Biology And Pathogenesis Of Rhabdo And Filoviruses

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Biology and Pathogenesis of Rhabdo- and Filoviruses

Asit K Pattnaik,Michael A Whitt
Biology and Pathogenesis of Rhabdo and Filoviruses Book PDF

Author : Asit K Pattnaik,Michael A Whitt
Publisher : World Scientific
Page : 640 pages
File Size : 54,8 Mb
Release : 2014-12-30
Category : Science
ISBN : 9789814635356

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Biology and Pathogenesis of Rhabdo- and Filoviruses by Asit K Pattnaik,Michael A Whitt Pdf

Rhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents. Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included. This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis. Contents:Overview of Rhabdo– and Filoviruses (Asit K Pattnaik and Michael A Whitt)Rhabdovirus Structure (Ming Luo)The Pathway of VSV Entry into Cells (Shem Johnson and Jean Gruenberg)Rhabdovirus Glycoproteins (Yves Gaudin and Michael A Whitt)VSV RNA Transcription and Replication (Jacques Perrault)Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, and Asit K Pattnaik)Cytopathogenesis of Rhabdoviruses (Douglas S Lyles)Assembly and Budding of Rhabdo– and Filoviruses (Ziying Han and Ronald N Harty)Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose and David K Clarke)Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell)Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl, and Andreas Frick)Evolution of Rhabdo– and Filoviruses (Isabel S Novella, John B Presloid, and R Travis Taylor)Emerging Rhabdoviruses (Imke Steffen and Graham Simmons)Rabies Virus Replication and Pathogenesis (Andrew W Hudacek and Matthias J Schnell)Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann)Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai, and Zhen F Fu)Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel R Beniac, Melissa J Rabb, and Lindsey L Lamboo)Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga and Hideki Ebihara)Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler, and Kartik Chandran)Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflubé, and Elke Muhlberger)Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe, and Daisy W Leung)Vaccines and Antivirals for Filoviruses (Chad E Mire and Thomas W Geisbe) Readership: Investigators, graduate students, and post-graduate researchers in the field of RNA virology. Key Features:The book describes the most recent advances in our understanding of cellular and molecular aspects of replication and pathogenic mechanisms of these two important viral pathogensUnlike other existing textbooks published earlier, this book brings together several major topics of research such as replication, host response to viral replication and viral countermeasures, viral evolution and emerging viruses, viral vectors, vaccines and antivirals, etcThe chapters in the book are written by renowned researchers in these fieldsKeywords:Negative-Strand RNA Virus;Mononegavirales;Rhabdovirus;Filovirus;VSV;Rabies Virus;Marburg Virus;Ebola Virus;Replication and Transcription;Virus Structure;Viral Pathogenesis;Epidemiology;Virus Entry;Virus Assembly and Budding;Cytopathogenesis;Neuronal Tracers;Viral Vectors;Oncolytic Viruses;Evolution;Emerging Viruses;Innate Immune Responses;Vaccines;Antivirals

Marburg- and Ebolaviruses

Elke Mühlberger,Lisa L. Hensley,Jonathan S. Towner
Marburg and Ebolaviruses Book PDF

Author : Elke Mühlberger,Lisa L. Hensley,Jonathan S. Towner
Publisher : Springer
Page : 460 pages
File Size : 50,6 Mb
Release : 2017-12-23
Category : Medical
ISBN : 9783319689487

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Marburg- and Ebolaviruses by Elke Mühlberger,Lisa L. Hensley,Jonathan S. Towner Pdf

This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy. For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure. Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike.

Encyclopedia of Virology

Anonim
Encyclopedia of Virology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 4109 pages
File Size : 53,7 Mb
Release : 2021-02-24
Category : Science
ISBN : 9780128145166

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Encyclopedia of Virology by Anonim Pdf

Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public. Offers students and researchers a one-stop shop for information on virology not easily available elsewhere Fills a critical gap of information in a field that has seen significant progress in recent years Authored and edited by recognized experts in the field, with a range of different expertise, thus ensuring a high-quality standard

Fields Virology: Emerging Viruses

Peter M. Howley,David M. Knipe
Fields Virology Emerging Viruses Book PDF

Author : Peter M. Howley,David M. Knipe
Publisher : Lippincott Williams & Wilkins
Page : 2597 pages
File Size : 44,6 Mb
Release : 2020-02-11
Category : Medical
ISBN : 9781975112554

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Fields Virology: Emerging Viruses by Peter M. Howley,David M. Knipe Pdf

Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.

Replication-Competent Reporter-Expressing Viruses

Luis Martinez-Sobrido
Replication Competent Reporter Expressing Viruses Book PDF

Author : Luis Martinez-Sobrido
Publisher : MDPI
Page : 339 pages
File Size : 41,6 Mb
Release : 2018-09-27
Category : Biology (General)
ISBN : 9783038422587

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Replication-Competent Reporter-Expressing Viruses by Luis Martinez-Sobrido Pdf

This book is a printed edition of the Special Issue "Replication-Competent Reporter-Expressing Viruses" that was published in Viruses

Spray Drying of Vaccines

Cordin Arpagaus
Spray Drying of Vaccines Book PDF

Author : Cordin Arpagaus
Publisher : Springer Nature
Page : 610 pages
File Size : 44,8 Mb
Release : 2023-04-03
Category : Medical
ISBN : 9783031243233

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Spray Drying of Vaccines by Cordin Arpagaus Pdf

This book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. The book aims to familiarize readers with the advances in vaccine spray drying technology to understand its application potential better. In particular, the book addresses the design of aseptic spray dryers, parameters affecting the spray drying process, sterile powder processing, cleaning procedures, and powder filling. In addition, different drying technologies for the production of dry powder vaccines are compared to discuss the unique capabilities of spray drying as a particle technology for vaccines. Special attention is given to research studies on spray-dried vaccines published over the past 30 years, with key findings from laboratory research to clinical trials. Potential applications of spray-dried vaccines and routes of administration are presented in detail. Finally, an outlook is given on how close the aseptic spray-drying of vaccines is to the market and the challenges that need to be overcome to be commercially successful. The book's target audience is academics, researchers, vaccine developers, industry experts, students, and possibly funders, including government agencies, who are active in the field. In addition, the book is a reference source for those involved in the vaccine formulation and biopharmaceutical processing industry.

Necessity, Use, and Care of Laboratory Dogs at the U.S. Department of Veterans Affairs

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Assessment of the Use and Care of Dogs in Biomedical Research Funded by or Conducted at the U.S. Department of Veterans Affairs
Necessity Use and Care of Laboratory Dogs at the U S Department of Veterans Affairs Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Assessment of the Use and Care of Dogs in Biomedical Research Funded by or Conducted at the U.S. Department of Veterans Affairs
Publisher : National Academies Press
Page : 171 pages
File Size : 53,6 Mb
Release : 2020-10-28
Category : Science
ISBN : 9780309676410

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Necessity, Use, and Care of Laboratory Dogs at the U.S. Department of Veterans Affairs by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Assessment of the Use and Care of Dogs in Biomedical Research Funded by or Conducted at the U.S. Department of Veterans Affairs Pdf

For many years, laboratory dogs have served as important animal models for biomedical research that has advanced human health. Conducted at the request of the U.S. Department of Veterans Affairs (VA), this report assesses whether laboratory dogs are or will continue to be necessary for biomedical research related to the VA's mission. The report concludes that using laboratory dogs in research at the VA is scientifically necessary for only a few areas of current biomedical research. The report recommends that the VA adopt an expanded set of criteria for determining when it is scientifically necessary to use laboratory dogs in VA biomedical research; that the VA promote the development and use of alternatives to laboratory dogs; and highlights opportunities for the VA to enhance the welfare of laboratory dogs that are being used in biomedical research areas for which they have been deemed necessary.

Orchid Biotechnology Iii

Chen Hong-hwa,Chen Wen-huei
Orchid Biotechnology Iii Book PDF

Author : Chen Hong-hwa,Chen Wen-huei
Publisher : World Scientific
Page : 480 pages
File Size : 50,9 Mb
Release : 2017-01-25
Category : Science
ISBN : 9789813109230

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Orchid Biotechnology Iii by Chen Hong-hwa,Chen Wen-huei Pdf

This book provides a first hand and complete information on orchid biotechnology for orchid lovers, graduate students, researchers and industry growers. It contains comprehensive genomics and transcriptomics data, and a thorough discussion of the molecular mechanism of orchid floral morphogenesis. The contributors to the book are all orchid enthusiasts with more than 20 years' experience in the field. With more than 25,000 species, orchids are the most species-rich of all angiosperm families. They show wide diversity of epiphytic and terrestrial growth forms and have successfully colonized almost every habitat on earth. Orchids are fantastic for their spectacular flowers with highly evolved petal, labellum, and fused androecium and gynoecium, gynostemium, to attract pollinators for effective pollination. In addition, orchids have attracted the interest of many evolutionary biologists due to their highly specialized evolution and adaptation strategies. Orchid Biotechnology III covers the most update knowledge of orchid biotechnology research on Phalaenopsis, Oncidium, Cymbidium, Anoectohilus, Paphiopedilum, and Erycina pusilla. It will provide graduate students, researchers, orchid lovers and breeders with an opportunity to understand the mechanism why the orchids are so mysterious and spectacular. Hopefully, this information will be helpful for breeders to enhance orchid breeding and create even more elegant and grace flowers.

RNA Viruses

Decheng Yang
RNA Viruses Book PDF

Author : Decheng Yang
Publisher : World Scientific
Page : 722 pages
File Size : 48,7 Mb
Release : 2009
Category : Medical
ISBN : 9789812833792

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RNA Viruses by Decheng Yang Pdf

This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection. Organized into 29 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host?virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.

Brief History Of Bacteria, A: The Everlasting Game Between Humans And Bacteria

Daijie Chen,Xiuping Qian
Brief History Of Bacteria A The Everlasting Game Between Humans And Bacteria Book PDF

Author : Daijie Chen,Xiuping Qian
Publisher : World Scientific
Page : 296 pages
File Size : 42,6 Mb
Release : 2017-12-08
Category : Science
ISBN : 9789813225176

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Brief History Of Bacteria, A: The Everlasting Game Between Humans And Bacteria by Daijie Chen,Xiuping Qian Pdf

This book explains how pathogenic bacteria cause diseases, how the human immune system launches timely and effective defense mechanisms against bacterial infection, why the discovery and application of penicillin and streptomycin are so important, how scientists have created medicines to defeat bacteria, and why these bacteria might outsmart modern medicine.On the other hand, bacteria can be beneficial to humans: some bacteria live in harmony with the human body, and they are indispensable to our health. They also help in refining biological energy in the post-fossil fuel era, and in producing fermented food.With accessible language, illustrations and comics, this book tells the story of our tumultuous relationship with bacteria and how it has shaped history.

From the Hallowed Halls of Herpesvirology

John A. Blaho
From the Hallowed Halls of Herpesvirology Book PDF

Author : John A. Blaho
Publisher : World Scientific
Page : 726 pages
File Size : 51,9 Mb
Release : 2012
Category : Medical
ISBN : 9789814338998

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From the Hallowed Halls of Herpesvirology by John A. Blaho Pdf

This book contains a series of review chapters from the world''s leaders in herpesvirus research. It is designed as a tribute to the famous virologist Prof Bernard Roizman. Former trainees of Prof Roizman were invited to contribute to this volume. The chapters cover all eight of the human herpesviruses, and the topics discussed span the past six decades of this exciting research field.

Emerging Topics in Physical Virology

Peter G. Stockley,Reidun Twarock
Emerging Topics in Physical Virology Book PDF

Author : Peter G. Stockley,Reidun Twarock
Publisher : World Scientific
Page : 333 pages
File Size : 53,5 Mb
Release : 2010
Category : Science
ISBN : 9781848164666

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Emerging Topics in Physical Virology by Peter G. Stockley,Reidun Twarock Pdf

Emerging Topics in Physical Virology is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevant experimental techniques, such as cryo-electron microscopy, atomic force microscopy and mass spectrometry with the latest results on the biophysical and mathematical modeling of viruses. The book comprehensively covers the structure and physical properties of the protein envelopes that encapsulate and hence protect the delicate viral genome, their assembly and disassembly, the organization of the viral genome, infection, evolution, as well as applications of viruses in Biomedical Nanotechnology. It is an essential primer for scientists working in all aspects of virology, including the increasing use of viruses and virus-like particles in bio- and nano-technology. Its review style makes it moreover suitable for non-experts as an introduction into this exciting research area.

Theoretical Information Studies: Information In The World

Mark Burgin,Gordana Dodig-crnkovic
Theoretical Information Studies Information In The World Book PDF

Author : Mark Burgin,Gordana Dodig-crnkovic
Publisher : World Scientific
Page : 534 pages
File Size : 54,6 Mb
Release : 2020-03-24
Category : Computers
ISBN : 9789813277502

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Theoretical Information Studies: Information In The World by Mark Burgin,Gordana Dodig-crnkovic Pdf

This is the first attempt to delineate the synthetic field of the theoretical study of information, treating information as the basic phenomenon on the fundamental level of the world, encompassing nature, technology, individuals and society. The exploration of information is done within Info-computational approaches, to natural and social phenomena such as Bioinformatics, Information Physics, Informational Chemistry, Computational Physics, Cognitive and Social sciences, with special emphasis on interdisciplinary, crossdisciplinary and transdisciplinary knowledge.The book presents results of collaboration across research fields within info-computational and info-structural frameworks, in attempt to better theoretically and conceptually capture the phenomenon of information and its dynamics (such as computation and communication), as they appear on different levels of organization, on different scales and in different contexts.

A Guide to the Study of Basic Medical Mycology

*pls see project notes - 3 authors*
A Guide to the Study of Basic Medical Mycology Book PDF

Author : *pls see project notes - 3 authors*
Publisher : Partridge Publishing Singapore
Page : 92 pages
File Size : 42,6 Mb
Release : 2014-09-11
Category : Medical
ISBN : 9781482824131

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A Guide to the Study of Basic Medical Mycology by *pls see project notes - 3 authors* Pdf

Mycotic diseases are gaining importance because of the increase in opportunistic fungal infections in patients whose immune systems are compromised. The identification of fungi isolated from clinical material has posed a variety of problems to many laboratories because of lack of expertise and experience, especially in the identification of recently emerged rare fungi that had not been previously reported. A Guide to the Study of Basic Medical Mycology offers an overview of the basic characteristics of fungi frequently isolated from clinical specimens. This comprehensive guide, developed by authors Kee Peng Ng, Tuck Soon Soo-Hoo, and Shiang Ling Na from the Department of Medical Microbiology, University Malaya Medical Centre, Malaysia, details the macro- and microscopic features of each fungus through graphics and illustrations. Including specimens not often found in all teaching modules, A Guide to the Study of Basic Medical Mycology serves to help medical students identify and learn to deal with clinically important fungi and fungal pathogens.

Virology

Leonard C. Norkin
Virology Book PDF

Author : Leonard C. Norkin
Publisher : Unknown
Page : 0 pages
File Size : 50,5 Mb
Release : 2010
Category : Medical
ISBN : 1555814530

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Virology by Leonard C. Norkin Pdf

Based on the author's experiences in teaching virology for more than 35 years, this new textbook enables readers to develop a deep understanding of fundamental virology by emphasizing principles and discussing viruses in the context of virus families.