Clinical Research In Diabetes And Obesity

Author : Boris Draznin,Robert Rizza
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 48,9 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781475739060

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Clinical Research in Diabetes and Obesity, Volume 2 by Boris Draznin,Robert Rizza Pdf

An unprecedented compilation of state-of-the-art advances in clinical research by premier clinical scientists around the world. This volume discusses the methods of clinical research and the interpretation of their results in studies of normal individuals, obese subjects, and patients with diabetes mellitus. Along the way, the authoritative contributors writing here illuminate how changes in the hormone action and substrate metabolism of healthy humans may lead to obesity and noninsulin-dependent diabetes mellitus.

Author : Boris Draznin,Robert Rizza
Publisher : Humana Press
Page : 392 pages
File Size : 53,5 Mb
Release : 2010-11-09
Category : Medical
ISBN : 1617370517

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Clinical Research in Diabetes and Obesity, Volume 2 by Boris Draznin,Robert Rizza Pdf

An unprecedented compilation of state-of-the-art advances in clinical research by premier clinical scientists around the world. This volume discusses the methods of clinical research and the interpretation of their results in studies of normal individuals, obese subjects, and patients with diabetes mellitus. Along the way, the authoritative contributors writing here illuminate how changes in the hormone action and substrate metabolism of healthy humans may lead to obesity and noninsulin-dependent diabetes mellitus.

Author : Boris Draznin,Robert Rizza
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 43,9 Mb
Release : 1997-03-25
Category : Medical
ISBN : UOM:39015039076883

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Clinical Research in Diabetes and Obesity, Volume 1 by Boris Draznin,Robert Rizza Pdf

An unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity by premier clinical scientists around the world. This volume critically reviews the limitations and strengths of today's major techniques in clinical diabetes research, and then reviews how those methods have been used to carry out cutting-edge studies of carbohydrate, lipid, and protein metabolism in the disease.

Author : Anonim
Publisher : Unknown
Page : 84 pages
File Size : 45,5 Mb
Release : 2004
Category : Biology
ISBN : UOM:39015069128612

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From Clinical Trials to Community by Anonim Pdf

Author : Andrew J. Krentz,Lutz Heinemann,Marcus Hompesch
Publisher : Springer
Page : 316 pages
File Size : 40,9 Mb
Release : 2014-11-29
Category : Medical
ISBN : 9781447149200

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Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development by Andrew J. Krentz,Lutz Heinemann,Marcus Hompesch Pdf

The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Page : 249 pages
File Size : 53,8 Mb
Release : 2016-06-07
Category : Science
ISBN : 9781681081854

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Frontiers in Clinical Drug Research - Diabetes and Obesity by Atta-ur-Rahman Pdf

Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The second volume of this series features 7 reviews presenting updates on hormones and several classes of drugs: -Osteocalcin action in glucose metabolism -Sodium-glucose co-transporter 2 (SGLT2) inhibitors -Glucagon-like peptide-1 (GLP-1) mimetics -Dipeptidyl peptidase 4 (DPP-4) inhibitors -New drugs in clinical trial and commercial phases

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Page : 257 pages
File Size : 46,6 Mb
Release : 2016-12-07
Category : Science
ISBN : 9781681082479

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Frontiers in Clinical Drug Research: Diabetes and Obesity by Atta-ur-Rahman Pdf

"Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The third volume of this series features 5 chapters that cover a variety of topics including: -Exendin-4 and its derivatives -The growth hormone/insulin-like growth factor system -Insulin and cardiovascular function -Diabetes mellitus related infertility -Adipocytokines as markers of insulin resistance "

Author : Michael Roden
Publisher : John Wiley & Sons
Page : 422 pages
File Size : 46,7 Mb
Release : 2007-08-20
Category : Medical
ISBN : 047051308X

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Clinical Diabetes Research by Michael Roden Pdf

A practical "how to" guide for multiple methods in metabolism, with a critical and objective discussion of strengths, limitations, and appropriate applications of the described methods. Edited by the winner of the Oskar-Minkowski Prize of the EASD in 2006 Clinical trials in populations at risk of or with overt diabetes mellitus are being performed all around the world to test novel drugs and approaches to managing these diseases. During the last decade, new methods and techniques have been introduced – and are being developed further – that facilitate monitoring of metabolism and even diagnosis of certain defects in human metabolism. While some of these methods are restricted to research facilities, others are already used in clinical practice. The correct beneficial use of these methods requires knowledge of the nature of the techniques and their clinical relevance. Clinical Diabetes Research: Methods and Techniques provides summaries of established state-of-the art-techniques and introduces the new technologies, evaluating their potential in clinical diabetes research. One section compares the efficacy of all metabolic tests that measure insulin action. Another section describes methods that allow quantification of whole body and intracellular metabolic fluxes relevant to diabetes research. The final section focuses on the planning and pitfalls of clinical studies in the field of metabolism. Each chapter throughout the book combines the theoretical basis of the approach with practical recommendations. There are further chapters on the design of clinical trials and ethical considerations. The publication is timely in view of the impressive development of the methods and techniques with their application to understanding the pathophysiology of diabetes, insulin resistance syndromes, obesity, and the metabolic effects of treatment. Clinical Diabetes Research: Methods and Techniques is of great relevance for researchers (from students and post-docs to principal investigators) in the field of human metabolism, clinical endocrinologists and diabetologists who are involved in clinical studies.

Author : Andrew J. Krentz,Christian Weyer,Marcus Hompesch
Publisher : Springer
Page : 556 pages
File Size : 42,9 Mb
Release : 2019-04-02
Category : Medical
ISBN : 9783030117481

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Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease by Andrew J. Krentz,Christian Weyer,Marcus Hompesch Pdf

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Page : 280 pages
File Size : 46,6 Mb
Release : 2019-01-18
Category : Science
ISBN : 9781681084459

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Frontiers in Clinical Drug Research - Diabetes and Obesity: Volume 4 by Atta-ur-Rahman Pdf

Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The fourth volume of this series features 7 chapters: -Pharmacologic Obesity Treatment -Interplay Between Bile Acid and GLP-1 Receptor Agonist Signaling Informs the Design of Drugs to Combat Obesity and its Metabolic Complications -Sodium–Glucose Co-Transporters Inhibitors for Type 2 Diabetes Mellitus -The Effects of Traditional Chinese Medicine on Inflammatory Cytokines in Diabetic Nephropathy -Through the Perspective of Histology – The Alzheimer’s Disease Promotion by Obesity and Glucose Metabolism: Type 3 Diabetes -Pharmacological Mechanism of PPARγ Ratio in Diabetes and Obesity -Hydrogen Sulfide and Carbohydrate Metabolism

Author : Joel Faintuch,Salomão Faintuch
Publisher : Springer
Page : 286 pages
File Size : 41,7 Mb
Release : 2014-12-29
Category : Medical
ISBN : 9783319131269

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Obesity and Diabetes by Joel Faintuch,Salomão Faintuch Pdf

This timely and clinically oriented book uniquely addresses the entire spectrum of treatment for severe obesity and diabetes. It thoroughly examines all aspects from robotic surgery to cell therapy, from the latest antidiabetic drugs to endoscopic procedures and devices, from appetite-inhibiting signals and nutrients to gastric arterial embolization. It offers objective and authoritative information for practicing professionals; not only are successful interventions discussed and updated, but cutting-edge and experimental pathways are also anticipated. Obesity is the foremost nutritional challenge worldwide. Its companion is type-2 diabetes, the most prevalent metabolic disease. Together they represent the diabesity epidemic, which is draining resources, overwhelming healthcare facilities, and impacting life expectancy and quality of life everywhere. No country has been spared, and most medical specialties have been affected. Many books focus on the surgical options for obesity and diabetes, namely bariatric and metabolic operations. Information on the clinical and pharmacological treatment is also available, conveyed by standard texts on internal medicine and endocrinology. Yet endoscopic maneuvers and prostheses, cell therapy for diabetes, and other innovative approaches are hard to come by, as conventional texts overlook such therapies. This timely publication bridges the gaps between all different therapeutic options, also covering advances in the conservative, surgical and parasurgical domains. This book will appeal to seasoned specialists, students and healthcare professionals in training alike.

Author : Shazia Anjum
Publisher : Bentham Science Publishers
Page : 228 pages
File Size : 42,6 Mb
Release : 2023-03-21
Category : Science
ISBN : 9789815123593

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Frontiers in Clinical Drug Research-Diabetes and Obesity: Volume 7 by Shazia Anjum Pdf

Affective computing is an emerging field situated at the intersection of artificial intelligence and behavioral science. Affective computing refers to studying and developing systems that recognize, interpret, process, and simulate human emotions. It has recently seen significant advances from exploratory studies to realworld applications. Multimodal Affective Computing offers readers a concise overview of the stateoftheart and emerging themes in affective computing, including a comprehensive review of the existing approaches in applied affective computing systems and social signal processing. It covers affective facial expression and recognition, affective body expression and recognition, affective speech processing, affective text, and dialogue processing, recognizing affect using physiological measures, computational models of emotion and theoretical foundations, and affective sound and music processing. This book identifies future directions for the field and summarizes a set of guidelines for developing nextgeneration affective computing systems that are effective, safe, and humancentered.The book is an informative resource for academicians, professionals, researchers, and students at engineering and medical institutions working in the areas of applied affective computing, sentiment analysis, and emotion recognition.

Author : Atta-ur-Rahman
Publisher : Bentham Science Publishers
Page : 178 pages
File Size : 48,9 Mb
Release : 2020-05-21
Category : Science
ISBN : 9781681087542

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Frontiers in Clinical Drug Research - Diabetes and Obesity: Volume 5 by Atta-ur-Rahman Pdf

Frontiers in Clinical Drug Research – Diabetes and Obesity is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases – diabetes and obesity. The scope of the series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research – Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The fifth volume of this series features 5 reviews which are informative guides to therapy and drug administration in diabetes and metabolic syndrome, for both the medical specialist and the pharmacologist. -Metabolic syndrome in schizophrenia -Insulin therapy and foetoplacental endothelial dysfunction in gestational diabetes mellitus -Insights on diabetes, oxidative stress and antioxidant therapeutic strategies -Administration of nano drugs in the treatment of diabetes mellitus -SGLT-2 inhibitors

Author : Atta Ur-Rahman
Publisher : Frontiers in Clinical Drug Res
Page : 258 pages
File Size : 49,5 Mb
Release : 2016-12-07
Category : Medical
ISBN : 1681082489

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Frontiers in Clinical Drug Research - Diabetes and Obesity by Atta Ur-Rahman Pdf

Frontiers in Clinical Drug Research - Diabetes and Obesity is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases - diabetes and obesity. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research - Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research. The third volume of this series features 5 chapters that cover a variety of topics including: -Exendin-4 and its derivatives -The growth hormone/insulin-like growth factor system -Insulin and cardiovascular function -Diabetes mellitus related infertility -Adipocytokines as markers of insulin resistance

Author : Anonim
Publisher : Unknown
Page : 264 pages
File Size : 55,7 Mb
Release : 1998
Category : Electronic
ISBN : STANFORD:24504113426

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Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults by Anonim Pdf