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Author : T. K. Chatterjee
Publisher : PHI Learning Pvt. Ltd.
Page : 196 pages
File Size : 51,9 Mb
Release : 2004-08
Category : Anti-infective agents
ISBN : 8120316118
Author : Urban Hellgren,Orjan Ericsson,Yakoub AdenAbdi,Lars L Gustafsson
Publisher : CRC Press
Page : 192 pages
File Size : 42,7 Mb
Release : 2003-05-20
Category : Medical
ISBN : 9780203211519
Parasitic infections such as malaria, schistosomiasis, trypanosomiasis and onchoceriasis are the scourge of the tropical countries. Many of the drugs used for the treatment of tropical parasitic infections were introduced more than 30 years ago. Most of these drugs are toxic and have complicated dosage regimens, but, because of the low economic incentive, pharmaceutical companies have shown little interest in developing new drugs to control diseases prevalent in developing countries.; However, there has been notable progress in research into parasitic diseases and a number of important drugs have been introduced for some diseases since the 1970s. Moreover, recent data on the pharmacokinetics and field evaluations of these drugs have revealed that their effectiveness can be improved and their safety increased.; This handbook is designed to provide information about the pharmacological properties and therapeutic uses of the major drugs currently employed to combat the human parasitic infections encountered in the tropics. Each of the 38 drugs covered in the book are presented under the following headings: chemical structure, physical properties, pharmacology and mechanism of action, pharmacokinetics, clinical trials, pregnancy and lactation, side effects, contraindications and precautions, dosage, preparations, and references.
Author : W.C. Campbell,R.S. Rew
Publisher : Springer Science & Business Media
Page : 658 pages
File Size : 48,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468412338
"Have a chew of dulie," said Crubog . . . "What is it?" asked Potter, half-suspiciously. "Seaweed. " "Is it good for the virility? . . . " "And what is the virility?" asked the old man. "Does it make you more attractive to women?" Potier shouted in his ear. "No. " "What is it good for then?" "WortnS. " "Worms?" "Intestinal worms. You'll never again pass a worm if you eat a fistful of dulse first thing in the morning and last thing at night. " "If it's an anthelmintic, I'll try a spot of it," said Potter. - From Bogmail, a novel by Patrick McGinley (1981) With modern techniques of chemical isolation and structure determination, the old distinction between herbal and chemical remedies has largely been broken down. By chemotherapy we now mean simply the treatment of disease by drugs (the word medicines has unhappily been eclipsed). The distinction made between chemotherapy and non chemical therapy (e. g. , radiation, physiotherapy, surgical intervention, immu nomodulation) remains useful despite some minor overlapping. The present work thus deals with drugs and their use in parasitic disease. (Since we are dealing with the treatment of incipient as well as established infection, chemotherapy subsumes chem oprophylaxis as well as chemotherapeusis per se. ) Definition of parasitism as a biological modus vivendi, although important in itself, need not concern us here. We need simply delimit the scope of the book, and that is easily done.
Author : Anonim
Publisher : Elsevier
Page : 682 pages
File Size : 41,5 Mb
Release : 2007-03-23
Category : Medical
ISBN : 9780080462943
Control of parasitic infections of humans has progressed rapidly over the last three decades. Such advances have resulted from focal disease control efforts based on historically effective interventions to new approaches to control following intensive research and pilot programs. Control of Human Parasitic Diseases focuses on the present state of control of the significant human parasitic infectious diseases. Includes the impact of recent research findings on control strategy Discusses the health policy implications of these findings and the importance of evaluation and monitoring Highlights the lessons learned and the interactions between control programs and health systems
Author : M. Hooper
Publisher : Unknown
Page : 126 pages
File Size : 55,7 Mb
Release : 1987-09-10
Category : Science
ISBN : UCAL:B4530739
The only book devoted entirely to drug development for the treatment of tropical diseases. Presents detailed information about longstanding tropical parasitic diseases, particularly those which are still a serious problem in developing countries. These diseases are associated with unusual and complex immunological changes which, when understood, will shed new light on the ways our natural defense mechanism can be modulated. This knowledge is also of importance in many non-parasitic diseases in the developed world, such as cancer and arthritis. Some of the old, imperfect drugs used to treat these parasitic diseases have led to novel therapies for a range of diseases, including dermatological diseases, arthritis, AIDS, and AIDS-related diseases. The individual reviews are creative and critical, providing stimulating reading for all of those interested in the development of new drugs to treat these diseases.
Author : L. L. Gustafsson
Publisher : CRC Press
Page : 0 pages
File Size : 50,8 Mb
Release : 1987-10-06
Category : Medical
ISBN : 0850664039
Author : L. H. Chappell,M. J. Doenhoff
Publisher : Cambridge University Press
Page : 116 pages
File Size : 53,6 Mb
Release : 1992
Category : Medical
ISBN : 0521448352
This specially commissioned text covers a range of topics relating to chemotherapy and the immune system.
Author : World Health Organization
Publisher : World Health Organization
Page : 75 pages
File Size : 41,7 Mb
Release : 2006
Category : Medical
ISBN : 9789241547109
This manual focuses on how and when a set of low-cost or free drugs should be used in developing countries to control a set of diseases caused by worm infections. Preventive chemotherapy in this context means using drugs that are effective against a broad range of worm infections to simultaneously treat the four most common diseases caused by worms: river blindness (onchocerciasis), elephantiasis (lymphatic filariasis), schistosomiasis, and soil-transmitted helminthiasis. Significant opportunities also exist to integrate these efforts with the prevention and control of diseases such as trachoma. The new approach provides a critical first step in combining treatment regimens for diseases which, although different in themselves, require common resources and delivery strategies for control or elimination.
Author : John M. Mansfield
Publisher : Unknown
Page : 323 pages
File Size : 51,7 Mb
Release : 1980
Category : Parasitic diseases
ISBN : OCLC:715334643
Author : J. D. Williams,A. M. Geddes
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468431292
The International Society of Chemotherapy meets every two years to review progress in chemotherapy of infections and of malignant disease. Each meeting gets larger to encompass the extension of chemotherapy into new areas. In some instances, expansion has been rapid, for example in cephalosporins, pen icillins and combination chemotherapy of cancer - in others slow, as in the field of parasitology. New problems of resistance and untoward effects arise; reduction of host toxicity without loss of antitumour activity by new substances occupies wide attention. The improved results with cancer chemotherapy, es pecially in leukaemias, are leading to a greater prevalence of severe infection in patients so treated, pharmacokinetics of drugs in normal and diseased subjects is receiving increasing attention along with related problems of bioavailability and interactions between drugs. Meanwhile the attack on some of the major bacterial infections, such as gonorrhoea and tubercu losis, which were among the first infections to feel the impact of chemotherapy, still continue to be major world problems and are now under attack with new agents and new methods. From this wide field and the 1,000 papers read at the Congress we have produced Proceedings which reflect the variety and vigour of research in this important field of medicine. It was not possible to include all of the papers presented at the Congress but we have attempted to include most aspects of cur rent progress in chemotherapy.
Author : J. D. Williams,A. M. Geddes
Publisher : Springer
Page : 434 pages
File Size : 54,5 Mb
Release : 1976-03-01
Category : Medical
ISBN : 0306382261
The International Society of Chemotherapy meets every two years to review progress in chemotherapy of infections and of malignant disease. Each meeting gets larger to encompass the extension of chemotherapy into new areas. In some instances, expansion has been rapid, for example in cephalosporins, pen icillins and combination chemotherapy of cancer - in others slow, as in the field of parasitology. New problems of resistance and untoward effects arise; reduction of host toxicity without loss of antitumour activity by new substances occupies wide attention. The improved results with cancer chemotherapy, es pecially in leukaemias, are leading to a greater prevalence of severe infection in patients so treated, pharmacokinetics of drugs in normal and diseased subjects is receiving increasing attention along with related problems of bioavailability and interactions between drugs. Meanwhile the attack on some of the major bacterial infections, such as gonorrhoea and tubercu losis, which were among the first infections to feel the impact of chemotherapy, still continue to be major world problems and are now under attack with new agents and new methods. From this wide field and the 1,000 papers read at the Congress we have produced Proceedings which reflect the variety and vigour of research in this important field of medicine. It was not possible to include all of the papers presented at the Congress but we have attempted to include most aspects of cur rent progress in chemotherapy.
Author : World Health Organization
Publisher : World Health Organization
Page : 211 pages
File Size : 51,6 Mb
Release : 2015-08-05
Category : Medical
ISBN : 9789241564861
"The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.
Author : F. M. A. Ukoli
Publisher : Unknown
Page : 216 pages
File Size : 52,6 Mb
Release : 1992
Category : Medical
ISBN : IND:30000042671606
In this unique book, Ukoli explores the main issues to be confronted in the formulation of policies and implementation of preventive and control measures against parasitic diseases in tropical Africa. The high prevalence of parasitic diseases, along with poverty, hunger and squalor, is an indisputable index of underdevelopment and a reliable indicator for assessing the health profile of the less developed countries of tropical Africa. However, though the fundamental principles of the various preventive and control measures are common knowledge, they do not seem to be yielding the desired results in tropical Africa. The provision of safe water and improvement of general sanitation which are fundamental to freedom from parasitic disease, along with other measures, are frustrated by acute financial, infrastructural and manpower contraints. Ukoli examines the implications of these issues and their socio-cultural and socio-economic impact in this fascinating study.
Author : Jerome O. Nriagu,Eric P. Skaar
Publisher : MIT Press
Page : 501 pages
File Size : 40,5 Mb
Release : 2024-06-11
Category : Medical
ISBN : 9780262552486
Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang
Author : Václav Bozdech,Peter Mason
Publisher : Unknown
Page : 220 pages
File Size : 45,8 Mb
Release : 1992
Category : Antiparasitic agents
ISBN : 0908307268