Biologic Markers In Urinary Toxicology

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Subcommittee on Biologic Markers in Urinary Toxicology
Publisher : National Academies Press
Page : 322 pages
File Size : 45,8 Mb
Release : 1995-08-28
Category : Science
ISBN : 9780309052283

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Biologic Markers in Urinary Toxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Subcommittee on Biologic Markers in Urinary Toxicology Pdf

Diseases of the kidney, bladder, and prostate exact an enormous human and economic toll on the population of the United States. This book examines prevention of these diseases through the development of reliable markers of susceptibility, exposure, and effect and the promise that new technologies in molecular biology and sophisticated understanding of metabolic pathways, along with classical approaches to the study of nephrotoxicants and carcinogens, can be developed and prevention of the diseases achieved. The specific recommendations included in this book complement those made in the previous three volumes on biomarkers, Biologic Markers in Reproductive Toxicology (1989), Biologic Markers in Pulmonary Toxicology (1989), and Biologic Markers in Immunotoxicology (1991).

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Reproductive and Neurodevelopmental Toxicology
Publisher : National Academies Press
Page : 424 pages
File Size : 54,5 Mb
Release : 1989-02-01
Category : Social Science
ISBN : 0309039797

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Biologic Markers in Reproductive Toxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Reproductive and Neurodevelopmental Toxicology Pdf

Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.

Author : National Research Council (U.S.). Subcommittee on Reproductive and Neurodevelopmental Toxicology
Publisher : Routledge
Page : 424 pages
File Size : 55,8 Mb
Release : 1989
Category : Medical
ISBN : NAP:13847

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Biologic Markers in Reproductive Toxicology by National Research Council (U.S.). Subcommittee on Reproductive and Neurodevelopmental Toxicology Pdf

Author : Curtis C. Travis
Publisher : Springer
Page : 286 pages
File Size : 54,8 Mb
Release : 1993-09-30
Category : Medical
ISBN : 9780306445392

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Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants by Curtis C. Travis Pdf

Biological markers (biomarkers) are useful tools for understanding the nature and extent of human exposure and risk from environmental toxicants. Biomarkers are classified into three basic categories: exposure, effect, or susceptibility. A marker of exposure is the product of the interaction between a target cell or molecule and a foreign substance (NAS, 1989). These markers can be used to determine the biologically effective dose necessary to elicit a particular physiological change in an organism. A marker of effect is a biochemical or physiological change in an organism that can predict the onset of adverse health effects resulting from a given exposure. Lastly, markers of susceptibility act as indicators of an inherent or acquired tendency of an organism to experience an adverse health effect (NAS, 1989). These markers are already used to detect a variety of diseases and show great promise for developing a better understanding of the mechanicisms of disease. Additionally, biomarkers can be used to establish a more rational basis for quantitative risk extrapolation between species, as weIl as to obtain more precise estimates of the time of critical exposure. These markers can also prove helpful in identifying potentially damaging exposures before the onset of adverse health effects. Biomarkers serve as a valuable exposure assessment tool because they take into account exposure from all routes and integrate exposure from all sources. They have the potential to yield better risk estimates than current monitoring and modeling protocols. In lune 1992, Dr. Travis and Dr.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on National Monitoring of Human Tissues
Publisher : National Academies Press
Page : 224 pages
File Size : 54,9 Mb
Release : 1991-02-01
Category : Science
ISBN : 9780309044370

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Monitoring Human Tissues for Toxic Substances by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on National Monitoring of Human Tissues Pdf

The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants
Publisher : National Academies Press
Page : 316 pages
File Size : 48,8 Mb
Release : 2006-10-30
Category : Science
ISBN : 9780309133906

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Human Biomonitoring for Environmental Chemicals by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants Pdf

Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 49,6 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Philip Wexler
Publisher : Academic Press
Page : 953 pages
File Size : 53,8 Mb
Release : 2000
Category : Medical
ISBN : 9780127447704

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Information Resources in Toxicology by Philip Wexler Pdf

History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...

Author : National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on the Review of Existing and Potential Standoff Explosives Detection Techniques
Publisher : National Academies Press
Page : 148 pages
File Size : 50,5 Mb
Release : 2004-05-14
Category : Technology & Engineering
ISBN : 9780309166034

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Existing and Potential Standoff Explosives Detection Techniques by National Research Council,Division on Earth and Life Studies,Board on Chemical Sciences and Technology,Committee on the Review of Existing and Potential Standoff Explosives Detection Techniques Pdf

Existing and Potential Standoff Explosives Detection Techniques examines the scientific techniques currently used as the basis for explosives detection and determines whether other techniques might provide promising research avenues with possible pathways to new detection protocols. This report describe the characteristics of explosives, bombs, and their components that are or might be used to provide a signature for exploitation in detection technology; considers scientific techniques for exploiting these characteristics to detect explosives and explosive devices; discusses the potential for integrating such techniques into detection systems that would have sufficient sensitivity without an unacceptable false-positive rate; and proposes areas for research that might be expected to yield significant advances in practical explosives and bomb detection technology in the near, mid, and long term.

Author : Anonim
Publisher : AIHA
Page : 112 pages
File Size : 44,8 Mb
Release : 2004
Category : Biological monitoring
ISBN : 9781931504515

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Biological Monitoring by Anonim Pdf

This guide covers the general basics of biological monitoring from the perspective of a field industrial hygienist and also constitutes a field manual for the trainee industrial hygienist. The guide is also suitable for undergraduate students because it contains a slide show and question and answer section: twenty case studies and 118-slide PowerPoint presentation on CD are included

Author : Barry L. Johnson
Publisher : CRC Press
Page : 503 pages
File Size : 43,7 Mb
Release : 2020-09-10
Category : Technology & Engineering
ISBN : 9781000157994

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Impact of Hazardous Waste on Human Health by Barry L. Johnson Pdf

The author of Impact of Hazardous Waste on Human Health is a public health official with the unique perspective that only insider status can provide. His book is intended for policy makers, environmentalists, toxicologists, public health officials, academic personnel, and health care providers. The author addresses six themes: hazardous waste issues must be more vigorously examined, site remediation is critical, risk management must extend beyond waste site clean up, disease prevention must be a priority, interagency partnership is mandatory, and the best technology must be applied. Johnson also considers the pros and cons of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) also known as the "Superfund." His years of experience with this law, and countless other issues related to hazardous waste, make Impact of Hazardous Waste on Human Health an important and positive contribution.

Author : Sudhir Srivastava,Donald Earl Henson,Adi F. Gazdar
Publisher : IOS Press
Page : 512 pages
File Size : 44,9 Mb
Release : 1999
Category : Cancer
ISBN : 9051993730

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Molecular Pathology of Early Cancer by Sudhir Srivastava,Donald Earl Henson,Adi F. Gazdar Pdf

This book describes the principles and the application of the existing molecular methodology for the detection of early cancer. Discussion focuses on the molecular changes characterizing preneoplastic lesions; molecular targets for early detection; validation of molecular targets; and new diagnostic technology for early detection. The advantages of molecular detection over current methods are examined, as well as the importance of identifying and characterizing preneoplastic lesions. In addition to the uses of highly specific molecular probes to detect early cancer, this book demonstrates the many ways in which molecular markers serve oncology. While meeting pressing needs in the practice of medicine, molecular detection of early cancer scientifically necessitates a confrontation with the biology of cancer, such as the genetic determinants of progression, regression, dormancy, and invasion. This work not only discusses the diagnostic value of these molecular methods but views their practical benefits against a background of conventional morphology.

Author : Marc E. de Broe,George A. Porter,William M. Bennett,G.A. Verpooten
Publisher : Springer Science & Business Media
Page : 475 pages
File Size : 52,5 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9789401590884

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Clinical Nephrotoxins by Marc E. de Broe,George A. Porter,William M. Bennett,G.A. Verpooten Pdf

GEORGE A. PORTER information is an international commodity whose The field of clinical nephrotoxicity involves toxins of interpretation and application are strongly influenced diverse origin and exposure. A significant contribution by both the cultural and ethnic background of the to this problem arises from registered and non-regis observer. The opportunity to share in the rich diversity tered drugs either prescribed or purchased over the of the international scientific community was a fun counter. Another major contributor comes from occu pational or industrial exposures. Each situation pre damental goal of this endeavor. To participate as sents the nephrologist with unique challenges con equals leads to mutual respect and peer appreciation. cerning diagnosis, confirrnation, and treatment includ The sharing of intellectual resources which such an ing limitation from future exposure. In selecting drugs effort fosters, should facilitate the advancement of for inclusions in this book the editors were guided by sound science. both frequency and current knowledge. For occupa Our approach to the field of nephrotoxicity is from tionall environmental exposures similar guidelines the perspective of a book which will be of value to the were applied. As one reviews the world's literature clinician. In this respect we have chosen compounds concerning nephrotoxicity two types of investigation wh ich are of current importance to the nephrologist and his/her patient rather than of historical interest.

Author : Jeanne Mager Stellman
Publisher : International Labour Organization
Page : 1232 pages
File Size : 54,9 Mb
Release : 1998
Category : Arbejdsmedicin
ISBN : 9221098141

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Encyclopaedia of Occupational Health and Safety by Jeanne Mager Stellman Pdf

Revised and expanded, this edition provides comprehensive coverage of occupational health and safety. A new CD-ROM version is available which provides the benefits of computer-assisted search capabilities

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Environmental Epidemiology
Publisher : National Academies Press
Page : 297 pages
File Size : 49,8 Mb
Release : 1991-01-01
Category : Science
ISBN : 9780309044967

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Environmental Epidemiology, Volume 1 by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Environmental Epidemiology Pdf

The amount of hazardous waste in the United States has been estimated at 275 million metric tons in licensed sites alone. Is the health of Americans at risk from exposure to this toxic material? This volume, the first of several on environmental epidemiology, reviews the available evidence and makes recommendations for filling gaps in data and improving health assessments. The book explores: Whether researchers can infer health hazards from available data. The results of substantial state and federal programs on hazardous waste dangers. The book presents the results of studies of hazardous wastes in the air, water, soil, and food and examines the potential of biological markers in health risk assessment. The data and recommendations in this volume will be of immediate use to toxicologists, environmental health professionals, epidemiologists, and other biologists.