Biomolecular Interfaces

Author : Ariel Fernández Stigliano
Publisher : Springer
Page : 372 pages
File Size : 42,9 Mb
Release : 2015-04-20
Category : Science
ISBN : 9783319168500

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Biomolecular Interfaces by Ariel Fernández Stigliano Pdf

The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

Author : Ariel Fernández
Publisher : Springer
Page : 483 pages
File Size : 45,6 Mb
Release : 2016-05-11
Category : Science
ISBN : 9783319308524

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Physics at the Biomolecular Interface by Ariel Fernández Pdf

This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines.

Author : James F. Rusling
Publisher : CRC Press
Page : 582 pages
File Size : 51,5 Mb
Release : 2003-02-26
Category : Medical
ISBN : 9781135544751

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Biomolecular Films by James F. Rusling Pdf

This text examines films of biomolecules that can provide solid surfaces for catalyzing enzyme reactions, serve in biosensors and as biorecognition elements, mediate nanoparticle formation, and provide a basis for fundamental studies and applications in biomedicine and biomedical devices.

Author : Franklin Tao,Steven Bernasek
Publisher : John Wiley & Sons
Page : 456 pages
File Size : 50,9 Mb
Release : 2012-04-10
Category : Technology & Engineering
ISBN : 9780470562949

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Functionalization of Semiconductor Surfaces by Franklin Tao,Steven Bernasek Pdf

This book presents both fundamental knowledge and latest achievements of this rapidly growing field in the last decade. It presents a complete and concise picture of the the state-of-the-art in the field, encompassing the most active international research groups in the world. Led by contributions from leading global research groups, the book discusses the functionalization of semiconductor surface. Dry organic reactions in vacuum and wet organic chemistry in solution are two major categories of strategies for functionalization that will be described. The growth of multilayer-molecular architectures on the formed organic monolayers will be documented. The immobilization of biomolecules such as DNA on organic layers chemically attached to semiconductor surfaces will be introduced. The patterning of complex structures of organic layers and metallic nanoclusters toward sensing techniques will be presented as well.

Author : Peter Horsman,Brian E. Conway,E. Yeager
Publisher : Springer Science & Business Media
Page : 580 pages
File Size : 40,6 Mb
Release : 1985-02-28
Category : Science
ISBN : 0306415410

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Comprehensive Treatise of Electrochemistry by Peter Horsman,Brian E. Conway,E. Yeager Pdf

1.1. Definition of Terms-Thrombosis, Thromboembolic Disease, Atherosclerosis, and Blood Clotting The terms heart attack or myocardial infarction are more commonly used than thrombosis. The infarct-muscle destruction is simply the end result and thrombosis is the real cause of the heart attack. Thrombosis may be defined as the process of formation of a coalescent or agglutinated solid mass of blood components in the blood stream. Thrombi formed in either arteries or veins often cause occlusion in the vascular system and prevent blood flow. Obstruc to the blood vessel usually occurs at the site where the thrombi deposit. tion Furthermore, thrombi may break loose, travel through the circulating blood stream, and cause obstruction at some distal point of narrowing elsewhere. The mass or thrombus that moves is referred to as an "embolus." The two phenomena are lumped together under the term thromboembolic disease. Thrombosis that reduces blood supply to the heart is the primary factor in heart attacks.

Author : Adam Liwo
Publisher : Springer Science & Business Media
Page : 809 pages
File Size : 46,9 Mb
Release : 2013-07-17
Category : Technology & Engineering
ISBN : 9783642285547

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Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes by Adam Liwo Pdf

Since the second half of the 20th century machine computations have played a critical role in science and engineering. Computer-based techniques have become especially important in molecular biology, since they often represent the only viable way to gain insights into the behavior of a biological system as a whole. The complexity of biological systems, which usually needs to be analyzed on different time- and size-scales and with different levels of accuracy, requires the application of different approaches, ranging from comparative analysis of sequences and structural databases, to the analysis of networks of interdependence between cell components and processes, through coarse-grained modeling to atomically detailed simulations, and finally to molecular quantum mechanics. This book provides a comprehensive overview of modern computer-based techniques for computing the structure, properties and dynamics of biomolecules and biomolecular processes. The twenty-two chapters, written by scientists from all over the world, address the theory and practice of computer simulation techniques in the study of biological phenomena. The chapters are grouped into four thematic sections dealing with the following topics: the methodology of molecular simulations; applications of molecular simulations; bioinformatics methods and use of experimental information in molecular simulations; and selected applications of molecular quantum mechanics. The book includes an introductory chapter written by Harold A. Scheraga, one of the true pioneers in simulation studies of biomacromolecules.

Author : Tamar Schlick
Publisher : Royal Society of Chemistry
Page : 380 pages
File Size : 41,8 Mb
Release : 2012-05-24
Category : Science
ISBN : 9781849735049

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Innovations in Biomolecular Modeling and Simulations by Tamar Schlick Pdf

The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and further analysed by modeling, and predictions from any approach can be tested and advanced through companion methodologies and technologies. This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts. With contributions from experts in the field, the books describe progress and innovation in areas including: simulation algorithms for dynamics and enhanced configurational sampling, force field development, implicit solvation models, coarse-grained models, quantum-mechanical simulations, protein folding, DNA polymerase mechanisms, nucleic acid complexes and simulations, RNA structure analysis and design and other important topics in structural biology modeling. The books are aimed at graduate students and experts in structural biology and chemistry and the emphasis is on reporting innovative new approaches rather than providing comprehensive reviews on each subject.

Author : William Kennedy Browne
Publisher : Unknown
Page : 240 pages
File Size : 45,6 Mb
Release : 2009
Category : Electronic
ISBN : UCAL:C3528033

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Strain and Interfaces, the Susceptibility of Fundamental Biomolecular Building Blocks to Their Intramolecular and Intermolecular Environment by William Kennedy Browne Pdf

Author : F.T. Hong
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461574828

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Molecular Electronics by F.T. Hong Pdf

The dream of developing a biocomputer should not be dismissed as a sheer fantasy. Although there is naturally some doubt as to whether it is possible to design a computer using carbon-based components as in living organisms, instead of silicon-based components as in existing computers, the fact that an average brain often outperforms the most sophisticated computer in terms of the complexity of tasks, if not in terms of speed, is a living testimony to this possibility. The remaining question is to what extent a biocomputer can mimic a living organism and whether it is possible to design and fabri cate such a biocomputer within the foreseeable future. This volume does not attempt to provide immediate and exact answers to these questions but instead attempts to provide a vision and a progress report of the initial efforts. This volume is mainly a collection of papers presented at the Symposium on Molecular Electronics - Biosensors and Biocomputers, sponsored by the Divi sion of Biotechnology, Health and Environment of the Fine Particle Society, held from July 19-22, 1989 at the Society's 19th Annual Meeting in Santa Clara, California. Also included are articles contributed by those who planned to attend the conference but were unable to do so. The emergence of the field of molecular electronics is largely the consequence of one person's crusade, that of Forrest L. Carter.

Author : Andrzej Wieckowski,Carol Korzeniewski,Björn Braunschweig
Publisher : John Wiley & Sons
Page : 396 pages
File Size : 45,7 Mb
Release : 2013-07-15
Category : Science
ISBN : 9781118658963

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Vibrational Spectroscopy at Electrified Interfaces by Andrzej Wieckowski,Carol Korzeniewski,Björn Braunschweig Pdf

Reviews the latest theory, techniques, and applications Surface vibrational spectroscopy techniques probe the structure and composition of interfaces at the molecular level. Their versatility, coupled with their non-destructive nature, enables in-situ measurements of operating devices and the monitoring of interface-controlled processes under reactive conditions. Vibrational Spectroscopy at Electrified Interfaces explores new and emerging applications of Raman, infrared, and non-linear optical spectroscopy for the study of charged interfaces. The book draws from hundreds of findings reported in the literature over the past decade. It features an internationally respected team of authors and editors, all experts in the field of vibrational spectroscopy at surfaces and interfaces. Content is divided into three parts: Part One, Nonlinear Vibrational Spectroscopy, explores properties of interfacial water, ions, and biomolecules at charged dielectric, metal oxide, and electronically conductive metal catalyst surfaces. In addition to offering plenty of practical examples, the chapters present the latest measurement and instrumental techniques. Part Two, Raman Spectroscopy, sets forth highly sensitive approaches for the detection of biomolecules at solid-liquid interfaces as well as the use of photon depolarization strategies to elucidate molecular orientation at surfaces. Part Three, IRRAS Spectroscopy (including PM-IRRAS), reports on wide-ranging systems from small fuel molecules at well-defined surfaces to macromolecular complexes that serve as the building blocks for functional interfaces in devices designed for chemical sensing and electric power generation. The Wiley Series on Electrocatalysis and Electrochemistry is dedicated to reviewing important advances in the field, exploring how these advances affect industry. The series defines what we currently know and can do with our knowledge of electrocatalysis and electrochemistry as well as forecasts where we can expect the field to be in the future.

Author : C.-M. Pradier,Y.J. Chabal
Publisher : Elsevier
Page : 344 pages
File Size : 45,8 Mb
Release : 2011-09-02
Category : Science
ISBN : 9780444535580

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Biointerface Characterization by Advanced IR Spectroscopy by C.-M. Pradier,Y.J. Chabal Pdf

"There is an increasing interest in research and applications of biosensors and bio-compatability in relation to environmental protection, food and medical safety, implants, early detection of diseases and pollutant detection. This book describes how to characterise amino acids, protein or bacterial strain adsorption on metal and oxide surfaces by using infrared spectroscopy, in a vacuum, in the air or in an aqueous medium. Features description of the principles, experimental setups and parameter interpretation, and the theory for several advanced IR-based techniques for interface characterisation Contains examples which demonstrate the capacity, potential and limits of the IR techniques Helps finding the most adequate mode of analysis."--Publisher.

Author : Michael R. King
Publisher : Elsevier
Page : 339 pages
File Size : 54,9 Mb
Release : 2011-04-28
Category : Science
ISBN : 9780080539638

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Principles of Cellular Engineering by Michael R. King Pdf

This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine. -Accessible to biologists looking for new ways to model their results and engineers interested in biomedical applications -Useful to researchers in biomaterials, inflammation, and vascular biology -Excellent resource for graduate students as a textbook in cell & tissue engineering or cell mechanics courses

Author : Ole Hammerich,J. Ulstrup
Publisher : Springer Science & Business Media
Page : 319 pages
File Size : 42,7 Mb
Release : 2008
Category : Science
ISBN : 9781402064999

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Bioinorganic Electrochemistry by Ole Hammerich,J. Ulstrup Pdf

Interfacial electrochemistry of redox metalloproteins and DNA-based molecules is presently moving towards new levels of structural and functional resolution. This is the result of powerful interdisciplinary efforts. Underlying fundamentals of biological electron and proton transfer is increasingly well understood although with outstanding unresolved issues. Comprehensive bioelectrochemical studies have mapped the working environments for bioelectrochemical electron transfer, supported by the availability of mutant proteins and other powerful biotechnology. Introduction of surface spectroscopy, the scanning probe microscopies, and other solid state and surface physics methodology has finally offered exciting new fundamental and technological openings in interfacial bioelectrochemistry of both redox proteins and DNA-based molecules. Inorganic Bioelectrochemistry provides a thorough and didactic overview of state-of-the-art bioelectrochemistry with prospects for forthcoming development. The book is organized in eight chapters written by leading international experts and covers crucial relevant topics such as electron and proton transfer in metalloprotein systems, electrochemistry and electrocatalysis of redox enzymes, and electrochemistry of DNA-based molecules. A wide variety of readers will find this volume of great interest. These include final year undergraduate and postgraduate students, university lecturers in inorganic and physical chemistry as well as the biochemical and biological sciences, and research staff in medical and biotechnological companies, catalysis research, and other industries.

Author : Matthew L. Tingey
Publisher : Unknown
Page : 348 pages
File Size : 41,5 Mb
Release : 2005
Category : Electronic
ISBN : WISC:89091734921

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Amplification of Biomolecular Interactions Using Liquid Crystals and Nanostructured Surfaces by Matthew L. Tingey Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 779 pages
File Size : 40,5 Mb
Release : 2013-01-10
Category : Science
ISBN : 9781481645423

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Issues in General Science and Scientific Theory and Method: 2012 Edition by Anonim Pdf

Issues in General Science and Scientific Theory and Method: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Science. The editors have built Issues in General Science and Scientific Theory and Method: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about General Science in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in General Science and Scientific Theory and Method: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.