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Author : Gorō Mimura
Publisher : Unknown
Page : 396 pages
File Size : 43,6 Mb
Release : 1982
Category : Health & Fitness
ISBN : UOM:39015001657058
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 51,9 Mb
Release : 1982
Category : Electronic
ISBN : OCLC:1414731289
Author : Gorō Mimura
Publisher : Unknown
Page : 358 pages
File Size : 43,9 Mb
Release : 1982-01-01
Category : Diabetes
ISBN : 0444902856
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1456 pages
File Size : 49,5 Mb
Release : 1983
Category : Medicine
ISBN : MINN:31951D00170007S
Author : Anonim
Publisher : Unknown
Page : 670 pages
File Size : 51,6 Mb
Release : 1985
Category : Diabetes
ISBN : PURD:32754004369975
Abstract: This document is a compilation of writings by diabetes experts which presents and evaluates data on diabetes and its complications. Four general areas are addressed : the demographic specificity of the disease in various segments of the population ; the risk of developing diabetes and its complications ; the impact of diabetes on the patient and on the population in terms of morbidity, disability, mortality and cost ; and its impact on resources of the health care system.
Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1442 pages
File Size : 43,8 Mb
Release : 1983
Category : Medicine
ISBN : UOM:39015074107650
First multi-year cumulation covers six years: 1965-70.
Author : United States. Dept. of Health and Human Services. Task Force on Black and Minority Health
Publisher : Unknown
Page : 392 pages
File Size : 54,7 Mb
Release : 1985
Category : African Americans
ISBN : PURD:32754062342351
Author : United States. Department of Health and Human Services. Task Force on Black and Minority Health
Publisher : Unknown
Page : 402 pages
File Size : 54,5 Mb
Release : 1985
Category : African Americans
ISBN : IND:30000143758625
Author : D.R. Owens
Publisher : Springer Science & Business Media
Page : 307 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400941618
Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness.
Author : Matthias G. Von Herrath
Publisher : Karger Medical and Scientific Publishers
Page : 371 pages
File Size : 42,6 Mb
Release : 2001-01-01
Category : Medical
ISBN : 9783805572408
Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.
Author : National Institutes of Health (U.S.)
Publisher : Unknown
Page : 492 pages
File Size : 43,7 Mb
Release : 1984
Category : Medical research personnel
ISBN : STANFORD:36105119623499
Author : John A. Thomas
Publisher : CRC Press
Page : 296 pages
File Size : 52,9 Mb
Release : 1993-06-30
Category : Medical
ISBN : 0781700809
In this volume, experts from academe, industry, and public health institutes discuss the issues involved in toxicology evaluation, safety assessment, and regulation of biotechnology-derived drugs, foods, and plant products. Coverage includes recombinant DNA agents, monoclonal antibodies, recombinant hormones and other proteins, biotechnology-derived drug delivery systems, gene therapy for genetic diseases, and genetically engineered plants and plant products. Full consideration is given to key methodological issues in product development and testing, such as use of "in vitro" and "in vivo" toxicology tests, choice of animal models, and use of transgenic animal models and genetically altered species to study human diseases. The book includes an appendix describing available animal models and a glossary of terms, definitions, and acronyms.
Author : Anonim
Publisher : Unknown
Page : 10 pages
File Size : 53,6 Mb
Release : 1986
Category : Diabetes
ISBN : UIUC:30112104110116
Author : Anonim
Publisher : Unknown
Page : 2696 pages
File Size : 43,9 Mb
Release : 1983
Category : American literature
ISBN : UOM:39015058373583
A world list of books in the English language.
Author : Sunthorn Tandhanand
Publisher : Unknown
Page : 368 pages
File Size : 54,7 Mb
Release : 1985
Category : Developing countries
ISBN : UCLA:31158011919296