Combinatorial Organic Chemistry

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Combinatorial Chemistry

Stephen R. Wilson,Anthony W. Czarnik
Combinatorial Chemistry Book PDF

Author : Stephen R. Wilson,Anthony W. Czarnik
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 54,7 Mb
Release : 1997-03-28
Category : Medical
ISBN : 047112687X

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Combinatorial Chemistry by Stephen R. Wilson,Anthony W. Czarnik Pdf

The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Combinatorial Chemistry

Nicholas K. Terrett
Combinatorial Chemistry Book PDF

Author : Nicholas K. Terrett
Publisher : Unknown
Page : 204 pages
File Size : 41,8 Mb
Release : 1998
Category : Combinatorial chemistry
ISBN : 0198502192

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Combinatorial Chemistry by Nicholas K. Terrett Pdf

Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.

Combinatorial Chemistry

Hicham Fenniri
Combinatorial Chemistry Book PDF

Author : Hicham Fenniri
Publisher : OUP Oxford
Page : 508 pages
File Size : 50,6 Mb
Release : 2000-10-05
Category : Science
ISBN : 9780191565939

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Combinatorial Chemistry by Hicham Fenniri Pdf

Combinatorial Chemistry is a genuine practical guide covering all the major areas of combinatorial chemistry from an experimental and conceptual point of view. Being one of the most powerful of modern technologies, combinatorial chemistry has had implications to many areas of chemistry and biology and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It also contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation. The use of automation and robotics is also explained. It is written at a level easily accessible to novices and will enable readers to use combinatorial techniques to the best advantage.

Combinatorial Chemistry

Günther Jung
Combinatorial Chemistry Book PDF

Author : Günther Jung
Publisher : John Wiley & Sons
Page : 634 pages
File Size : 51,7 Mb
Release : 2008-07-11
Category : Science
ISBN : 9783527613519

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Combinatorial Chemistry by Günther Jung Pdf

The story of success goes on and on - with a new book on combinatorial chemistry, edited by Gunther Jung! Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Gunther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.

Combinatorial Organic Chemistry

Sherif El-Basil
Combinatorial Organic Chemistry Book PDF

Author : Sherif El-Basil
Publisher : Nova Publishers
Page : 246 pages
File Size : 47,9 Mb
Release : 2000
Category : Combinatorial chemistry
ISBN : 1560727446

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Combinatorial Organic Chemistry by Sherif El-Basil Pdf

This is a book which considers several isomer-enumeration methods in organic chemistry. Three main topics are exemplified here: viz., theorem of polya, coset representation theory and marks of a group (method of Fujita) and wreath and generalized wreath product groups (method of Balasubramanian). Rigorous proofs have been replaced by an example-oriented, intuitive approach which exposes many problems of real chemical importance.

Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries

D. Obrecht,J.M. Villalgordo
Solid Supported Combinatorial and Parallel Synthesis of Small Molecular Weight Compound Libraries Book PDF

Author : D. Obrecht,J.M. Villalgordo
Publisher : Elsevier
Page : 338 pages
File Size : 40,8 Mb
Release : 1998-10-02
Category : Science
ISBN : 9780080517360

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Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries by D. Obrecht,J.M. Villalgordo Pdf

The words "Combinatorial Chemistry" have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, and even inorganic solids. All of these activities have in common an attempt to expand the diversity of structure available to the chemist as well as the access to this diversity, permitting the discovery of new and valuable biological acid material properties. In this outstanding survey of combinatorial organic chemistry, the authors, Obrecht who has established a new combinatorial chemistry company called Polyphor, and Villalgardo have brought together the literature, including that from 1998, and have concisely analysed the applications and achievements of this new field. This work will be of value to all chemists engaged in preparative work, both in industry and academe.

Combinatorial Chemistry and Technologies

Stanislav Miertus,Giorgio Fassina
Combinatorial Chemistry and Technologies Book PDF

Author : Stanislav Miertus,Giorgio Fassina
Publisher : CRC Press
Page : 616 pages
File Size : 55,6 Mb
Release : 2005-04-12
Category : Medical
ISBN : 9780824758370

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Combinatorial Chemistry and Technologies by Stanislav Miertus,Giorgio Fassina Pdf

Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Combinatorial Chemistry and Technology

Stanislav Miertus,Giorgio Fassina
Combinatorial Chemistry and Technology Book PDF

Author : Stanislav Miertus,Giorgio Fassina
Publisher : CRC Press
Page : 456 pages
File Size : 49,6 Mb
Release : 1999-07-01
Category : Science
ISBN : 142000056X

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Combinatorial Chemistry and Technology by Stanislav Miertus,Giorgio Fassina Pdf

"Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular ""libraries."" Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules."

Combinatorial Chemistry

Guillermo A. Morales,Barry A. Bunin
Combinatorial Chemistry Book PDF

Author : Guillermo A. Morales,Barry A. Bunin
Publisher : Academic Press
Page : 608 pages
File Size : 53,7 Mb
Release : 2003
Category : Amino acid sequence
ISBN : 9780121822729

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Combinatorial Chemistry by Guillermo A. Morales,Barry A. Bunin Pdf

Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques *Direct sorting split and pool combinatorial synthesis *Linkers and their applications *Microwave assisted synthesis *Oligosaccharide chemistry *Peptide Synthesis and Screening *Polymer assisted approaches *Small molecule and heterocycle synthesis.

Combinatorial Chemistry

Willi Bannwarth,Berthold Hinzen
Combinatorial Chemistry Book PDF

Author : Willi Bannwarth,Berthold Hinzen
Publisher : John Wiley & Sons
Page : 694 pages
File Size : 47,5 Mb
Release : 2006-05-12
Category : Science
ISBN : 9783527607389

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Combinatorial Chemistry by Willi Bannwarth,Berthold Hinzen Pdf

The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)

Combinatorial Chemistry, Part B

Anonim
Combinatorial Chemistry Part B Book PDF

Author : Anonim
Publisher : Elsevier
Page : 607 pages
File Size : 51,9 Mb
Release : 2004-01-26
Category : Science
ISBN : 9780080497105

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Combinatorial Chemistry, Part B by Anonim Pdf

Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions. *Analytical techniques*Direct sorting split and pool combinatorial synthesis*Linkers and their applications*Microwave assisted synthesis*Oligosaccharide chemistry*Peptide Synthesis and Screening*Polymer assisted approaches*Small molecule and heterocycle synthesis

Optimization of Solid-Phase Combinatorial Synthesis

Bing Yan,Anthony W. Czarnik
Optimization of Solid Phase Combinatorial Synthesis Book PDF

Author : Bing Yan,Anthony W. Czarnik
Publisher : CRC Press
Page : 408 pages
File Size : 47,5 Mb
Release : 2001-12-04
Category : Science
ISBN : 9781482271058

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Optimization of Solid-Phase Combinatorial Synthesis by Bing Yan,Anthony W. Czarnik Pdf

"Addresses the key topic in combinatorial synthesis--how to optimize the quality of a combinatorial library--by determining the usefulness of synthesized compunds, the reliability of biological assay results, and analyzing acadmic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies."

Analytical Methods in Combinatorial Chemistry

Bing Yan,Bin Zhang
Analytical Methods in Combinatorial Chemistry Book PDF

Author : Bing Yan,Bin Zhang
Publisher : CRC Press
Page : 335 pages
File Size : 45,6 Mb
Release : 2010-08-09
Category : Science
ISBN : 9781439857601

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Analytical Methods in Combinatorial Chemistry by Bing Yan,Bin Zhang Pdf

Since the publication of the benchmark first edition of this book, chemical library and combinatorial chemistry methods have developed into mature technologies. There have also been significant shifts in emphasis in combinatorial synthesis. Reflecting the growth in the field and the heightened focus on select areas, Analytical Methods in Combinator

Molecular Diversity and Combinatorial Chemistry

Michael C. Pirrung
Molecular Diversity and Combinatorial Chemistry Book PDF

Author : Michael C. Pirrung
Publisher : Elsevier
Page : 192 pages
File Size : 52,6 Mb
Release : 2004-11-09
Category : Business & Economics
ISBN : 0080444938

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Molecular Diversity and Combinatorial Chemistry by Michael C. Pirrung Pdf

Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.

Handbook of Combinatorial Chemistry

K. C. Nicolaou,Rudolf Hanko,Wolfgang Hartwig
Handbook of Combinatorial Chemistry Book PDF

Author : K. C. Nicolaou,Rudolf Hanko,Wolfgang Hartwig
Publisher : Wiley-VCH
Page : 652 pages
File Size : 51,6 Mb
Release : 2002-04-29
Category : Medical
ISBN : UOM:39015051613373

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Handbook of Combinatorial Chemistry by K. C. Nicolaou,Rudolf Hanko,Wolfgang Hartwig Pdf

In two volumes, this comprehensive handbook provides coverage of the whole area of combinatorial synthetic chemistry, including compound library design and synthesis.