Chemical Relaxation In Molecular Biology

Author : I. Pecht,R. Rigler
Publisher : Springer Science & Business Media
Page : 435 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642811173

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Chemical Relaxation in Molecular Biology by I. Pecht,R. Rigler Pdf

The development of an area of scientific research is a dynamic process with its own kinetic equations and its own physical mech anism. The study of fast chemical interactions and transformations is such an area, and while it is tempting to draw analogies or to speculate about the simplest model system, the lack of ade quately averaged observables is an annoying obstacle to such an undertaking. Sciences suffering from such conditions usually avoid quantitative models, be they primitive or complex. Instead, they prove their point by "case histories". Chemical relaxation kinetics started as an offspring of research in acoustics. In some aqueous ionic solutions anomalous acoustic absorption had been observed. A systematic study traced the cause of this absorption, showing that the covered frequency range and the intensity of the absorption were related in a predictable manner to the rate at which ions can interact and form structures differing in volume from the non interacting species. The step from this experimental observation and its correct, non trivial explanation to the discovery that all fast chemical pro cesses must reveal themselves quantitatively in the relaxation rate of a perturbed equilibrium state, and that perturbation para meters other than sound waves can be used for its exploitation, was made by MANFRED EIGEN in 1954. The foresightedness of K.F.

Author : I. Pecht,R. Rigler
Publisher : Springer
Page : 418 pages
File Size : 45,7 Mb
Release : 1977-08-01
Category : Science
ISBN : 3540081739

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Chemical Relaxation in Molecular Biology by I. Pecht,R. Rigler Pdf

The development of an area of scientific research is a dynamic process with its own kinetic equations and its own physical mech anism. The study of fast chemical interactions and transformations is such an area, and while it is tempting to draw analogies or to speculate about the simplest model system, the lack of ade quately averaged observables is an annoying obstacle to such an undertaking. Sciences suffering from such conditions usually avoid quantitative models, be they primitive or complex. Instead, they prove their point by "case histories". Chemical relaxation kinetics started as an offspring of research in acoustics. In some aqueous ionic solutions anomalous acoustic absorption had been observed. A systematic study traced the cause of this absorption, showing that the covered frequency range and the intensity of the absorption were related in a predictable manner to the rate at which ions can interact and form structures differing in volume from the non interacting species. The step from this experimental observation and its correct, non trivial explanation to the discovery that all fast chemical pro cesses must reveal themselves quantitatively in the relaxation rate of a perturbed equilibrium state, and that perturbation para meters other than sound waves can be used for its exploitation, was made by MANFRED EIGEN in 1954. The foresightedness of K.F.

Author : Francis K. Fong
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 53,5 Mb
Release : 1975
Category : Science
ISBN : UOM:39015015997177

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Theory of Molecular Relaxation by Francis K. Fong Pdf

Author : E. Wyn-Jones
Publisher : Springer Science & Business Media
Page : 504 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401018555

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Chemical and Biological Applications of Relaxation Spectrometry by E. Wyn-Jones Pdf

Chemical relaxation spectrometry involves the application of several different relaxation techniques to investigate the kinetics and mechanisms of fast chemical reactions and also dynamic molecul 10 ar processes that occur in liquids in the time range 1 - 10- secs. These methods have been used widely in several disciplines of the natural sciences including molecular biology, biochemistry, organic stereochemistry, detergent chemistry and inorganic chemistry. The purpose of the Advanced Study Institute was to provide a forum for scientists to discuss the role, scope and limitations of the various applications of chemical relaxation methods in order to stimulate discussion and interaction between workers in these different fields. The papers described in this volume are a summary of the contributions that were discussed at the meeting. The brief given to the authors was to attempt to prepare an article contain ing a good supply of references so that the book can be used not only by those starting in the field, but also by the specialist and research worker. These contributions cover a varied range of topics summarizing the achievements, the current state of knowledge and possible application in many disciplines. It is to be hoped that this volume will help to point out some new directions towards which research efforts are required and to attract new researchers with fresh points of view.

Author : David Davies
Publisher : Springer Science & Business Media
Page : 528 pages
File Size : 49,6 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781468442205

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Structural Molecular Biology by David Davies Pdf

Structural biology is undergoing a revolution in both the sophistication of new biophysical methods and the complexity of problems in biomolecular structure and organization opened up for study. These changes are directly attributable to major advances in computer technology, computational methods, development of high intensity synchrotron radiation sources, new magnetic resonance methods, laser optical techniques, etc. Structure-function problems previously considered intractable may now be solved. As this area of specialisation continues to expand, there is a need to review the various physical methods currently being used and developed in struc tural molecular biology. At the same time that individual techniques and their applications become more specialized, the need for effect ive communication between investigators gains in imperative. It is vital to forge links among sub-disciplines and to emphasise the complementary nature of results observed by different biophysical methods. This publication contains the review lectures given at a meeting on "Current Methods in Structural Molecular Biology" spon sored by NATO as an Advanced Study Institute and by FEBS ~s Advanced Course No. 78. The aim of the meeting was to bring together, in a teaching environment, students and specialists in diverse biophysical methodologies with the specific purpose of exploring, questioning and critically assessing the present and future state of biological structure research. The scientific content of the interdisciplinary Study Institute centred around three interrelated aspects; biophysical methods and instrumentation, their application to biological structure problems, and derivation of structural information and insights.

Author : Thomas E. Creighton
Publisher : Unknown
Page : 160 pages
File Size : 46,7 Mb
Release : 2011
Category : Chemical kinetics
ISBN : 0956478131

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The Physical and Chemical Basis of Molecular Biology by Thomas E. Creighton Pdf

The subject of molecular biology continues to be the most exciting and dynamic area of science and is predicted to dominate the 21st century. Only by investigating biological phenomena at the molecular level is it possible to understand it in detail. This volume describes the most fundamental aspects of molecular biology.

Author : Abraham Nitzan
Publisher : Oxford University Press
Page : 743 pages
File Size : 50,9 Mb
Release : 2006-04-06
Category : Science
ISBN : 0198529791

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Chemical Dynamics in Condensed Phases by Abraham Nitzan Pdf

Graduate level textbook presenting some of the most fundamental processes that underlie physical, chemical and biological phenomena in complex condensed phase systems. Includes in-depth descriptions of relevant methodologies, and provides ample introductory material for readers of different backgrounds.

Author : Meni Wanunu,Yitzhak Tor
Publisher : CRC Press
Page : 397 pages
File Size : 46,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439839744

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Methods for Studying Nucleic Acid/Drug Interactions by Meni Wanunu,Yitzhak Tor Pdf

Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the eff

Author : Theodor Dingermann,Dieter Steinhilber,Gerd Folkers
Publisher : John Wiley & Sons
Page : 435 pages
File Size : 44,9 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527605187

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Molecular Biology in Medicinal Chemistry by Theodor Dingermann,Dieter Steinhilber,Gerd Folkers Pdf

This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

Author : E. Grell
Publisher : Springer Science & Business Media
Page : 509 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642815379

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Membrane Spectroscopy by E. Grell Pdf

The last 10 years have seen an enormous growth in our understanding of the molecular organisation of biological membranes. Experimental methods have been devised to meas ure the translational and rotational mobility of lipids and proteins, thereby furnishing a quantitative basis for the concept of membrane fluidity. Likewise, the asymmetry of bi layer membranes as evidenced by the asymmetric insertion of proteins and lipids has been put on firm experimental ground. At higher molecular resolution it has been possible to provide a detailed pi2ture of the molecular conformation and dynamics of lipids and, to some extent, even of small peptides embedded in a bilayer matrix. Many of these achieve ments would not have been possible without the application of modem spectroscopic methods. Since these techniques are scattered in a variety of specialized textbooks the present monograph attempts to describe the key spectroscopic methods employed in present-day membrane research at an intermediate level. There is no question that the elusive detailed structure of the biological membrane demands a multiplicity of experi mental approaches and that no single spectroscopic method can cover the full range of physical phenomena encountered in a membrane. Much confusion in the literature has arisen by undue generalizations without considering the frequency range or other limi tations of the methods employed. It is to be hoped that the present monograph with its comprehensive description of most modem spectroscopic techniques, will contribute to- .

Author : Yann A. Henry,Annie Guissani,Beatrice Ducastel
Publisher : Springer Science & Business Media
Page : 343 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461311850

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Nitric Oxide Research from Chemistry to Biology: EPR Spectroscopy of Nitrosylated Compounds by Yann A. Henry,Annie Guissani,Beatrice Ducastel Pdf

Author : Anonim
Publisher : Academic Press
Page : 556 pages
File Size : 55,5 Mb
Release : 1995-11-29
Category : Medical
ISBN : 9780080581262

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Biochemistry, Molecular Biology, and Therapeutic Implications by Anonim Pdf

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types. Presents comprehensive coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions for nitric oxide Contains the most current and detailed documentation of the properties and regulation of nitric oxide synthases Provides the most up-to-date review of inhalational nitric oxide therapy for treatment of respiratory dysfunction

Author : G. Govil,R. V. Hosur
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 48,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642680977

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Conformation of Biological Molecules by G. Govil,R. V. Hosur Pdf

The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to the fascinating field of molecular biology. Stereochemical details of biological macromolecules and their interactions with pharmacological agents form the basis for drug design. Naturally, the study of the structure and function of biological molecules has aroused tremendous interest and investigations in this area are being carried out in a large number of laboratories. The techniques used for this purpose include both experimental methods (X-ray and neutron diffraction measurements, study of NMR, ESR, vibrational and electronic spectra, ORD, CD and dipole moment measurements, biochemical modifications etc. ) and the oretical methods (quantum mechanical and classical potential energy calculations, Monte Carlo simulations and molecular graphics). F or several years now, X-ray diffraction [1] has served as our only source of infor mation on the three-dimensional arrangements of atoms in biopolymers. Fiber-diffrac tion of DNA led to the proposal of the DNA double helix. Fibers of long~hain polymers show ordering in the direction of the fibre-axis but not in the transverse plane. Accurate estimates of the dimensions of helical structures can be made using techniques on the basis of which models of biopolymers can be constructed.

Author : A. Pullman
Publisher : Springer Science & Business Media
Page : 527 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400998827

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Nuclear Magnetic Resonance Spectroscopy in Molecular Biology by A. Pullman Pdf

Proceedings of the 11th Jerusalem Symposium on Quantum Chemistry and Biochemistry held in Jerusalem, Israel, April 3-7, 1978

Author : Library of Congress
Publisher : Unknown
Page : 1544 pages
File Size : 43,8 Mb
Release : 1989
Category : Subject headings, Library of Congress
ISBN : OSU:32435065917916

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Library of Congress Subject Headings by Library of Congress Pdf