Chemotherapy For Trypanosomiasis

Author : Leonor Leon,Eduard Caio Torres-Santos
Publisher : Unknown
Page : 240 pages
File Size : 40,5 Mb
Release : 2017
Category : Medical
ISBN : 1536108642

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Different Aspects on Chemotherapy of Trypanosomatids by Leonor Leon,Eduard Caio Torres-Santos Pdf

With the knowledge that there are several pieces of information concerning the chemotherapy of trypanosomatids, it is important to put together the different aspects of this subject. This book is an updated version of several areas such as molecular biology, biochemistry, immune response to the studied compounds, pharmacology, etc. The chapters were written by experts in those different specialties. It reinforces the necessity to look to those trypanosomatids associated with severe diseases, such as Chagas disease, leishmaniases and African trypanosomiasis, which constitute a public health problem in poor countries where basic sanitary conditions are non-existent. This book intends to show the importance of specific methodologies to save time and money during the drug development process. Each step should be carefully planned from the selection of test compounds, the choice of a molecular target within parasites, the definition of a lead compound and the adequacy of the animal models. It is also important to focus on the activity of compounds, synthetic or from natural sources, in different species and life stages of the parasites, besides the way these compounds are metabolized in these laboratory conditions. In conclusion, this book will bring you information that could stimulate the development of better treatments for these highly neglected diseases.

Author : S. K. Sen
Publisher : Unknown
Page : 230 pages
File Size : 45,7 Mb
Release : 1959
Category : Trypanosomiasis
ISBN : CORNELL:31924104578400

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Chemotherapy of Animal Trypanosomiasis by S. K. Sen Pdf

Author : A. S. Peregrine
Publisher : ILRI (aka ILCA and ILRAD)
Page : 173 pages
File Size : 52,8 Mb
Release : 1990-01-01
Category : African trypanosomiasis
ISBN : 9789290552918

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Chemotherapy for Trypanosomiasis by A. S. Peregrine Pdf

Author : International Laboratory for Research on Animal Diseases,United Nations Development Programme
Publisher : Unknown
Page : 168 pages
File Size : 43,5 Mb
Release : 1990
Category : Trypanosomiasis
ISBN : OCLC:606056933

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Chemotherapy for Trypanosomiasis by International Laboratory for Research on Animal Diseases,United Nations Development Programme Pdf

Author : United States. Animal and Plant Health Inspection Service. Veterinary Services. Emergency Programs
Publisher : Unknown
Page : 196 pages
File Size : 49,7 Mb
Release : 1978
Category : Trypanosomiasis
ISBN : IND:30000090093026

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Trypanosomiasis Bibliography by United States. Animal and Plant Health Inspection Service. Veterinary Services. Emergency Programs Pdf

Author : B. T. Terry
Publisher : Createspace Independent Publishing Platform
Page : 70 pages
File Size : 49,5 Mb
Release : 2017-01-13
Category : Electronic
ISBN : 1542547938

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Chemo-Therapeutic Trypanosome by B. T. Terry Pdf

From the Introduction. Immunity Following Treatment. - In 1904, Ehrlich and Shiga discovered an interesting method for producing immunity. On curing, by one or more injections of trypanred, mice infected with the parasites of caderas, they found that these could no longer be acutely infected if re-inoculated with the same trypanosomes. As a result of the cure an immunity had developed. No signs of immunity, however, were observed among the untreated mice. There was never a spontaneous cure or even a chronic course of the disease. Protection not Due to the Dye. - That the resistance to infection manifested by the treated mice was not due to unexcreted medicament, Ehrlich and Shiga proved by treating normal mice and subsequently inoculating them with trypanosomes. They found that injections of virus made as early as one and two days after treatment could infect. In these cases, however, the incubation period might last eighteen days or longer. After the second day the protection due to the dye diminished rapidly, and in one of their tables it is seen that mice inoculated on the fourth, fifth, or sixth day after treatment became infected as quickly as their normal controls, and died either at the same time or only one or two days later than these animals. The Immunity Inefficient. - The immunity which followed cure was not, however, efficient. Even when mice were reinoculated as early as one to seven days after the curative treatment, none of them survived for any length of time. Two died negative for trypanosomes at dates too early to exclude the possibility of relapses, and, after incubation periods of twelve to fifty-three days, all of the others became infected and died. The Immunity Temporary. - Their experiments also indicated that the immunity was of short duration. The sooner the tests were made after the curative treatment, the longer, as a rule, was the incubation period. Twenty days after the treatment the delay in infection was slight, and by the thirtieth day it was scarcely noticeable....

Author : Michel Dumas,Bernard Bouteille,Alain Buguet
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 46,7 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9782817808574

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Progress in Human African Trypanosomiasis, Sleeping Sickness by Michel Dumas,Bernard Bouteille,Alain Buguet Pdf

Human African Trypaniosomiasis (HAT) or sleeping sickness is an old disease to be now considered as reemergent. HAT is endemic in 36 sub-Saharan African countries, in areas where tsetse flies are found. The public health importance of HAT is underestimated, but the disease causes severe social disruption in many rural areas. Along the past fifteen years, numerous studies were made, and now, the mechanisms involved in the disease pathogenesis and in the characteristics of sleep-wake disruption become to be better understood. But, since 50 years, when current drugs were introduced, problems regarding HAT chemotherapy have not been solved. Nevertheless, in-depth studies about trypanosome metabolism have permitted to discover new drug targets. Written by specialists who are very experienced in their respective fields, the contributions provide an indispensable tool for practitioners and scientists.

Author : Benjamin Taylor Terry
Publisher : Unknown
Page : 70 pages
File Size : 45,9 Mb
Release : 1911
Category : Trypanosomiasis
ISBN : LCCN:11026503

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Chemo-therapeutic Trypanosome Studies with Special Reference to the Immunity Following Cure by Benjamin Taylor Terry Pdf

Author : Ian Maudlin,P. H. Holmes,Michael A. Miles
Publisher : CABI
Page : 644 pages
File Size : 55,8 Mb
Release : 2004-07-09
Category : Medical
ISBN : 0851990347

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The Trypanosomiases by Ian Maudlin,P. H. Holmes,Michael A. Miles Pdf

This state-of-the-art reference book includes comprehensive coverage of the biology and control of African, Asian and South American trypanosomiasis ("sleeping sickness") in man and animals. It describes recent research developments in the biology and molecular biology of trypanosomes (the protozoan parasite) and their vectors, and methods in diagnosis and control, such as trapping tsetse fly vectors. Different sections of the book are devoted to biology of trypanosomes, vector biology, epidemiology and diagnosis, pathogenesis, disease impact, chemotherapy and disease control, and vector control. The book contains contributions from leading experts from Europe, North and South America, and Africa.

Author : W.C. Campbell,R.S. Rew
Publisher : Springer Science & Business Media
Page : 658 pages
File Size : 44,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468412338

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Chemotherapy of Parasitic Diseases by W.C. Campbell,R.S. Rew Pdf

"Have a chew of dulie," said Crubog . . . "What is it?" asked Potter, half-suspiciously. "Seaweed. " "Is it good for the virility? . . . " "And what is the virility?" asked the old man. "Does it make you more attractive to women?" Potier shouted in his ear. "No. " "What is it good for then?" "WortnS. " "Worms?" "Intestinal worms. You'll never again pass a worm if you eat a fistful of dulse first thing in the morning and last thing at night. " "If it's an anthelmintic, I'll try a spot of it," said Potter. - From Bogmail, a novel by Patrick McGinley (1981) With modern techniques of chemical isolation and structure determination, the old distinction between herbal and chemical remedies has largely been broken down. By chemotherapy we now mean simply the treatment of disease by drugs (the word medicines has unhappily been eclipsed). The distinction made between chemotherapy and non chemical therapy (e. g. , radiation, physiotherapy, surgical intervention, immu nomodulation) remains useful despite some minor overlapping. The present work thus deals with drugs and their use in parasitic disease. (Since we are dealing with the treatment of incipient as well as established infection, chemotherapy subsumes chem oprophylaxis as well as chemotherapeusis per se. ) Definition of parasitism as a biological modus vivendi, although important in itself, need not concern us here. We need simply delimit the scope of the book, and that is easily done.

Author : Timo Jäger,Oliver Koch,Leopold Flohé
Publisher : John Wiley & Sons
Page : 850 pages
File Size : 44,5 Mb
Release : 2013-03-19
Category : Medical
ISBN : 9783527670406

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Trypanosomatid Diseases by Timo Jäger,Oliver Koch,Leopold Flohé Pdf

This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides. As such, it covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference.

Author : Michel Dumas,Bernard Bouteille,Alain Buguet
Publisher : Unknown
Page : 364 pages
File Size : 51,5 Mb
Release : 2014-09-01
Category : Electronic
ISBN : 2817808584

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Progress in Human African Trypanosomiasis, Sleeping Sickness by Michel Dumas,Bernard Bouteille,Alain Buguet Pdf

Author : R. J. Schnitzer,Frank Hawking
Publisher : Elsevier
Page : 1027 pages
File Size : 55,6 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483273082

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Experimental Chemotherapy by R. J. Schnitzer,Frank Hawking Pdf

Experimental Chemotherapy, Volume I, attempts to condense the existing knowledge in the broad field of experimental chemotherapy in a comprehensive form. The arrangement of the subject matter follows a plan by which the not always avoidable repetitive description is reduced to a minimum. In most of the protozoan and metazoan infections it appeared advantageous to discuss the different series of active compounds according to the specific diseases and their causative agents. In other cases, owing to the wide range of activity of certain antibacterials, the material is arranged according to the groups of compounds. This first volume deals with infections caused by parasites, both protozoan and metazoan; it also contains general chapters on history of chemotherapy, toxicology, statistics, and drug resistance. It is hoped that the treatise will be useful to experimental workers engaged in the search for new chemotherapeutic remedies and in the study of their mechanism of action; to all who are involved in the teaching of pharmacology and therapeutics; and to physicians and veterinarians interested in the experimental basis of the drugs they are using.

Author : R Schnitzer
Publisher : Elsevier
Page : 695 pages
File Size : 49,6 Mb
Release : 1966-01-01
Category : Technology & Engineering
ISBN : 9780323143301

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Experimental Chemotherapy V4 by R Schnitzer Pdf

Experimental Chemotherapy, Volume IV: Chemotherapy of Neoplastic Diseases, Part I focuses on the use of chemotherapy to counteract neoplastic ailments. The book first discusses the chemotherapy of neoplastic diseases, and this includes approaches to cancer chemotherapy, methods of drug evaluation, and the effects of antitumor antibiotics. The text also presents an appendix to the previous volumes. Toxicity and drug resistance in chemotherapy; chemotherapy of trypanosomiasis, giardiasis, and histomoniasis; and the use of antibiotics in chemotherapy are discussed. Experiments on the processes, methodologies, and medical interventions on the chemotherapy of these ailments are given importance. The book also identifies some antibiotics used in the chemotherapy of fungal and bacterial infections. These antibiotics include pimaricin, fucidin, gramicidin, lincomycin, and rifamycin SV. The book is a vital reference for readers wanting to explore the potential of chemotherapy on medical interventions on neoplastic diseases.

Author : Veeranoot Nissapatorn,Helieh S. Oz
Publisher : Unknown
Page : 0 pages
File Size : 50,9 Mb
Release : 2018
Category : Chagas' disease
ISBN : 1838813691

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Chagas Disease by Veeranoot Nissapatorn,Helieh S. Oz Pdf