Chemical Process Development Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Chemical Process Development book. This book definitely worth reading, it is an incredibly well-written.
Written by an experienced professional, this book introduces chemists to process development, using examples from the pharmaceutical, agrochemical and fragrance industries. The focus is on small molecules rather than biomolecules, and on relatively small-scale production rather than bulk petrochemicals. The coverage is broad, going from initial route development, through pilot plant operations, to full-scale production.
Guiding readers through all steps of the complex process, this book covers the most diverse aspects of chemicals production, including those not or insufficiently covered in natural science courses. These comprise economic feasibility, patenting and licensing, demands on the location and the problem of waste disposal. Throughout, the author does not rely on simple references to other literature but instead reiterates many facts and places them in context, as well as succinctly explaining formulas, thus removing the need to look up items in secondary reference works. As such, the book is suitable for both newcomers as well as those already working in the field. Those working in R&D as well as plant managers will learn how to avoid pitfalls, resulting in higher safety. A common basis and indispensable ready reference for engineers and chemists.
The Management of Chemical Process Development in the Pharmaceutical Industry by Derek Walker Pdf
Here is a practical guide that not only presents insights into the organization and management of the disciplines involved in chemical process development but also provides basic knowledge of these disciplines, enabling process development practitioners to recognize and assimilate them in their work. This book illustrates practical considerations through many examples of the successful direction and integration of the activities of chemists, analysts, chemical engineers, and biologists, as well as safety, regulatory, and environmental professionals in productive teams. Moreover, this reference provides guidance on: Directing and carrying out specific tasks and courses of action Making and communicating clear and achievable decisions Solving problems on the spot Managing the administrative aspects of chemical process development The author, Dr. Derek Walker, has directed chemical process development work for four decades, combining firsthand chemical synthesis experience with many other disciplines needed to create chemical processes. You will benefit from his advice and unique insights into: Understanding the workings of matrix organizations Defining missions and creating action plans Developing interdisciplinary approaches to problem solving Holding review meetings, revising goals, and motivating staff Prioritizing programs and responses to emergencies In addition, you'll learn how successful chemists, in collaboration with other disciplines, define the best (green) chemistry for process scale-up, including accommodating FDA requirements in the last process steps and addressing safety and environmental matters early in their work. Case studies provide incisive perspective on these issues. A chapter on recognizing and patenting intellectual property emphasizes the importance of comprehensive literature surveys and understanding invention. A chapter on the future challenges you to think beyond narrow constraints and explore new horizons.
Author : John Blacker,Michael T Williams Publisher : Royal Society of Chemistry Page : 374 pages File Size : 44,5 Mb Release : 2011-08-17 Category : Science ISBN : 9781849733076
Pharmaceutical Process Development by John Blacker,Michael T Williams Pdf
Pharmaceutical process research and development is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation. The book ends with an assessment of future trends and challenges. The book provides a valuable overview of: both early and late stage chemical development, how safe and scaleable synthetic routes are designed, selected and developed, the importance of the chemical engineering, analytical and manufacturing interfaces, the key enabling technologies, including catalysis and biocatalysis, the importance of the green chemical perspective and solid form issues. The book, written and edited by experts in the field, is a contemporary, holistic treatise, with a logical sequence for process development and mini-case histories within the chapters to bring alive different aspects of the process. It is completely pharmaceutical themed, encompassing all essential aspects, from route and reagent selection to manufacture of the active compound. The book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry. It informs them about the breadth of the work carried out in chemical research and development departments, and gives them a feel for the challenges involved in the job. The book is also of value to academics who often understand the drug discovery arena, but have far less appreciation of the drug development area, and are thus unable to advise their students about the relative merits of careers in chemical development versus discovery.
Practical Process Research and Development by Neal G. Anderson Pdf
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes
Biocatalysis for Green Chemistry and Chemical Process Development by Junhua (Alex) Tao,Romas Joseph Kazlauskas Pdf
This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.
Developing An Industrial Chemical Process by Joseph Mizrahi Pdf
The development and implementation of a new chemical process involves much more than chemistry, materials, and equipment. It is a very complex endeavor and its success depends on the effective interactions and organization of professionals in many different positions - scientists, chemical engineers, managers, attorneys, economists, and specialists. Developing An Industrial Chemical Process: An Integrated Approach is the first professional reference to examine the actual process development practices of industrial corporations, research organizations, engineering companies and universities. Backed by 45 years of experience within R&D, design, and management positions in various countries, the author presents his know-how for better and faster results and fewer start-up problems. While most books on chemical processes concentrate only on the scientific/technical aspect, this book also deals with the range of people and "real life" issues involved. Developing An Industrial Chemical Process serves as a "how to" guide for the effective management of process development procedures. The issues start with the "why" and "how" concerns of the executives and project managers and proceed with the actual implementation by professionals, each in his/her particular role. The author addresses the working organization and the different activities involved in a process development program, including the implementation, design, construction and start-up of a new plant. Finally, each chapter provides a short summary of the key issues along with suggestions for further reading. This book can help you handle the problems normally associated with the development and implementation of a new process and reduce the time and resources that you and your organization spend on this critical activity.
Industrial Chemical Process Analysis and Design by Mariano Martín Martín Pdf
Industrial Chemical Process Analysis and Design uses chemical engineering principles to explain the transformation of basic raw materials into major chemical products. The book discusses traditional processes to create products like nitric acid, sulphuric acid, ammonia, and methanol, as well as more novel products like bioethanol and biodiesel. Historical perspectives show how current chemical processes have developed over years or even decades to improve their yields, from the discovery of the chemical reaction or physico-chemical principle to the industrial process needed to yield commercial quantities. Starting with an introduction to process design, optimization, and safety, Martin then provides stand-alone chapters—in a case study fashion—for commercially important chemical production processes. Computational software tools like MATLAB®, Excel, and Chemcad are used throughout to aid process analysis. Integrates principles of chemical engineering, unit operations, and chemical reactor engineering to understand process synthesis and analysis Combines traditional computation and modern software tools to compare different solutions for the same problem Includes historical perspectives and traces the improving efficiencies of commercially important chemical production processes Features worked examples and end-of-chapter problems with solutions to show the application of concepts discussed in the text
Jacob A. Moulijn,Michiel Makkee,Annelies E. van Diepen
Author : Jacob A. Moulijn,Michiel Makkee,Annelies E. van Diepen Publisher : John Wiley & Sons Page : 691 pages File Size : 48,6 Mb Release : 2013-03-21 Category : Technology & Engineering ISBN : 9781118570753
Chemical Process Technology by Jacob A. Moulijn,Michiel Makkee,Annelies E. van Diepen Pdf
With a focus on actual industrial processes, e.g. the production of light alkenes, synthesis gas, fine chemicals, polyethene, it encourages the reader to think “out of the box” and invent and develop novel unit operations and processes. Reflecting today’s emphasis on sustainability, this edition contains new coverage of biomass as an alternative to fossil fuels, and process intensification. The second edition includes: New chapters on Process Intensification and Processes for the Conversion of Biomass Updated and expanded chapters throughout with 35% new material overall Text boxes containing case studies and examples from various different industries, e.g. synthesis loop designs, Sasol I Plant, Kaminsky catalysts, production of Ibuprofen, click chemistry, ammonia synthesis, fluid catalytic cracking Questions throughout to stimulate debate and keep students awake! Richly illustrated chapters with improved figures and flow diagrams Chemical Process Technology, Second Edition is a comprehensive introduction, linking the fundamental theory and concepts to the applied nature of the subject. It will be invaluable to students of chemical engineering, biotechnology and industrial chemistry, as well as practising chemical engineers. From reviews of the first edition: “The authors have blended process technology, chemistry and thermodynamics in an elegant manner... Overall this is a welcome addition to books on chemical technology.” – The Chemist “Impressively wide-ranging and comprehensive... an excellent textbook for students, with a combination of fundamental knowledge and technology.” – Chemistry in Britain (now Chemistry World)
Developing An Industrial Chemical Process by Joseph Mizrahi Pdf
The development and implementation of a new chemical process involves much more than chemistry, materials, and equipment. It is a very complex endeavor and its success depends on the effective interactions and organization of professionals in many different positions - scientists, chemical engineers, managers, attorneys, economists, and specialists. Developing An Industrial Chemical Process: An Integrated Approach is the first professional reference to examine the actual process development practices of industrial corporations, research organizations, engineering companies and universities. Backed by 45 years of experience within R&D, design, and management positions in various countries, the author presents his know-how for better and faster results and fewer start-up problems. While most books on chemical processes concentrate only on the scientific/technical aspect, this book also deals with the range of people and "real life" issues involved. Developing An Industrial Chemical Process serves as a "how to" guide for the effective management of process development procedures. The issues start with the "why" and "how" concerns of the executives and project managers and proceed with the actual implementation by professionals, each in his/her particular role. The author addresses the working organization and the different activities involved in a process development program, including the implementation, design, construction and start-up of a new plant. Finally, each chapter provides a short summary of the key issues along with suggestions for further reading. This book can help you handle the problems normally associated with the development and implementation of a new process and reduce the time and resources that you and your organization spend on this critical activity.
Principles of Process Research and Chemical Development in the Pharmaceutical Industry by Oljan Repic Pdf
This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.
Handbook for Chemical Process Research and Development by Wenyi Zhao Pdf
The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.
