Biological Chirality

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Biological Chirality

Gyula Palyi
Biological Chirality Book PDF

Author : Gyula Palyi
Publisher : Academic Press
Page : 268 pages
File Size : 49,9 Mb
Release : 2019-11-06
Category : Science
ISBN : 9780128123386

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Biological Chirality by Gyula Palyi Pdf

Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Progress in Biological Chirality

Gyula Palyi,Claudia Zucchi,Luciano Caglioti
Progress in Biological Chirality Book PDF

Author : Gyula Palyi,Claudia Zucchi,Luciano Caglioti
Publisher : Elsevier
Page : 445 pages
File Size : 43,5 Mb
Release : 2004-12-13
Category : Science
ISBN : 9780080474038

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Progress in Biological Chirality by Gyula Palyi,Claudia Zucchi,Luciano Caglioti Pdf

Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Advances in BioChirality

C. Zucchi,L. Caglioti,Gyula Palyi
Advances in BioChirality Book PDF

Author : C. Zucchi,L. Caglioti,Gyula Palyi
Publisher : Elsevier
Page : 417 pages
File Size : 55,5 Mb
Release : 1999-09-08
Category : Science
ISBN : 9780080526621

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Advances in BioChirality by C. Zucchi,L. Caglioti,Gyula Palyi Pdf

Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

Chiral Drugs

Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Chiral Drugs Book PDF

Author : Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
Publisher : John Wiley & Sons
Page : 469 pages
File Size : 52,9 Mb
Release : 2011-08-08
Category : Science
ISBN : 9781118075630

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Chiral Drugs by Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng Pdf

An integrated view of chiral drugs from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies asymmetric synthesis, biocatalytic process, and chiral resolution to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective and safer drugs.

Current Topics in Chirality

Takashiro Akitsu
Current Topics in Chirality Book PDF

Author : Takashiro Akitsu
Publisher : BoD – Books on Demand
Page : 198 pages
File Size : 52,6 Mb
Release : 2021-09-01
Category : Science
ISBN : 9781839689536

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Current Topics in Chirality by Takashiro Akitsu Pdf

Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.

Chirality and Biological Activity of Drugs

Roger J. Crossley
Chirality and Biological Activity of Drugs Book PDF

Author : Roger J. Crossley
Publisher : CRC Press
Page : 216 pages
File Size : 40,8 Mb
Release : 1995-09-11
Category : Medical
ISBN : 0849391407

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Chirality and Biological Activity of Drugs by Roger J. Crossley Pdf

This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Chirality in Biological Nanospaces

Nilashis Nandi
Chirality in Biological Nanospaces Book PDF

Author : Nilashis Nandi
Publisher : CRC Press
Page : 200 pages
File Size : 47,9 Mb
Release : 2011-07-27
Category : Medical
ISBN : 9781439840030

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Chirality in Biological Nanospaces by Nilashis Nandi Pdf

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reacti

Asymmetric Synthesis with Chemical and Biological Methods

Dieter Enders,Karl-Erich Jaeger
Asymmetric Synthesis with Chemical and Biological Methods Book PDF

Author : Dieter Enders,Karl-Erich Jaeger
Publisher : John Wiley & Sons
Page : 470 pages
File Size : 40,6 Mb
Release : 2007-06-27
Category : Science
ISBN : 9783527610631

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Asymmetric Synthesis with Chemical and Biological Methods by Dieter Enders,Karl-Erich Jaeger Pdf

Edited by two of the leading researchers in the field, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this continuously expanding area. A plethora of top German scientists with an international reputation covers various aspects, from classical organic chemistry to process development, and from the theoretical background to biological methods using enzymes. Throughout the focus is on the development of new synthetic methods in asymmetric synthesis, the synthesis of natural and bioactive compounds and the latest developments in both chemical and biological methods of catalysis, as well as the investigation of special technical and biotechnical aspects.

Chirality in Biological Nanospaces

Nilashis Nandi
Chirality in Biological Nanospaces Book PDF

Author : Nilashis Nandi
Publisher : CRC Press
Page : 212 pages
File Size : 43,7 Mb
Release : 2011-07-27
Category : Medical
ISBN : 9781439840023

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Chirality in Biological Nanospaces by Nilashis Nandi Pdf

Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Chirality and Biological Activity

Hartmut Frank,Bo Holmstedt,Bernard Testa
Chirality and Biological Activity Book PDF

Author : Hartmut Frank,Bo Holmstedt,Bernard Testa
Publisher : Wiley-Liss
Page : 312 pages
File Size : 52,8 Mb
Release : 1990
Category : Science
ISBN : UCAL:B4494559

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Chirality and Biological Activity by Hartmut Frank,Bo Holmstedt,Bernard Testa Pdf

Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.

Biochirality

Pedro Cintas
Biochirality Book PDF

Author : Pedro Cintas
Publisher : Springer
Page : 318 pages
File Size : 40,6 Mb
Release : 2014-07-08
Category : Science
ISBN : 9783642376269

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Biochirality by Pedro Cintas Pdf

Early History of the Recognition of Molecular Biochirality, by Joseph Gal, Pedro Cintas Synthesis and Chirality of Amino Acids Under Interstellar Conditions, by Chaitanya Giri, Fred Goesmann, Cornelia Meinert, Amanda C. Evans, Uwe J. Meierhenrich Chemical and Physical Models for the Emergence of Biological Homochirality, by son E. Hein, Dragos Gherase, Donna G. Blackmond Biomolecules at Interfaces: Chiral, Naturally, by Arántzazu González-Campo and David B. Amabilino Stochastic Mirror Symmetry Breaking: Theoretical Models and Simulation of Experiments, by Celia Blanco, David Hochberg Self-Assembly of Dendritic Dipeptides as a Model of Chiral Selection in Primitive Biological Systems, by Brad M. Rosen, Cécile Roche, Virgil Percec Chirality and Protein Biosynthesis, by Sindrila Dutta Banik, Nilashis Nandi

Asymmetry in Biological Homochirality

David Hochberg
Asymmetry in Biological Homochirality Book PDF

Author : David Hochberg
Publisher : MDPI
Page : 102 pages
File Size : 40,6 Mb
Release : 2021-06-04
Category : Science
ISBN : 9783036504421

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Asymmetry in Biological Homochirality by David Hochberg Pdf

Chirality, or handedness, is a fundamental physical characteristic, which spans the length scales ranging from elementary particles to the chiral asymmetry of spiral galaxies. The way in which chirality in chemistry, or molecular handedness, may have emerged in a primitive terrestrial environment, and how it can be triggered, amplified, and transferred, are deeply challenging problems rooted in both fundamental scientific interests and the technological potentials for science and society. Chirality constitutes a unifying feature of the living world and is a prime driving force for molecular selection and genetic evolution in biology. In this book, we offer a selection of five distinct approaches to this problem by leading experts in the field. The selected topics range from protein chirality and its relevance to protein ageing, protein aggregation and neurodegeneration, entropy production associated with chiral symmetry breaking in closed systems, chiral oscillations in polymerization models involving higher-order oligomers, the mirror symmetry breaking in liquids and its implications for the development of homochirality in abiogenesis, the role of chirality in the chemical sciences, and some philosophical implications of chirality.

Chiral Nanoprobes for Biological Applications

Chuanlai Xu
Chiral Nanoprobes for Biological Applications Book PDF

Author : Chuanlai Xu
Publisher : John Wiley & Sons
Page : 308 pages
File Size : 40,8 Mb
Release : 2022-05-16
Category : Technology & Engineering
ISBN : 9783527349425

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Chiral Nanoprobes for Biological Applications by Chuanlai Xu Pdf

A comprehensive overview exploring the biological applications of chiral nanomaterials Chirality has been the centerpiece of many multidisciplinary fields within the broader umbrella of the sciences. Recent advancements in nanoscience have spurred a growing interest in the dynamic field of chiral nanomaterials. In particular, the recent breakthroughs in chiral nanocrystals have presented an intriguing avenue whose potential application may address some key issues at the heart of nanosciences. While little attention has been focused on the biological implications of such advances, this arena is attracting theoretical and applicative interests. Seeking to provide a thorough introduction to the field as well as fill this gap in scholarship, Chiral Nanoprobes for Biological Applications first provides a comprehensive review of the state-of-the-art development of strong chiroptical nanomaterials, describing how a synthesis and self-assembly approach can enable one to design and create a number of functional chiral nanomaterials. From there, the authors discuss the biological applications of chiral nanomaterials, such as extracellular bioanalysis, intracellular bioanalysis, and chiral recognition, as well as photothermal and photodynamics therapy. In doing so, the book seeks emphasize the potential in multidisciplinary approaches to this up-and-coming field. Chiral Nanoprobes for Biological Applications readers will also find: A particular emphasis on milestones achieved for key chiral nanoprobes research from the last five years A discussion of future research directions A helpful guide for new researchers and established professionals alike Chiral Nanoprobes for Biological Applications is a useful reference for materials scientists, biochemists, protein chemists, stereo chemists, polymer chemists, and physical chemists. It is also a useful tool for libraries.

Chirality in Biological Nanospaces

Anonim
Chirality in Biological Nanospaces Book PDF

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 50,6 Mb
Release : 2011
Category : Electronic
ISBN : OCLC:754329633

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Chirality in Biological Nanospaces by Anonim Pdf

Chirality in Biological Nanospaces: Reactions in Active Sites.

Chirality in Supramolecular Assemblies

F. Richard Keene
Chirality in Supramolecular Assemblies Book PDF

Author : F. Richard Keene
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 53,7 Mb
Release : 2017-01-03
Category : Science
ISBN : 9781118867310

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Chirality in Supramolecular Assemblies by F. Richard Keene Pdf

Supramolecular chemistry deals with the organisation of molecules into defined assemblies using non-covalent interactions, including weaker and reversible interactions such as hydrogen bonds, and metal-ligand interactions. The aspect of stereochemistry within such chemical architectures, and in particular chirality, is of special interest as it impacts on considerations of molecular recognition, the development of functional materials, the vexed question of homochirality, nanoscale effects of interactions at interfaces, biocatalysis and enzymatic catalysis, and applications in organic synthesis. Chirality in Supramolecular Assemblies addresses many of these aspects, presenting a broad overview of this important and rapidly developing interdisciplinary field. Topics covered include: Origins of molecular and topological chirality Homochirogenesis Chirality in crystallinity Host-guest behavior Chiral influences in functional materials Chirality in network solids and coordination solids Aspects of chirality at interfaces Chirality in organic assemblies Chirality related to biocatalysis and enzymes in organic synthesis. This book is a valuable reference for researchers in the molecular sciences, materials science and biological science working with chiral supramolecular systems. It provides summaries and special insights by acknowledged international experts in the various fields.