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Author : Claudio Nicolini
Publisher : Springer
Page : 385 pages
File Size : 42,6 Mb
Release : 2014-11-14
Category : Science
ISBN : 9781468409734
Author : Claudio Nicolini
Publisher : Springer
Page : 0 pages
File Size : 42,8 Mb
Release : 1979-03-01
Category : Science
ISBN : 0306400758
Author : Alan P. Wolffe
Publisher : Academic Press
Page : 462 pages
File Size : 45,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080926605
The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. The book is written in a clear and concise fashion, with 60 new illustrations. Chromatin: Structure and Function provides the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and its active involvement in the processes of DNA transcription, replication and repair. This book consistently interrelates the structure of eukaryotic DNA with the nuclear processes it undergoes, and will be essential reading for students and molecular biologists who want to really understand how DNA works. Written in a clear and concise fashion Includes 60 new illustrations Extensively rewritten Brings the reader up-to-date with the remarkable progress in chromatin research over the past three years.
Author : Kensal E. van Holde
Publisher : Springer Science & Business Media
Page : 509 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461234906
Contemporary views on the structure and function of chromatin are presented and the history of the development of these ideas as well as the nature of the nucleic acid and protein components of chromatin are reviewed. The structure of chromatin is studied at several levels, and its modes of transcription and replication are analyzed. Chromatin provides researchers with a critical evaluation of current knowledge. It combines much information that has never before been assembled, and evaluates and interrelates it in a critical way. This has not been done before so that readers are not only provided with an overview, but with extensive references to the literature (there are about 2000 references in all).
Author : Claudio Nicolini
Publisher : Springer Science & Business Media
Page : 517 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468409765
This volume is the second part of the book on "Chromatin Structure and Function", which resulted from a NATO-Advanced Study Institute held at Erice during April 1978. In addition to giving an updated and detailed description of various levels of chromatin organization, i. e. octamers, nucleosomes, multimers, solenoid and higher order fibers (including the most recent, yet unpublished, findings), it focuses, in a tutorial and organic format, on the possible mechanisms controlling transcription and on the basic biological phenomena (either genetic or epigenetic) related to cell aging, cell cycle, differentiation, transformation and chemical carcinogenesis. The most significant (sometime spirite~ discussion sessions have been included at the end of every section. Their clarifying nature is further supported by the final section (V), which summarizes and reviews the current state of the art on the genetic apparatus and its constituents. All chapters have selected up-to-date references; quite a few have an extensive bibliography both in terms of basic reference books and most recent findings. A few chapters, dealing at the level of intact cell and/or in classical genetic terms, with aging, differentiation and neoplastic transformation, have been included to furnish a more comprehensive view of fundamental cell functions directly and indirectly related to the structure and function of the genetic apparatus. At the same time it is hoped that interested students and investigators will find in the chapters of this volume the necessary and stimulating introduction to the wide variety of fundamental mechanism and phenomena occurring in higher eukaryotes.
Author : Srikumar P. Chellappan
Publisher : Humana
Page : 416 pages
File Size : 46,7 Mb
Release : 2016-08-23
Category : Science
ISBN : 1493956264
Significant advancements have been made in the study of chromatin structure and function over the past fifty years but none as spectacular as those made in the last decade due to the development of novel techniques and the ability to sequence large stretches of DNA. In Chromatin Protocols, Second Edition, expert researchers delineate these cutting-edge techniques via step-by-step laboratory methods and protocols, which encompass a wide array of topics from the isolation of nucleosomes, assembly of nucleosomes and study of the basic chromatin structure to detailed analysis of histone modifications and chromatin function. Written in the highly successful Methods in Molecular BiologyTM series style, chapters include brief introductions to the subjects, lists of the necessary materials and reagents, readily reproducible protocols, and Notes sections which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Chromatin Protocols, Second Edition is a valuable tool for scientists studying various aspects of chromatin function and an ideal guide to aid in the development of new techniques as well as new ideas in the field of chromatin biology.
Author : Kenneth W. Adolph
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461236528
Chromosomes have structure, determined by the interactions of proteins with DNA, and chromosomes have functions, in particular, replication of DNA and transcription of messenger RNA. Chromosome structure and function are not separate topics, since chromosome organization pro foundly influences the activity of the genome in replication and transcrip tion. This is especially clear for higher cells, including human cells, in which chromatin fibers are created by the binding of histone proteins to the DNA, and folding of the fibers produces mitotic chromosomes and interphase nuclei. The intricate organization of DNA in higher cells is now recognized as being closely involved with genome activity. Many fundamental results have originated from studies of bacterial and viral systems, which have been systems of choice because of their less complex life cycles. The processes of replication and transcription show differences between the higher and simpler systems (e. g. , different enzymes and protein factors are involved). But the parallels are as striking as the differences in detail. Even for bacteria and viruses, a full understanding of these processes will require integrating the results of molecular biology with those of structural biology and cell biology. Three important subjects are covered in this volume: DNA replication and recombination, gene transcription, and chromosome organization. The sections dealing with replication and transcription examine recent results obtained by applying the techniques of molecular biology and biochemistry. Eukaryotic, prokaryotic, and viral systems are discussed.
Author : Claudio A. Nicolini
Publisher : Unknown
Page : 548 pages
File Size : 44,8 Mb
Release : 1979
Category : Carcinogenesis
ISBN : WISC:89017609421
Papers presented at the 1978 NATO Advanced Study Institute conference on chromatin.
Author : Remus T. Dame
Publisher : Humana Press
Page : 419 pages
File Size : 55,7 Mb
Release : 2018-08-15
Category : Science
ISBN : 1493986740
This volume brings together a wide range of methods to explore the structure and function of bacterial chromatin from molecular to the cellular scale. Chapters detail experimental protocols of in vivo and in vitro approaches, approaches to genome structure modeling, and data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.
Author : Remus T. Dame,Charles J. Dorman
Publisher : Springer
Page : 0 pages
File Size : 45,5 Mb
Release : 2014-11-12
Category : Science
ISBN : 9400790880
The birth and the development of molecular biology and, subsequently, of genetic engineering and biotechnology cannot be separated from the advancements in our knowledge of the genetics, biochemistry and physiology of bacteria and bacter- phages. Also most of the tools employed nowadays by biotechnologists are of bacterial (or bacteriophage) origin and the playground for most of the DNA manipulations still remains within bacteria. The relative simplicity of the bacterial cell, the short gene- tion times, the well defined and inexpensive culturing conditions which characterize bacteria and the auto-catalytic process whereby a wealth of in-depth information has been accumulated throughout the years have significantly contributed to generate a large number of knowledge-based, reliable and exploitable biological systems. The subtle relationships between phages and their hosts have produced a large amount of information and allowed the identification and characterization of a number of components which play essential roles in fundamental biological p- cesses such as DNA duplication, recombination, transcription and translation. For instance, to remain within the topic of this book, two important players in the or- nization of the nucleoid, FIS and IHF, have been discovered in this way. Indeed, it is difficult to find a single fundamental biological process whose structural and functional aspects are better known than in bacteria.
Author : Claudio Nicolini
Publisher : Springer
Page : 367 pages
File Size : 50,6 Mb
Release : 1979-03-01
Category : Science
ISBN : 0306400758
Author : Kenneth W. Adolph
Publisher : Unknown
Page : 431 pages
File Size : 50,8 Mb
Release : 1989
Category : Biologie moléculaire
ISBN : 3540969829
Author : Gary S. Stein,Janet L. Stein
Publisher : CRC Press
Page : 426 pages
File Size : 53,9 Mb
Release : 1989-06-30
Category : Science
ISBN : 084935515X
This comprehensive book is a compilation of Professor Lubomir S. Hnilica's twenty years of research experimentally addressing the chemistry and the biological functions of chromosomal proteins. The histones and other nuclear proteins found associated with DNA in a number of tissues and cell types are featured. Lubomir Hnilica played a major role in establishing the extent to which these basic chromosomal polypeptides are conserved and the manner in which they interact with DNA to modify chromatin structure. In addition, non-histone chromosomal protein research is explained, and his technique of applying several biochemical and immunological approaches to the characterization of this complex and heterogeneous class of chromosomal polypeptides is discussed. Highlighted is the use of chemical crosslinking for studying protein/DNA interactions in intact cells. The proteins as well as the structure, organization, and regulation of the genes are also presented.
Author : Tom Scott
Publisher : Springer Science & Business Media
Page : 569 pages
File Size : 44,5 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9781468435122
By the year 2000, the most critical world problem--as things stand now--will be sustaining the human race. The quality and the availability of food will continue to be central to this issue. However, since the beginning of the final quarter of the twentieth century, few attempts have been made to organize and integrate information applying our knowledge of the regulation of plant growth to the enhancement of the world's yield of food, forage, fiber, and other useful plants. It is appropriate, therefore, to approach a solution to future human needs by combining an area of basic science with a defined and needed application of it. The purpose of this NATO Advanced Study Institute--Plant Regulation and World Agriculture--is reflected in the content of this volume. It covers a wide range of physiological processes including photosynthesis, translocation, seed germination, source sink relationships, water relationships, flowering, fruiting, and adaptations to stress. The identification, chemistry, and bio chemistry of naturally occurring as well as known and new synthetic plant growth regulators are discussed in relation to productivity, growth retardation, and herbicidal activity. Other topics include plant breeding and genetics, tissue culture and its use in the improvement of and the increase in plant varieties, and ecological implications in agriculture. Chapter titles in bold print in the Table of Contents designate keynote presentations for the three major subtopics in Section II.
Author : Claudio Nicolini
Publisher : Springer Science & Business Media
Page : 471 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461321293
Since the early times of the Greek philosophers Leucippus and Democritus, and later of the Roman philosopher Lucretius, a simple, fundamental idea emerged that brought the life sciences into the realm of the physical sciences. Atoms, after various interactions, were assumed to acquire stable configurations that corresponded either to the living or to the inanimate world. This simple and unitary theory, which has evolved in successive steps to our present time, remarkably maintained its validity despite several centuries of alternative vicissitudes, and is the foundation of modern biophysics. Some of the recent developments of this ancient idea are the discovery of the direct relationship between spatial structures and chemical activity of such molecules as methane and benzene, and the later discovery of the three-dimensional structure of double-helical DNA, and of its relationship with biological activity. The relationship between the structure of various macromolecules and the function of living cells was one of the most striking advancements of modern science, obtained by the cooperation of physicists, chemists, mathematicians, engineers, biologists, and physicians. This crossing of the life and physical sciences has given rise to new and exciting frontiers, and to a new synthesis where there is a frequent interconnection of expertise, and where there is an exchange of roles among traditionally separated soft and hard sciences. Even if knowledge is still transmitted to new generations within univer sities as separate disciplines, new knowledge is acquired today in the laboratory by truly interdisciplinary teams.