Cellular And Molecular Approaches To Regeneration And Repair

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Cellular and Molecular Approaches to Regeneration and Repair

Paul A. Lapchak,John H. Zhang
Cellular and Molecular Approaches to Regeneration and Repair Book PDF

Author : Paul A. Lapchak,John H. Zhang
Publisher : Springer
Page : 541 pages
File Size : 51,7 Mb
Release : 2017-11-04
Category : Medical
ISBN : 9783319666792

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Cellular and Molecular Approaches to Regeneration and Repair by Paul A. Lapchak,John H. Zhang Pdf

This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.

Wound Regeneration and Repair

Robert G. Gourdie,Tereance A. Myers
Wound Regeneration and Repair Book PDF

Author : Robert G. Gourdie,Tereance A. Myers
Publisher : Humana Press
Page : 0 pages
File Size : 49,6 Mb
Release : 2013-09-13
Category : Science
ISBN : 1627035044

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Wound Regeneration and Repair by Robert G. Gourdie,Tereance A. Myers Pdf

In Wound Regeneration and Repair: Methods and Protocols, expert researchers in the field detail classical and cutting-edge methods for studying wound healing and regeneration. These techniques include cellular and molecular methods, genetic approaches, surgical procedures, clinical advances, drug discovery and delivery modalities, animal and humanized models and new applications in the treatment of pathological wounds in a variety of organs and tissues. Written in the highly successful Methods in Molecular Biology series format, chapters include an introduction to their respective topics, a detailed list of the necessary materials and reagents for each procedure, step-by-step, reproducible laboratory protocols, and a set notes, developed by the authors, for troubleshooting and avoiding known pitfalls. Authoritative and practical, Wound Regeneration and Repair: Methods and Protocols seeks to aid scientists and entrepreneurs in their further study of technologies, models, techniques, and critical new areas and approaches to clinical and commercial translation of research.

Cellular and Molecular Basis of Regeneration

Patrizia Ferretti,Jacqueline Géraudie
Cellular and Molecular Basis of Regeneration Book PDF

Author : Patrizia Ferretti,Jacqueline Géraudie
Publisher : Unknown
Page : 490 pages
File Size : 41,7 Mb
Release : 1998-05-29
Category : Medical
ISBN : UOM:39015047075414

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Cellular and Molecular Basis of Regeneration by Patrizia Ferretti,Jacqueline Géraudie Pdf

Provides an extensive overview of the fundamental issues of regeneration, and surveys selected models throughout phylogenesis. Eighteen contributions integrate information obtained from anatomical and experimental embryology studies with that derived from cellular and molecular approaches, and genetics. The emphasis throughout is on how information accumulating from each of the models discussed is shedding light both on the mechanisms underlying regeneration, and on whether and how this could be translated into clinical practice. Annotation copyrighted by Book News, Inc., Portland, OR

Stem Cells & Regenerative Medicine

Krishnarao Appasani,Raghu K. Appasani
Stem Cells Regenerative Medicine Book PDF

Author : Krishnarao Appasani,Raghu K. Appasani
Publisher : Springer Science & Business Media
Page : 629 pages
File Size : 53,6 Mb
Release : 2010-11-01
Category : Science
ISBN : 9781607618607

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Stem Cells & Regenerative Medicine by Krishnarao Appasani,Raghu K. Appasani Pdf

Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Principles of Regenerative Medicine

Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Principles of Regenerative Medicine Book PDF

Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publisher : Academic Press
Page : 1202 pages
File Size : 46,9 Mb
Release : 2010-12-16
Category : Science
ISBN : 0123814235

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Principles of Regenerative Medicine by Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem Pdf

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Stem Cell Repair and Regeneration

Nagy A Habib,Myrtle Y Gordon,Nataša Levičar,Long Jiao,Gilbert Thomas-Black
Stem Cell Repair and Regeneration Book PDF

Author : Nagy A Habib,Myrtle Y Gordon,Nataša Levičar,Long Jiao,Gilbert Thomas-Black
Publisher : World Scientific
Page : 256 pages
File Size : 54,5 Mb
Release : 2005-09-12
Category : Science
ISBN : 9781783260294

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Stem Cell Repair and Regeneration by Nagy A Habib,Myrtle Y Gordon,Nataša Levičar,Long Jiao,Gilbert Thomas-Black Pdf

Stem cell research is one of the leading “cutting edge” areas of life science research in the world today and is a topic of significant interest to a broad range of the medical and scientific community. This authoritative book provides reviews by the field's leading scientists and covers many of the areas in which stem cells are becoming increasingly important, such as in organ repair and regeneration. Stem cells offer the possibility of cell therapy issues to treat a myriad of diseases, conditions, and disabilities including Parkinson's and Alzheimer's diseases, spinal cord injury, stroke, heart disease, and diabetes. Contents:An Introduction to Stem and Progenitor Cell Biology (M R Alison)Asymmetric Self-Renewal: The Mark of the Adult Stem Cell (J L Sherley)Transcriptional Regulation of Blood Stem Cells (B Göttgens)Post-natal Neovascularization — The Role of Endothelil Progenitor Cells, Growth Factors and the Extracellular Matrix (S Rahman et al.)Creating Designer Cells: Genetic Engineering of Stem Cells by Site-Specific Recombination (F Edenhofer & M Peitz)Kinetic Considerations for Stem Cell Therapy (M Gordon)Stem Cells and Tissue Engineering (A Vats et al.)Human Foetal Mesenchymal Stem Cells (J Chan et al.)Gene-Modified Mesenchymal Stem Cells as Cytoreagents for Regenerative Therapy (H Hamada)Pharmacological Characterisation of Embryonic Stem Cell-Derived Cardiomyoctye Cultures (N N Ali et al.)Adult Stem Cells in Cardiac Cellular Transplantation (I Dimarakis)Pancreas and Liver Regeneration and Neogenesis (R R Dodge)Extrahepatic Stem Cells in Liver Regeneration and Repair (A D Sharma & M Ott)Overview of Progress in the Differentiation of Embryonic Stem Cells into Pancreatic Beta-Cell Derivatives (J Jones et al.)Stem Cells and Clinical Application (N Levičar)Application of MRI to Stem Cell Imaging (K Bhakoo et al.) Readership: Life scientists, medical doctors and surgeons in academia and industry interested in stem cells and developing stem cell therapies. Scientists in biotechnology and pharmaceutical industries. Key Features:Comprehensive collection of many significant topics; from stem cell basics to stem cell therapyDefinitive and up-to-date guide to where and how stem cells can be used in repair and regenerationKeywords:Stem Cells;Cell Therapy;Tissue Engineering;Organ Regeneration;Liver;Pancreas;Heart

Stem Cells & Regenerative Medicine

Krishnarao Appasani,Raghu K. Appasani
Stem Cells Regenerative Medicine Book PDF

Author : Krishnarao Appasani,Raghu K. Appasani
Publisher : Humana Press
Page : 629 pages
File Size : 42,9 Mb
Release : 2011-07-21
Category : Science
ISBN : 1607618613

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Stem Cells & Regenerative Medicine by Krishnarao Appasani,Raghu K. Appasani Pdf

Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Stem Cells and Tissue Repair

Chrissa Kioussi
Stem Cells and Tissue Repair Book PDF

Author : Chrissa Kioussi
Publisher : Humana
Page : 0 pages
File Size : 48,7 Mb
Release : 2020-05-31
Category : Science
ISBN : 1071606549

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Stem Cells and Tissue Repair by Chrissa Kioussi Pdf

This volume looks at a collection of stem cell and regenerative techniques used by both novice and expert scientists. Chapters cover topics such as tissue repaired by expansion and reprogramming; induced pluripotent stem cells driven in neuronal or vascular differentiation; using mesenchymal stem cells to derive skeletal muscle, osteoblasts, and spermatogonial cells; and the technique of monitoring the development of sub-organ microenvironments in the developing pancreas. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Stem Cells and Tissue Repair: Methods and Protocols, Second Edition is a valuable resource that provides readers with the latest descriptions and references for exploring this vast field in regenerative medicine.

Whole-Body Regeneration

Simon Blanchoud,Brigitte Galliot
Whole Body Regeneration Book PDF

Author : Simon Blanchoud,Brigitte Galliot
Publisher : Humana
Page : 685 pages
File Size : 53,5 Mb
Release : 2022-04-01
Category : Science
ISBN : 1071621742

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Whole-Body Regeneration by Simon Blanchoud,Brigitte Galliot Pdf

This Open Access volume provides a comprehensive overview of the latest tools available to scientists to study the many facets of whole-body regeneration (WBR). The chapters in this book are organized into six parts. Part One provides a historical overview on the study of the WBR phenomena focusing on the primary challenges of this research. Parts Two and Three explore a series of non-vertebrate zoological contexts that provide experimental models for WBR, showing how they can be approached with cellular tools. Parts Four, Five, and Six discuss the future advancements of WBR, reporting about the cutting-edge techniques in genetics and omics used to dissect the underlying mechanisms of WBR, and systems biology approaches to reach a synthetic view of WBR. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Whole-Body Regeneration: Methods and Protocols is a valuable resource for scientists and researchers who want to learn more about this important and developing field.

Cellular and Molecular Mechanisms of Lung Regeneration, Repair, and Fibrosis

Chunheng Mo,Xiao Xiao Tang,Shigeyuki Shichino,Gianluca Bagnato
Cellular and Molecular Mechanisms of Lung Regeneration Repair and Fibrosis Book PDF

Author : Chunheng Mo,Xiao Xiao Tang,Shigeyuki Shichino,Gianluca Bagnato
Publisher : Frontiers Media SA
Page : 123 pages
File Size : 50,7 Mb
Release : 2024-01-23
Category : Science
ISBN : 9782832543252

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Cellular and Molecular Mechanisms of Lung Regeneration, Repair, and Fibrosis by Chunheng Mo,Xiao Xiao Tang,Shigeyuki Shichino,Gianluca Bagnato Pdf

Organ fibrosis seriously threatens human health. Globally, more than 30% of the diseases that cause disability and death are due to organ fibrosis. However, there have been so far only a few effective treatments for organ fibrosis. Idiopathic pulmonary fibrosis (IPF) is progressive, lethal fibrotic lung disease. Approximately, 10/100,000 people globally suffer from pulmonary fibrosis, and the incidence is on the rise. The median survival for patients is only 3-5 years. Currently there is no effective treatment for lung fibrosis. Therefore, new insights into lung fibrosis and therapeutic strategy should be explored and developed. This Research Topic aims to deepen the understanding and research on the pathogenesis of lung fibrosis to develop effective treatments. Studies have shown that effective lung repair and regeneration are critical biological processes for the restoration of original physiological function of lung after injury. The intrinsic ability of regeneration and repair is often suppressed in lung with chronic injury or the diseased organs, leading to fibrosis and loss of function. Targeting key pathways in the process of lung regeneration can promote the repair of the impaired lung and alleviate fibrosis in animal models. How to induce regeneration and repair of the impaired organ to alleviate fibrosis is a frontier research topic. Hence, this Research Topic focuses on the cellular and molecular mechanisms of lung regeneration, repair, and fibrosis. Moreover, this topic will also focus on the study of lung development to provide new insights into the pathogenesis of lung injury and fibrosis.

Elastic Fiber Matrices

Anand Ramamurthi,Chandrasekhar Kothapalli
Elastic Fiber Matrices Book PDF

Author : Anand Ramamurthi,Chandrasekhar Kothapalli
Publisher : CRC Press
Page : 352 pages
File Size : 54,6 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9781498721936

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Elastic Fiber Matrices by Anand Ramamurthi,Chandrasekhar Kothapalli Pdf

Elastic Fiber Matrices: Biomimetic Approaches to Regeneration and Repair provides a comprehensive resource on the intrinsic and pathological aberrations of the complex process of elastic matrix assembly and/or variations thereof in different elastic tissue types, and on strategies to regenerate or restore lost elastin matrix, either in vitro or in vivo, including biomimetic elastin-like-peptides, gene therapy, drug delivery, tissue engineering (biomolecules, scaffolds, and mechanical stimuli), pharmacological approaches, elastin stabilization and preservation, stem cell therapy, allografts/xenografts, and synthetic/biological elastomers. Comprised of individual chapters contributed by leading researchers and scientists in the field, the text details current approaches for elastin matrix regeneration and repair, identifying their various advantages and limitations while offering valuable insight into emerging trends. Thus, this book is a must-have guide for academicians and industry professionals working in the areas of connective tissue biology, tissue engineering, dermal and cardiovascular biomaterials, and drug delivery.

Stem Cell Repair and Regeneration

Natasa Levicar
Stem Cell Repair and Regeneration Book PDF

Author : Natasa Levicar
Publisher : Imperial College Press
Page : 318 pages
File Size : 42,8 Mb
Release : 2008
Category : Medical
ISBN : 9781860949814

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Stem Cell Repair and Regeneration by Natasa Levicar Pdf

Stem cell research is one of the leading "cutting edge" areas of life science research in the world today and is a topic of significant interest to a broad range of the medical and scientific community. This authoritative book provides reviews by the field's leading scientists and covers many of the areas in which stem cells are becoming increasingly important, such as in organ repair and regeneration. Stem cells offer the possibility of cell therapy issues to treat a myriad of diseases, conditions, and disabilities including Parkinson's and Alzheimer's diseases, spinal cord injury, stroke, heart disease, and diabetes.

Stem Cells for Myocardial Regeneration

Randall J. Lee
Stem Cells for Myocardial Regeneration Book PDF

Author : Randall J. Lee
Publisher : Humana
Page : 267 pages
File Size : 50,6 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493961268

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Stem Cells for Myocardial Regeneration by Randall J. Lee Pdf

The feld of regenerative medicine is in its infancy state. Enthusiasm for the potential of organ regeneration lies with the potential pluripotency of stem cells to differentiate into various tissue types. This volume of Methods in Molecular Biology will focus on the use of stem cells for myocardial repair and regeneration. The emphasis of this issue will be to provide basic scientists, translational investigators, and cardiologists a means to evaluate the effcacy and safety of stem cells in a standardized fashion for myocardial regeneration. Many different cell types have been considered for myocardial repair. Adult card- myocytes are unable to survive even when transplanted into normal myocardium. The use of fetal or neonatal cardiomyocytes is not a feasible source of cells due to ethical concerns and donor availability. Therefore, the use of pluripotent stem cells has become the focus of a cell source for myocardial repair and regeneration. A variety of stem cell types have been suggested to participate in myocardial repair. This has led the investigators to search for the “optimal cell type for myocardial repair”. Reliable isolation of the cell source with the ability to expand the cell population is a prerequisite. In the frst section of this book, methods for isolation of commonly used stem cells being investigated for myocardial regeneration are presented. Once a stem cell source has been selected, the stem cell needs to be tested in an app- priate animal model before being translated into clinical practice.

On Tissue Engineering and Regenerative Medicine of Skin and Its Appendages

Marianna Bei,Basak E. Uygun
On Tissue Engineering and Regenerative Medicine of Skin and Its Appendages Book PDF

Author : Marianna Bei,Basak E. Uygun
Publisher : Frontiers Media SA
Page : 109 pages
File Size : 40,7 Mb
Release : 2019-11-01
Category : Electronic
ISBN : 9782889631070

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On Tissue Engineering and Regenerative Medicine of Skin and Its Appendages by Marianna Bei,Basak E. Uygun Pdf

Skin is the largest organ of the body and is necessary for survival, since it performs many functions such as providing a physical barrier to the external environment, sensation, retention of normal hydration and thermal regulation. Significant skin loss is associated with high mortality and morbidity in the acute phase, and with physically and cosmetically drastic scarring in the long term. Although there are a number of tissue-engineered products in the clinic that are used as skin substitutes to promote healing of traumatic burn and diabetic wounds, yet they lack several important functions including those provided by the appendages such as the hair follicles, sebaceous and sweat glands. The understanding of cellular, molecular and engineering aspects of the pathology, repair and/or regeneration of skin after wound induction is of paramount importance in order to develop the next generation of tissue engineered products with gene-enhanced capacity. In that context, we brought together scientists from basic research, translational and bioengineering fields, whose work focus on cutting-edge research associated with the acquisition of new therapeutic approaches towards skin regeneration.

Organ Regeneration

Joydeep Basu,John W. Ludlow
Organ Regeneration Book PDF

Author : Joydeep Basu,John W. Ludlow
Publisher : Unknown
Page : 377 pages
File Size : 49,8 Mb
Release : 2013
Category : Regenerative medicine
ISBN : 1627033637

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Organ Regeneration by Joydeep Basu,John W. Ludlow Pdf

Tissue engineering and regenerative medicine represents a wide array of cell, biomaterial and cell/biomaterial based approaches focusing on the repair, augmentation, and regeneration of diseases tissues and organs. Organ Regeneration: Methods and Protocols has been assembled in response to the growing interest in organ and tissue regeneration as a means to treat disease. Topics cover methods such as isolation and characterization of cells from selected soft tissues and solid organs, preparation and evaluation of natural and synthetic biomaterial scaffolding, implantation of regenerative constructs within experimental animals, and evaluation of regenerative outcomes by molecular and histological methodologies. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Organ Regeneration: Methods and Protocols serves as a detailed guide to aid newcomers and seasoned veterans in their developmental and experimental work in tissue engineering and regenerative medicine.