Clinical And Translational Science

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Clinical and Translational Science

David Robertson,Gordon H. Williams
Clinical and Translational Science Book PDF

Author : David Robertson,Gordon H. Williams
Publisher : Academic Press
Page : 812 pages
File Size : 53,8 Mb
Release : 2016-11-25
Category : Science
ISBN : 9780128021118

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Clinical and Translational Science by David Robertson,Gordon H. Williams Pdf

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Principles of Translational Science in Medicine

Martin Wehling
Principles of Translational Science in Medicine Book PDF

Author : Martin Wehling
Publisher : Academic Press
Page : 364 pages
File Size : 41,7 Mb
Release : 2015-04-02
Category : Science
ISBN : 9780128007211

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Principles of Translational Science in Medicine by Martin Wehling Pdf

Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Pharmaceutical Medicine and Translational Clinical Research

Divya Vohora,Gursharan Singh
Pharmaceutical Medicine and Translational Clinical Research Book PDF

Author : Divya Vohora,Gursharan Singh
Publisher : Academic Press
Page : 526 pages
File Size : 55,9 Mb
Release : 2017-11-14
Category : Medical
ISBN : 9780128020982

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Pharmaceutical Medicine and Translational Clinical Research by Divya Vohora,Gursharan Singh Pdf

Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features. As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery

Clinical and Translational Perspectives on WILSON DISEASE

Nanda Kerkar,Eve A Roberts
Clinical and Translational Perspectives on WILSON DISEASE Book PDF

Author : Nanda Kerkar,Eve A Roberts
Publisher : Academic Press
Page : 502 pages
File Size : 51,6 Mb
Release : 2018-09-18
Category : Medical
ISBN : 9780128105337

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Clinical and Translational Perspectives on WILSON DISEASE by Nanda Kerkar,Eve A Roberts Pdf

Clinical and Translational Perspectives on Wilson Disease brings together the genetics, cell and structural biology of Wilson Disease into one contemporary, easy to navigate handbook. Created to meet the diverse needs of the clinical and research communities surrounding Wilson Disease, this reference provides a worldwide approach that is concise and translational. Specifically, it provides a basis for clinicians to appreciate ‘basic science’ aspects of Wilson disease, presenting a guide for researchers to understand the clinical disorder on which their research is focused and fostering constructive dialogue and progress for this puzzling disorder. Delivers numerous, succinct, expert chapters with summaries designed for quick reference Includes a 'How-to appendix' for diagnosis and management tips Contains access to a companion website with a self-help teaching module, links to key resources, and an extended reference list

Translational Regenerative Medicine

Anthony Atala,Julie Allickson
Translational Regenerative Medicine Book PDF

Author : Anthony Atala,Julie Allickson
Publisher : Academic Press
Page : 606 pages
File Size : 48,6 Mb
Release : 2014-12-01
Category : Science
ISBN : 9780124104570

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Translational Regenerative Medicine by Anthony Atala,Julie Allickson Pdf

Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine

Progress in Molecular Biology and Translational Science

Anonim
Progress in Molecular Biology and Translational Science Book PDF

Author : Anonim
Publisher : Academic Press
Page : 418 pages
File Size : 55,9 Mb
Release : 2019-03-22
Category : Science
ISBN : 9780128177396

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Progress in Molecular Biology and Translational Science by Anonim Pdf

Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer Biology and Its Clinical Applications, Retrospective Analysis of Glycan-Related Biomarkers Based on Clinical Laboratory Data in Two Medical Centers, and many related topics. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Translating Expertise

Marisa L. Conte
Translating Expertise Book PDF

Author : Marisa L. Conte
Publisher : Rowman & Littlefield
Page : 280 pages
File Size : 46,6 Mb
Release : 2016-08-29
Category : Language Arts & Disciplines
ISBN : 9781442262683

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Translating Expertise by Marisa L. Conte Pdf

Translating Expertise: The Librarian’s Role in Translational Research provides background and context on the CTSA program. Case studies detail routes to librarian involvement in translational research, including collection development, relationships with researchers and administrators, instruction and training, data management, and team science.

Translational Medicine - What, Why and How

Barbara Alving,Kerong Dai,Samuel H. H. Chan
Translational Medicine What Why and How Book PDF

Author : Barbara Alving,Kerong Dai,Samuel H. H. Chan
Publisher : Karger Medical and Scientific Publishers
Page : 136 pages
File Size : 42,7 Mb
Release : 2012-12-01
Category : Science
ISBN : 9783318022841

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Translational Medicine - What, Why and How by Barbara Alving,Kerong Dai,Samuel H. H. Chan Pdf

This book is the first to provide an aerial view, as well as detailed information, on 'how' activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan. Institutions in each country are training investigators to work as sophisticated interdisciplinary teams. Investigators from 11 US academic health centers explain how they are incentivizing collaborations through pilot project programs, forming partnerships with business schools to promote efficient management of basic and clinical research, creating ethical, high- value public-private (industry) partnerships, improving efficiency with utilization of informatics, and engaging the community in research. The essential role of evaluation is explained in a clear and concise manner. The readers will also learn about the role of private funding in Taiwan and the vision of the government in China in developing multiple translational research centers. The UK is developing methodical approaches to patient needs across their lifespans; ongoing innovation is encouraged through incubator programs. With the emphasis on open innovation and sharing, the concepts and practice of translational medicine are spreading rapidly on an international scale.

Translational Immunology

Seng-Lai Tan
Translational Immunology Book PDF

Author : Seng-Lai Tan
Publisher : Academic Press
Page : 384 pages
File Size : 42,6 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9780128017579

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Translational Immunology by Seng-Lai Tan Pdf

Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field. Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategies Presents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine development Discusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppression Provides information on new strategies and outstanding issues that should be addressed in future research

Translational and Experimental Clinical Research

Daniel P. Schuster,William J. Powers (MD.)
Translational and Experimental Clinical Research Book PDF

Author : Daniel P. Schuster,William J. Powers (MD.)
Publisher : Lippincott Williams & Wilkins
Page : 520 pages
File Size : 46,9 Mb
Release : 2005
Category : Medical
ISBN : 0781755654

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Translational and Experimental Clinical Research by Daniel P. Schuster,William J. Powers (MD.) Pdf

This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.

Clinical and Translational Science

David Robertson,Gordon H. Williams
Clinical and Translational Science Book PDF

Author : David Robertson,Gordon H. Williams
Publisher : Academic Press
Page : 600 pages
File Size : 40,7 Mb
Release : 2009-03-02
Category : Medical
ISBN : 0080920195

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Clinical and Translational Science by David Robertson,Gordon H. Williams Pdf

Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science. Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications Contributions from international leaders provide insight into background and future understanding for clinical and translational science Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

Translational Pain Research

Lawrence Kruger,Alan R Light
Translational Pain Research Book PDF

Author : Lawrence Kruger,Alan R Light
Publisher : CRC Press
Page : 432 pages
File Size : 52,8 Mb
Release : 2009-11-24
Category : Health & Fitness
ISBN : 9781439812105

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Translational Pain Research by Lawrence Kruger,Alan R Light Pdf

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Translational Neuroimaging

Robert A. McArthur
Translational Neuroimaging Book PDF

Author : Robert A. McArthur
Publisher : Academic Press
Page : 464 pages
File Size : 43,6 Mb
Release : 2012-10-26
Category : Medical
ISBN : 9780123869456

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Translational Neuroimaging by Robert A. McArthur Pdf

This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders.

Broadly Engaged Team Science in Clinical and Translational Research

Debra Lerner,Marisha E. Palm,Thomas W. Concannon
Broadly Engaged Team Science in Clinical and Translational Research Book PDF

Author : Debra Lerner,Marisha E. Palm,Thomas W. Concannon
Publisher : Springer Nature
Page : 254 pages
File Size : 41,6 Mb
Release : 2022-02-27
Category : Medical
ISBN : 9783030830281

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Broadly Engaged Team Science in Clinical and Translational Research by Debra Lerner,Marisha E. Palm,Thomas W. Concannon Pdf

Despite the large U.S. investment in health science, and the vast and growing body of peer-reviewed research findings it has produced, a compelling body of evidence suggests that research too often has been slow, inefficient, and fallen short of desired impacts on health. A key question is how research might be changed to be more innovative, less wasteful, and more responsive to unmet health needs. One emerging response within clinical and translational science is to advance an approach that attempts to close the gap between research scientists and key stakeholders; the individuals and groups responsible for or affected by health-related decisions. Broadly engaged team science promises to support this aim by transforming the gold standard, multi-disciplinary team science, to include key stakeholders in activities across the research spectrum. These new roles and responsibilities range from generating research questions to implementing research projects, to aiding in the translation of discoveries from the laboratory to the community. A transition to broadly engaged team science reflects the idea that inclusivity and a diversity of perspectives are necessary to achieving progress in addressing complex health issues while representing a new benchmark for ethical research practice. This is one of the first collections of papers describing how clinical and translational science researchers are defining and implementing new research practices, and the successes and challenges involved. This book represents a first and critical step towards organizing knowledge of broadly engaged team science and advancing the development of evidence-based practices. Written in an accessible style, this book is intended to highlight the breadth of broadly engaged team science within one community, motivate researchers and stakeholders to build inclusive teams, bring rigor to often informal stakeholder engagement research practices and encourage people to think more broadly about the development of scientific knowledge. It includes examples of multi-disciplinary, broadly engaged team science projects, the perspectives of academic leaders about the changes needed to encourage scientists to conduct broadly engaged team science, and a resource directory.

Biomaterials in Translational Medicine

Lei Yang,Sarit Bhaduri,Thomas J. Webster
Biomaterials in Translational Medicine Book PDF

Author : Lei Yang,Sarit Bhaduri,Thomas J. Webster
Publisher : Academic Press
Page : 358 pages
File Size : 47,8 Mb
Release : 2018-11-30
Category : Technology & Engineering
ISBN : 9780128134788

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Biomaterials in Translational Medicine by Lei Yang,Sarit Bhaduri,Thomas J. Webster Pdf

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials