Cardiovascular Regulation

Author : Roland N. Pittman
Publisher : Biota Publishing
Page : 117 pages
File Size : 40,5 Mb
Release : 2016-08-18
Category : Medical
ISBN : 9781615047215

Get Book

Regulation of Tissue Oxygenation, Second Edition by Roland N. Pittman Pdf

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Author : David Jordan,Janice Marshall
Publisher : Ashgate Publishing
Page : 159 pages
File Size : 42,5 Mb
Release : 1995
Category : Medical
ISBN : 1855780240

Get Book

Cardiovascular Regulation by David Jordan,Janice Marshall Pdf

The Studies in Physiology series provides a concise introduction to developments in complex areas of physiology for a wide audience. Published on behalf of the Physiology Society, Cardiovascular Regulation provides an up-to-date account of our current understanding of the control of the cardiovascular system that is not covered by existing textbooks. Both students and lecturers of cardiovascular and exercise physiology, medicine, dentistry and biomedical sciences will find this book informative and easy to read. Each chapter has numerous summary boxes. 'Essential reading' suggestions provide additional reading for undergraduates and the suggestions for 'Further reading' cover the subject to postgraduate level.

Author : Nae J. Dun,Benedito H. Machado,Paul M. Pilowsky
Publisher : Springer Science & Business Media
Page : 420 pages
File Size : 49,7 Mb
Release : 2011-06-27
Category : Medical
ISBN : 9781441990549

Get Book

Neural Mechanisms of Cardiovascular Regulation by Nae J. Dun,Benedito H. Machado,Paul M. Pilowsky Pdf

Neural Mechanisms of Cardiovascular Regulation responds to current questions about how neurons in the central and peripheral nervous systems regulate the cardiovascular system. It includes a series of thoughtful reviews that are intended to provoke and illuminate the reader, with the intention of revealing some of the ideas that current practitioners in the field of cardiovascular research are using to generate their current studies.

Author : Paul Pilowsky
Publisher : Springer Science & Business Media
Page : 545 pages
File Size : 48,5 Mb
Release : 2013-03-13
Category : Science
ISBN : 9781461594710

Get Book

Central and Peripheral Mechanisms of Cardiovascular Regulation by Paul Pilowsky Pdf

There is increasing awareness that the autonomic nervous system, through its central and peripheral pathways, plays a critical role in the regulation of the circulation. Peripherally, the autonomic representation, largely that of sympathetic nerves, innervate virtually all segments of the vascular tree as well as the adrenal medulla. Through the interaction of nerve terminals, their transmitters, receptors and intracellular mediators in smooth muscle, sympathetic neurons control vascular tone as well as the basal performance of the heart. In turn, the performance of the autonomic nervous system is highly controlled by the brain. Once viewed as a black box with only a vague influence on cardiovascular performance, the introduction of concepts and techniques of neuroscience into the field of cardiovascular medicine has led to the realization of the critical role of this organ in cardiovascular control. It is now well recognized that within the brain, the represenation of cardiovascular function is highly restricted anatomically, engages a number of specific transmitters for its actions, and has highly selective and topographically restricted functions to influence circulatory performance.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 52,7 Mb
Release : 1981
Category : Electronic
ISBN : 0080268218

Get Book

Cardiovascular Physiology by Anonim Pdf

Author : Albert M. Magro
Publisher : Springer
Page : 566 pages
File Size : 46,6 Mb
Release : 1986-09-30
Category : Science
ISBN : UOM:39015011476416

Get Book

Central and Peripheral Mechanisms of Cardiovascular Regulation by Albert M. Magro Pdf

There is increasing awareness that the autonomic nervous system, through its central and peripheral pathways, plays a critical role in the regulation of the circulation. Peripherally, the autonomic representation, largely that of sympathetic nerves, innervate virtually all segments of the vascular tree as well as the adrenal medulla. Through the interaction of nerve terminals, their transmitters, receptors and intracellular mediators in smooth muscle, sympathetic neurons control vascular tone as well as the basal performance of the heart. In turn, the performance of the autonomic nervous system is highly controlled by the brain. Once viewed as a black box with only a vague influence on cardiovascular performance, the introduction of concepts and techniques of neuroscience into the field of cardiovascular medicine has led to the realization of the critical role of this organ in cardiovascular control. It is now well recognized that within the brain, the represenation of cardiovascular function is highly restricted anatomically, engages a number of specific transmitters for its actions, and has highly selective and topographically restricted functions to influence circulatory performance.

Author : KUNOS,CIRIELLO
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461598343

Get Book

Central Neural Mechanisms of Cardiovascular Regulation by KUNOS,CIRIELLO Pdf

With the help of recent technological advances in the study of cen tral nervous system function, important strides have been made in our knowledge regarding the pathophysiology of high blood pres sure. The understanding of neural mechanisms involved in the reg ulation of the cardiovascular system is of critical importance to the development of rational approaches to both the treatment and pre vention of this disease. It was in this spirit that a satellite symposium of the 13th Scientific Meeting of the International Society of Hyper tension was held in June 1990, in Bethesda, Maryland. The chapters, in this first of two volumes on the same general theme, are based on lectures presented at the symposium and it is hoped that these sum maries of recent research findings from prominent laboratories around the world will provide a stimulus for future research. The symposium would not have been possible without generous support from the National Institute on Alcohol Abuse and Alcoholism, Merck Frosst Canada, G.D. Searle Co., Squibb Institute of Medical Research, Smith, Kline & Beecham Co., Pfizer Co., E.I. Dupont de Nemours Co., Merck, Sharp & Dohme Co., The UpJohn Co., and Wyeth-Ayerst Co. While this volume was being prepared for publication, one of its contributors, Dr. Michael J. Brody, died suddenly. It is with deep sorrow and sympathy that we mourn the loss of our colleague. Dr.

Author : R. John Solaro
Publisher : Biota Publishing
Page : 46 pages
File Size : 49,5 Mb
Release : 2011-04-01
Category : Medical
ISBN : 9781615041756

Get Book

Regulation of Cardiac Contractility by R. John Solaro Pdf

Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension generation and shortening capability of the molecular motors (myosin cross-bridges) of the sarcomeres as determined by the rates and extent of Ca activation, the turnover kinetics of the cross-bridges, and the relative Ca responsiveness of the sarcomeres. Engagement of the regulatory signaling cascades controlling contractility occurs with occupancy and signal transduction by receptors for neurohumors of the autonomic nervous system as well as growth and stress signaling pathways. Contractility is also determined by the prevailing conditions of pH, temperature, and redox state. Short-term control of contractility is fully expressed during exercise. In long-term responses to stresses on the heart, contractility is modified by cellular remodeling and altered signaling that may compensate for a time but which ultimately may fail, leading to disorders.

Author : Bengt Saltin
Publisher : Human Kinetics
Page : 368 pages
File Size : 41,7 Mb
Release : 2000
Category : Blood
ISBN : 9780880116329

Get Book

Exercise and Circulation in Health and Disease by Bengt Saltin Pdf

Explores the functioning cardiovascular system from an integrative viewpoint. Includes both historical developments and recent findings on the diverse aspects of cardiovascular function. Provides a conceptual framework for understanding cardiovascular function in health, as well as analysis of altered cardiovascular control during illness or under various physical and environmental conditions. Topics are presented from a basic science perspective with relevant implactions for clinical and applied settings offered.

Author : D. Ganten,D. Pfaff
Publisher : Springer Science & Business Media
Page : 195 pages
File Size : 51,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642684906

Get Book

Central Cardiovascular Control by D. Ganten,D. Pfaff Pdf

The most prominent function of the central nervous system is the control of motor functions by rapidly transmitted impulses through efferent cranial and spinal peripheral nerves. Besides electrically transmitted neural impulses, humoral mechanisms with more sustained actions are exercised by the brain and spinal cord to regulate body homeostasis. Thus, the brain may be regarded as an "endocrine gland" discharging neurohormones (peptides) either into the general circulation (neurohypophyseal hormones) or into the hypothalamo-adenohypophyseal portal circulation (releasing and inhibiting hormones). The brain, therefore, which is protected by the blood-brain barrier from disturbing and potentially noxious exogenous and endogenous agents circulating in the blood, has to have certain neurohemal regions beyond this barrier, such as the neural lobe and the median eminence (infundibulum), where neurohor mones have free access to the blood stream. To regulate somatic and autonomic functions in the best possible way, the central nervous system is highly dependent on feedback signals conveyed through somatic and visceral afferent nerves as well as on peripheral humoral signals such as peripheral hormones and other circulating substances that are under homeostatic regulation, e. g. , peptides, arnines, electrolytes, and other biologically active agents. In this chapter, the role of the blood-brain barrier in the regulation of these sub stances will be discussed with special emphasis on the access through the blood-brain barrier to cardiovascular centers. 2 The Blood-Brain Barrier 2.

Author : Alberto Malliani
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 41,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461543831

Get Book

Principles of Cardiovascular Neural Regulation in Health and Disease by Alberto Malliani Pdf

This book is an attempt to indicate to researchers and clinicians a simple way to approach the complexity of cardiovascular neural regulation. A conceptual pillar like homeostasis is contrasted with instability and a continuous interaction of opposing mechanisms that have negative and positive feedback characteristics, and is considered to subserve the multitude of patterns pertaining to physiology. However, in pathophysiological conditions the final design is most often replaced by largely purposeless neural mechanisms. The complexity of cardiovascular neural regulation, reflected by the state of sympathovagal balance, is also assessed in the frequency domain. Power spectrum analysis of heart rate and arterial pressure variability, a sophisticated but simply explained approach, provides an unprecedented tool to evaluate this interaction in both physiological and pathophysiological conditions. The elementary characteristics of nonlinear dynamics are also outlined. Finally, the need for an ethical structure for science and medicine is analyzed.

Author : 3Island Press
Publisher : Unknown
Page : 400 pages
File Size : 52,6 Mb
Release : 1992-10-01
Category : Electronic
ISBN : 1468491857

Get Book

Central Neural Mechanisms of Cardiovascular Regulsation by 3Island Press Pdf

Author : Michitoshi Inoue,Masatsugu Hori,Shoichi Imai,Robert M. Berne
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 45,9 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9784431683674

Get Book

Regulation of Coronary Blood Flow by Michitoshi Inoue,Masatsugu Hori,Shoichi Imai,Robert M. Berne Pdf

Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Author : KUNOS,CIRIELLO
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468491845

Get Book

Central Neural Mechanisms in Cardiovascular Regulation by KUNOS,CIRIELLO Pdf

High blood pressure disease is one of the most prevalent pathological conditions in modem society with potentially serious consequences. During the last two decades major progress has been made in the development of rational approaches to the treatment of high blood pressure. A key factor in this progress has been an increase in our understanding of how the brain controls blood pressure. The chapters in the present book, together with those in a previous volume, provide a broad overview of recent progress in our knowledge of the central neural mechanisms involved in the regulation of the cardiovascular system. It is our hope that these essays by leading experts in the field will not only provide a useful source of information, but will also stimulate inquiry leading to new discoveries in this critically important field of research. George Kunos John Ciriello vii List of Contributors Jeffrey J. Anderson, Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46208, USA Katsuyuki Ando, Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo 112, Japan Jaideep S. Bains, Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3N6 Kathleen H. Berecek, Department of Physiology and Biophysics and the Vascular Biology and Hypertension Program, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA Vernon S. Bishop, Department of Physiology, The University of Texas Health Science Center, San Antonio, Texas 78284-7756, USA P. A.

Author : Hasso 04Scholz,Masao Endoh,Toshihiko Iijima,Martin Morad,Hasso Scholz
Publisher : Springer Science & Business Media
Page : 452 pages
File Size : 50,5 Mb
Release : 2013-12-14
Category : Medical
ISBN : 9784431659525

Get Book

Molecular and Cellular Mechanisms of Cardiovascular Regulation by Hasso 04Scholz,Masao Endoh,Toshihiko Iijima,Martin Morad,Hasso Scholz Pdf

This volume contains selected papers presented at the Sendai International Sympo sium on Molecular and Cellular Mechanisms of Cardiovascular Regulation held from May 10-12, 1995, to honor the contributions ofProfessorNorio Taira, Chairman of the Department of Pharmacology (1972-1995), Tohoku University School of Medicine, Sendai, Japan. The Department of Pharmacology at Sendai has a long tradition of significant contribution to the development of drug therapy for cardiovascular diseases. The late Professor Koroku Hashimoto, the predecessor of Professor Norio Taira, first suggested the mode of action of calcium antagonists and their potential usefulness in therapy of ischemic heart disease and hypertension at an early stage of their development. The need for greater understanding of the pathophysiology of cardiovascular dis eases is more critical now than ever before because modern advances in basic and clinical sciences have prolonged the average life expectancy. Using a wide range of molecular and electrophysiological techniques, major advances are occurring frequently in the field of cardiovascular physiology and pharmacology. Such multifaceted approaches are preferred because human cardiovascular diseases are complex, requiring multiple interventions and an in-depth understanding of molecular mechanisms underlying the disease. The first section of this book focuses on molecular mechanisms of ion channel regulation. Eight of ten chapters in this section are devoted to the recent advances in molecular characterization and regulation of various types of potassium channels in cardiac, vascular, and neuronal tissues. A discussion of the structure and function of sodium and calcium channels is also included.