Botanical Leads For Drug Discovery

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Botanical Leads for Drug Discovery

Bikarma Singh
Botanical Leads for Drug Discovery Book PDF

Author : Bikarma Singh
Publisher : Springer Nature
Page : 481 pages
File Size : 41,8 Mb
Release : 2020-10-05
Category : Medical
ISBN : 9789811559174

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Botanical Leads for Drug Discovery by Bikarma Singh Pdf

Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Drug Discovery & Development

Bhushan Patwardhan
Drug Discovery Development Book PDF

Author : Bhushan Patwardhan
Publisher : New India Publishing
Page : 368 pages
File Size : 52,5 Mb
Release : 2007
Category : Medical
ISBN : 8189422294

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Drug Discovery & Development by Bhushan Patwardhan Pdf

While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.

Phytochemicals as Lead Compounds for New Drug Discovery

Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Phytochemicals as Lead Compounds for New Drug Discovery Book PDF

Author : Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal
Publisher : Elsevier
Page : 382 pages
File Size : 55,8 Mb
Release : 2019-09-07
Category : Science
ISBN : 9780128178911

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Phytochemicals as Lead Compounds for New Drug Discovery by Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal Pdf

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Plant Natural Products for Human Health

Chun-Tao Che,Hongjie Zhang
Plant Natural Products for Human Health Book PDF

Author : Chun-Tao Che,Hongjie Zhang
Publisher : MDPI
Page : 514 pages
File Size : 55,5 Mb
Release : 2019-03-21
Category : Social Science
ISBN : 9783038977124

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Plant Natural Products for Human Health by Chun-Tao Che,Hongjie Zhang Pdf

Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs. This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

Lead Compounds from Medicinal Plants for the Treatment of Cancer

Christophe Wiart
Lead Compounds from Medicinal Plants for the Treatment of Cancer Book PDF

Author : Christophe Wiart
Publisher : Academic Press
Page : 432 pages
File Size : 41,5 Mb
Release : 2012-11-23
Category : Medical
ISBN : 9780123983824

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Lead Compounds from Medicinal Plants for the Treatment of Cancer by Christophe Wiart Pdf

Lead Compounds from Medicinal Plants for the Treatment of Cancer is the first volume in the series, Pharmaceutical Leads from Medicinal Plants. The plant species described in this reference have been carefully selected based on pharmacological evidence and represent today’s most promising sources of natural products for the discovery of anti-cancer drugs. Containing references to primary source material, over a hundred botanical illustrations, a table of chemical structures and much more, this book is an essential starting point for cancer researchers and those involved in anti-cancer drug discovery helping you identify the best novel lead molecules for further anti-cancer drug development. Provides a compilation of hundreds of medicinal plants from Europe, Asia, North and South America and Africa that contain prominent lead candidates for anti-cancer drug discovery Contains primary source references and hundreds of the most relevant citations from the current literature for additional research Offers cancer researchers and pharmaceutical scientists valuable tools such as chemical structures and promising pharmacological data to help them select the novel lead compounds that will best aid drug discovery.

Natural Product Experiments in Drug Discovery

Karuppusamy Arunachalam,Xuefei Yang,Sreeja Puthanpura Sasidharan
Natural Product Experiments in Drug Discovery Book PDF

Author : Karuppusamy Arunachalam,Xuefei Yang,Sreeja Puthanpura Sasidharan
Publisher : Springer Nature
Page : 569 pages
File Size : 44,6 Mb
Release : 2022-09-20
Category : Science
ISBN : 9781071626832

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Natural Product Experiments in Drug Discovery by Karuppusamy Arunachalam,Xuefei Yang,Sreeja Puthanpura Sasidharan Pdf

This detailed volume explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.

Drug Discovery And Development

Bhushan Patwardhan
Drug Discovery And Development Book PDF

Author : Bhushan Patwardhan
Publisher : Nipa
Page : 0 pages
File Size : 52,8 Mb
Release : 2023-06-14
Category : Medical
ISBN : 8119072855

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Drug Discovery And Development by Bhushan Patwardhan Pdf

While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.

Ethnobotany and the Search for New Drugs

Derek J. Chadwick,Joan Marsh
Ethnobotany and the Search for New Drugs Book PDF

Author : Derek J. Chadwick,Joan Marsh
Publisher : John Wiley & Sons
Page : 290 pages
File Size : 50,8 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470514641

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Ethnobotany and the Search for New Drugs by Derek J. Chadwick,Joan Marsh Pdf

A compilation of articles by prominent experts in their respective fields on compensation for and collaboration with indigenous people in regard to their knowledge and provision of rare plants which are used for some of the most potent drugs in Western medicine.

Out of Nature

Kara Rogers
Out of Nature Book PDF

Author : Kara Rogers
Publisher : University of Arizona Press
Page : 216 pages
File Size : 55,8 Mb
Release : 2012-02-01
Category : Science
ISBN : 9780816529698

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Out of Nature by Kara Rogers Pdf

About half of all species under threat of extinction in the world today are plants. The loss of plant biodiversity is disturbing for many reasons, but especially because it is a reflection of the growing disconnect between humans and nature. Plants have been used for millennia in traditional systems of healing and have held a significant place in drug development for Western medicine as well. Despite the recent dominance of synthetic drug production, natural product discovery remains the backbone of drug development. As the diversity of life on Earth is depleted and increasing numbers of species become lost to extinction, we continue to lose opportunities to achieve advances in medicine. Through stories of drug revelation in nature and forays into botany, human behavior, and conservation, Kara Rogers sheds light on the multiple ways in which humans, medicine, and plants are interconnected. Rogers also highlights the role that plant-based products can play in encouraging conservation and protecting the heritage and knowledge of indigenous peoples. The book delves into the complexity of biophilia--the innate human attraction to life in the natural world--and suggests that the reawakening of this drive is fundamental to expanding conservation efforts and improving medicine.--Publisher information

Poisonous Plants and Phytochemicals in Drug Discovery

Andrew G. Mtewa,Chukwuebuka Egbuna,G. M. Narasimha Rao
Poisonous Plants and Phytochemicals in Drug Discovery Book PDF

Author : Andrew G. Mtewa,Chukwuebuka Egbuna,G. M. Narasimha Rao
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 43,6 Mb
Release : 2020-12-04
Category : Science
ISBN : 9781119650270

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Poisonous Plants and Phytochemicals in Drug Discovery by Andrew G. Mtewa,Chukwuebuka Egbuna,G. M. Narasimha Rao Pdf

Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more - Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

Human-Plant Relations And Future Drug Discovery

Yash Pal Sharma,Bikarma Singh
Human Plant Relations And Future Drug Discovery Book PDF

Author : Yash Pal Sharma,Bikarma Singh
Publisher : New India Publishing Agency
Page : 4 pages
File Size : 49,6 Mb
Release : 2020-06-26
Category : Medical
ISBN : 9789389547979

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Human-Plant Relations And Future Drug Discovery by Yash Pal Sharma,Bikarma Singh Pdf

At present, a multifaceted in drug discovery from medicinal plants continues to unravel novel and important cues against various pharmacological targets including cancer, HIV/AIDS, Alzheimer's, malaria, and inflammation. Several plant-based natural product drugs have found their way into the commercial medicines as dietary supplements or as chemo-preventive agents while others are currently under clinical trials. This book gives an insight into the novel approach of integrated drug discovery, where traditional wisdom and traditional documented use can synergize with drug discovery from plant sources.

Natural Products and Drug Discovery

Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Natural Products and Drug Discovery Book PDF

Author : Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Publisher : Elsevier
Page : 776 pages
File Size : 55,8 Mb
Release : 2018-02-16
Category : Science
ISBN : 9780081021040

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Natural Products and Drug Discovery by Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi Pdf

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

The Plant Hunter

Cassandra Leah Quave
The Plant Hunter Book PDF

Author : Cassandra Leah Quave
Publisher : Penguin
Page : 385 pages
File Size : 53,6 Mb
Release : 2022-06-14
Category : Biography & Autobiography
ISBN : 9781984879134

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The Plant Hunter by Cassandra Leah Quave Pdf

The uplifting, adventure-filled memoir of one groundbreaking scientist’s quest to develop new ways to fight illness and disease through the healing powers of plants. “A fascinating and deeply personal journey.” ­—Amy Stewart, author of Wicked Plants and The Drunken Botanist Traveling by canoe, ATV, mule, airboat, and on foot, Dr. Cassandra Quave has conducted field research everywhere from the flooded forests of the remote Amazon to the isolated mountaintops in Albania and Kosovo—all in search of natural compounds, long-known to traditional healers, that could help save us all from the looming crisis of untreatable superbugs. Dr. Quave is a leading medical ethnobotanist—someone who identifies and studies plants that may be able to treat antimicrobial resistance and other threatening illnesses—helping to provide clues for the next generation of advanced medicines. And as a person born with multiple congenital defects of her skeletal system, she's done it all with just one leg. In The Plant Hunter, Dr. Quave weaves together science, botany, and memoir to tell us the extraordinary story of her own journey.

Handbook of Preformulation

Sarfaraz K. Niazi
Handbook of Preformulation Book PDF

Author : Sarfaraz K. Niazi
Publisher : CRC Press
Page : 470 pages
File Size : 45,7 Mb
Release : 2006-09-18
Category : Medical
ISBN : 9781420006629

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Handbook of Preformulation by Sarfaraz K. Niazi Pdf

Preformulation studies are the physical, chemical, and biological studies needed to characterize a drug substance for enabling the proper design of a drug product, whereas the effectiveness of a drug product is determined during the formulation studies phase. Though the two disciplines overlap in practice, each is a significantly distinct phase of

Recent Trends in Medicinal Plants Research

Anonim
Recent Trends in Medicinal Plants Research Book PDF

Author : Anonim
Publisher : Academic Press
Page : 440 pages
File Size : 40,8 Mb
Release : 2012-07
Category : Science
ISBN : 1493301306

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Recent Trends in Medicinal Plants Research by Anonim Pdf

Plants and other living organisms have great potential to treat human disease. There are two distinct types of biomedical research that seek to develop this potential. One type of research explores the value of medicinal plants as traditionally used andstudies of these plants have the potential to determine which plants are most potent, optimize dosages and dose forms, and identify safety risks. Another type of research uses bioassays to identify single molecules from plants that have interesting bioactivities in isolation and might be useful lead compounds for the development of pharmaceutical drugs. This new volume of Advances in Botanical Research covers the recent trends in Medicinal Plants Research over 11 chapters. Topics that are covered include Development of Drugs from Plants - Regulation and Evaluation, Chinese Herbal Medicines for Rheumatoid Arthritis, and Taxol, camptothecin and beyond for cancer therapy. Covers the recent trends in medicinal plants research over 11 chaptersTopics that are covered include Development of Drugs from Plants - Regulation and Evaluation, Chinese Herbal Medicines for Rheumatoid Arthritis, and Taxol, camptothecin and beyond for cancer therapy"