Cancer Through The Lens Of Evolution And Ecology

Author : Jason A. Somarelli,Norman A. Johnson
Publisher : CRC Press
Page : 306 pages
File Size : 54,5 Mb
Release : 2024-05-29
Category : Medical
ISBN : 9781040027684

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Cancer through the Lens of Evolution and Ecology by Jason A. Somarelli,Norman A. Johnson Pdf

Cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms. Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.

Author : Beata Ujvari,Benjamin Roche,Frederic Thomas
Publisher : Academic Press
Page : 290 pages
File Size : 54,9 Mb
Release : 2017-02-08
Category : Medical
ISBN : 9780128043806

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Ecology and Evolution of Cancer by Beata Ujvari,Benjamin Roche,Frederic Thomas Pdf

Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Author : Andrei P. Kozlov
Publisher : Academic Press
Page : 248 pages
File Size : 44,6 Mb
Release : 2014-02-15
Category : Science
ISBN : 9780128004982

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Evolution by Tumor Neofunctionalization by Andrei P. Kozlov Pdf

Evolution by Tumor Neofunctionalization explores the possibility of the positive role of tumors in evolution of multicellular organisms. This unique perspective goes beyond recent publications on how evolution may influence tumors, to consider the possible role of tumors in evolution. Widespread in nature tumors represent a much broader category than malignant tumors only. The majority of tumors in humans and other animals may never undergo malignant transformation. Tumors may differentiate with the loss of malignancy, and malignant tumors may spontaneously regress. Cellular oncogenes and tumor suppressor genes play roles in normal development. Many features of tumors could be used in evolution, and there are examples of tumors that have played a role in evolution. This book will stimulate thinking on this topic by specialists in the fields of evolutionary biology, oncology, molecular biology, molecular evolution, embryology, evo-devo, tumor immunology, pathology and clinical oncology. Covers the role that tumors might play in evolution. Provides multidisciplinary approach that will appeal to a wide circle of professionals in the fields of evolutionary biology, oncology, molecular biology, and more

Author : Carlo C. Maley,Mel Greaves
Publisher : Springer
Page : 258 pages
File Size : 47,7 Mb
Release : 2016-11-21
Category : Medical
ISBN : 9781493964604

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Frontiers in Cancer Research by Carlo C. Maley,Mel Greaves Pdf

This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.

Author : Athena Aktipis
Publisher : Princeton University Press
Page : 256 pages
File Size : 48,5 Mb
Release : 2021-09-07
Category : Medical
ISBN : 9780691212197

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The Cheating Cell by Athena Aktipis Pdf

A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.

Author : Anonim
Publisher : Unknown
Page : 1066 pages
File Size : 42,6 Mb
Release : 2009-07
Category : Cancer
ISBN : NYPL:33433078242439

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Journal of the National Cancer Institute by Anonim Pdf

Author : Frederick R. Adler,Sarah R. Amend,Christopher J. Whelan,Etienne Baratchart
Publisher : Frontiers Media SA
Page : 259 pages
File Size : 54,6 Mb
Release : 2022-03-08
Category : Science
ISBN : 9782889746156

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From Ecology to Cancer Biology and Back Again by Frederick R. Adler,Sarah R. Amend,Christopher J. Whelan,Etienne Baratchart Pdf

Author : Mel Greaves
Publisher : Unknown
Page : 276 pages
File Size : 42,8 Mb
Release : 2004-11
Category : Medical
ISBN : 0756781450

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Cancer by Mel Greaves Pdf

Every day, 1500 Americans die of cancer, and yet for most of us this deadly disease remains mysterious. Why is it so common? Why are there so many different causes? Why does treatment so often fail? What, ultimately, is cancer? In this fascinating new book, a leading cancer researcher offers general readers clear and convincing answers to these and many other questions.Mel Greaves places cancer in its evolutionary context, arguing that we can best answer the big questions about cancer by looking through a Darwinian lens. Drawing on both ancient and more modern evolutionary legacies, he shows how human development has changed the rules of evolutionary games, trapping us in a nature-nurture mismatch. Compelling examples, from the King of Naples intestinal tumor in the 15th century, through the epidemic of scrotal skin cancer in 18th-century chimney sweeps, to the current surge of cases of prostate cancer illustrate his thesis. He also shows why the old paradigms of infectious diseases or genetic disorders have proved fruitless when trying to explain this complex and elusive disease. And finally, he looks at the implications for research, prevention, and treatment of cancer that an evolutionary perspective provides.Drawing on the most recent research, this is the first book to put cancer in its evolutionary framework. At a time when Darwinian perspectives on everything from language acquisition to economics are providing new breakthroughs in understanding, medicine seems to have much to gain from the insights provided by evolutionary biology. Written in an exceptionally lucid and entertaining style, this book will be of broad interest to all those who wish to know more about this dread disease.

Author : Jay Schulkin,Michael Power
Publisher : Oxford University Press
Page : 288 pages
File Size : 43,9 Mb
Release : 2019-12-19
Category : Medical
ISBN : 9780192543905

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Integrating Evolutionary Biology into Medical Education by Jay Schulkin,Michael Power Pdf

Clinicians and scientists are increasingly recognising the importance of an evolutionary perspective in studying the aetiology, prevention, and treatment of human disease; the growing prominence of genetics in medicine is further adding to the interest in evolutionary medicine. In spite of this, too few medical students or residents study evolution. This book builds a compelling case for integrating evolutionary biology into undergraduate and postgraduate medical education, as well as its intrinsic value to medicine. Chapter by chapter, the authors - experts in anthropology, biology, ecology, physiology, public health, and various disciplines of medicine - present the rationale for clinically-relevant evolutionary thinking. They achieve this within the broader context of medicine but through the focused lens of maternal and child health, with an emphasis on female reproduction and the early-life biochemical, immunological, and microbial responses influenced by evolution. The tightly woven and accessible narrative illustrates how a medical education that considers evolved traits can deepen our understanding of the complexities of the human body, variability in health, susceptibility to disease, and ultimately help guide treatment, prevention, and public health policy. However, integrating evolutionary biology into medical education continues to face several roadblocks. The medical curriculum is already replete with complex subjects and a long period of training. The addition of an evolutionary perspective to this curriculum would certainly seem daunting, and many medical educators express concern over potential controversy if evolution is introduced into the curriculum of their schools. Medical education urgently needs strategies and teaching aids to lower the barriers to incorporating evolution into medical training. In summary, this call to arms makes a strong case for incorporating evolutionary thinking early in medical training to help guide the types of critical questions physicians ask, or should be asking. It will be of relevance and use to evolutionary biologists, physicians, medical students, and biomedical research scientists.

Author : James DeGregori DeGregori
Publisher : Harvard University Press
Page : 250 pages
File Size : 41,5 Mb
Release : 2018-03-09
Category : Science
ISBN : 9780674985940

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Adaptive Oncogenesis by James DeGregori DeGregori Pdf

Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer’s occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in the ecosystem of the body’s tissues. His theory ties cancer’s progression, or lack thereof, to evolved strategies to maximize reproductive success. Through natural selection, humans evolved genetic programs to maintain bodily health for as long as necessary to increase the odds of passing on our genes—but not much longer. These mechanisms engender a tissue environment that favors normal stem cells over precancerous ones. Healthy tissues thwart cancer cells’ ability to outcompete their precancerous rivals. But as our tissues age or accumulate damage from exposures such as smoking, normal stem cells find themselves less optimized to their ecosystem. Cancer-causing mutations can now help cells adapt to these altered tissue environments, and thus outcompete normal cells. Just as changes in a species’ habitat favor the evolution of new species, changes in tissue environments favor the growth of cancerous cells. DeGregori’s perspective goes far in explaining who gets cancer, when it appears, and why. While we cannot avoid mutations, it may be possible to sustain our tissues’ natural and effective system of defense, even in the face of aging or harmful exposures. For those interested in learning how cancers arise within the human body, the insights in Adaptive Oncogenesis offer a compelling perspective.

Author : Yolanda F. Wiersma
Publisher : Springer Nature
Page : 229 pages
File Size : 42,7 Mb
Release : 2022-04-07
Category : Science
ISBN : 9783030951894

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Experimental Landscape Ecology by Yolanda F. Wiersma Pdf

This book offers the first guide to landscape ecologists on the art and science of doing experiments, both observational and manipulative. How do you conduct an experiment when your study subject is as big as a landscape? Issues of scale, spatial heterogeneity and limitations on replication may challenge scientists seeking to carry out robust experiments in landscape ecology. Beginning with an overview of the history and philosophy of the scientific method, and tracing the development of experimental approaches in ecology broadly, the first half of the book discusses the broader issues of what makes a good experiment. Individual chapters describe unique aspects of landscape ecology that present challenges to experimentation, with suggestions for solutions on issues of scale, and how to apply controls, randomization and adequate replication in a landscape setting. The second half of the book describes different kinds of landscape ecology experimental approaches including: large-scale manipulations experimental model landscapes mesocosms and microcosms in silico experiments novel landscapes Each chapter describes the advantages and disadvantages of each approach, and identifies the types of landscape ecology concepts and questions that a research can address. Examples from around the world, in a myriad of different environments, help to illustrate the ideas in each chapter. Together with an annotated resources section, this book aims to stimulate ideas and inspire creativity for graduate students and early career researchers who want to conduct better experiments in landscape ecology.

Author : James Graham
Publisher : Aculeus Pr
Page : 213 pages
File Size : 40,5 Mb
Release : 1992
Category : Science
ISBN : 0963024205

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Cancer selection by James Graham Pdf

Conventional evolutionary theory cannot explain the existence of humans & other complex animals; another mechanism is needed, says James Graham, & it is none other than cancer. This radical theory, already published in a science journal, is aimed at amateurs & professionals. "I think I agree with him... a good idea," John W. Galloway, Nature. "Intriguing...resolves many outstanding problems," SciTech Book News. Literary reviewers like it too: "absorbing...provocative." The Small Press Book Review. "fascinating...sheer intellectual virtuosity." West Coast Review of Books. "distinguished." The Book Reader. Order from: James Graham, PO Box 142, Lexington Virginia 24450 telephone 540 464 4554. Also available from Amazon.com, Barnes & Noble and other retailers.

Author : Joseph Panno
Publisher : Infobase Publishing
Page : 177 pages
File Size : 44,8 Mb
Release : 2005
Category : Biology
ISBN : 9780816067329

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Cancer by Joseph Panno Pdf

Examines what is known about cancer cells and current cancer research.

Author : Matteo Conti
Publisher : Springer Science & Business Media
Page : 97 pages
File Size : 41,5 Mb
Release : 2008-07-25
Category : Medical
ISBN : 9781402086427

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The Selfish Cell by Matteo Conti Pdf

A long time has passed since the war act on Cancer declared by former USA president Nixon, almost half a century ago. Today, after so many years of feverish research and uncountable efforts worldwide, the end of the war appears far as ever, whereas the fight is leading researchers to newer and newer battlefronts while frontiers in bioscience are continuously being surpassed. In this scenario, “The Selfish Cell” is a script record of the most important strategic points gathered during these years of war, with the goal to provide solid ground onto which to step ahead for future assaults against this terrible disease. At the same time, it is an attempt to shift the debate on cancer toward a more peaceful and possibly productive semantic terrain, where to reflect with the aid of superior wisdom to finally get out of that terrible chaos of fight and death dominating our days. In this perspective, “The selfish cell” becomes an occasion for reflecting the limits of our human selfishness and their consequences on both our social and natural environment.

Author : Kat Arney
Publisher : BenBella Books
Page : 256 pages
File Size : 52,6 Mb
Release : 2020-10-20
Category : Medical
ISBN : 9781950665518

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Rebel Cell by Kat Arney Pdf

Why do we get cancer? Is it our modern diets and unhealthy habits? Chemicals in the environment? An unwelcome genetic inheritance? Or is it just bad luck? The answer is all of these and none of them. We get cancer because we can't avoid it—it's a bug in the system of life itself. Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us. Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy. We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move. Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.