Download Full eBooks in PDF
Circulating Life Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Circulating Life book. This book definitely worth reading, it is an incredibly well-written.
Author : Cherie Winner
Publisher : Twenty-First Century Books
Page : 114 pages
File Size : 40,7 Mb
Release : 2007-01-01
Category : Juvenile Nonfiction
ISBN : 9780822566069
A history of the art of transfusions and a scientific discourse on the chemistry of blood.
Author : Young Kim
Publisher : Lulu.com
Page : 54 pages
File Size : 42,5 Mb
Release : 2015-07-18
Category : Religion
ISBN : 9781329393615
My name is Young Kim and I wanted to share my personal experiences with DMT in this book. A while I ago I had a near death experience which led me to seek out the molecule released during these traumatic events and at birth and death. DMT is known to be the substance behind these experiences and I sought to use it in order to explore the very boundaries of the mind and the soul. The following book was my own journey which lasted a week in South America. What I unveiled made me completely reevaluate my understanding of consciousness. I came to some incredible discoveries on this sacred ancient molecule and I truly believe anyone seeking profound answers in their lives and those who are suffering with deep traumas would be greatly helped by taking the molecule in a safe set and setting.
Author : C. Th. Smit-Sibinga
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 50,5 Mb
Release : 2010-05-10
Category : Medical
ISBN : 9780387236001
Proceedings of the Twenty-Eighth International Symposium on Blood Transfusion, Groningen, NL, Organized by the Sanquin Division Blood Bank North-East, Groningen. It is in many ways fitting that the last of these international symposia on blood transfusion should end with neonatal blood transfusion. The most fragile, least well studied and most at risk population requires special care and concern. We need to expand our knowledge of their unique physiology, biochemical pathways and in planning treatment and interventions, always "do no harm." This proceedings of the last Groningen symposium presents a wealth of information on developmental immunology, the molecular basis of haematopoeisis, physiological basis of bleeding and thrombosis, transfusion risks and benefits and lastly, future therapies. Infants provide us with much to learn but in turn they will be the providers of (through cord blood) and the recipients of (through cellular engineering) the best that science can offer. Translational research, which has been the thrust of these presentations for 28 years, will benefit them in a way that no scientist could have ever predicted.
Author : Sir Patrick Manson
Publisher : Unknown
Page : 642 pages
File Size : 42,5 Mb
Release : 1898
Category : Medicine
ISBN : UOM:39015029857862
Author : Amy Rosenberg,Barthélemy Demeule
Publisher : Springer
Page : 378 pages
File Size : 51,5 Mb
Release : 2015-08-21
Category : Medical
ISBN : 9781493925438
“Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.
Author : Anonim
Publisher : Unknown
Page : 950 pages
File Size : 50,5 Mb
Release : 1898
Category : Christian Science
ISBN : CORNELL:31924057396784
Author : Anonim
Publisher : Unknown
Page : 768 pages
File Size : 50,7 Mb
Release : 1882
Category : Medicine
ISBN : UOM:39015074804629
Author : Anonim
Publisher : Unknown
Page : 880 pages
File Size : 49,9 Mb
Release : 1894
Category : American literature
ISBN : NYPL:33433081646220
Author : Anonim
Publisher : Unknown
Page : 842 pages
File Size : 52,7 Mb
Release : 1872
Category : Literature
ISBN : UOM:39015078140442
Author : William Carleton
Publisher : Unknown
Page : 698 pages
File Size : 52,7 Mb
Release : 1882
Category : Electronic
ISBN : UOM:39015030326816
Author : William Carleton
Publisher : Unknown
Page : 700 pages
File Size : 54,8 Mb
Release : 1882
Category : Irish fiction
ISBN : NYPL:33433074935168
Author : Kenneth W Hinchcliff,Andris J. Kaneps,Raymond J. Geor
Publisher : Elsevier Health Sciences
Page : 1320 pages
File Size : 40,9 Mb
Release : 2013-07-01
Category : Medical
ISBN : 9780702054228
Equine Sports Medicine and Surgery provides the most up-to-date, in-depth coverage of the basic and clinical sciences required for management of the equine athlete. The unique treatment of exercise physiology and training within a clinical context, together with detailed review of all diseases affecting athletic horses, makes this the most comprehensive text available. The book will provide a thorough grounding in the basic physiology of each body system, and in particular the responses of each body system to exercise and training, that will be separate, but highly relevant to, the succeeding sections on clinical disorders of each body system. The highly respected editors have brought together an internationally renowned team of 50 contributors, producing the ultimate reference for veterinarians, students, horse-owners, and all those involved in the world of equine athletics. High quality artwork, including relevant radiographic, ultrasonographic, CAT scan, and MRI images, aid understanding and diagnosis Provides a truly international perspective, including guidelines pertinent to different geographic areas, and racing jurisdictions In-depth coverage of the role of the veterinarian in the management of athletic horses Explores the use of complementary therapies ~
Author : Anonim
Publisher : Unknown
Page : 586 pages
File Size : 51,5 Mb
Release : 1884
Category : Electronic
ISBN : UOM:39015073797600
Includes music.
Author : Anonim
Publisher : Unknown
Page : 798 pages
File Size : 40,8 Mb
Release : 1849
Category : England
ISBN : PRNC:32101076890035
Author : Isaac Newton Carleton
Publisher : Unknown
Page : 140 pages
File Size : 48,5 Mb
Release : 1878
Category : Electronic
ISBN : HARVARD:HN23M4