Biology Of The Lymphokines

Author : Stanley Cohen,Edgar Pick,Joost J. Oppenheim
Publisher : Academic Press
Page : 644 pages
File Size : 49,5 Mb
Release : 2013-09-17
Category : Health & Fitness
ISBN : 9781483271422

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Biology of the Lymphokines by Stanley Cohen,Edgar Pick,Joost J. Oppenheim Pdf

Biology of the Lymphokines discusses the scope and diversity of lymphokine research. This book focuses on the studies on lymphokines, such as those involving cellular source, chemical nature, purification strategies, and bioassay limitations. The mechanism of lymphokine action, lymphokines in vivo, and value of lymphokine quantitations are also covered. This text describes the repertoire of lymphokines produced by various lymphoblastoid cell lines and its significance for coping with the problem of large scale lymphokine production. The anti-viral and general immunoregulatory properties of interferons and rationale developed for integrating interferons with the family of lymphokines are likewise deliberated. This publication is a good source for students and researchers conducting work on lymphokines.

Author : Amanullah Khan
Publisher : Elsevier
Page : 756 pages
File Size : 40,6 Mb
Release : 2012-12-02
Category : Health & Fitness
ISBN : 9780323142670

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Human Lymphokines by Amanullah Khan Pdf

Human Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17, 1981 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors explore the role of human lymphokines in immune responses and their applications in immunotherapy. The focus is on lymphokines that have either entered clinical trials or are nearing clinical evaluation. Some of the activities of possible immediate significance, such as Glia cell stimulating factor and polyclonal B-cell activator, are also described. This volume is organized into six sections encompassing 56 chapters and begins with an overview of assay systems, touching on topics such as the activation of macrophages by interferon to produce plasminogen and macrophage activation by lymphokine factors. The next sections turn to the production, purification, and biological and chemical characterization of lymphokines. The discussion then shifts to the mechanisms of action of lymphokines in vitro and the use of animal models in lymphokine investigations, including lymphokine fractions in a mouse tumor model and enhancement of natural killing activity by different types of interferon. A great deal of emphasis is placed on macrophage migration inhibitory factor, lymphotoxins, gamma interferon, and interleukins. The book concludes with chapters devoted to the immunoregulatory effects of lymphokines and clinical studies.

Author : Clemens Sorg,Anneliese Schimpl
Publisher : Unknown
Page : 896 pages
File Size : 54,6 Mb
Release : 1985
Category : Medical
ISBN : UCAL:B4499641

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Cellular and Molecular Biology of Lymphokines by Clemens Sorg,Anneliese Schimpl Pdf

Author : Ken-Ichi Arai,Jan Egbert De Vries
Publisher : Unknown
Page : 256 pages
File Size : 53,6 Mb
Release : 1991-01-01
Category : Lymphokines
ISBN : 0935859616

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Lymphokines by Ken-Ichi Arai,Jan Egbert De Vries Pdf

Author : Edgar Pick
Publisher : Academic Press
Page : 488 pages
File Size : 51,9 Mb
Release : 2013-09-17
Category : Medical
ISBN : 9781483268187

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Lymphokines by Edgar Pick Pdf

Lymphokines: A Forum for Immunoregulatory Cell Products, Volume 14, reviews the state of knowledge on lymphokines. The book opens with an integrative view of the role of lymphokines in the generation of fever. It stresses that pirogenicity is the attribute of more than one lymphokine: interleukin 1 (IL-1), interferon α, and tumor necrosis factor (TNF) all possess this quality. This is followed by separate chapters on the chemistry of IL-1 molecules and cloning of the gene for human monocyte IL-1; the production of lymphokine by cells of the central nervous system; the acute phase plasma protein response studied at the level of gene structure and expression; and the involvement of calcium and calcium-linked enzymes in T cell proliferation. Subsequent chapters deal with the involvement of pteridines in T cell activation; the discovery of cachectin and the establishment of its identity with TNF; the effect of IFN-γ and several cytotoxic cytokines on the proliferation, differentiation, and function of normal and leukemic myeloid cells; and the cytotoxic lymphokines produced by effector T cells. The final chapter discusses the ways in which chemically defined changes in cell membranes affect cell division.

Author : Nikolaĭ Vasilʹevich Medunitsyn,Vitaliĭ Ilʹich Litvinov,A. M. Moroz
Publisher : Routledge
Page : 348 pages
File Size : 46,5 Mb
Release : 1987
Category : Medical
ISBN : UOM:39015011756288

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Mediators of the Immune Response by Nikolaĭ Vasilʹevich Medunitsyn,Vitaliĭ Ilʹich Litvinov,A. M. Moroz Pdf

Author : John W. Hadden,William E. Stewart
Publisher : Unknown
Page : 472 pages
File Size : 42,8 Mb
Release : 1981-10-31
Category : Medical
ISBN : UOM:39015004401421

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The Lymphokines by John W. Hadden,William E. Stewart Pdf

Author : David R. Webb,Carl W. Pierce,Stanley Cohen
Publisher : Springer Science & Business Media
Page : 495 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461245988

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Molecular Basis of Lymphokine Action by David R. Webb,Carl W. Pierce,Stanley Cohen Pdf

The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.

Author : Alain L. de Weck,Clemens Sorg,Anneliese Schimpl,Flemming Kristensen,Maurice Landy
Publisher : Unknown
Page : 896 pages
File Size : 50,7 Mb
Release : 1980
Category : Lymphokines
ISBN : UOM:39015009570121

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Cellular and Molecular Biology of Lymphokines by Alain L. de Weck,Clemens Sorg,Anneliese Schimpl,Flemming Kristensen,Maurice Landy Pdf

Author : Maureen Dawson
Publisher : Unknown
Page : 200 pages
File Size : 43,9 Mb
Release : 1991
Category : Electronic
ISBN : 0471932140

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Lymphokines and Interleukins by Maureen Dawson Pdf

Lymphokines are molecules which exert biological effects on various aspects of the immune system, often by modulating the activities of other components within the system. This book emphasizes their importance for the immune response, and considers general methods for in-vitro production, such as lymphocyte cloning and T-cell hybridoma technology. Their therapeutic and commercial potential makes them the subject of research activity, and the author considers those which may have industrial and clinical significance.

Author : John W. Hadden,William E. Stewart II
Publisher : Humana Press
Page : 437 pages
File Size : 52,7 Mb
Release : 2013-12-29
Category : Medical
ISBN : 1475717342

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The Lymphokines by John W. Hadden,William E. Stewart II Pdf

Author : Joost J. Oppenheim
Publisher : Unknown
Page : 624 pages
File Size : 49,8 Mb
Release : 1990
Category : Cytokines
ISBN : UOM:39015019652356

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Molecular and Cellular Biology of Cytokines by Joost J. Oppenheim Pdf

Cytokines are regulatory polypeptides synthesized by a variety of cells in response to injury, inflammation or infection and which act on different tissues by changing gene expression and cellular metabolism. This book provides the results from recent in vitro studies of the structure and function of various cytokines. It offers an up-to-date overview of the latest advances in cytokine research, including research developments dealing with colony stimulating factors, interferons and growth and differentiation factors - as well as classical hormones such as insulin, neurokinin, somatomedin and parathormones. Several newly identified cytokine receptor structures are also discussed, as are certain activities of the recently discovered 8,000-10,000 m.w. cytokine family.

Author : David R. Webb,Carl W. Pierce,Stanley Cohen
Publisher : Humana Press
Page : 482 pages
File Size : 49,5 Mb
Release : 2012-02-09
Category : Medical
ISBN : 1461289432

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Molecular Basis of Lymphokine Action by David R. Webb,Carl W. Pierce,Stanley Cohen Pdf

The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.

Author : Allan Goldstein
Publisher : Springer
Page : 738 pages
File Size : 55,6 Mb
Release : 1984-11
Category : Science
ISBN : UCAL:B4494537

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Thymic Hormones and Lymphokines by Allan Goldstein Pdf

The Third Annual Symposium on Health Sciences attracted over 400 scientists from 15 countries. It was held at the National Academy of Sciences in Washington, D.C. The theme of this meeting was "Thymic Hormones and Lymphokines: Basic Chem istry and Clinical Applications." The meeting emphasized the state of the art with regard to chemistry, mech anism of action, and clinical applications of thymic hormones and lymphokines. In addition to the five sessions, the chairmen of each session were asked to prepare a synthesis and overview of each of the sessions. Some of the chairmen used this time to summarize the new material presented while others addressed important areas of conflict and terminology. The chairmen of the plenary sessions prepared short summary papers which have been incorporated into this volume at the end of each major section. We also invited several of the scientists who took part in the poster presentations to submit short papers. In addition to the scientific sessions, there were two awards and lectures. One, the Abraham White Distinguished Science Award, was given to Dr. Robert C. Gallo, who gave the keynote lecture. He was recognized for his pioneering research and scientific contributions to our understanding of the regulation of hematopoietic cell differentiation and the role of viruses in the development of human leukemias.

Author : Maurice Landy
Publisher : Unknown
Page : 471 pages
File Size : 48,6 Mb
Release : 1987-12-01
Category : Limfokine
ISBN : OCLC:159688266

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Lymphokines by Maurice Landy Pdf