Biological Diagnostic And Therapeutic Advances In Alzheimer S Disease

Author : Ghulam Md Ashraf,Athanasios Alexiou
Publisher : Springer Nature
Page : 293 pages
File Size : 52,9 Mb
Release : 2019-10-11
Category : Medical
ISBN : 9789811396366

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Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease by Ghulam Md Ashraf,Athanasios Alexiou Pdf

This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers various non-pharmacological therapies like immunotherapy, use of natural products, and employing nanotechnology in both the detection and treatment of AD. This book also highlights the role of diet and nutrition in healthy aging. Given its scope, it offers a valuable asset for researchers and clinicians alike.

Author : Harald Hampel,Maria C. Carrillo
Publisher : Karger Medical and Scientific Publishers
Page : 200 pages
File Size : 44,7 Mb
Release : 2012
Category : Medical
ISBN : 9783805598026

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Alzheimer's Disease by Harald Hampel,Maria C. Carrillo Pdf

How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the amyloid' or tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Author : Elena Poole
Publisher : American Medical Publishers
Page : 0 pages
File Size : 50,6 Mb
Release : 2023-09-26
Category : Health & Fitness
ISBN : 1639276580

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Diagnostic and Therapeutic Advances in Alzheimer's Disease by Elena Poole Pdf

Alzheimer's disease (AD) refers to a type of neurologic condition, which causes the brain to shrink and brain cells to die over time. AD is the most frequent form of dementia in which a progressive loss in social, cognitive and behavioral abilities occurs that impairs a person's capacity to operate independently. The primary symptom of AD is forgetting recent events or discussions. A person with AD will have severe memory impairment, while losing the capacity to perform daily tasks, as the disease progress. Drug development for AD relies heavily on biomarkers and they can also be used to facilitate diagnosis, safety monitoring, demonstrating target engagement and supporting the modification of disease. AD is incurable due to its multifactorial and complex nature. Biomarkers aid in characterizing the baseline state, a therapy response or a disease process. This book is compiled in such a manner, that it will provide in-depth knowledge about the assessment and management of Alzheimer's disease. It presents researches and studies performed by experts across the globe.

Author : Robert Becker,Ezio Giacobini
Publisher : Springer Science & Business Media
Page : 571 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461241164

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Alzheimer Disease by Robert Becker,Ezio Giacobini Pdf

Author : Elias K. Michaelis,Mary Lou Michaelis
Publisher : Academic Press
Page : 400 pages
File Size : 54,8 Mb
Release : 2012-08-02
Category : Medical
ISBN : 9780123948168

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Current State of Alzheimer's Disease Research and Therapeutics by Elias K. Michaelis,Mary Lou Michaelis Pdf

"Providing a cross-section of current research, treatments and potential clinical developments, this volume of Advances in Pharmacology is an essential resource for biologists, pharmacologists and those engaged with Alzheimer's research."--P. [4] of cover.

Author : Khalid Iqbal,Bengt Winblad,Tsuyoshi Nishimura,Masatoshi Takeda,Henry M. Wisniewski
Publisher : Wiley
Page : 0 pages
File Size : 43,7 Mb
Release : 1997-05-12
Category : Medical
ISBN : 0471969648

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Alzheimer's Disease by Khalid Iqbal,Bengt Winblad,Tsuyoshi Nishimura,Masatoshi Takeda,Henry M. Wisniewski Pdf

The past 15 years have witnessed a remarkable increase in our knowledge of the neurobiology of Alzheimer?s disease, and as new findings occur, the need for sharing and evaluating the information becomes even more important. An indispensable and detailed volume, this book is a nucleus of the latest information, covering all aspects of the neurobiology of Alzheimer?s disease, its treatment and psychosocial aspects. Over the past two years, since the publication of the last volume, major advances have been made towards understanding the aetiology and the pathogenesis of this disease. These include the discoveries of the genes whose mutations associate with Alzheimer?s disease in familial cases; the mechanisms of neuronal degeneration and identification of specific steps in the neurodegenerative process that provide targets for therapeutic intervention. This volume also presents advances in the generation of cellular and animal models of ß-amyloid and tau pathology, the two hallmark lesions of Alzheimer?s disease. The chapters in this book are at the cutting edge of Alzheimer?s disease research and will be of enormous value not only to Alzheimer?s disease researchers, but also to neurobiologists, clinicians and caregivers.

Author : Thimmaiah Govindaraju
Publisher : Royal Society of Chemistry
Page : 695 pages
File Size : 44,9 Mb
Release : 2022-01-12
Category : Medical
ISBN : 9781839162305

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Alzheimer's Disease by Thimmaiah Govindaraju Pdf

Handbook on Alzheimer's disease from aetiology and neurochemistry to diagnostic and therapeutic approaches. Intended to provide an introduction to all aspects of the disease.

Author : Magisetty Obulesu
Publisher : Academic Press
Page : 80 pages
File Size : 55,8 Mb
Release : 2019-01-20
Category : Medical
ISBN : 9780128167397

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Alzheimer’s Disease Theranostics by Magisetty Obulesu Pdf

Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics

Author : Gary Fiskum
Publisher : Springer Science & Business Media
Page : 500 pages
File Size : 41,6 Mb
Release : 1996-04-30
Category : Science
ISBN : 0306452987

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Neurodegenerative Diseases by Gary Fiskum Pdf

Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995

Author : Sangram S. Sisodia,Rudolph E. Tanzi
Publisher : Springer
Page : 0 pages
File Size : 53,5 Mb
Release : 2010-10-29
Category : Medical
ISBN : 1441941959

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Alzheimer's Disease by Sangram S. Sisodia,Rudolph E. Tanzi Pdf

This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.

Author : Vinod Kumar,Carl Eisdorfer
Publisher : Unknown
Page : 456 pages
File Size : 53,7 Mb
Release : 1998
Category : Medical
ISBN : UOM:39015040153192

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Advances in the Diagnosis and Treatment of Alzheimer's Disease by Vinod Kumar,Carl Eisdorfer Pdf

Author : Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf
Publisher : Frontiers Media SA
Page : 501 pages
File Size : 50,8 Mb
Release : 2019-12-04
Category : Electronic
ISBN : 9782889631285

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The Alzheimer's Disease Challenge by Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf Pdf

Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.

Author : Jorge D. Brioni,Michael W. Decker
Publisher : Wiley-Liss
Page : 594 pages
File Size : 51,5 Mb
Release : 1997-03-10
Category : Medical
ISBN : UOM:39015041315170

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Pharmacological Treatment of Alzheimer's Disease by Jorge D. Brioni,Michael W. Decker Pdf

Prominent Alzheimer's investigators provide a comprehensive and balanced overview of the neuropharmacological basis for therapeutics in this devastating disease. Divided into three parts, the book begins with basic research on the neurobiology of cognitive function, offering relevant information on the way the brain encodes and stores data. The second segment explores the molecular aspects of Alzheimer's Disease (AD), emphasizing investigations of possible etiological factors. In the final section, a variety of issues important in developing treatments are discussed including cholinergic-based treatments, the role of neuroinflammin in AD and the therapeutic potential of anti-inflammatory agents.

Author : Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch
Publisher : Springer
Page : 0 pages
File Size : 45,8 Mb
Release : 2000-07-14
Category : Medical
ISBN : 321183513X

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Advances in Dementia Research by Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch Pdf

Dementia is a major health problem that becomes increasingly common with advancing age. Despite recent progress in neurobiology and molecular genetics, the aetiology and pathogenesis of most dementia disorders are still poorly understood, and early exact diagnosis as a prerequisite of effective treatment needs to be improved. The present volume includes the contributions of renowned experts in the field of neurodegeneration presented at the International Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging techniques, and the role of vascular, immunological and other mechanisms including oxidative stress and estrogens in the development of neurodegeneration and dementia. Recent developments in diagnosis and therapy of Alzheimer disease and related disorders are reviewed and future therapeutic approaches are discussed. Thus, this volume provides a timely overview of most recent developments in dementia research and treatment strategies of dementia disorders.

Author : Renee D. Wegrzyn,Alan S. Rudolph
Publisher : CRC Press
Page : 298 pages
File Size : 45,8 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9781439827093

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Alzheimer's Disease by Renee D. Wegrzyn,Alan S. Rudolph Pdf

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores: The basis of AD and the role of Aβ oligomers in development of disease Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies In vivo imaging diagnostic approaches Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.