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Author : Gerhard F Fueger
Publisher : Unknown
Page : 504 pages
File Size : 51,8 Mb
Release : 1984-08-31
Category : Electronic
ISBN : 940096031X
Author : Gerhard F. Fueger
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400960305
G. F. FUEGER Among the many processes in Physiology few appear mo~e inviting to be studied by tracers and external imaging than the variety of the routes of migratory (blood) cells in health and disease. Much emphasis has been placed lately on the methods of labelling of the white blood cells. It is obviously quite important and necessary to refine the methods of leucocytic labelling, particularly to search for ways to label selectively a specific group of white blood cells, but there is also the need to review and keep abreast with the developing knowledge of the white blood cells themselves, especially their behaviour under pathological conditions, as seen by histology and scintigraphy, their biological properties, their immunological characteristics and the mechanisms of the control of leucocytic functions. Similarly, it appears desirable to analyze animal models of inflammation as well as to review the dosimetry and the biodistribution of labelled white blood cells in humans. This book is the result of a cooperative effort to review certain highlights of the physiology of leucocytes, labelled and unlabelled, as a corollary to the effort concerning the labelling of white blood cells. In preparing this book we aim for a better understanding and definition of the goals to be achieved by the successful labelling of the migratory cells of the body. XI CONTRIBUTORS Becker, H. Medizinische Universitaetsklinik der Uni versitaet Graz, Graz, Landeskrankenhaus, haus, Austria Bjurman, B. Department of Radiation Physics, General Hospital, Malmoe, Sweden Chiles, C.
Author : M.R. Hardeman,Y. Najean
Publisher : Springer Science & Business Media
Page : 419 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400960275
Xi List of first authors xiii Acknowledgements xv INTRODUCTICN Approaches to radiolabelling blood d-c cells: past, present and future M.L. Thakur 3 CELL LABELLllJG TEDlNIQUES 2 Labelling techniques of granulocytes and platelets 17 with 111 In-oxinate M.R. Hardeman, E.G.J. Eitjes-van Overbeek, A.J.M. van Velzen, M.H. Rovekarnp 111rndium-labelling of human washed platelets; kinetics 3 29 and in vivo sequestration sites M. Eber, J.P. Cazenave, J.C. Grob, J. Abecassis, G.!o1ethlin 111Indium loss from platelets by in vitro and ex 4 44 vivo manipulation R.J. Hawker, C.E. Hall, H. C-oldman, C.N. McCollum PIATELEl'S: KrnETIC STUDIES 5 The maturation of megakaryocytes and their precursors 65 J.H. Paulus 6!o1egakaryocytic precursors 74 J. Breton-Gorius, W. Vainchenker 7!-1ethods of quantification of platelet production 86 in man. A critical analysis Y. Najean vi 8 Platelet production rate deteDmination with (75se)_ seleno-m:thionine R. Cardinaud, E. Dassin 96 9 Platelet kinetics: the state of the art A. duP Heyns 110 10 Platelet kinetics A.M. Peters 130 Evaluation of models to deteDmine platelet life 11 span and survival curve shape M.G. LOtter, C.P. Herbst, P.N. Badenhorst, A. duP Heyns, P. Wessels, P.C. Minnaar 139 12 Canparison of three m:thods evaluating platelet survival tim: in patients with prosthetic heart valve J. Schbath, D. Ville, B. Hathy, B. Sanchini, E. Benveniste, J. Belleville, M. Dechavanne, J.P. Boissel, J.
Author : M. R. Hardeman,Y. Najean
Publisher : Unknown
Page : 438 pages
File Size : 52,5 Mb
Release : 1984-06-30
Category : Electronic
ISBN : 940096028X
Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 53,8 Mb
Release : 1984
Category : Electronic
ISBN : OCLC:834591702
Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine
Publisher : National Academies Press
Page : 173 pages
File Size : 51,5 Mb
Release : 2007-09-11
Category : Medical
ISBN : 9780309134156
Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1728 pages
File Size : 45,8 Mb
Release : 1985
Category : Medicine
ISBN : MINN:31951M013754299
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1712 pages
File Size : 40,8 Mb
Release : 1985
Category : Medicine
ISBN : UOM:39015010011107
First multi-year cumulation covers six years: 1965-70.
Author : Francisco José H.N. Braga
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 46,5 Mb
Release : 2002-09-30
Category : Medical
ISBN : 1402071914
"More than half of the world's population is at risk of the tropical diseases malaria, leprosy, schistosomiasis, lymphatic filariasis, onchocerciasis, Chagas' disease, African trypanosomiasis and leishmaniasis and half a billion are infected with at least one of these diseases". J. H. F. Remme, World Health Organisation, 1993. "If it is true that science is not limited by frontiers and all research Institutions then belong to mankind, so it is natural for each Institution to be responsible for the problems of those who live in the geographic area under its influence. There are no specific aspects concerning physical, chemical or philosophical concepts and facts, but specificity does exist concerning geology, sociology and pathology. It is the duty of each Institution to study the particular aspects concerning its geographic region, as missing links of the chain of universal knowledge may be found there." H. L. de Oliveira, fonner Rector of the University ofSiio Paulo, 1967. "Nuclear Medicine is cost effective, especially in the developing countries. ( ... ).
Author : Bital Savir-Baruch,Bruce J. Barron
Publisher : Springer
Page : 237 pages
File Size : 55,8 Mb
Release : 2016-07-28
Category : Medical
ISBN : 9783319246369
This book is a learning aid and reference tool that provides all the important information pertaining to radioactive tracers within a single, easy-to-read volume. It introduces a new learning methodology that will help the reader to recall key facts on each tracer, including production, physical and chemical characteristics, study protocols, mechanism of action, distribution, and clearance. In addition, normal and abnormal tracer distributions are graphically reproduced on an outline of the human body using multiple colors. The book will be of value for all radiologists and medical students seeking a reliable source of essential information on radioactive tracers that can be readily consulted during everyday practice and used in preparation for examinations.
Author : E. Gordon DePuey,Ernest V. Garcia,Daniel Sholom Berman
Publisher : Lippincott Williams & Wilkins
Page : 366 pages
File Size : 40,5 Mb
Release : 2001
Category : Medical
ISBN : 0781720079
Cardiac SPECT Imaging, Second Edition offers the best of all possible worlds--a critical topic, internationally recognized authors and cutting-edge coverage. It guides you through all aspects of the modality--from basic principles (acquiring and processing images, quality control)...and clinical applications (evaluating myocardial infarction and coronary artery disease)...to the very latest equipment. It even compares SPECT with other modalities (PET, CT, MRI, and echocardiography) to ensure smart, cost-effective decisions by both the cardiologist and nuclear medicine physician.Look for new chapters on attenuation correction, gated perfusion SPECT, radiopharmaceuticals, and myocardial perfusion SPECT, as well as the very latest on myocardial perfusion SPECT in conjunction with exercise and pharmacologic stress, assessment of perfusion/viability with Tc-99m agents, how SPECT compares with other advanced cardiac imaging modalities, and more!
Author : J.C Baron,D. Comar,L. Farde,J.L. Martinot,B.M. Mazoyer
Publisher : Springer Science & Business Media
Page : 206 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401135283
Imaging of the Dopaminergic system in the human brain with the in vivo use of Positron Emis sion Tomography has emerged in the late 1980s as a tool of major importance in Clinical Neuros ciences and Pharmacology. The last few years have witnessed the rapid development of new radiotracers specific to receptors, reuptake sites and enzymes of the dopamine system; the application of these radiotracers has led to major breakthroughs in the pathophysiology and therapy of movement disorders and schizophrenic-like psychoses. This book is the first to collect, in a single volume, state-of-the-art contributions to the various aspects of this research. Its contents address methodological issues related to the design, labelling, quantitative imaging and compartmental modelisation of radioligands of the post-synaptic, pre-synaptic and enzyme sites of the dopamine system and to their use in clinical research in the fields of Parkinson's disease as well as other movement disorders, psychoses and neuroleptic receptor occupancy. The chapters were written by leading European scientists in the field of Positron Emission Tomography, gathered together in Caen (France, November 1990) under the aegis of the EEC Concerted Action on "PET Investigations of Cellular Regeneration and Degeneration. This book provides a current and comprehensive overview on PET studies of the brain dopamine system which should aid and interest neurologists, psychiatrists, pharmacologists and medical imaging scientists. J.C. Baron D. Comar L. Farde J.L. Martinot B. Mazoyer August 1991 ix LIST OF CONTRffiUTORS Dr Yves Agid DrL.
Author : B.M. Mazoyer,WD Heiss,D. Comar
Publisher : Springer Science & Business Media
Page : 270 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401116206
Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts: biochemistry and animal studies; amino acids labelling with positron emittors, quality control and metabolites measurement; kinetic modelling of amino acids transport, metabolism, and protein incorporation; clinical use of amino acids. This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.
Author : G. Stöcklin,V.W. Pike
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 46,6 Mb
Release : 1993-06-30
Category : Medical
ISBN : 0792323408
Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today. This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.
Author : Mrinal K. Dewanjee
Publisher : Springer Science & Business Media
Page : 627 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461535089
Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.
