Chasing Pain The Search For A Neurobiological Mechanism

Author : Kenneth L. Casey
Publisher : Oxford University Press
Page : 208 pages
File Size : 47,7 Mb
Release : 2019-02-22
Category : Medical
ISBN : 9780190920081

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Chasing Pain: The Search for a Neurobiological Mechanism by Kenneth L. Casey Pdf

Conceptual models of how pain is created influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Given the broad scope of pain experiences, realistic models of pain neurobiology must consider the correlation between pain and tissue damage and how it is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes. Recent discoveries have made it clear that both sensory and affective systems are strongly modulated by activity in other sensory pathways and by affective and cognitive processes originating in the brain. As a result, pain should then be conceived as emerging from the conjoint activity of both sensory and affective neural systems, each becoming a target for pain treatment. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically and physiologically unique structures in the nervous system. Observations made during the early and mid- 20th century showed that pain and pain-like behaviors normally require not only sensory detectors of noxious events (called nociceptors) but also brain affective (hedonic) mechanisms that generate emotional experience and expression. In Chasing Pain, pain specialists and neuroscientists will find a thoughtful discussion of the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. Written in a concise and annotated format, Doctor Kenneth Casey reveals that while contemporary research has greatly enriched our model of pain neurobiology, several important and therapeutically challenging clinical conditions remain poorly understood.

Author : Kenneth L. Casey
Publisher : Oxford University Press
Page : 208 pages
File Size : 52,5 Mb
Release : 2019-02-22
Category : Medical
ISBN : 9780190920074

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Chasing Pain: The Search for a Neurobiological Mechanism by Kenneth L. Casey Pdf

Conceptual models of how pain is created influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Given the broad scope of pain experiences, realistic models of pain neurobiology must consider the correlation between pain and tissue damage and how it is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes. Recent discoveries have made it clear that both sensory and affective systems are strongly modulated by activity in other sensory pathways and by affective and cognitive processes originating in the brain. As a result, pain should then be conceived as emerging from the conjoint activity of both sensory and affective neural systems, each becoming a target for pain treatment. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically and physiologically unique structures in the nervous system. Observations made during the early and mid- 20th century showed that pain and pain-like behaviors normally require not only sensory detectors of noxious events (called nociceptors) but also brain affective (hedonic) mechanisms that generate emotional experience and expression. In Chasing Pain, pain specialists and neuroscientists will find a thoughtful discussion of the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. Written in a concise and annotated format, Doctor Kenneth Casey reveals that while contemporary research has greatly enriched our model of pain neurobiology, several important and therapeutically challenging clinical conditions remain poorly understood.

Author : Mark Sullivan,Jane Ballantyne
Publisher : Oxford University Press
Page : 305 pages
File Size : 43,9 Mb
Release : 2023-01-24
Category : Medical
ISBN : 9780197615720

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The Right to Pain Relief and Other Deep Roots of the Opioid Epidemic by Mark Sullivan,Jane Ballantyne Pdf

"Pain has always been a problem for Western Society, but not the same kind of problem. Until about 1500, pain was primarily understood as a religious problem. Pain and suffering challenged the truth of religious belief and the legitimacy of the Church: How could a just, merciful, and all-powerful God allow so much pain and suffering in the world? As our society became more secular over the next 300 years, pain came to be understood primarily as a social problem. This modernizing society aimed to create the best environment for human flourishing: How might human society be designed and regulated to reduce the pain and suffering of everyone to the minimum possible? At least since 1900, we have separated pain as a medical problem from the remainder of human suffering. We have aimed to reduce this problem to a minimum through medical treatment. This quest has led us to our opioid epidemic. To fully comprehend the limitations of this medical interpretation, we must appreciate how the medical explanation of pain grew out of earlier religious and social interpretations of pain"--

Author : Paul W. Glimcher,Ernst Fehr
Publisher : Academic Press
Page : 560 pages
File Size : 50,5 Mb
Release : 2013-08-13
Category : Psychology
ISBN : 9780123914699

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Neuroeconomics by Paul W. Glimcher,Ernst Fehr Pdf

In the years since it first published, Neuroeconomics: Decision Making and the Brain has become the standard reference and textbook in the burgeoning field of neuroeconomics. The second edition, a nearly complete revision of this landmark book, will set a new standard. This new edition features five sections designed to serve as both classroom-friendly introductions to each of the major subareas in neuroeconomics, and as advanced synopses of all that has been accomplished in the last two decades in this rapidly expanding academic discipline. The first of these sections provides useful introductions to the disciplines of microeconomics, the psychology of judgment and decision, computational neuroscience, and anthropology for scholars and students seeking interdisciplinary breadth. The second section provides an overview of how human and animal preferences are represented in the mammalian nervous systems. Chapters on risk, time preferences, social preferences, emotion, pharmacology, and common neural currencies—each written by leading experts—lay out the foundations of neuroeconomic thought. The third section contains both overview and in-depth chapters on the fundamentals of reinforcement learning, value learning, and value representation. The fourth section, “The Neural Mechanisms for Choice, integrates what is known about the decision-making architecture into state-of-the-art models of how we make choices. The final section embeds these mechanisms in a larger social context, showing how these mechanisms function during social decision-making in both humans and animals. The book provides a historically rich exposition in each of its chapters and emphasizes both the accomplishments and the controversies in the field. A clear explanatory style and a single expository voice characterize all chapters, making core issues in economics, psychology, and neuroscience accessible to scholars from all disciplines. The volume is essential reading for anyone interested in neuroeconomics in particular or decision making in general. Editors and contributing authors are among the acknowledged experts and founders in the field, making this the authoritative reference for neuroeconomics Suitable as an advanced undergraduate or graduate textbook as well as a thorough reference for active researchers Introductory chapters on economics, psychology, neuroscience, and anthropology provide students and scholars from any discipline with the keys to understanding this interdisciplinary field Detailed chapters on subjects that include reinforcement learning, risk, inter-temporal choice, drift-diffusion models, game theory, and prospect theory make this an invaluable reference Published in association with the Society for Neuroeconomics—www.neuroeconomics.org Full-color presentation throughout with numerous carefully selected illustrations to highlight key concepts

Author : Kenneth Blum
Publisher : Gardner Press
Page : 67 pages
File Size : 44,6 Mb
Release : 1997-09-01
Category : Science
ISBN : 0848821114

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The Reward Deficiency Syndrome by Kenneth Blum Pdf

Author : J. Eric Ahlskog, PhD, MD
Publisher : Oxford University Press
Page : 544 pages
File Size : 47,6 Mb
Release : 2015-08-03
Category : Health & Fitness
ISBN : 9780190231880

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The New Parkinson's Disease Treatment Book by J. Eric Ahlskog, PhD, MD Pdf

The fundamental guide to the most effective treatments for Parkinson's Disease, from a Mayo Clinic doctor with thirty years of clinical and research experience. In this second edition follow-up to the extremely successful first edition, Dr. Ahlskog draws on thirty years of clinical experience to present the definitive guide to dealing with all aspects of Parkinson's Disease, from treatment options and side effects to the impact of the disease on caregivers and family. Dr. Ahlskog's goal is to educate patients so that they can better team up with their doctors to do battle with the disease, streamlining the decision-making process and enhancing their treatment. To do this, Dr. Ahlskog offers a gold mine of information, distilled from his years of experience treating people with Parkinson's at the Mayo Clinic. In addition to providing a comprehensive account of Parkinson's medications, this book also examines additional aspects of treatment, such as the role of nutrition, exercise, and physical therapy. Although many commendable texts have been written on the subject of Parkinson's Disease, their discussions of treatment have not been in depth. Dr. Ahlskog sifts through aspects of the disease in order to give the reader a comprehensive sense of Parkinson's and the best available treatment options. With a broader understanding of the disease and the available options, patients are able to make more informed choices, and doctors are able to provide more tailored care. This book delivers hopeful, helpful, and extensive information to all parties concerned: patients, caregivers, and doctors. The ultimate guide to symptoms and treatment, this thoroughly updated second edition is the first place patients should turn for reliable, easy-to-grasp information on Parkinson's Disease.

Author : Jaak Panksepp
Publisher : Oxford University Press
Page : 481 pages
File Size : 48,9 Mb
Release : 2004-09-30
Category : Psychology
ISBN : 9780198025672

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Affective Neuroscience by Jaak Panksepp Pdf

Some investigators have argued that emotions, especially animal emotions, are illusory concepts outside the realm of scientific inquiry. However, with advances in neurobiology and neuroscience, researchers are demonstrating that this position is wrong as they move closer to a lasting understanding of the biology and psychology of emotion. In Affective Neuroscience, Jaak Panksepp provides the most up-to-date information about the brain-operating systems that organize the fundamental emotional tendencies of all mammals. Presenting complex material in a readable manner, the book offers a comprehensive summary of the fundamental neural sources of human and animal feelings, as well as a conceptual framework for studying emotional systems of the brain. Panksepp approaches emotions from the perspective of basic emotion theory but does not fail to address the complex issues raised by constructionist approaches. These issues include relations to human consciousness and the psychiatric implications of this knowledge. The book includes chapters on sleep and arousal, pleasure and fear systems, the sources of rage and anger, and the neural control of sexuality, as well as the more subtle emotions related to maternal care, social loss, and playfulness. Representing a synthetic integration of vast amounts of neurobehavioral knowledge, including relevant neuroanatomy, neurophysiology, and neurochemistry, this book will be one of the most important contributions to understanding the biology of emotions since Darwins The Expression of the Emotions in Man and Animals

Author : Christopher Dodds,Chandra Kumar,Bernadette Veering
Publisher : OUP Oxford
Page : 336 pages
File Size : 45,7 Mb
Release : 2014-03-27
Category : Medical
ISBN : 9780191081170

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Oxford Textbook of Anaesthesia for the Elderly Patient by Christopher Dodds,Chandra Kumar,Bernadette Veering Pdf

As the global population lives to an increasing older age, there is a need to research, develop and deliver appropriate anaesthesia and pain management care to these increasingly frail and vulnerable patients. This book provides a comprehensive and detailed overview of all aspects of anaesthesia for the elderly patient looking at the effect of ageing on the systems of the body and the role that age has on drug mechanisms. Designed for both consultants and traineeswho care for elderly patients, chapters address the clinical management of the older patient in pain, trauma, intensive care as well as anaesthesia for all aspects of surgery. The expert author team use their experience to provide a practical and stimulating book which informs everyday clinical activity and explores the unanswered questions which face anaesthetists in this changing patient population. This book will give all consultants and trainees a thorough grounding in this growing and demanding area of anaesthetic practice.

Author : Mark B. Bromberg,Diane Banks Bromberg
Publisher : Oxford University Press
Page : 281 pages
File Size : 44,5 Mb
Release : 2017
Category : Medical
ISBN : 9780190241629

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Navigating Life with Amyotrophic Lateral Sclerosis by Mark B. Bromberg,Diane Banks Bromberg Pdf

Navigating Life with Amyotrophic Lateral Sclerosis provides accessible, comprehensive, and up-to-date information about the challenges patients, family members, and caregivers face when confronted by ALS, a disease that affects approximately 5,600 Americans every year, with as many as 30,000 people managing the disease at any given time. ALS is a difficult disease for the patient and is also challenging for the caregiver and family as there are many questions, issues relating to care, and problems to manage. This guide covers all aspects of managing ALS, from the onset of symptoms, diagnosis, treatments, and coping strategies, to the use of home health care or hospice, and new research in the field. The book also sheds lights on difficult topics, such as end-of-life care and managing legal affairs. Navigating Life with Amyotrophic Lateral Sclerosis is unique because it covers two perspectives: one author is a neurologist with 30 years of experience treating ALS patients, and the other author experienced first-hand the issues in providing care for a parent with ALS. Formatted in a question-and-answer style, peppered throughout with patient stories, and with sections devoted to family members and caregivers, this compassionate resource provides guidance to those seeking to understand how to live with this disease.

Author : Michael H. Ebert,Robert D. Kerns
Publisher : Cambridge University Press
Page : 507 pages
File Size : 47,6 Mb
Release : 2010-11-25
Category : Medical
ISBN : 9781139493543

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Behavioral and Psychopharmacologic Pain Management by Michael H. Ebert,Robert D. Kerns Pdf

Pain is the most common symptom bringing a patient to a physician's attention. Physicians training in pain medicine may originate from different disciplines and approach the field with varying backgrounds and experience. This book captures the theory and evidence-based practice of behavioral, psychotherapeutic and psychopharmacological treatments in modern pain medicine. The book's contributors span the fields of psychiatry, psychology, anesthesia, neurology, physical medicine and rehabilitation, and nursing. Thus the structure and content of the book convey the interdisciplinary approach that is the current standard for the successful practice of pain management. The book is designed to be used as a text for training fellowships in pain medicine, as well as graduate courses in psychology, nursing, and other health professions.

Author : Viviane Déprez,M. Teresa Espinal
Publisher : Oxford University Press, USA
Page : 889 pages
File Size : 54,6 Mb
Release : 2020-03-31
Category : Language Arts & Disciplines
ISBN : 9780198830528

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The Oxford Handbook of Negation by Viviane Déprez,M. Teresa Espinal Pdf

In this volume, international experts in negation provide a comprehensive overview of cross-linguistic and philosophical research in the field, as well as accounts of more recent results from experimental linguistics, psycholinguistics, and neuroscience. The volume adopts an interdisciplinary approach to a range of fundamental questions ranging from why negation displays so many distinct linguistic forms to how prosody and gesture participate in the interpretation of negative utterances. Following an introduction from the editors, the chapters are arranged in eight parts that explore, respectively, the fundamentals of negation; issues in syntax; the syntax-semantics interface; semantics and pragmatics; negative dependencies; synchronic and diachronic variation; the emergence and acquisition of negation; and experimental investigations of negation. The volume will be an essential reference for students and researchers across a wide range of disciplines, and will facilitate further interdisciplinary work in the field.

Author : Bruce H. Dobkin
Publisher : Contemporary Neurology
Page : 616 pages
File Size : 49,7 Mb
Release : 2003
Category : Medical
ISBN : 9780195150643

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The Clinical Science of Neurologic Rehabilitation by Bruce H. Dobkin Pdf

This work translates neuroscientific research to illuminate ongoing and future practices for the rehabilitation of patients with neurologic diseases. It dissects fundamental concepts to define what researchers must consider as they pursue best practices and areas ripe for exploration

Author : Robert M. Sapolsky
Publisher : Penguin
Page : 802 pages
File Size : 44,5 Mb
Release : 2017-05-02
Category : Science
ISBN : 9780735222786

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Behave by Robert M. Sapolsky Pdf

Why do we do the things we do? Over a decade in the making, this game-changing book is Robert Sapolsky's genre-shattering attempt to answer that question as fully as perhaps only he could, looking at it from every angle. Sapolsky's storytelling concept is delightful but it also has a powerful intrinsic logic: he starts by looking at the factors that bear on a person's reaction in the precise moment a behavior occurs, and then hops back in time from there, in stages, ultimately ending up at the deep history of our species and its genetic inheritance. And so the first category of explanation is the neurobiological one. What goes on in a person's brain a second before the behavior happens? Then he pulls out to a slightly larger field of vision, a little earlier in time: What sight, sound, or smell triggers the nervous system to produce that behavior? And then, what hormones act hours to days earlier to change how responsive that individual is to the stimuli which trigger the nervous system? By now, he has increased our field of vision so that we are thinking about neurobiology and the sensory world of our environment and endocrinology in trying to explain what happened. Sapolsky keeps going--next to what features of the environment affected that person's brain, and then back to the childhood of the individual, and then to their genetic makeup. Finally, he expands the view to encompass factors larger than that one individual. How culture has shaped that individual's group, what ecological factors helped shape that culture, and on and on, back to evolutionary factors thousands and even millions of years old. The result is one of the most dazzling tours de horizon of the science of human behavior ever attempted, a majestic synthesis that harvests cutting-edge research across a range of disciplines to provide a subtle and nuanced perspective on why we ultimately do the things we do...for good and for ill. Sapolsky builds on this understanding to wrestle with some of our deepest and thorniest questions relating to tribalism and xenophobia, hierarchy and competition, morality and free will, and war and peace. Wise, humane, often very funny, Behave is a towering achievement, powerfully humanizing, and downright heroic in its own right.

Author : Mervyn J. Eadie
Publisher : OUP USA
Page : 322 pages
File Size : 46,9 Mb
Release : 2012-05-22
Category : Medical
ISBN : 9780199860975

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Headache by Mervyn J. Eadie Pdf

Headache: Through the Centuries illuminates the history of headaches with a particular interest in how the disorder has been understood and treated since the earliest recorded accounts, dating from around 4000 BC. Different types of headache were being recognized as early as the 2nd century AD. Over the years, though, the classification of types of headache has changed so that headache patterns described in the past are often difficult to relate to present-day types of headache. Since that time, a great deal of material on the topic has become available, the full gamut of manifestations of the disorder has been described, and considerable insight into its mechanisms has been obtained, though no completely satisfactory explanation of the disorder has yet become available. Providing an extensive history and the development of our understanding of headache over the course of six millennia, Headache: Through the Centuries is thought-provoking and relevant reading for neurologists, medical historians, and anyone interested in headaches.

Author : David L. Brody
Publisher : Oxford University Press, USA
Page : 257 pages
File Size : 47,7 Mb
Release : 2019
Category : Medical
ISBN : 9780190054793

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Concussion Care Manual by David L. Brody Pdf

It is hard to find a medical condition that has as much media attention as concussion. With growing interest in concussion care by the NFL, NHL, NBA, and many other sports organizations, the military, and by regular patients, the number of concussion care providers has rapidly increased. Concussion Care Manual, Second Edition is the perfect step-by-step concussion management guide for clinicians, coaches, and even parents of athletic children. This pocket-sized volume discusses how to manage a variety of complexities associated with concussions including proper diagnosis, management strategies, headaches, anxiety and depression, PTSD, dizziness, fatigue, and changes to mood, balance, personality, and sleep. This book also covers the essential elements on how to set up and run a concussion clinic, focusing on the administrative need-to-know. A much-needed list of references, scales, and resources are provided at the end of the book for further investigation. New to the Second EditionEL -Fully revised based on the most up-to-date research in the field across disciplines - Evidence-based, this new edition summarizes what works and what doesn't from recent clinical trials and real world concussion care experience -Provides step by step guidance on how to provide appropriate active management when treating concussion