Chemical Probes In Biology

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Chemical Probes in Biology

Manfred P. Schneider
Chemical Probes in Biology Book PDF

Author : Manfred P. Schneider
Publisher : Springer Science & Business Media
Page : 403 pages
File Size : 43,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400709584

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Chemical Probes in Biology by Manfred P. Schneider Pdf

This NATO Advanced Study Institute (co-sponsored by FEBS and INTAS) under the title "Chemical Probes in Biology" was designed to summarize and disseminate recent expert knowledge regarding a deeper understanding ofbiological phenomena on a molecular level. Such scientific activities -frequently termed Bio-organic Chemistry or Chemical Biology are constituting a highly interdisciplinary branch of chemistry beyond the traditional ways in which chemists and biologists have been working in the past. Thus, on this occasion we were bringing together senior experts from the disciplines of Chemistry and Biology in order to amalgamate their diverse yet basically common interests in this area. Ultimate goal was - next to an exchange of information between the two scientific cultures - the communication ofexciting possibilities in interdisciplinary research to the young scientists present. The meeting was held in the Anargyros and Korgialenios School on the Island ofSpeteses, Greece from 18-30 August 2002. The ASI was attended by a total of 91 scholars from 23 different countries. A group of 27 speakers presented a series of 34 highly stimulating, informative and educational lectures covering a broad range of topics relevant to the general theme ofthis meeting: Science at the InteifaceofChemistry, Biology and Medicine. The lectures were complemented by a total of 89 posters presented by the young scholars and a series of short lectures derived thereof This was clearly one ofthe highlites of the meeting creating a lively atmosphere of interaction and intellectual creativity - typical phenomena for the whole meeting.

The Discovery and Utility of Chemical Probes in Target Discovery

Paul Brennan,Saleta Vazquez-Rodriguez
The Discovery and Utility of Chemical Probes in Target Discovery Book PDF

Author : Paul Brennan,Saleta Vazquez-Rodriguez
Publisher : Royal Society of Chemistry
Page : 343 pages
File Size : 45,7 Mb
Release : 2020-11-25
Category : Science
ISBN : 9781788015899

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The Discovery and Utility of Chemical Probes in Target Discovery by Paul Brennan,Saleta Vazquez-Rodriguez Pdf

Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.

Chemical Probes in Biology

Philip J. Snodgrass
Chemical Probes in Biology Book PDF

Author : Philip J. Snodgrass
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781441990624

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Chemical Probes in Biology by Philip J. Snodgrass Pdf

Ornithine Transcarbamylase: Basic Science and Clinical Considerations, written by a leading expert on OTC, for the first time assembles and analyzes more than 40 years of basic science and clinical research. It will be the definitive resource on the topic for pediatricians, geneticists, and internists who care for patients with OTC deficiency, as well as for basic scientists and genetic researchers who study the urea cycle in mammals and the arginine biosynthetic pathway in bacteria and fungi.

Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Prokaryotic and Eukaryotic Systems

Anonim
Chemical Tools for Imaging Manipulating and Tracking Biological Systems Diverse Methods for Prokaryotic and Eukaryotic Systems Book PDF

Author : Anonim
Publisher : Academic Press
Page : 360 pages
File Size : 54,8 Mb
Release : 2020-05-14
Category : Science
ISBN : 9780128201480

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Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Prokaryotic and Eukaryotic Systems by Anonim Pdf

Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Prokaryotic and Eukaryotic Systems, Volume 638, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sample chapters from this new release include In vitro characterization of the colibactin-activating peptidase ClbP enables development of a fluorogenic activity probe, Using FDAA probes to study cell division in Bacillus subtilis, Chemoenzymatic synthesis of UDP-sugars, Chemical tools for selective activity profiling of bacterial penicillin-binding proteins, Chemical Probes Reveal and Extraseptal Mode of Cross-linking in Staphylococcus Aureus, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways

Mass Spectrometry-Based Chemical Proteomics

W. Andy Tao,Ying Zhang
Mass Spectrometry Based Chemical Proteomics Book PDF

Author : W. Andy Tao,Ying Zhang
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 46,5 Mb
Release : 2019-07-10
Category : Science
ISBN : 9781118970218

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Mass Spectrometry-Based Chemical Proteomics by W. Andy Tao,Ying Zhang Pdf

PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind protein functions, their modifications and interactions, and applications in drug discovery. It provides a basic overview and presents concepts in chemical proteomics through three angles: Strategies, Technical Advances, and Applications. Chapters cover those many technical advances and applications in drug discovery, from target identification to validation and potential treatments. The first section of Mass Spectrometry-Based Chemical Proteomics starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative proteomics, and data analyses. The next section covers a variety of techniques and strategies coupling chemical probes to MS-based proteomics to provide functional insights into the proteome. In the last section, it focuses on using chemical strategies to study protein post-translational modifications and high-order structures. Summarizes chemical proteomics, up-to-date concepts, analysis, and target validation Covers fundamentals and strategies, including the profiling of enzyme activities and protein-drug interactions Explains technical advances in the field and describes on shotgun proteomics, quantitative proteomics, and corresponding methods of software and database usage for proteomics Includes a wide variety of applications in drug discovery, from kinase inhibitors and intracellular drug targets to the chemoproteomics analysis of natural products Addresses an important tool in small molecule drug discovery, appealing to both academia and the pharmaceutical industry Mass Spectrometry-Based Chemical Proteomics is an excellent source of information for readers in both academia and industry in a variety of fields, including pharmaceutical sciences, drug discovery, molecular biology, bioinformatics, and analytical sciences.

Concepts and Case Studies in Chemical Biology

Herbert Waldmann,Petra Janning
Concepts and Case Studies in Chemical Biology Book PDF

Author : Herbert Waldmann,Petra Janning
Publisher : John Wiley & Sons
Page : 468 pages
File Size : 40,5 Mb
Release : 2014-06-30
Category : Science
ISBN : 9783527676002

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Concepts and Case Studies in Chemical Biology by Herbert Waldmann,Petra Janning Pdf

Retaining the proven didactic concept of the successful "Chemical Biology - Learning through Case Studies", this sequel features 27 new case studies, reflecting the rapid growth in this interdisciplinary topic over the past few years. Edited by two of the world's leading researchers in the field, this textbook introduces students and researchers to the modern approaches in chemical biology, as well as important results, and the techniques and methods applied. Each chapter presents a different biological problem taken from everyday lab work, elucidated by an international team of renowned scientists. With its broad coverage, this is a valuable source of information for students, graduate students, and researchers working on the borderline between chemistry, biology, and biochemistry.

Optical Probes in Biology

Jin Zhang,Sohum Mehta,Carsten Schultz
Optical Probes in Biology Book PDF

Author : Jin Zhang,Sohum Mehta,Carsten Schultz
Publisher : CRC Press
Page : 511 pages
File Size : 54,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781466510128

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Optical Probes in Biology by Jin Zhang,Sohum Mehta,Carsten Schultz Pdf

Optical probes, particularly the fluorescent varieties, enable researchers to observe cellular events in real time and with great spatial resolution. Optical Probes in Biology explores the diverse capabilities of these powerful and versatile tools and presents various approaches used to design, develop, and implement them. The book examines the use of optical probes to detect and track numerous molecular processes in living cells, including GTPase and kinase activities, membrane lipids, voltage, metal ions, metabolic signals, RNA, and histone modifications. It critically reviews the different probe designs and delves into the strategies for developing new fluorescent protein varieties with enhanced capabilities. It also covers sophisticated imaging techniques and equipment, such as intensity and lifetime-based fluorescence microscopy methods, used to visualize and track optical probes. In addition, the book goes beyond live-cell tracking to discuss the growing application of activity-based probes for performing pharmacological drug screening and probing molecular processes in living animals. It also discusses emerging techniques that are expanding optical probe-based approaches into new biological frontiers. With contributions from top international scientists, this book offers a thorough overview of the latest optical probes in cell biology and biochemistry. Both newcomers and established researchers will discover how to incorporate state-of-the-art optical probes and fluorescence imaging into their research.

Chemogenomics in Drug Discovery

Hugo Kubinyi,Gerhard Müller
Chemogenomics in Drug Discovery Book PDF

Author : Hugo Kubinyi,Gerhard Müller
Publisher : John Wiley & Sons
Page : 487 pages
File Size : 40,7 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527604029

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Chemogenomics in Drug Discovery by Hugo Kubinyi,Gerhard Müller Pdf

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.

Enzymes of Epigenetics

Anonim
Enzymes of Epigenetics Book PDF

Author : Anonim
Publisher : Elsevier
Page : 440 pages
File Size : 41,6 Mb
Release : 2016-07-14
Category : Science
ISBN : 9780128119020

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Enzymes of Epigenetics by Anonim Pdf

Enzymes of Epigenetics: Part B, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods that are employed in the study of epigenetic regulation, including structural, biochemical, molecular, biological, cellular, computational, and systems approaches. Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies, and small molecule epigenetic regulators and biological connections. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Contains two new volumes that cover research methods in enzymes of epigenetics Covers such topics as chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators, and biological connections

Chemical Genomics

Stefan Jaroch,Hilmar Weinmann
Chemical Genomics Book PDF

Author : Stefan Jaroch,Hilmar Weinmann
Publisher : Springer Science & Business Media
Page : 187 pages
File Size : 43,5 Mb
Release : 2007-05-26
Category : Science
ISBN : 9783540376354

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Chemical Genomics by Stefan Jaroch,Hilmar Weinmann Pdf

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Cheminformatics and its Applications

Amalia Stefaniu,Azhar Rasul,Ghulam Hussain
Cheminformatics and its Applications Book PDF

Author : Amalia Stefaniu,Azhar Rasul,Ghulam Hussain
Publisher : BoD – Books on Demand
Page : 192 pages
File Size : 44,7 Mb
Release : 2020-07-15
Category : Medical
ISBN : 9781838800673

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Cheminformatics and its Applications by Amalia Stefaniu,Azhar Rasul,Ghulam Hussain Pdf

Cheminformatics has emerged as an applied branch of Chemistry that involves multidisciplinary knowledge, connecting related fields such as chemistry, computer science, biology, pharmacology, physics, and mathematical statistics.The book is organized in two sections, including multiple aspects related to advances in the development of informatic tools and their specific use in compound structure databases with various applications in life sciences, mainly in medicinal chemistry, for identification and development of new therapeutically active molecules. The book covers aspects related to genomic analysis, semantic similarity, chemometrics, pattern recognition techniques, chemical reactivity prediction, drug-likeness assessment, bioavailability, biological target recognition, machine-based drug discovery and design. Results from various computational tools and methods are discussed in the context of new compound design and development, sharing promising opportunities, and perspectives.

Diversity-Oriented Synthesis

Andrea Trabocchi
Diversity Oriented Synthesis Book PDF

Author : Andrea Trabocchi
Publisher : John Wiley & Sons
Page : 550 pages
File Size : 53,6 Mb
Release : 2013-06-17
Category : Science
ISBN : 9781118618141

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Diversity-Oriented Synthesis by Andrea Trabocchi Pdf

Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.

Chemical and Biological Synthesis

Nick J Westwood,Adam Nelson
Chemical and Biological Synthesis Book PDF

Author : Nick J Westwood,Adam Nelson
Publisher : Royal Society of Chemistry
Page : 339 pages
File Size : 43,7 Mb
Release : 2018-08-16
Category : Science
ISBN : 9781788015073

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Chemical and Biological Synthesis by Nick J Westwood,Adam Nelson Pdf

Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.

Fragment-Based Drug Discovery

Steven Howard,Chris Abell
Fragment Based Drug Discovery Book PDF

Author : Steven Howard,Chris Abell
Publisher : Royal Society of Chemistry
Page : 314 pages
File Size : 43,8 Mb
Release : 2015-07-03
Category : Medical
ISBN : 9781849739085

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Fragment-Based Drug Discovery by Steven Howard,Chris Abell Pdf

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

Chemical Biology

Marco F. Schmidt
Chemical Biology Book PDF

Author : Marco F. Schmidt
Publisher : Springer Nature
Page : 217 pages
File Size : 46,9 Mb
Release : 2022-01-31
Category : Science
ISBN : 9783662644126

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Chemical Biology by Marco F. Schmidt Pdf

The focus of this textbook is on application, rather than pure knowledge transfer of the results of all chemical biological work (which would also be beyond the scope of a book). It gives the reader, through the specific selection of chemical biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems. After an introduction to the problems addressed by chemical biology in drug discovery, the three levels of molecular biology dogma: DNA, RNA and proteins and their role as drug targets serve as the common thread of this book. This book is a translation of the original German 1st edition Chemische Biologie by Marco F. Schmidt, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2020. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.