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Author : Jacob A. Brody,Werner Henle,Hilary Koprowsky
Publisher : Springer Science & Business Media
Page : 79 pages
File Size : 53,5 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9783642460593
Author : W. Arber,S. Falkow,W. Henle,P. H. Hofschneider,J. H. Humphrey,J. Klein,P. Koldovský,H. Koprowski,O. Maaløe,F. Melchers,R. Rott,H. G. Schweiger,L. Syru?ek,P. K. Vogt
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 45,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642673221
The study of the genetic regulation of immune response to natural multidetermi nant immunogens was undertaken by the method of bidirectional selective breed ing of High or Low antibody responder lines of mice. Five Selections are described: Selection I, carried out for agglutinin responsiveness to sheep erythrocytes and pigeon erythrocytes alternated in each generation. Selection II, carried out for agglutinin responsiveness to sheep erythrocytes repeated in each generation. Selection III and Selection IV performed respectively for agglutinin response to flagellar or somatic antigens of Salmonella typhimurium and Salmonella oranienburg alternated in each generation. Selection V, performed for passive agglutinin response to bovine serum albumin and rabbit gamma globulin alternated in each generation. In each Selection the character investigated is polygenic. High and Low responder lines diverge progressively during the selective breeding. The maximal interline separation (selection limit) is reached in the 7th-16th generations. High and Low responder lines at selection limit are considered homozygous for the character submitted to se~ection. Their variance is therefore only due to environ mental effects. The difference in agglutinin titre between High and Low lines is 220-fold in Selection I, 103-fold in Selection II, 90-fold in Selection III, 85-fold in Selection IV and 275-fold in Selection V. The partition of genetic and environmental variances in the foundation popu lations of the five Selections is established. The proportion of genetic variance is 60% in Selection I; 49% in Selection II; 51% in Selection III; 47% in Selection IV and 76% in Selection V.
Author : W. Arber,W. Henle,P. H. Hofschneider,J. H. Humphrey,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt
Publisher : Springer Science & Business Media
Page : 204 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642665301
Expression of an immune response is the net result of complex synergis tic and antagonistic activities performed by a variety of cell types. It includes macrophages, T and B populations which may interact in performance of a response, and suppressor cells interfering with it. Accordingly, a lack of res ponse may not necessarily indicate absence of immunocompetent cells, but rather nonexpression of competence. Thus, one should consider two possible situations, which are by no means mutually exclusive, to account for immuno logic unresponsiveness: (a) one or more of the cell populations composing the synergistic unit is absent or immature, and (b) an antagonistic unit which interferes with the response is dominating. In view of this, an approach to development of immune reactivity necessitates parallel surveys of development of cells with the potential to perform, as well as of cells which can suppress the response. Classification of the various cell types has been based so far on their phenotypic properties (e. g. , membrane antigen markers, cell receptors, pro duction and secretion of immunoglobulins, etc. ). Genotypically, T and B cells may represent either separate, independent cell lines, or different stages of development within the same cell lineage.
Author : United States. Public Health Service
Publisher : Unknown
Page : 412 pages
File Size : 55,8 Mb
Release : 1966
Category : Electronic
ISBN : STANFORD:36105216538277
Author : Daniel Carleton Gajdusek,Michael P. Alpers,Steven G. Ono
Publisher : Unknown
Page : 228 pages
File Size : 50,5 Mb
Release : 1975
Category : Kuru
ISBN : MINN:30000005139930
Over 1600 entries, generally to literature written between 1957-1974. Covers books, journal articles, and unpublished reports. Includes basic bibliography (arranged by authors) and supplements in related fields, i.e., social and physical anthropology, linguistics, and natural history. Author index.
Author : Anonim
Publisher : Unknown
Page : 424 pages
File Size : 48,6 Mb
Release : 1968
Category : Communicable diseases
ISBN : UCAL:B4116207
Author : Anonim
Publisher : Unknown
Page : 1828 pages
File Size : 50,5 Mb
Release : 1997
Category : Medicine
ISBN : OSU:32436010520193
Author : Anonim
Publisher : Unknown
Page : 516 pages
File Size : 40,8 Mb
Release : 1965
Category : Public health
ISBN : UOM:39015069619453
Author : C.L. Coe,Leonard A. Rosenblum
Publisher : Springer Science & Business Media
Page : 515 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781475708127
As the editors of the first book on the squirrel monkey prophesied in 1968,* there has been an incredible expansion in primate research during the past 16 years. Their projection that the squirrel monkey would play an increasingly important role in this research effort has also come to be true during the ensuing years. One inadvertent result of the rapid growth, however, is that it has become more and more difficult for investigators to keep track of new information, both in their own disciplines and in related fields. For scientists who study and use the squirrel monkey in research, this problem is particularly pronounced, because articles are often published in specialized and disparate journals. We felt that a new synthesis of the vast amount of information on Saimiri would resolve this problem and would provide an extremely valuable com panion volume to the first book. The idea grew out of a small symposium held at the IX Congress of the International Primatological Society in Atlanta, Geor gia, during August, 1982. Following the format of The Squirrel Monkey, ad ditional authors were invited to discuss advances in areas which had experi enced exceptional growth or to review basic information that would be of practical value to future researchers. Even with focused topics and synthetic reviews, the wealth of new data resulted in many long manuscripts. In response to the continuing problems with Saimiri nomenclature, Richard Thorington has provided us with a definitive statement on squirrel monkey taxonomy.
Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 50,7 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 976 pages
File Size : 48,9 Mb
Release : 1965
Category : Medicine
ISBN : MINN:31951M013680686
Author : Emilio Weiss
Publisher : Springer Science & Business Media
Page : 310 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642652240
To lose is human, to win is fortune, but to try is our destiny. EARL C. SUITOR, JR. The idea of a Symposium on "Arthropod Cell Cultures" started in July of 1969 shortly after the untimely death of our colleague, EARL C. SUITOR, JR. , at the age of 38. At first we thought an afternoon or evening session would be sufficient, but we were soon convinced that the scope of the Symposium should be greatly enlarged. Interest in this topic was increasing at an astonishing rate. Since EARL SUITOR had made a distinct imprint in this new field, many scientists who knew him well or just casually wished to honor him in this manner. EARL SUITOR was born and raised in New England and received a B. S. degree in bacteriology from the University of Massachusetts in 1952. As a spirited young man, he enlisted in the U. S. Navy to see the world. Instead, he was assigned for most of his four-year "hitch" to the Naval Medical Research Institute. I met him there in 1954, an enthusiastic and imaginative young fellow with many interests, an avid reader of the classics, an occasional writer of poetry, who blended his interest in scientific literature with that of Science Fiction. In 1956, EARL left the Navy to attend George Washington University, where he earned an M. S. degree in 1958 and a Ph. D. degree in 1963.
Author : Daniel Carleton Gajdusek,Juliette Harvey
Publisher : Unknown
Page : 80 pages
File Size : 43,8 Mb
Release : 1969
Category : Scrapie
ISBN : MINN:30000010569253
Author : W. Arber,W. Braun,R. Haas,W. Henle,P. H. Hofschneider,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Svru?ek,P. K. Vogt,E. Wecker
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 46,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642652417
The expression of many bacterial genes adapts itself in an almost in stantaneous and reversible way to specific environmental changes. More specifically, the concentration of a number of metabolites, a function of the amounts of enzymes involved in their synthesis or degradation, in turn retroacts on the rate of synthesis of these enzymes. The genetic bases for this regulation were established by JACOB and MONOD (1961). These authors also showed how the known elements of these regulatory mechanisms could be connected into a wide variety of circuits endowed with any desired degree of stability, in order to account for essentially irreversible processes like differentiation (MONOD and JACOB, 1961). The general principles used by JACOB and MONOD in their study of negative regulation were extended to positive regulation by ENGLESBERG et al. (1965). An independent approach permitted the discovery of positive controls in temperate bacteriophages (see below, III). Each control operation is mediated by a pair of complementary genetic elements (hereafter called "control cell"): a control gene which produces a l control (or regulator) protein and a control site which is the target for the regulator protein. Negative control means that the control protein (repressor) prevents gene expression. One deals with positive control when the control protein (activator) is necessary for this expression. It has become apparent that, as initially postulated by JACOB and MONOD, control of gene expression operates, at least to a large extent, at the transcriptional level.
Author : H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt,E. Wecker,W. Arber,W. Braun,R. Haas,W. Henle,P. H. Hofschneider,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 41,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642653575
Phenomena as diverse as tuberculin sensitivity, delayed sensitivity to soluble proteins other than tuberculin, contact allergy, homograft rejection, experimental autoallergies, and the response to many microorganisms, have been classified as members of the class of immune reactions known as delayed or cellular hypersensitivity. Similarities in time course, histology, and absence of detectable circulating immunoglobulins characterize these cell-mediated immune reactions in vivo. The state of delayed or cellular hypersensitivity can be transferred from one animal to another by means of sensitized living lymphoid cells (CHASE, 1945; LANDSTEINER and CHASE, 1942; MITCHISON, 1954). The responsible cell has been described by GOWANS (1965) as a small lymphocyte. Passive transfer has also been achieved in the human with extracts of sensitized cells (LAWRENCE, 1959). The in vivo characteristic of delayed hypersensitivity from which the class derives its name is the delayed skin reaction. When an antigen is injected intradermally into a previously immunized animal, the typical delayed reaction begins to appear after 4 hours, reaches a peak at 24 hours, and fades after 48 hours. It is grossly characterized by induration, erythyma, and occasionally necrosis. The histology of the delayed reaction has been studied by numerous investigators (COHEN et al., 1967; GELL and HINDE, 1951; KOSUNEN, 1966; KOSUNEN et al., 1963; MCCLUSKEY et al., 1963; WAKSMAN, 1960; WAKSMAN, 1962). Initially dilatation of the capillaries with exudation of fluid and cells occurs.