Cancer And Autoimmunity

Author : M.E. Gershwin,Yehuda Shoenfeld
Publisher : Elsevier
Page : 468 pages
File Size : 46,7 Mb
Release : 2000-03-27
Category : Medical
ISBN : 0080528457

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Cancer and Autoimmunity by M.E. Gershwin,Yehuda Shoenfeld Pdf

Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike. The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival. This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art. This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Author : Akihiko Yoshimura
Publisher : Springer
Page : 267 pages
File Size : 55,5 Mb
Release : 2017-11-25
Category : Medical
ISBN : 9783319689296

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Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity by Akihiko Yoshimura Pdf

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

Author : Gábor J. Szebeni,László G. Puskás
Publisher : MDPI
Page : 170 pages
File Size : 50,9 Mb
Release : 2020-12-02
Category : Science
ISBN : 9783039434664

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Immunophenotyping in Autoimmune Diseases and Cancer by Gábor J. Szebeni,László G. Puskás Pdf

The cooperation of highly specialized cell types maintains the homeostasis of multicellular organisms. The disturbance of that harmony contributes to the development of several diseases. Most of the cellular functions are executed by proteins, so it is essential to investigate biological processes at the protein level. Antibodies, complex biomolecules with high specificity, are used to recognize our protein of interest in a process known as “immunophenotyping”. One of the routinely used methods to study cellular proteins is flow cytometry, which detects cell surface or intracellular proteins at single-cell resolution. The other most frequent technique is the traditional immunohistochemical investigation of microscopic sections of human tissues. We called authors to publish their latest data studying cancer or autoimmune diseases by immunophenotyping.

Author : Gheorghita Isvoranu
Publisher : BoD – Books on Demand
Page : 194 pages
File Size : 45,5 Mb
Release : 2017-07-12
Category : Medical
ISBN : 9789535133438

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Lymphocyte Updates by Gheorghita Isvoranu Pdf

This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

Author : Erwan Mortier,Averil Ma,Barbara A. Malynn,Markus Neurath
Publisher : Frontiers Media SA
Page : 202 pages
File Size : 48,6 Mb
Release : 2020-12-11
Category : Medical
ISBN : 9782889662111

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Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer by Erwan Mortier,Averil Ma,Barbara A. Malynn,Markus Neurath Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Soner Şahin
Publisher : Unknown
Page : 128 pages
File Size : 41,8 Mb
Release : 2022-08-25
Category : Electronic
ISBN : 1685079377

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Autoimmunity and Cancer by Soner Şahin Pdf

The significance of autoimmune diseases increases day by day. Cancer is an important cause of mortality for which no definitive treatment has yet been found. Cancer can occur for many reasons. Studies have shown that autoimmunity underlies some types of cancer. On the contrary, antitumor immune responses may become cross-reactive with their own tissues, resulting in the development of autoimmunity. Further investigation of the relationship between autoimmunity and cancer will open new horizons for diagnosis and treatment of both groups of disease. This book presents studies of potential mechanisms linking autoimmunity and cancer and the relationship of malignancies with autoimmune disorders.

Author : Martin S. Staege,Alexander Emmer
Publisher : Frontiers Media SA
Page : 147 pages
File Size : 44,7 Mb
Release : 2019-03-20
Category : Electronic
ISBN : 9782889457632

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Endogenous Viral Elements – Links Between Autoimmunity and Cancer? by Martin S. Staege,Alexander Emmer Pdf

In this eBook, original and review papers on various aspects of endogenous viral elements (EVEs) are included. EVEs are integral parts of the genomes of eukaryotic organisms and are involved in various physiological and pathological processes. The focus of this eBook is on the involvement of EVEs in cancer and autoimmune diseases. Frontiers in Microbiology 3 February 2019 | EVEs, Autoimmunity and Cancer In particular, research on endogenous retroviruses and endogenous bornaviruses is included. The presented data demonstrate that EVEs are fascinating objects that are still worth exploring.

Author : R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld
Publisher : Elsevier
Page : 540 pages
File Size : 54,8 Mb
Release : 1997-11-19
Category : Medical
ISBN : 0080534430

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Idiotypes in Medicine: Autoimmunity, Infection and Cancer by R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld Pdf

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Author : Reem Saleh,Murugaiyan Gopal,Omer Gilan,Simon Keam
Publisher : Frontiers Media SA
Page : 133 pages
File Size : 41,8 Mb
Release : 2023-02-09
Category : Medical
ISBN : 9782832514115

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Recent advances and challenges in cancer immunotherapies for patients with autoimmune diseases by Reem Saleh,Murugaiyan Gopal,Omer Gilan,Simon Keam Pdf

Author : Jagat Kanwar
Publisher : BoD – Books on Demand
Page : 536 pages
File Size : 41,7 Mb
Release : 2012-05-09
Category : Medical
ISBN : 9789535105923

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Recent Advances in Immunology to Target Cancer, Inflammation and Infections by Jagat Kanwar Pdf

Immunology is the branch of biomedical sciences to study of the immune system physiology both in healthy and diseased states. Some aspects of autoimmunity draws our attention to the fact that it is not always associated with pathology. For instance, autoimmune reactions are highly useful in clearing off the excess, unwanted or aged tissues from the body. Also, generation of autoimmunity occurs after the exposure to the non-self antigen that is structurally similar to the self, aided by the stimulatory molecules like the cytokines. Thus, a narrow margin differentiates immunity from auto-immunity as already discussed. Hence, finding answers for how the physiologic immunity turns to pathologic autoimmunity always remains a question of intense interest. However, this margin could be cut down only if the physiology of the immune system is better understood. The individual chapters included in this book will cover all the possible aspects of immunology and pathologies associated with it. The authors have taken strenuous effort in elaborating the concepts that are lucid and will be of reader's interest.

Author : Richard T. Smith
Publisher : Elsevier
Page : 553 pages
File Size : 41,5 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323146265

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Immune Surveillance by Richard T. Smith Pdf

Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

Author : Lawrence M. Agius
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 52,5 Mb
Release : 2021
Category : Autoimmunity
ISBN : 153619610X

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Autoimmunity Versus Carcinogenesis in Tissue Injury by Lawrence M. Agius Pdf

"This book is a critical appraisal of the data and evidence available in literature of the relative roles of the immune response to neoplastic cells. An attempt has been made to render a better understanding of the various modes of impact of the immune response against tumors in general, particularly gliomas in some of the chapters. Autoimmune response is one mode of reactivity to native component cells within the body. Neoplastic transformation, on the other hand, critically necessitated the absence of an effective immune response to the transformed tumor cells in order for the lesion to grow and metastasize. This book is aimed towards a wider readership, but its particularly for oncologists and the various clinical and academic professionals that care for patients with cancer. It is especially meant to provide a clear exposition of known facts regarding the genesis and further development of neoplasms. Examples of some of the commoner lesions are accounted for"--

Author : Anonim
Publisher : BoD – Books on Demand
Page : 131 pages
File Size : 55,5 Mb
Release : 2021-12-22
Category : Technology & Engineering
ISBN : 9781789857993

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Fibroblasts by Anonim Pdf

Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer presents recent advances in understanding the roles of fibroblasts and mesenchymal stem cells in tissue homeostasis and the development of human disease. The book delves into general principles of fibroblast and mesenchymal stem cell biology and their diversity across the human body. It highlights these cells’ unique and shared characteristics across organs (e.g., vasculature, kidney, joints and exocrine glands) and specific pathologies (e.g., tissue damage, inflammation, fibrosis and cancer). A particular focus is set on the roles of fibroblasts in disease chronicity, recurrence, progression, therapeutic resistance and utilisation of the advancing knowledge for developing new therapeutic approaches within and beyond disease boundaries.

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 489 pages
File Size : 54,9 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Author : Carlo Perricone,Yehuda Shoenfeld
Publisher : Academic Press
Page : 728 pages
File Size : 48,9 Mb
Release : 2019-02-15
Category : Medical
ISBN : 9780128143070

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Mosaic of Autoimmunity by Carlo Perricone,Yehuda Shoenfeld Pdf

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications