Clinical Epigenetics Current Research

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Clinical Epigenetics: Current Research

Elias Foster
Clinical Epigenetics Current Research Book PDF

Author : Elias Foster
Publisher : American Medical Publishers
Page : 247 pages
File Size : 43,6 Mb
Release : 2021-11-16
Category : Medical
ISBN : 1639272445

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Clinical Epigenetics: Current Research by Elias Foster Pdf

Epigenetics delves into the heritable phenotype changes which do not involve changes in DNA sequence. Epigenetics usually show changes that affect the activity of gene and expression along with any heritable phenotypic change. Epigenetics in medicine consist of the use of drugs and epigenome influencing techniques in order to treat medical conditions. Epigenetic mechanisms have three categories- DNA methylation, histone modifications and regulatory RNA. It influences many diseases like cancer, diabetes, mental illness and heart diseases. In such situation epigenetic therapy helps in influencing these pathways. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of epigenetics. The various advancements in epigenetics in medicine are glanced at and their applications as well as ramifications are looked at in detail. This book, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels.

Clinical Epigenetics

Luke B. Hesson,Antonia L. Pritchard
Clinical Epigenetics Book PDF

Author : Luke B. Hesson,Antonia L. Pritchard
Publisher : Springer Nature
Page : 265 pages
File Size : 45,6 Mb
Release : 2019-08-31
Category : Medical
ISBN : 9789811389580

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Clinical Epigenetics by Luke B. Hesson,Antonia L. Pritchard Pdf

In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.

Epigenetic Biomarkers and Diagnostics

José Luis García-Giménez
Epigenetic Biomarkers and Diagnostics Book PDF

Author : José Luis García-Giménez
Publisher : Academic Press
Page : 696 pages
File Size : 40,6 Mb
Release : 2015-12-07
Category : Science
ISBN : 9780128019214

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Epigenetic Biomarkers and Diagnostics by José Luis García-Giménez Pdf

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Handbook of Epigenetics

Trygve Tollefsbol
Handbook of Epigenetics Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 682 pages
File Size : 54,6 Mb
Release : 2017-07-10
Category : Science
ISBN : 9780128054772

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Handbook of Epigenetics by Trygve Tollefsbol Pdf

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Environmental Epigenetics

L. Joseph Su,Tung-chin Chiang
Environmental Epigenetics Book PDF

Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Page : 321 pages
File Size : 47,5 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9781447166788

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Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Medical Epigenetics

Trygve Tollefsbol
Medical Epigenetics Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 944 pages
File Size : 46,5 Mb
Release : 2016-06-21
Category : Science
ISBN : 9780128032404

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Medical Epigenetics by Trygve Tollefsbol Pdf

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Epigenetics Methods

Trygve Tollefsbol
Epigenetics Methods Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 736 pages
File Size : 42,7 Mb
Release : 2020-07-08
Category : Medical
ISBN : 9780128194157

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Epigenetics Methods by Trygve Tollefsbol Pdf

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Prognostic Epigenetics

Anonim
Prognostic Epigenetics Book PDF

Author : Anonim
Publisher : Academic Press
Page : 442 pages
File Size : 55,9 Mb
Release : 2019-11-01
Category : Medical
ISBN : 9780128142608

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Prognostic Epigenetics by Anonim Pdf

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers

Epigenetics in Human Disease

Trygve O. Tollefsbol
Epigenetics in Human Disease Book PDF

Author : Trygve O. Tollefsbol
Publisher : Academic Press
Page : 618 pages
File Size : 52,9 Mb
Release : 2012-07-26
Category : Medical
ISBN : 9780123884152

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Epigenetics in Human Disease by Trygve O. Tollefsbol Pdf

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Transgenerational Epigenetics

Trygve Tollefsbol
Transgenerational Epigenetics Book PDF

Author : Trygve Tollefsbol
Publisher : Elsevier
Page : 413 pages
File Size : 50,8 Mb
Release : 2014-05-02
Category : Science
ISBN : 9780124059221

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Transgenerational Epigenetics by Trygve Tollefsbol Pdf

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies

Handbook of Epigenetics

Trygve Tollefsbol
Handbook of Epigenetics Book PDF

Author : Trygve Tollefsbol
Publisher : Academic Press
Page : 639 pages
File Size : 40,9 Mb
Release : 2010-11-21
Category : Science
ISBN : 9780123757104

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Handbook of Epigenetics by Trygve Tollefsbol Pdf

Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications Integrates methods and biological topics with basic and clinical discoveries Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders

Clinical Epigenetics: Mechanisms, Diagnosis and Prognosis

Elias Foster
Clinical Epigenetics Mechanisms Diagnosis and Prognosis Book PDF

Author : Elias Foster
Publisher : Unknown
Page : 251 pages
File Size : 54,7 Mb
Release : 2019-06-18
Category : Electronic
ISBN : 1632418037

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Clinical Epigenetics: Mechanisms, Diagnosis and Prognosis by Elias Foster Pdf

The study of the changes in the heritable phenotypes, which do not involve any alterations in the DNA sequence, is known as epigenetics. It usually denotes the changes which affect gene activity and expression. It can also be used to describe heritable phenotypic changes. The effects on the physiological and cellular phenotypic traits often result from external or environmental factors. Epigenetics has several medical applications. It plays a major role in congenital genetic diseases such as Prader-Willi syndrome and Angelman syndrome. The study of epigenetic modifications to the DNA of cancer cells, which do not involve a change in the nucleotide sequence, is called cancer epigenetics. The ever-growing need of advanced technology is the reason that has fueled the research in the field of clinical epigenetics in recent times. The objective of this book is to give a general view of the different areas of clinical epigenetics and their applications. As this field is emerging at a rapid pace, the contents of this book will help the readers understand the modern concepts and applications of the subject.

Epigenetics in Precision Medicine

Jose Luis Garcia-Gimenez
Epigenetics in Precision Medicine Book PDF

Author : Jose Luis Garcia-Gimenez
Publisher : Elsevier
Page : 616 pages
File Size : 43,7 Mb
Release : 2021-11-12
Category : Medical
ISBN : 9780323858052

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Epigenetics in Precision Medicine by Jose Luis Garcia-Gimenez Pdf

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Computational Epigenetics and Diseases

Anonim
Computational Epigenetics and Diseases Book PDF

Author : Anonim
Publisher : Academic Press
Page : 450 pages
File Size : 55,7 Mb
Release : 2019-02-06
Category : Business & Economics
ISBN : 9780128145142

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Computational Epigenetics and Diseases by Anonim Pdf

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Epigenetics in Biology and Medicine

Manel Esteller
Epigenetics in Biology and Medicine Book PDF

Author : Manel Esteller
Publisher : CRC Press
Page : 312 pages
File Size : 42,6 Mb
Release : 2008-09-17
Category : Science
ISBN : 1420007076

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Epigenetics in Biology and Medicine by Manel Esteller Pdf

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its