Cellular Molecular And Environmental Contribution In Cardiac Remodeling

Author : Asim K. Duttaroy,Rahul Mallick
Publisher : Elsevier
Page : 342 pages
File Size : 52,9 Mb
Release : 2024-04-16
Category : Science
ISBN : 9780323995719

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Cellular, Molecular, and Environmental Contribution in Cardiac Remodeling by Asim K. Duttaroy,Rahul Mallick Pdf

Cellular, Molecular and Environmental Contribution in Cardiac Remodeling: From Lab Bench to Clinical Perspective consolidates the most recent research advances on cellular, molecular, biochemical, and heterogeneous factors contributing to the physiological and pathological cardiac remodeling, elucidating their mechanisms of action and the clinical outcomes of cardiac remodeling. It extensively covers the factors determining cardiac remodeling, including cardiomyocyte regeneration, cardiac stem cells and their therapeutic potential, cardiac resident pericytes, the role of natural bioactive compounds in cardiac remodeling, chronic cardiac adaptations to exercise and more. This book provides basic science researchers and clinical investigators in cardiology with a current and comprehensive resource on molecular mechanisms and contributing factors to cardiac remodeling, and its effects and impacts on heart health. New research areas for the future, aimed at preventing, limiting, and reversing bad remodeling, are also discussed. Provides a concise summary of recent developments in cardiac remodeling research, combining novel information and the latest data published in this field Discusses not only cellular and molecular factors impacting cardiac remodeling, but also environmental contributions such as lifestyle and exercise Identifies areas for future research and potential novel strategies for translating basic research knowledge to applications in patients

Author : Bodh I. Jugdutt,Naranjan S. Dhalla
Publisher : Springer Science & Business Media
Page : 566 pages
File Size : 49,9 Mb
Release : 2013-02-15
Category : Medical
ISBN : 9781461459309

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Cardiac Remodeling by Bodh I. Jugdutt,Naranjan S. Dhalla Pdf

The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees. This book should stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.

Author : Leonardo Roever,Antonio C. Palandri Chagas
Publisher : Frontiers Media SA
Page : 119 pages
File Size : 50,9 Mb
Release : 2017-11-15
Category : Electronic book
ISBN : 9782889453313

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Cardiac Remodeling: New Insights in Physiological and Pathological Adaptations by Leonardo Roever,Antonio C. Palandri Chagas Pdf

The effective management of Cardiac remodeling(CR), remains a major challenge. Heart failure remains the leading cause of death in industrialized countries. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising agents were found to decrease mortality in patients recovering from myocardial infarction. Cardiac remodeling is defined as molecular and interstitial changes, manifested clinically by changes in size, mass , geometry and function of the heart in response to certain aggression. Initially, ventricular remodeling aims to maintain stable cardiac function in situations of aggression.

Author : Monte Willis,Jonathon W. Homeister,James R. Stone
Publisher : Academic Press
Page : 338 pages
File Size : 53,9 Mb
Release : 2013-12-23
Category : Science
ISBN : 9780124055254

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Cellular and Molecular Pathobiology of Cardiovascular Disease by Monte Willis,Jonathon W. Homeister,James R. Stone Pdf

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology

Author : Pawan K. Singal,Ian M.C. Dixon,Naranjan S. Dhalla,Lorrie A. Kirshenbaum
Publisher : Springer Science & Business Media
Page : 570 pages
File Size : 52,6 Mb
Release : 2003-02-28
Category : Medical
ISBN : 1402071779

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Cardiac Remodeling and Failure by Pawan K. Singal,Ian M.C. Dixon,Naranjan S. Dhalla,Lorrie A. Kirshenbaum Pdf

The importance of the developmental approach for experimental and clinical cardiology is indisputable. Clinical-epidemiological studies have clearly shown that the risk factors of serious cardiovascular diseases, such as atherosclerosis and ischemic heart disease, are already present during the early phases of ontogenetic development. Furthermore, congenital cardiovascular malformations remain the single largest cause of infant mortality from congenital defects in industrial countries. It is therefore not surprising that the interest of theoretical and clinical cardiologists in the developmental approach keeps increasing. Advances in molecular biology accelerated this trend substantially. This book is based on contributions presented at the international symposium The Developing Heart in Prague in May 2000. It is our contention that the biological, electrophysiological, morphological, functional, biochemical and functional approaches employed by distinguished scientists worldwide will provide the reader with a global picture for changes characterizing the developing heart. It should stimulate the curiosity of cardiovascular scientists in gaining insight into the mechanisms of normal and pathological development.

Author : Samuel Alexandre Almeida Hónorio,Marcos Baptista,João Monteiro Serrano,Maria-Raquel Silva
Publisher : Unknown
Page : 128 pages
File Size : 52,9 Mb
Release : 2020
Category : Sports
ISBN : 1839681829

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Sports, Health and Exercise Medicine by Samuel Alexandre Almeida Hónorio,Marcos Baptista,João Monteiro Serrano,Maria-Raquel Silva Pdf

Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
Publisher : Springer
Page : 274 pages
File Size : 40,8 Mb
Release : 2017-10-27
Category : Medical
ISBN : 9783319561066

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Cardiac Regeneration by Masaki Ieda,Wolfram-Hubertus Zimmermann Pdf

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Author : Milica Radisic,Lauren D. Black III
Publisher : Humana Press
Page : 0 pages
File Size : 53,7 Mb
Release : 2014-07-29
Category : Science
ISBN : 1493910469

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Cardiac Tissue Engineering by Milica Radisic,Lauren D. Black III Pdf

Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.

Author : Anonim
Publisher : Unknown
Page : 1000 pages
File Size : 51,8 Mb
Release : 1993
Category : Environmental health
ISBN : STANFORD:36105112093344

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Environmental Health Perspectives by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 184 pages
File Size : 54,8 Mb
Release : 2001
Category : Ecology
ISBN : IND:30000143535734

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Reviews in Environmental Health, 2001 by Anonim Pdf

Author : Kenneth Scott Campbell,Amy Li,Sean Lal
Publisher : Frontiers Media SA
Page : 187 pages
File Size : 47,8 Mb
Release : 2023-09-06
Category : Medical
ISBN : 9782832533185

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Molecular and Cellular Mechanisms of Heart Failure: Pathophysiology, pathogenesis and therapeutics by Kenneth Scott Campbell,Amy Li,Sean Lal Pdf

Author : Ulrich Flogel,Eric Ahrens
Publisher : CRC Press
Page : 462 pages
File Size : 55,9 Mb
Release : 2016-10-26
Category : Medical
ISBN : 9789814745321

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Fluorine Magnetic Resonance Imaging by Ulrich Flogel,Eric Ahrens Pdf

Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.

Author : Naranjan S. Dhalla
Publisher : Lippincott Williams & Wilkins
Page : 570 pages
File Size : 47,6 Mb
Release : 1995
Category : Heart Failure, Congestive
ISBN : UOM:39015035021438

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The Failing Heart by Naranjan S. Dhalla Pdf

Author : Yan Yang,Yi Zhang,Ming Lei,Gui-Rong Li
Publisher : Frontiers Media SA
Page : 227 pages
File Size : 46,9 Mb
Release : 2023-08-25
Category : Medical
ISBN : 9782832531686

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Cardiovascular Remodeling by Yan Yang,Yi Zhang,Ming Lei,Gui-Rong Li Pdf

Although the treatment has greatly progressed, the mortality of cardiovascular diseases remains the leading cause of death worldwide. Serious cardiovascular diseases, e.g., myocardial infarction, heart failure, cardiac dysrhythmias, and stroke, are resulted from cardiovascular remodeling secondary to the cardiovascular risk factors, including hypertension, atherosclerosis, cigarette smoking, diabetes mellitus, hyperlipidemia, aging, etc. Cardiac remodeling involves a series of molecular, cellular, and interstitial alterations, which manifest clinically as changes in size, mass, geometry, and function of the heart. In addition, vascular remodeling is an active process of structural alteration involving vascular wall thickening and lumen stenosis due to endothelial injury, vascular smooth muscle cell proliferation, and matrix deposition. This results in atherosclerosis and/or stenosis followed by myocardial infarction, stroke, etc. Thus, studies on the mechanism of cardiovascular remodeling and new therapeutic approaches are important scientifically and clinically. Cardiovascular remodeling is a response of specific cardiovascular cells, including cardiomyocytes, endothelial, smooth muscle cells, and interstitial cells, to noxious hemodynamic, metabolic, and inflammatory stimuli. The remodeling may initially be functional, compensatory, and adaptive, but it progresses to structural alterations that become pathogenic when the damaging stimuli are sustained. The mechanism of cardiovascular remodeling is complex, and recent studies focus on improving and/or reversing the remodeling by clarifying molecular mechanisms and identifying novel therapies. Pharmacological anti-remodeling, RNA-based (long non-coding RNA and microRNA) treatment, cell-based (iPS) cardiac repair, and cell-free exosome approaches have been shown to improve cardiovascular remodeling alongside proangiogenic, pro-survival, proliferative, and immunogenic factors, stimulating endogenous proliferative potential of cardiomyocytes. However, though advanced studies have progressed, the prognosis of the affected patients remains poor. Therefore, understanding novel mechanisms, identifying remodeling biomarkers, and developing new therapeutic drugs and approaches can lead to new therapeutic options for treating patients with cardiovascular diseases.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 46,5 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.