Cerebral Ischemic Reperfusion Injuries Ciri

Author : Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang
Publisher : Springer
Page : 259 pages
File Size : 46,9 Mb
Release : 2018-06-29
Category : Medical
ISBN : 9783319901947

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Cerebral Ischemic Reperfusion Injuries (CIRI) by Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang Pdf

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Author : Reza Behrouz, DO,Lee Birnbaum, MD
Publisher : Springer Publishing Company
Page : 301 pages
File Size : 48,8 Mb
Release : 2019-03-26
Category : Medical
ISBN : 9780826124791

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Complications of Acute Stroke by Reza Behrouz, DO,Lee Birnbaum, MD Pdf

Awareness and preparedness for potential complications in the aftermath of acute stroke is as important as initial treatment to achieve favorable clinical outcomes. Complications of Acute Stroke: A Concise Guide to Prevention, Recognition, and Management is the first book to focus exclusively on specific post-acute stroke complications that require timely and urgent attention. This practical, evidence-based guide is written for clinicians who provide in-hospital care to stroke patients and covers the broad range of medical and neurological issues that may manifest in the first 24 to 72 hours following ischemic or hemorrhagic stroke. This book will assist neurologists, neurosurgeons, intensivists, hospitalists, and other team members in the optimal management of acute stroke patients. It provides a roadmap for assessing risk and monitoring, recognizing, and managing emergent problems that can lead to neurological deterioration or worsening. Chapters by specialists on the frontlines are formatted with structured headings that detail pathophysiology, preventive measures, identification, and management strategies. For quick and targeted reference at the point of care, boxed “Key Points”, tables, flowcharts or algorithms, and associated imaging are also included. Key Features: Practical guide to identify complications in acute stroke patients Easy to understand description of the pathophysiology underlying various complications Structured format for quick access to essential content Three-pillar approach of prevention, recognition, and effective management Detailed prevention strategies and treatment interventions for each complication Purchase includes access to the eBook for use on most mobile devices or computer

Author : Yuwen Li,Gang-Min Hur,Tiejun Zhang
Publisher : Frontiers Media SA
Page : 218 pages
File Size : 42,5 Mb
Release : 2024-03-01
Category : Science
ISBN : 9782832545430

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Pharmaceutical Strategies to Prevent, Treat, and Recover: Advances and Challenges in Ischemic Stroke and Hemorrhagic Stroke by Yuwen Li,Gang-Min Hur,Tiejun Zhang Pdf

Stroke is one of the leading causes of death and disability worldwide. Among them, ischemic stroke is attributed to an abrupt blockage of blood flow to brain, while hemorrhagic stroke is caused by bleeding into brain. The principal aim of stroke therapy is to decrease mortality and reduce persistent neurologic injury and long-term disability. It also targets to prevent complications and recurrence after stroke as well as minimize the brain function loss caused by the cerebral damage. Fortunately, many strokes could be prevented through healthy lifestyle changes and controlling stroke risk factors, such as cigarette or tobacco smoking, high blood pressure, diabetes, and heart disease. Carotid endarterectomy and stenting of the cervical and intracranial vessels may help reduce recurrent stroke in some cases. Advanced treatments and rehabilitation are helping many stroke patients return to society and their families.

Author : Qingkun Liu,Yan Wang,Jui-Hung Jimmy Yen
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 53,5 Mb
Release : 2023-06-01
Category : Science
ISBN : 9782832525319

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Ischemic Stroke as Systemic Disorder Involving Both Nervous and Immune Systems by Qingkun Liu,Yan Wang,Jui-Hung Jimmy Yen Pdf

Author : Zhang Pengyue,Yuchuan Ding,Yulong Bai,Xiangjian Zhang,Yunping Deng
Publisher : Frontiers Media SA
Page : 182 pages
File Size : 47,6 Mb
Release : 2021-08-24
Category : Science
ISBN : 9782889712205

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Plasticity and Reconstruction of Neural Network in Brain Injury by Zhang Pengyue,Yuchuan Ding,Yulong Bai,Xiangjian Zhang,Yunping Deng Pdf

Author : Tianhao Liu,Ya Xiao,Yilin Ren,Lianlin Su
Publisher : Frontiers Media SA
Page : 179 pages
File Size : 47,7 Mb
Release : 2023-09-15
Category : Science
ISBN : 9782832529133

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The Interactional Role of Host and Microbiota in Diseases and Intervention Strategies of Traditional Chinese Medicine by Tianhao Liu,Ya Xiao,Yilin Ren,Lianlin Su Pdf

Author : Nesrine Salah El Dine El Sayed,Riham Salah El Dine,Jolanta Kotlinska,Barbara Budzynska,Anna Boguszewska-Czubara
Publisher : Frontiers Media SA
Page : 270 pages
File Size : 44,5 Mb
Release : 2023-04-14
Category : Science
ISBN : 9782832506615

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Central Nervous System Acting Drugs – Molecular Mechanisms of Neuroprotection and Neurodegeneration by Nesrine Salah El Dine El Sayed,Riham Salah El Dine,Jolanta Kotlinska,Barbara Budzynska,Anna Boguszewska-Czubara Pdf

Author : Bo Li,Guangzhi Ning,Ruiping Wang
Publisher : Frontiers Media SA
Page : 206 pages
File Size : 44,5 Mb
Release : 2023-07-24
Category : Medical
ISBN : 9782832529980

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Neuro-immune interaction in CNS injury and disease by Bo Li,Guangzhi Ning,Ruiping Wang Pdf

Author : John D. Lambris,Dimitrios C. Mastellos,Edimara S. Reis
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 53,7 Mb
Release : 2020-02-14
Category : Electronic
ISBN : 9782889634705

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Therapeutic Modulation of the Complement System: Clinical Indications and Emerging Drug Leads by John D. Lambris,Dimitrios C. Mastellos,Edimara S. Reis Pdf

The complement system is a multi-tasking gatekeeper of innate immunity thatintricately interacts with other key defense systems, such as the endothelial barrier,contact activation and coagulation systems, in maintaining tissue immunosurveillanceand homeostasis. Its rapid and forceful activation in the bloodstream not onlyensures the effective containment of microbial infections through potent cytolyticmechanisms, but also alerts the adaptive immune compartment to ensure the mountingof a proper humoral immune response against foreign antigens. However, there isa lurking ‘dark side’ that can lead complement astray, fueling a self-perpetuatingvicious cycle of inflammation, exuberant immune activation and irreversible tissueinjury that collectively exacerbate both acute and chronic pathologies. Indeed,complement dysregulation or excessive activation have been widely recognized askey pathogenic drivers in a wide spectrum of inflammatory or immune-mediateddiseases. Targeted modulation of the complement system at various points ofthe cascade has revealed promising therapeutic targets for ameliorating diseasescores in a number of conditions ranging from ocular, neurodegenerative andthromboinflammatory disorders, to cancer, periodontal diseases, chronic hemolyticanemias, ischemia-reperfusion organ injury, antibody-mediated transplant rejectionand hemodialysis-triggered inflammation. Elegant pre-clinical studies employing a diversified toolbox of highly specificcomplement inhibitors in rodent or primate models of disease have opened newavenues of therapeutic exploration by providing proof of concept for the therapeuticefficacy of complement modulation. At the same time, the clinical experience gainedduring this last decade with the sole complement-specific drug currently in the clinic,eculizumab, has rekindled the interest of biopharmaceutical companies in developingnew and potent complement therapeutics for complement-driven diseases. In this respect, the complement field is witnessing a new surge of clinical trialsthat are evaluating the safety, PK/PD profile and clinical efficacy of promising drugcandidates in a number of clinical conditions driven by complement imbalance orover-activation.

Author : Murali Muralidhara,Padmanabhan S. Rajini
Publisher : Elsevier
Page : 752 pages
File Size : 53,5 Mb
Release : 2023-08-07
Category : Medical
ISBN : 9780443153969

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Ayurvedic Herbal Preparations in Neurological Disorders by Murali Muralidhara,Padmanabhan S. Rajini Pdf

Ayurvedic Herbal Preparations in Neurological Disorders provides a comprehensive and mechanistic understanding of the therapeutic potential of many ayurvedic herbal preparations in disease management. Examining research data for evidence-based ayurvedic approaches, this volume begins with a focused introduction to major ayurvedic plants, discussing various mechanisms underlying their neuromodulatory potential in preclinical and clinical settings. Major subsets of ayurvedic plants are discussed, including Bacopa monnieri, Centella asiatica, Withania somnifera, and others. This volume outlines the importance of integrative approaches along with existing treatments in the intervention/management of Alzheimer’s disease, Parkinson’s disease, depressive mood disorders, epilepsy, schizophrenia, and more. More than a mere compilation of studies, this volume identifies relevant gaps for future research avenues and encourages interdisciplinary collaboration and sharing of knowledge to together identify the most efficacious ayurvedic approaches. Highlighting recent developments (e.g., Ayurgenomics, Ayurahar) and other pertinent research for neuroprotection, this book is crucial for anyone researching or working in the field of neurological disorder treatment and prevention. Provides a focused introduction to major Ayurvedic plants and their therapeutic potential in the management of neurodegenerative diseases Discusses various mechanisms underlying the neuromodulatory potential of several ayurvedic herbal preparations in preclinical and clinical settings Examines major subsets of ayurvedic plants (e.g., Bacopa monnieri, Centella asiatica, Withaniasomnifera, and others) and potential of several other plants in various neurological disorders Outlines the importance of integrative approaches along with existing treatments in the intervention/management of depressive mood disorders, epilepsy, schizophrenia, and more Highlights recent developments (e.g., Ayurgenomics, Ayurahar) and other pertinent research for neuroprotection

Author : Zhi Sun,Erxi Wu,Yi Wang
Publisher : Frontiers Media SA
Page : 168 pages
File Size : 46,7 Mb
Release : 2023-08-25
Category : Medical
ISBN : 9782832531662

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Mechanism and Pharmacodynamic Material Basis of Neurodegenerative Disease Therapies by Zhi Sun,Erxi Wu,Yi Wang Pdf

Neurodegenerative diseases are debilitating disorders defined as loss of function or progressive destructing structure of the nervous system with high prevalence among the aging population. These diseases mainly include Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). They are significantly associated with age and degeneration, becoming a devastating global health issue as a result of the growth of mean life expectancy worldwide. Few or no effective treatments are available for age-related neurodegenerative diseases, causing large socioeconomic and personal costs. The last 15 years have seen a boom in the use and integration of “omic” approaches (such as genomic, transcriptomic, epigenomic and metabolomic techniques) to study neurodegenerative disease in an unprecedented way. While, to date, no therapy based on these approaches is available to cure neurodegenerative diseases. Therefore, it is necessary to search for new, safe, and effective drug candidates and treatment strategies. In this Research Topic, our prime focus would be on the use and integration of “omic” approaches to study biomarkers, pathogenesis, disease progression and new therapeutic target of neurodegenerative diseases, so as to search for new, safe, and effective drug candidates.

Author : Jie Jia,Jingchun Guo,Lin Yao,Dingguo Zhang
Publisher : Frontiers Media SA
Page : 245 pages
File Size : 51,5 Mb
Release : 2024-04-04
Category : Science
ISBN : 9782832547243

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Novel Technologies Targeting the Rehabilitation of Neurological Disorders by Jie Jia,Jingchun Guo,Lin Yao,Dingguo Zhang Pdf

With the gradual aging of the population, neurological disorders, including stroke, Alzheimer's disease, Parkinson's disease, etc., are causing increasing distress and may even cause the loss of ability to perform activities of daily living. These disorders are generally progressive. Once onset, they may affect the entire life span with subsequent functional impairments such as motor impairment, speech impairment, swallowing impairment, sensory impairment, and cognitive impairment. Rehabilitation therapy is essential for the dysfunction caused by such disorders. Proper rehabilitation programs can improve or compensate for patients' dysfunction, and thus facilitate the restoration of their ability to daily living, help them return to social life, and reduce family and social stress.

Author : Rashid Giniatullin,Arn M. J. M. Van Den Maagdenberg,Rustem Khazipov,Jukka Jolkkonen
Publisher : Frontiers Media SA
Page : 146 pages
File Size : 41,6 Mb
Release : 2023-04-10
Category : Science
ISBN : 9782832520192

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Common and distinct mechanisms of migraine and stroke by Rashid Giniatullin,Arn M. J. M. Van Den Maagdenberg,Rustem Khazipov,Jukka Jolkkonen Pdf

Author : Sergio Serrano-Villar,Marius Trøseid,Ivan Vujkovic-Cvijin,Giulia Carla Marchetti
Publisher : Frontiers Media SA
Page : 228 pages
File Size : 43,7 Mb
Release : 2023-05-12
Category : Medical
ISBN : 9782832523360

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Targeting the microbiota to attenuate chronic inflammation by Sergio Serrano-Villar,Marius Trøseid,Ivan Vujkovic-Cvijin,Giulia Carla Marchetti Pdf

Author : Haroon Khan,Michael Aschner,Hamed Mirzaei
Publisher : Academic Press
Page : 418 pages
File Size : 51,7 Mb
Release : 2023-07-11
Category : Medical
ISBN : 9780323859783

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Phytonutrients and Neurological Disorders by Haroon Khan,Michael Aschner,Hamed Mirzaei Pdf

Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects provides and assesses the latest research and developments surrounding the use of phytonutrients for the treatment of neurological disorders. The volume analyzes advances in phytonutrient isolation, characterization and therapeutic applications, giving particular emphasis to mechanisms and safety profiles. The book takes toxicological considerations into account, including adverse drug reactions, toxicokinetics and toxicodynamics. Sections cover bioactive compound classes and biosynthesis pathways, general considerations, including quality control, standardization, and technology, and toxicology. This title is a comprehensive work on the latest research in phytonutrients and neurological disorders that will be useful to researchers and medical practitioners. Presents a comprehensive resource on phytonutrients and their relationship to neurological disorders Analyzes the isolation, characterization and mechanisms of phytonutrients in neurology Focuses on various signaling pathways followed by phytonutrients in neuroprotection Gives the latest thinking on quality control parameters and specifications for phytonutrient study Considers the toxicology of phytonutrients, including adverse drug reactions, toxicokinetics and toxicodynamics