Cancer Virus Hunters

Author : Gregory J. Morgan
Publisher : JHU Press
Page : 388 pages
File Size : 48,5 Mb
Release : 2022-08-02
Category : Science
ISBN : 9781421444024

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Cancer Virus Hunters by Gregory J. Morgan Pdf

Traces the history of the study of tumor viruses and its role in driving breakthroughs in cancer research. Worldwide, approximately one-fifth of human cancers are caused by tumor viruses, with hepatitis B virus and HPV being the leading culprits. While the explosive growth in molecular biology in the late twentieth century is well known, the role that the study of tumor viruses has played in driving many of the greatest breakthroughs is not. Without the insights gained by studying tumor viruses, many significant theoretical advancements over the last four decades in cellular and molecular biology would not have been made. More practically, the study of tumor viruses has saved thousands, if not millions, of lives. In Cancer Virus Hunters, Gregory J. Morgan traces the high points in the development of tumor virology, from Peyton Rous's pioneering work on chicken tumors in 1909 to the successful development of an HPV vaccine for cervical cancer in 2006. Morgan offers a novel approach to understanding the interconnectedness of a long series of biomedical breakthroughs, including those that led to seven Nobel prizes. Among other advances, Morgan describes and contextualizes the science that prompted the discoveries of reverse transcriptase, RNA splicing, the tumor suppressor p53, the vaccine for hepatitis B, and the HIV test. He also explores how "cancer virus hunters" have demonstrated the virtue of beginning with a simple system, even when investigating a complex disease like cancer. Based on extensive archival research and over fifty interviews with experts, Cancer Virus Hunters is a tour de force summarizing a century of research to show how discoveries made with tumor viruses came to dominate the contemporary understanding of cancer. By showcasing the scientists themselves, the book makes for an unusually accessible journey through the history of science. It will be of interest to biomedical professionals—especially in oncology, hepatology, and infectious disease—in addition to historians of science and anyone interested in cancer research.

Author : Robin Wolfe Scheffler
Publisher : University of Chicago Press
Page : 391 pages
File Size : 45,8 Mb
Release : 2019-06-15
Category : Science
ISBN : 9780226628400

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A Contagious Cause by Robin Wolfe Scheffler Pdf

Is cancer a contagious disease? In the late nineteenth century this idea, and attending efforts to identify a cancer “germ,” inspired fear and ignited controversy. Yet speculation that cancer might be contagious also contained a kernel of hope that the strategies used against infectious diseases, especially vaccination, might be able to subdue this dread disease. Today, nearly one in six cancers are thought to have an infectious cause, but the path to that understanding was twisting and turbulent. ? A Contagious Cause is the first book to trace the century-long hunt for a human cancer virus in America, an effort whose scale exceeded that of the Human Genome Project. The government’s campaign merged the worlds of molecular biology, public health, and military planning in the name of translating laboratory discoveries into useful medical therapies. However, its expansion into biomedical research sparked fierce conflict. Many biologists dismissed the suggestion that research should be planned and the idea of curing cancer by a vaccine or any other means as unrealistic, if not dangerous. Although the American hunt was ultimately fruitless, this effort nonetheless profoundly shaped our understanding of life at its most fundamental levels. A Contagious Cause links laboratory and legislature as has rarely been done before, creating a new chapter in the histories of science and American politics.

Author : Greer Williams
Publisher : Unknown
Page : 568 pages
File Size : 50,6 Mb
Release : 1959
Category : Microbiology
ISBN : UOM:39015003213447

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Virus Hunters by Greer Williams Pdf

Author : Robert C. Gallo
Publisher : Unknown
Page : 384 pages
File Size : 53,6 Mb
Release : 1991-05-15
Category : Biography & Autobiography
ISBN : UOM:49015001165753

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Virus Hunting by Robert C. Gallo Pdf

Examines the discovery of AIDS and other notable discoveries, Gallo's investigation by the NIH, and provides a personal chronicle of the scientist's life.

Author : Joseph B. McCormick,Susan Fisher-Hoch,Leslie Alan Horvitz
Publisher : Unknown
Page : 381 pages
File Size : 47,9 Mb
Release : 1996
Category : Communicable diseases
ISBN : 0733603904

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Level 4 by Joseph B. McCormick,Susan Fisher-Hoch,Leslie Alan Horvitz Pdf

Author : Joseph B. McCormick,Susan Fisher-Hoch,Leslie Alan Horvitz
Publisher : Bloomsbury Publishing
Page : 379 pages
File Size : 55,9 Mb
Release : 1997
Category : Virology
ISBN : 0747534888

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The Virus Hunters by Joseph B. McCormick,Susan Fisher-Hoch,Leslie Alan Horvitz Pdf

Ebola, Lassa fever, HIV/AIDS, anthrax, leprosy, meningitis - Drs Joseph McCormick and Susan Fisher-Hoch have confronted, studied, probed and fought them all, case by case and on an epidemic scale. This is their story of a quarter-of-a-century on the front lines of the struggle to hold the narrow line separating humankind from what might well be the true inheritors of the Earth: viruses.;This book combines accounts of cutting-edge medical research with dramatic stories of survival in some of the most remote places on Earth, where the climate, the terrain and the politics can kill just as surely as any disease.

Author : Jane Qiu
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 2023-03-30
Category : Electronic
ISBN : 0008443890

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The Virus Hunters by Jane Qiu Pdf

Author : Joseph B. McCormick,Susan Fisher-Hoch,Leslie Alan Horvitz
Publisher : Unknown
Page : 397 pages
File Size : 43,8 Mb
Release : 1999
Category : Epidemiologists
ISBN : 1435160606

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Level 4 by Joseph B. McCormick,Susan Fisher-Hoch,Leslie Alan Horvitz Pdf

Author : Peter H. Duesberg
Publisher : Regnery Publishing
Page : 740 pages
File Size : 44,9 Mb
Release : 1998-05-01
Category : Health & Fitness
ISBN : 0895263998

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Inventing the AIDS Virus by Peter H. Duesberg Pdf

Investigates the political and financial forces that have shaped AIDS research, including the growing dissension within scientific ranks, the power politics among virologists, and other controversial issues

Author : C.J. Peters,Mark Olshaker
Publisher : National Geographic Books
Page : 0 pages
File Size : 54,9 Mb
Release : 1998-04-13
Category : Biography & Autobiography
ISBN : 9780385485586

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Virus Hunter by C.J. Peters,Mark Olshaker Pdf

A New York Times Notable Book The man who led the battle against Ebola in The Hot Zone teams up with the bestselling co-author of Mind Hunter to chronicle his extraordinary thirty-year career fighting deadly viruses. For three decades, Dr. C. J. Peters was on the front lines of our biological battle against “hot” viruses around the world. In the course of that career, he learned countless lessons about our interspecies turf wars with infectious agents. Called in to contain an outbreak of deadly hemorrhagic fever in Bolivia, he confronted the despair of trying to save a colleague who accidentally infected himself with an errant scalpel. Working in Level 4 labs on the Machupo and Ebola viruses, he saw time and again why expensive high-tech biohazard containment equipment is only as safe as the people who use it. Because of new, emerging viruses, and the return of old, “vanquished” ones for which vaccines do not exist, there remains a very real danger of a new epidemic that could, without proper surveillance and early intervention, spread worldwide virtually overnight. And the possibility of foreign countries or terrorist groups using deadly airborne viruses—the poor man’s nuclear arsenal—looms larger than ever. High-octane science writing at its best and most revealing, Virus Hunter is a thrilling first-person account of what it is like to be a warrior in the Hot Zone.

Author : Bryan J. Ellison,Peter Duesberg
Publisher : Unknown
Page : 314 pages
File Size : 43,9 Mb
Release : 1994
Category : Health & Fitness
ISBN : UCSC:32106015826644

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Why We Will Never Win the War on AIDS by Bryan J. Ellison,Peter Duesberg Pdf

Author : Jessica Wapner
Publisher : The Experiment, LLC
Page : 345 pages
File Size : 45,8 Mb
Release : 2014-04-08
Category : Health & Fitness
ISBN : 9781615191659

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The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment by Jessica Wapner Pdf

One of The Wall Street Journal’s 10 Best Nonfiction Books of the Year Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

Author : David Quammen
Publisher : W. W. Norton & Company
Page : 592 pages
File Size : 49,5 Mb
Release : 2012-10-01
Category : Science
ISBN : 9780393239225

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Spillover: Animal Infections and the Next Human Pandemic by David Quammen Pdf

"[Mr. Quammen] is not just among our best science writers but among our best writers, period." —Dwight Garner, New York Times The next big human pandemic—the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza—is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event “spillover” and they warn us to brace ourselves. David Quammen has tracked this subject from the jungles of Central Africa, the rooftops of Bangladesh, and the caves of southern China to the laboratories where researchers work in space suits to study lethal viruses. He illuminates the dynamics of Ebola, SARS, bird flu, Lyme disease, and other emerging threats and tells the story of AIDS and its origins as it has never before been told. Spillover reads like a mystery tale, full of mayhem and clues and questions. When the Next Big One arrives, what will it look like? From which innocent host animal will it emerge? Will we be ready?

Author : Nathan Wolfe
Publisher : Macmillan
Page : 319 pages
File Size : 45,7 Mb
Release : 2011-10-11
Category : Health & Fitness
ISBN : 9780805091946

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The Viral Storm by Nathan Wolfe Pdf

"The "Indiana Jones" of virus hunters reveals the complex interactions between humans and viruses, and the threat from viruses that jump from species to species"-- Provided by publisher.

Author : Michael B. A. Oldstone
Publisher : Oxford University Press, USA
Page : 513 pages
File Size : 55,8 Mb
Release : 2020
Category : Medical
ISBN : 9780190056780

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Viruses, Plagues, and History by Michael B. A. Oldstone Pdf

"Here, my previous edition of Viruses, Plagues, & History is updated to reflect both progress and disappointment since that publication. This edition describes newcomers to the range of human infections, specifically, plagues that play important roles in this 21st century. The first is Middle East Respiratory Syndrome (MERS), an infection related to Sudden Acute Respiratory Syndrome (SARS). SARS was the first new-found plague of this century. Zika virus, which is similar to yellow fever virus in being transmitted by mosquitos, is another of the recent scourges. Zika appearing for the first time in the Americas is associated with birth defects and a paralytic condition in adults. Lastly, illness due to hepatitis viruses were observed prominently during the second World War initially associated with blood transfusions and vaccine inoculations. Since then, hepatitis virus infections have afflicted millions of individuals, in some leading to an acute fulminating liver disease or more often to a life-long persistent infection. A subset of those infected has developed liver cancer. However, in a triumph of medical treatments for infectious diseases, pharmaceuticals have been developed whose use virtually eliminates such maladies. For example, Hepatitis C virus infection has been eliminated from almost all (>97%) of its victims. This incredible result was the by-product of basic research in virology as well as cell and molecular biology during which intelligent drugs were designed to block events in the hepatitis virus life-cycle"--