinks, applications, and regulatory pathways. Topics covered include 3D bioprinting technologies, materials such as bioinks and bioink design, applications of bioprinting complex tissues, tissue and disease models, vasculature, and musculoskeletal tissue. The final chapter is devoted to clinical applications of bioprinting, including the safety, ethical, and regulatory aspects. This book serves as a go-to reference on bioprinting and is ideal for students, researchers and professionals, including those in academia, government, the medical industry, and healthcare.

3D Bioprinting

Jeremy M. Crook
3D Bioprinting Book PDF

Author : Jeremy M. Crook
Publisher : Springer Nature
Page : 264 pages
File Size : 52,6 Mb
Release : 2020-03-23
Category : Science
ISBN : 9781071605202

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3D Bioprinting by Jeremy M. Crook Pdf

This volume explores the latest developments and contributions to the field of 3D bioprinting, and discusses its use for quality R&D and translation. The chapters in this book are divided into two parts: Part one covers generic themes in bioprinting to introduce novice readers to the field, while also providing experts with new and helpful information. Part two discusses protocols used to prepare, characterize, and print a variety of biomaterials, cells, and tissues. These chapters also emphasize methods used for printing defined and humanized constructs suitable for human tissue modelling in research and applicable to clinical product development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, 3D Bioprinting: Methods and Protocols is a valuable resource for researchers and bioprinting laboratories/facilities interested in learning more about this rapidly evolving technology.

Biofabrication

Bertrand Guillotin,Muhammad Ali,Alexandre Ducom,Sylvain Catros,Virginie Keriquel,Agnès Souquet,Murielle Remy,Jean-Christophe Fricain,Fabien Guillemot
Biofabrication Book PDF

Author : Bertrand Guillotin,Muhammad Ali,Alexandre Ducom,Sylvain Catros,Virginie Keriquel,Agnès Souquet,Murielle Remy,Jean-Christophe Fricain,Fabien Guillemot
Publisher : Elsevier Inc. Chapters
Page : 288 pages
File Size : 40,5 Mb
Release : 2013-03-18
Category : Medical
ISBN : 9780128090534

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Biofabrication by Bertrand Guillotin,Muhammad Ali,Alexandre Ducom,Sylvain Catros,Virginie Keriquel,Agnès Souquet,Murielle Remy,Jean-Christophe Fricain,Fabien Guillemot Pdf

Laser-assisted bioprinting (LAB) is an emerging technology in the field of tissue engineering. Its physical mechanism makes it possible to print cells and liquid materials with a cell-level resolution. By giving tissue engineers control over cell density and organization of 3D tissue constructs, LAB holds much promise for fabricating living tissues with physiological functionality. After introducing the rationale of applying LAB to tissue engineering, we present exhaustively the physical parameters related to the laser-induced forward transfer technique (LIFT), which is implemented in LAB. These parameters are critical to controlling the cell printing process and must work together to print viable cell patterns with respect to cell-level histological organization and to high-throughput manufacturing. After describing the experimental requirements that should be considered to fabricate 3D tissues by LAB, we present some of the main breakthroughs, including multicomponent printing, 3D printing approaches, and bioprinting in vivo that may serve in tissue engineering and regenerative medicine.

Self-Organized 3D Tissue Patterns

Xiaolu Zhu,Zheng Wang
Self Organized 3D Tissue Patterns Book PDF

Author : Xiaolu Zhu,Zheng Wang
Publisher : CRC Press
Page : 142 pages
File Size : 43,7 Mb
Release : 2022-05-26
Category : Science
ISBN : 9781000400847

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Self-Organized 3D Tissue Patterns by Xiaolu Zhu,Zheng Wang Pdf

Therapies for regenerating damaged tissue and organs have been attracting much attention. In order to efficiently regenerate the functions of living tissue and organs, diverse attempts have been made to utilize scaffolds to “mold” artificial tissue structures. However, the structural complexity of reconstituted tissue is limited by the mechanical precision of scaffolds, which still cause problems arising from their degradation, immunogenic reactions, and so forth. It is also being realized that ultimately the best approach might be to rely on the innate self-organizing properties of cells and the regenerative capability of the organism itself. This book investigates the 3D-pattern formation and evolution mechanism in multipotent cells embedded in 3D semi-synthetic hydrogels and the control methodology for self-organized patterns. The authors theoretically and experimentally demonstrate several types of topological 3D-pattern formation by cells in a 3D matrix in vitro, which can be modeled and predicted by mathematical models based on the reaction-diffusion dynamics of various chemical, physical, and mechanical cues. The study, focused on the 3D pattern formation of cells, provides (i) a unique perspective for understanding the self-organized 3D tissue structures based on Turing instability, (ii) the scheme for rationally controlling the cellular self-organization via exogenous factors or tailored inner interfaces inside hydrogels, and (iii) the elaborate and sophisticated regulating method for tuning collective cellular behaviors in 3D matrices.

Bioprinting in Regenerative Medicine

Kursad Turksen
Bioprinting in Regenerative Medicine Book PDF

Author : Kursad Turksen
Publisher : Springer
Page : 140 pages
File Size : 44,9 Mb
Release : 2015-09-02
Category : Science
ISBN : 9783319213866

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Bioprinting in Regenerative Medicine by Kursad Turksen Pdf

This volume presents the current state of laser-assisted bioprinting, a cutting edge tissue engineering technology. Nineteen chapters discuss the most recent developments in using this technology for engineering different types of tissue. Beginning with an overview, the discussion covers bioprinting in cell viability and pattern viability, tissue microfabrication to study cell proliferation, microenvironment for controlling stem cell fate, cell differentiation, zigzag cellular tubes, cartilage tissue engineering, osteogenesis, vessel substitutes, skin tissue and much more. Because bioprinting is on its way to becoming a dominant technology in tissue-engineering, Bioprinting in Regenerative Medicine is essential reading for those researching or working in regenerative medicine, tissue engineering or translational research. Those studying or working with stem cells who are interested in the development of the field will also find the information invaluable.