Cancer Stem Cells And Signaling Pathways

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Cancer Stem Cells and Signaling Pathways

Surajit Pathak,Antara Banerjee
Cancer Stem Cells and Signaling Pathways Book PDF

Author : Surajit Pathak,Antara Banerjee
Publisher : Elsevier
Page : 703 pages
File Size : 53,8 Mb
Release : 2023-11-14
Category : Science
ISBN : 9780443132117

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Cancer Stem Cells and Signaling Pathways by Surajit Pathak,Antara Banerjee Pdf

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. Presents cancer stem characteristics and their signaling pathways Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

Stem Cells and Signaling Pathways

Surajit Pathak,Antara Banerjee
Stem Cells and Signaling Pathways Book PDF

Author : Surajit Pathak,Antara Banerjee
Publisher : Elsevier
Page : 513 pages
File Size : 54,9 Mb
Release : 2023-10-11
Category : Science
ISBN : 9780443188015

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Stem Cells and Signaling Pathways by Surajit Pathak,Antara Banerjee Pdf

Stem Cells and Signaling Pathways provides mechanistic insights into the role of stem cells to combat the COVID-19 outbreak and other pathologies where a cytokine storm is the cause of concern for e.g., radiation exposure, multiple organ failure and sepsis. The advent of SARS-CoV-2 resulted in a global pandemic, putting individuals with other comorbidities at a higher risk of infection. The whole world witnessed a massive shortage of medical and other essential supplies needed to combat the virus. That said, stem cell therapy has emerged as a potential treatment for viral diseases, including but not limited to COVID-19. Interestingly, the clinical trials in the patients having COVID-19 complications depicted faster recovery in patients post mesenchymal stem cells therapy owing to the decreased cytokines levels, anti-viral effects and regeneration of the infected tissue. Evaluates the role of MSCs to combat cytokine storm, the challenges regarding COVID-19 therapy, and how they can be countered with the use of stem cells and the risk of opportunistic infections post COVID-19 Presents how stem cell therapy has emerged as a potential treatment for viral diseases, including but not limited to COVID-19 Provides a detailed understanding of the novel coronavirus, with an emphasis on the therapeutic aspects

Cancer Stem Cells

Stanley Shostak
Cancer Stem Cells Book PDF

Author : Stanley Shostak
Publisher : BoD – Books on Demand
Page : 634 pages
File Size : 41,6 Mb
Release : 2011-08-01
Category : Medical
ISBN : 9789533075808

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Cancer Stem Cells by Stanley Shostak Pdf

Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo- and radiotherapy has been the notion of cancer stem cells.The twenty-eight chapters assembled in Cancer Stem Cells - The Cutting Edge summarize the work of cancer researchers and oncologists at leading universities and hospitals around the world on every aspect of cancer stem cells, from theory and models to specific applications (glioma), from laboratory research on signal pathways to clinical trials of bio-therapies using a host of devices, from solutions to laboratory problems to speculation on cancers' stem cells' evolution. Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but research on cancer stem cells has paid dividends for cancer prevention, detection, targeted treatment, and improved prognosis.

Cancer Stem Cell Markers and Related Network Pathways

Shihori Tanabe
Cancer Stem Cell Markers and Related Network Pathways Book PDF

Author : Shihori Tanabe
Publisher : Springer Nature
Page : 163 pages
File Size : 47,9 Mb
Release : 2023-02-02
Category : Medical
ISBN : 9783031129742

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Cancer Stem Cell Markers and Related Network Pathways by Shihori Tanabe Pdf

This book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype. This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways. The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in the field of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.

Cancer Stem Cells in Solid Tumors

Alison L. Allan
Cancer Stem Cells in Solid Tumors Book PDF

Author : Alison L. Allan
Publisher : Springer Science & Business Media
Page : 479 pages
File Size : 47,9 Mb
Release : 2011-08-12
Category : Science
ISBN : 9781617792465

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Cancer Stem Cells in Solid Tumors by Alison L. Allan Pdf

The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Cancer Stem Cells: New Horizons in Cancer Therapies

Surajit Pathak,Antara Banerjee
Cancer Stem Cells New Horizons in Cancer Therapies Book PDF

Author : Surajit Pathak,Antara Banerjee
Publisher : Springer Nature
Page : 369 pages
File Size : 55,9 Mb
Release : 2020-10-17
Category : Medical
ISBN : 9789811551208

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Cancer Stem Cells: New Horizons in Cancer Therapies by Surajit Pathak,Antara Banerjee Pdf

This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

Advances in Cancer Stem Cell Biology

Roberto Scatena,Alvaro Mordente,Bruno Giardina
Advances in Cancer Stem Cell Biology Book PDF

Author : Roberto Scatena,Alvaro Mordente,Bruno Giardina
Publisher : Springer Science & Business Media
Page : 343 pages
File Size : 45,8 Mb
Release : 2011-10-06
Category : Medical
ISBN : 1461408091

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Advances in Cancer Stem Cell Biology by Roberto Scatena,Alvaro Mordente,Bruno Giardina Pdf

In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

Stem Cells and Cancer

Lopa Mishra
Stem Cells and Cancer Book PDF

Author : Lopa Mishra
Publisher : IOS Press
Page : 112 pages
File Size : 51,5 Mb
Release : 2007
Category : Cancer
ISBN : 1586038028

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Stem Cells and Cancer by Lopa Mishra Pdf

Describes the role of cancer stem cells and progenitor cells in the progression to cancer. This volume refers to the role of stem cells in well-characterized diseases such as prostate and hepatocellular cancer, melanoma, chronic myeloid leukaemia and stem cell/cancer stem cell properties.

Stem Cells and Cancer Stem Cells, Volume 11

M.A. Hayat
Stem Cells and Cancer Stem Cells Volume 11 Book PDF

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 47,9 Mb
Release : 2013-10-21
Category : Medical
ISBN : 9789400773295

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Stem Cells and Cancer Stem Cells, Volume 11 by M.A. Hayat Pdf

Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods.

Role of Cancer Stem Cells in Cancer Biology and Therapy

Thomas Dittmar,Kurt S. Zänker
Role of Cancer Stem Cells in Cancer Biology and Therapy Book PDF

Author : Thomas Dittmar,Kurt S. Zänker
Publisher : CRC Press
Page : 332 pages
File Size : 41,8 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781466577367

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Role of Cancer Stem Cells in Cancer Biology and Therapy by Thomas Dittmar,Kurt S. Zänker Pdf

This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.

Signaling Pathways in Cancer Pathogenesis and Therapy

David A. Frank
Signaling Pathways in Cancer Pathogenesis and Therapy Book PDF

Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 148 pages
File Size : 53,9 Mb
Release : 2011-11-12
Category : Medical
ISBN : 1461412161

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Signaling Pathways in Cancer Pathogenesis and Therapy by David A. Frank Pdf

In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.

Stem Cells and Cancer Stem Cells, Volume 5

M.A. Hayat
Stem Cells and Cancer Stem Cells Volume 5 Book PDF

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 309 pages
File Size : 42,7 Mb
Release : 2012-02-21
Category : Medical
ISBN : 9789400729001

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Stem Cells and Cancer Stem Cells, Volume 5 by M.A. Hayat Pdf

It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although conventional chemotherapy kills most cells in a tumor, cancer stem cells remain intact. Vast applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, human mesenchymal stem cells, cancer stem cells, arterial stem cells, neural stem cells, cardiac stem cells, dental stem cells, limbal stem cells, and hematopoietic stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. These cells are used in tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. It is pointed out that the formation of embryoid bodies, which are three-dimensional aggregates of embryonic cells, is the initial step in the differentiation of these cells. Therapeutic implications of signalling pathways in cancer stem cells are pointed out. Targeting self-renewal pathways in cancer stem cells are also included. Application of mesenchymal stem cells for treating ischemic brain injury is explained. Neural stem cells proliferation into the surrounding area of the traumatic brain injury is explained.

Stem Cells and Human Diseases

Rakesh K. Srivastava,Sharmila Shankar
Stem Cells and Human Diseases Book PDF

Author : Rakesh K. Srivastava,Sharmila Shankar
Publisher : Springer Science & Business Media
Page : 633 pages
File Size : 47,6 Mb
Release : 2012-02-01
Category : Medical
ISBN : 9789400728004

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Stem Cells and Human Diseases by Rakesh K. Srivastava,Sharmila Shankar Pdf

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

Stem Cells and Cancer Stem Cells, Volume 4

M.A. Hayat
Stem Cells and Cancer Stem Cells Volume 4 Book PDF

Author : M.A. Hayat
Publisher : Springer Science & Business Media
Page : 325 pages
File Size : 52,7 Mb
Release : 2012-02-09
Category : Medical
ISBN : 9789400728271

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Stem Cells and Cancer Stem Cells, Volume 4 by M.A. Hayat Pdf

Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role of cancer stem cells, specifically in breast cancer is explained. Transplantation of mesenchymal stem cells to aid the injured brain is included. Immune recovery after stem cells transplantation in severe combined immunodeficiency patients is described. The role of mesenchymal stem cells in enhancing the growth and metastasis of colon cancer is discussed. Clinical application of human follicle stem cells is presented. Treatment of malignant gliomas using genetically-modified neural stem cells as a marker is discussed. The impact of cancer stem cell hypothesis on designing new cancer therapies is explained. In the field of regenerative medicine, the use of stem cells in the repair of the central nervous system, tendon injury, and as a cardiac regenerative medicine is described. The role of DNA methylation in maintaining stemness induced pluripotent stem cells from human extraembryonic amnion cells is discussed. Insights on the understanding of molecular pathways involved in tumor biology are explained, which lead to the development of effective drugs. Information on pathways, such as hedgehog, facilitates targeted therapies in cancer.

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

Sadegh Babashah
Cancer Stem Cells Emerging Concepts and Future Perspectives in Translational Oncology Book PDF

Author : Sadegh Babashah
Publisher : Springer
Page : 560 pages
File Size : 46,8 Mb
Release : 2015-11-12
Category : Medical
ISBN : 9783319210308

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Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology by Sadegh Babashah Pdf

The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.