Download Full eBooks in PDF
Brain Targeted Autoimmunity Beyond Multiple Sclerosis Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Brain Targeted Autoimmunity Beyond Multiple Sclerosis book. This book definitely worth reading, it is an incredibly well-written.
Author : Serge Nataf,Roland S. Liblau,Guillaume Dorothee,Stéphane Hunot
Publisher : Frontiers Media SA
Page : 136 pages
File Size : 54,9 Mb
Release : 2021-06-01
Category : Medical
ISBN : 9782889668311
Author : Anonim
Publisher : Elsevier
Page : 568 pages
File Size : 54,8 Mb
Release : 2016-03-11
Category : Science
ISBN : 9780444634467
Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Author : Gregory Atkins,Sandra Amor,Jean Fletcher,Kingston Mills
Publisher : Cambridge University Press
Page : 128 pages
File Size : 53,8 Mb
Release : 2012-11-08
Category : Medical
ISBN : 9781139851060
Multiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students.
Author : Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Multiple Sclerosis: Current Status and Strategies for the Future
Publisher : National Academies Press
Page : 457 pages
File Size : 48,5 Mb
Release : 2001-08-10
Category : Medical
ISBN : 9780309072854
Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Author : Alastair Wilkins
Publisher : Springer
Page : 0 pages
File Size : 51,6 Mb
Release : 2018-09-05
Category : Medical
ISBN : 3319881329
This revised, updated second edition draws together the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. Each chapter addresses specific aspects of progressive multiple sclerosis providing an extensive review of the current literature and a discussion of the likely mechanisms of tissue injury relevant to the disease. New additions to the second edition include a description of clinical scales used to determine levels of disability; recent trials specifically directed at reducing disease progression; rehabilitation; and an in depth discussion of the similarities and differences between primary and secondary multiple sclerosis. The biological processes underlying disease progression are elucidated as are specific pathophysiological mechanisms. The basic science of axonal degeneration and the clinical understanding of progressive multiple sclerosis are discussed in the context of emerging and future therapies for disease progression as are trials which have been and will be conducted for progressive multiple sclerosis. An overview of biomarkers for the disease is included and existing symptomatic therapies for progressive multiple sclerosis are covered in detail. Progressive Multiple Sclerosis, Second Edition is ideal for both general neurologists and those with a specialist interest in multiple sclerosis. It will also be of interest to neurologists in training and other medical professionals treating this common disease.
Author : Alireza Minagar
Publisher : Elsevier
Page : 540 pages
File Size : 44,8 Mb
Release : 2010-12-17
Category : Science
ISBN : 0123849144
Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities
Author : M. Filippi,M. Rovaris,G. Comi
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 55,7 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9788847003910
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
Author : John Greenlee,Stacey L. Clardy,Christian Vedeler
Publisher : Frontiers Media SA
Page : 136 pages
File Size : 51,8 Mb
Release : 2022-06-07
Category : Medical
ISBN : 9782889762682
Author : Lewis Thomas
Publisher : Penguin
Page : 178 pages
File Size : 54,8 Mb
Release : 1995-05-01
Category : Science
ISBN : 9780140243284
This magnificent collection of essays by scientist and National Book Award-winning writer Lewis Thomas remains startlingly relevant for today’s world. Luminous, witty, and provocative, the essays address such topics as “The Attic of the Brain,” “Falsity and Failure,” “Altruism,” and the effects the federal government’s virtual abandonment of support for basic scientific research will have on medicine and science. Profoundly and powerfully, Thomas questions the folly of nuclear weaponry, showing that the brainpower and money spent on this endeavor are needed much more urgently for the basic science we have abandoned—and that even medicine’s most advanced procedures would be useless or insufficient in the face of the smallest nuclear detonation. And in the title essay, he addresses himself with terrifying poignancy to the question of what it is like to be young in the nuclear age. “If Wordsworth had gone to medical school, he might have produced something very like the essays of Lewis Thomas.”—TIME “No one better exemplifies what modern medicine can be than Lewis Thomas.”—The New York Times Book Review
Author : Christian Dettmers,John DeLuca
Publisher : Frontiers Media SA
Page : 89 pages
File Size : 40,6 Mb
Release : 2016-02-03
Category : Electronic book
ISBN : 9782889197637
Dear Readers, If you are engaged in the treatment of patients with MS (pwMS), this e-book’s aim is to offer novel insights to improve on an understanding of one of the major problems of pwMS: fatigue. Although there is increasing research into fatigue and its impact on MS, this collection of ten articles supports a better understanding of fatigue in MS patients. It explores pathophysiological concepts, provoking mechanisms, objective measurements, personality interactions, pharmacological and non-pharmacological interventions and summarizes clinical management. It is written by neurologists, psychologists, scientists and therapists and addresses this group of people, who deal with pwMS in private, clinical, rehabilitation or scientific settings. Its aim is to communicate high-quality information, knowledge and experience on MS to healthcare professionals, while providing global support for the international MS community.
Author : Jeffrey A. Cohen,Alexander Rae-Grant
Publisher : Springer Science & Business Media
Page : 88 pages
File Size : 49,8 Mb
Release : 2013-11-05
Category : Medical
ISBN : 9781907673504
Over the past 30 years there have been significant advances in our understanding of multiple sclerosis (MS) due to the use of MRIs to better visualize the disease and because of the introduction of new ameliorating drugs. However, MS is still an incurable disease and diagnosis remains challenging for many physicians; for instance symptoms often mimic MS and there is not a specific test for the disease. To ensure optimal patient care there is a need for physicians to remain up to date with new drugs on the market, disease detection, diagnosis, and latest management options. The Handbook of Multiple Sclerosis (Second Edition) provides a concise, easily assessable guide for all healthcare professionals involved in the diagnosis and management of this condition, including standard therapies, as well as more novel treatments. The book includes comprehensive evaluations of the pharmacological treatments available, including novel investigational agents currently in development.
Author : Alastair Compston,Douglas McAlpine
Publisher : Unknown
Page : 620 pages
File Size : 41,7 Mb
Release : 1998
Category : Multiple sclerosis
ISBN : UOM:39015046891498
This is the latest edition of the classic book on the subject of multiple sclerosis. An international group of authors has been involved in updating this edition which features more information on imaging and investigations, and a new chapter on neurobiology and glial development.
Author : Irun R. Cohen,Ariel Miller
Publisher : Academic Press
Page : 360 pages
File Size : 47,6 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015017426167
Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.
Author : Gareth W. Roberts,Julia M. Polak
Publisher : Cambridge University Press
Page : 204 pages
File Size : 55,9 Mb
Release : 1995-06-08
Category : Medical
ISBN : 0521425581
This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 52,7 Mb
Release : 2017
Category : Electronic
ISBN : OCLC:1368429553
Multiple sclerosis is degenerative disease of the central nervous system (CNS) in which myelin destruction and axon loss leads to the accumulation of physical, cognitive, and mental deficits. MS affects more than a million people worldwide and managing this chronic disease presents a significant health challenge. Multiple lines of evidence indicate that MS is an autoimmune disorder in which immune cells launch an inflammatory attack targeting myelin antigens. Indeed, myelin-reactive T cells and antibodies have been identified in MS patients and in animal models (namely experimental autoimmune encephalomyelitis, or EAE) that recapitulate many features of human disease. Animal model studies have demonstrated that T cells are both necessary and sufficient to initiate and sustain CNS autoimmunity. However, most MS animal models rely on the role played by CD4+ T cells and partially replicate the multiple aspects of MS pathogenesis. Thus, research in the past has focused heavily on the contribution of CD4+ T cells to the disease process; searching PubMed for "MS AND CD4" yields twice the results as corresponding searches for "CD8" or "B cell" and four times that for "NK cells". While CD4+ T cells may represent the minimum requirement to mediate CNS autoimmunity, it is clear that the immune response underlying human MS is far more complex and involves numerous other immune cells and subsets. This is well illustrated by the observation that MS patients treated with an anti-CD4 depleting antibody did not gain any clinical benefits whereas removal of several lymphocyte subsets using an anti-CD52 depleting antibody has been shown to impede disease progression. In particular, the pathogenic role(s) of non-CD4+ T cell lymphocytes is relatively poorly understood and under-researched, despite evidence that these subsets contribute to disease pathology or regulation. For example, the observed oligoclonal expansion of CD8+ T cells within the CNS compartment supports a local activation. CD8+ T cells with polarized cytolytic granules are seen in close proximity to oligodendrocytes and demyelinated axons in MS tissues. The presence of B cells in inflammatory lesions and antibodies in the CSF have long been recognized as features of MS and Rituximab, a B cell depleting therapy, has been shown to be highly effective to treat MS. Intriguingly, the putative MS therapeutic reagent Daclizumab may function in part through the expansion of a subset of immunoregulatory NK cells. NKT and ?d T cells may also play a role in CNS autoimmunity, given that they respond to lipid antigens and that myelin is lipid-rich. While different animal models recapitulate some of these aspects of human disease, identifying appropriate models and measures to investigate the role of these less well-understood lymphocytes in MS remains a challenge for the field. This Frontiers research topic aims to create a platform for both animal- and human-focused researchers to share their original data, hypotheses, future perspectives and commentaries regarding the role of these less-well understood lymphocyte subsets (CD8+ T cells, B cells, NK cells, NK T cells, ?d T cells) in the pathogenesis of CNS autoimmunity.