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Author : Y. W. Loke,A. Whyte
Publisher : Elsevier Publishing Company
Page : 736 pages
File Size : 51,5 Mb
Release : 1983
Category : Medical
ISBN : UOM:39015013589893
Author : Ashley Moffett,Charlie Loke,Anne McLaren
Publisher : Cambridge University Press
Page : 246 pages
File Size : 41,9 Mb
Release : 2011-08-18
Category : Medical
ISBN : 9781139452540
Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.
Author : Sandeep Raha
Publisher : Springer Nature
Page : 249 pages
File Size : 44,6 Mb
Release : 2023-12-31
Category : Science
ISBN : 9781071634950
This volume explores the latest approaches used to assess trophoblast angiogenesis, transport function, cellular respirations, migration, and invasion. The chapters in this book cover topics such as various methods to study and manipulate primary trophoblast cells; strategies using liposomes to deliver biomolecules to trophoblasts; in vitro models of the placenta that emulate the cellular interactions in the 3D uterine environment; and models exploring heterogenous cell types and 3D-organoid structures that represent cell-to-cell interactions in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Trophoblasts: Methods and Protocols is a valuable resource that will help researchers better understand the function of the placenta and its complex contribution to maternal health and fetal development, and also provide greater insights to the area of study known as the developmental origins of health and diseases (DoHaD).
Author : H.W. Denker,J.D. Aplin
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461306153
Interest in mechanisms of embryo implantation is increasing, particularly with the realization that failure of implantation after in vitro fertilization and embryo transfer places significant limits on the success of treatment. In addition, there is a need to provide hypotheses, and ultimately mechanisms, for the high rates of embryonic loss in women in the population at large. Traditionally, implantation research has concentrated on genetics and endocrinology without providing many therapeutic benefits. A new era is now beginning with the application of modem cellular and molecular approaches to the investigation of the relationship between trophoblast and endometrium. At the same time, older data can be reevaluated in the light of current research into cell cell and cell-matrix interactions. The feeling that new avenues of research are open was apparent when an international group of scientists came together at a workshop on "The Cell Biology of Trophoblast Invasion In Vivo and In Vitro" held during the XXIV Annual Meeting of the Cell, Tissue and Organ Culture Study Group (C.T.O.C.) at Heidelberg in 1986. What was unusual about this Conference was the interdisciplinary dialogue between implantation researchers and tumor biologists, highlighting aspects common to invasion of trophoblast and tumor cells.
Author : Michael J. Soares,Stuart Handwerger,Frank Talamantes
Publisher : Springer Science & Business Media
Page : 315 pages
File Size : 44,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461227182
Trophoblast cells coordinate the activities of maternal and embryonic tissues by secreting hormones, cytokines, and various growth factors that selectively and specifically gain access to maternal and embryonic compartments. Abnormalities associated with trophoblast cell growth, differentiation, or function result in impaired embryonic development. Understanding the complexities of the trophoblast cell signaling system was the focus of the Serono Symposia, USA conference entitled Tropho blast Cells: Pathways for Maternal-Embryonic Communication, held August 6-9, 1992, in Las Vegas, Nevada. The conference was designed to provide a forum for morphologists, cell biologists, endocrinologists, and molecular biologists and for scientists investigating primate, ru minant, and rodent trophoblast biology. An important outcome of the conference was the communication achieved between basic scientists and clinicians. This volume represents the contributions of the invited symposium speakers. The opening keynote address of the conference was entitled "Chorio carcinoma and the Embryo" and was presented by G. Barry Pierce, M. D. , Centennial Distinguished Research Professor of the University of Colorado School of Medicine. The address is not represented in this volume, but deserves a special comment. Dr. Pierce's scientific con tributions have significantly influenced our understanding of trophoblast cells. Dr. Pierce, together with Dr. A. Rees Midgley, identified the origin of syncytial trophoblast cells of the primate placenta and discovered that these cells were responsible for the production of chorionic gonadotropin (J Exp Med 1962;115:289-94; Am J Pathol 1963;43:929-43; and Science 1963;141:349-50).
Author : Yuping Wang (MD.),Shuang Zhao
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 46,5 Mb
Release : 2010
Category : Health & Fitness
ISBN : 9781615040452
The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.
Author : Y. W. Loke,Ashley King
Publisher : Cambridge University Press
Page : 332 pages
File Size : 48,6 Mb
Release : 1995-11-30
Category : Medical
ISBN : 0521441935
This book explains and reviews some of the significant events involved in human implantation and the establishment of the placenta in the uterus. This critical phase in human reproduction has proved to be an elusive and challenging area of research, not least because of the immunological and genetic interactions between the mother and fetus. The volume focuses on the most recent advances in our understanding of the basic mechanisms involved, with a particular emphasis on cell biology and immunology. This lucid volume will benefit all those studying and undertaking research in reproductive biology and immunology, perinatal pathology, fetal medicine and obstetrics.
Author : Gernot Desoye,Richard Kermit Miller,Colin Sibley
Publisher : Unknown
Page : 122 pages
File Size : 40,5 Mb
Release : 2000
Category : Placenta
ISBN : OCLC:45141152
Author : Michael J. Soares,Joan S. Hunt
Publisher : Springer Science & Business Media
Page : 472 pages
File Size : 49,6 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592599837
A collection of cutting-edge laboratory techniques for the study of trophoblast and placental biology. The techniques presented range from experimental animal models, to animal and human placental organ and cell culture systems, to morphological, biochemical, and molecular strategies for assessing trophoblast/placental growth, differentiation and function. Volume 1 provides readily reproducible protocols for studying embryo-uterine implantation, trophoblast cell development, and the organization and molecular characterization of the placenta. Highlights include strategies for the isolation and culture of trophoblast cells from primates, ruminants, and rodents, and precise guidance to the molecular and cellular analysis of the placental phenotype. A companion second volume concentrates on methods for investigating placental function.
Author : Michael J. Soares,Joan S. Hunt
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 44,5 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592599899
The aim of the two-volume set of Placenta and Trophoblast: Methods and Protocols is to offer contemporary approaches for studying the biology of the placenta. The chapters contained herein also address critical features of the female organ within which the embryo is housed, the uterus, and some aspects of the embryo–fetus itself, particularly those of common experimental animal models. In keeping with the organization used effectively in other volumes in this series, each chapter has a brief introduction followed by a list of required items, protocols, and notes designed to help the reader perform the expe- ments without difficulty. In both volumes, sources of supplies are given and illustrations highlight particular techniques as well as expected outcomes. A key aspect of these volumes is that the contributors are at the forefronts of their disciplines, thus ensuring the accuracy and usefulness of the chapters. Placenta research has progressed rapidly over the past several decades by taking advantage of the technical advances made in other fields. For example, the reader will note that many techniques, such as reverse transcriptase po- merase chain reaction, northern and western blotting, microarray analyses and in situ hybridization experiments, are routinely used for dissecting a wide range of experimental questions. Protein analysis and functional experiments on tissues and cells that comprise the maternal–fetal interface benefit from studies in en- crinology, immunology, and developmental biology. These volumes also present new ideas on investigating gene imprinting and gene transfer via viral vectors.
Author : Robert Geoffrey Edwards,C. W. S. Howe,M. H. Johnson
Publisher : CUP Archive
Page : 304 pages
File Size : 47,9 Mb
Release : 1975-08-21
Category : Health & Fitness
ISBN : 0521206367
Author : Hans-Werner Denker
Publisher : Unknown
Page : 462 pages
File Size : 50,7 Mb
Release : 1990
Category : Electronic
ISBN : OCLC:818796328
Author : Richard Miller
Publisher : Springer
Page : 625 pages
File Size : 49,7 Mb
Release : 2013-11-27
Category : Medical
ISBN : 1475719388
Author : Kurt Benirschke,Peter Kaufmann,Rebecca N Baergen
Publisher : Springer Science & Business Media
Page : 1050 pages
File Size : 49,7 Mb
Release : 2006-11-17
Category : Medical
ISBN : 9780387267425
Pathology of the Human Placenta remains the authoritative text in the field and is respected and used by pathologists and obstetrician-gynecologists alike. This fifth edition reflects new advances in the field and includes 800 illustrations, 173 of them in color. The detailed index has been improved and the tables updated. Defined terms are highlighted in bold for easy identification, and further findings are discussed in small type throughout each chapter. Advances in genetics and molecular biology continue to make the study of the placenta one of vast diagnostic and legal importance.
Author : Kenneth Dawson Bagshawe
Publisher : Hodder Education
Page : 380 pages
File Size : 44,7 Mb
Release : 1969
Category : Choriocarcinoma
ISBN : UOM:39015000785389