Combinatorial Peptide And Nonpeptide Libraries

Author : Günther Jung
Publisher : John Wiley & Sons
Page : 571 pages
File Size : 49,8 Mb
Release : 2008-09-26
Category : Science
ISBN : 9783527614905

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Combinatorial Peptide and Nonpeptide Libraries by Günther Jung Pdf

With combinatorial chemistry millions of organic compounds can be produced simultaneously, quickly, and in most cases by automated procedures. These compound libraries are a cost-effective resource for the pharmaceutical industry in their search for biologically active lead structures. Furthermore simultaneous parallel synthesis of single peptides and peptide libraries solve the problem of the worldwide increasing demand for peptides. The synthetic methods described here in detail contribute to a forward-looking technology that has a high impact for industrial and academic research. Fast and efficient analytical techniques are essential for using the complicated product mixtures and detecting by-products. Various synthetic approaches and technologies, mass spectrometry, and screening assays are discussed extensively. This book is a must and an indispensible source of information for every researcher in this rapidly developing field, which spans organic synthesis, biochemistry, biotechnology, pharmaceutical, medicinal, and clinical chemistry.

Author : Shmuel Cabilly
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 43,8 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592595716

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Combinatorial Peptide Library Protocols by Shmuel Cabilly Pdf

During the course of evolution, an imbalance was created between the rate of vertebrate genetic adaptation and that of the lower forms of living organisms, such as bacteria and viruses. This imbalance has given the latter the advantage of generating, relatively quickly, molecules with unexpected structures and features that carry a threat to vertebrates. To compensate for their weakness, vertebrates have accelerated their own evolutionary processes, not at the level of whole organism, but in specialized cells containing the genes that code for antibody molecules or for T-cell receptors. That is, when an immediate requirement for molecules capable of specific interactions arose, nature has preferred to speed up the mode of Darwinian evolution in pref- ence to any other approach (such as the use of X-ray diffraction studies and computergraphic analysis). Recently, Darwinian rules have been adapted for test tube research, and the concept of selecting molecules having particular characteristics from r- dom pools has been realized in the form of various chemical and biological combinatorial libraries. While working with these libraries, we noticed the interesting fact that when combinatorial libraries of oligopeptides were allowed to interact with different selector proteins, only the actual binding sites of these proteins showed binding properties, whereas the rest of the p- tein surface seemed "inert. " This seemingly common feature of protein- having no extra potential binding sites--was probably selected during evolution in order to minimize nonspecific interactions with the surrounding milieu.

Author : Nicholas K. Terrett
Publisher : Unknown
Page : 204 pages
File Size : 52,7 Mb
Release : 1998
Category : Combinatorial chemistry
ISBN : 0198502192

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Combinatorial Chemistry by Nicholas K. Terrett Pdf

Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context.It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes thebeneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists inchemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.

Author : Bernd Gutte
Publisher : Elsevier
Page : 527 pages
File Size : 43,8 Mb
Release : 1995-10-24
Category : Science
ISBN : 9780080538594

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Peptides by Bernd Gutte Pdf

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines

Author : Stephen R. Wilson,Anthony W. Czarnik
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 54,5 Mb
Release : 1997-03-28
Category : Medical
ISBN : 047112687X

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Combinatorial Chemistry by Stephen R. Wilson,Anthony W. Czarnik Pdf

The new time-saving revolution in drug discovery. Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation. Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world's leading chemists, many of whom played a key role in its development. Including examples of both solution-phase and solid-phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes: * Concepts and terms of combinatorial chemistry * Polymer-supported synthesis of organic compounds * Macro beads as microreactors * Solid-phase methods in combinatorial chemistry * Encoded combinatorial libraries, including Rf-encoding of synthesis beads * Strategies for combinatorial libraries of oligosaccharides * Combinatorial libraries of peptides, proteins, and antibodies using biological systems. While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique's wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost-effective, and practical technique, which has unlocked creative potential for the next millennium.

Author : Robert A. Meyers
Publisher : Wiley-Blackwell
Page : 0 pages
File Size : 52,9 Mb
Release : 1996-12-12
Category : Science
ISBN : 3527284753

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Encyclopedia of Molecular Biology and Molecular Medicine, Plasmids to Synthetic Peptide and Nonpeptide Combinatorial Libraries by Robert A. Meyers Pdf

This six volume Encyclopedia is the most comprehensive, detailed treatment of molecular biology and molecular medicine available today! The Encyclopedia provides a single-source library of molecular genetics and the molecular basis of life, with a focus on molecular medicine. Genetic screening, gene therapy, structural biology, and the technology and findings of the Human Genome Project are discussed in detail. The articles that comprise the set are designed as self-contained treatments. Each of the nearly 300 articles begins with an outline and a key word section which includes definitions. These features assist the scientist or student who is unfamiliar with a specific subject area. A glossary of basic terms completes each volume and defines the most commonly used terms in molecular biology. Together with the introductory illustrations found in each volume, these definitions enable readers to understand articles without referring to a dictionary, textbook, or other reference.

Author : Roger Epton
Publisher : Unknown
Page : 432 pages
File Size : 48,9 Mb
Release : 1999
Category : Electronic
ISBN : OCLC:1081901752

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Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries by Roger Epton Pdf

Author : Anonim
Publisher : Unknown
Page : 328 pages
File Size : 52,8 Mb
Release : 2003
Category : Nucleic acids
ISBN : STANFORD:36105026582929

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Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, 2002 by Anonim Pdf

Author : Riccardo Cortese
Publisher : de Gruyter
Page : 256 pages
File Size : 43,6 Mb
Release : 1996
Category : Business & Economics
ISBN : UOM:39015037865014

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Combinatorial Libraries by Riccardo Cortese Pdf

No detailed description available for "Combinatorial Libraries".

Author : Anonim
Publisher : Unknown
Page : 100 pages
File Size : 47,5 Mb
Release : 1995
Category : Combinatorial chemistry
ISBN : STANFORD:36105021462994

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Combinatorial Libraries by Anonim Pdf

Author : D. Obrecht,J.M. Villalgordo
Publisher : Elsevier
Page : 338 pages
File Size : 44,9 Mb
Release : 1998-10-02
Category : Science
ISBN : 9780080517360

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Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries by D. Obrecht,J.M. Villalgordo Pdf

The words "Combinatorial Chemistry" have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, and even inorganic solids. All of these activities have in common an attempt to expand the diversity of structure available to the chemist as well as the access to this diversity, permitting the discovery of new and valuable biological acid material properties. In this outstanding survey of combinatorial organic chemistry, the authors, Obrecht who has established a new combinatorial chemistry company called Polyphor, and Villalgardo have brought together the literature, including that from 1998, and have concisely analysed the applications and achievements of this new field. This work will be of value to all chemists engaged in preparative work, both in industry and academe.

Author : Anonim
Publisher : John Wiley & Sons
Page : 541 pages
File Size : 48,6 Mb
Release : 2011-06-03
Category : Science
ISBN : 9783527641574

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Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis by Anonim Pdf

This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Author : Roger Epton
Publisher : Unknown
Page : 376 pages
File Size : 51,7 Mb
Release : 2004
Category : Nucleic acids
ISBN : STANFORD:36105126892152

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Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries by Roger Epton Pdf

Author : Roger Epton
Publisher : Unknown
Page : 414 pages
File Size : 45,5 Mb
Release : 2001
Category : Nucleic acids
ISBN : 0951573535

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Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries 2000 by Roger Epton Pdf

Author : W.H. Moos,M.R. Pavia,B.K. Kay,Andrew D. Ellington
Publisher : Springer Science & Business Media
Page : 376 pages
File Size : 43,8 Mb
Release : 1997-04-30
Category : Medical
ISBN : 9072199235

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Annual Reports in Combinatorial Chemistry and Molecular Diversity by W.H. Moos,M.R. Pavia,B.K. Kay,Andrew D. Ellington Pdf

Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.