Computational Design Of Chemicals For The Control Of Mosquitoes And Their Diseases

Author : James Devillers
Publisher : CRC Press
Page : 473 pages
File Size : 41,8 Mb
Release : 2017-12-15
Category : Medical
ISBN : 9781498741811

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Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases by James Devillers Pdf

There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases. Environmentally safe, but effective insecticides that address the problems of resistance are required. Computational Design of Chemicals for the Control of Mosquitoes and Their Diseases explains how the search for new substances effective against mosquitoes and their diseases has benefited from the use of in silico techniques. QSAR modeling is suited to identify the key structural features and/or physicochemical properties explaining an activity and to propose candidate molecules for further evaluation by laboratory tests. Homology modeling is useful to approximate the 3D structure of proteins of interest. Pharmacophore modeling is a powerful means to capture the chemical features responsible for an activity and to identify new potentially active compounds via the virtual screening of databases. Fugacity modeling and a wealth of other modeling paradigms are useful for risk assessment in vector borne disease control.

Author : Subhash C. Basak,Marjan Vračko
Publisher : Elsevier
Page : 503 pages
File Size : 52,8 Mb
Release : 2022-12-06
Category : Science
ISBN : 9780323857147

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Big Data Analytics in Chemoinformatics and Bioinformatics by Subhash C. Basak,Marjan Vračko Pdf

Big Data Analytics in Chemoinformatics and Bioinformatics: With Applications to Computer-Aided Drug Design, Cancer Biology, Emerging Pathogens and Computational Toxicology provides an up-to-date presentation of big data analytics methods and their applications in diverse fields. The proper management of big data for decision-making in scientific and social issues is of paramount importance. This book gives researchers the tools they need to solve big data problems in these fields. It begins with a section on general topics that all readers will find useful and continues with specific sections covering a range of interdisciplinary applications. Here, an international team of leading experts review their respective fields and present their latest research findings, with case studies used throughout to analyze and present key information. Brings together the current knowledge on the most important aspects of big data, including analysis using deep learning and fuzzy logic, transparency and data protection, disparate data analytics, and scalability of the big data domain Covers many applications of big data analysis in diverse fields such as chemistry, chemoinformatics, bioinformatics, computer-assisted drug/vaccine design, characterization of emerging pathogens, and environmental protection Highlights the considerable benefits offered by big data analytics to science, in biomedical fields and in industry

Author : Azamal Husen
Publisher : CRC Press
Page : 477 pages
File Size : 43,5 Mb
Release : 2024-04-22
Category : Science
ISBN : 9781003857631

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Antimalarial Medicinal Plants by Azamal Husen Pdf

Malaria continues to affect a large population of the world, especially in third world countries. The spread of drug-resistant parasites demonstrates the need for antimalarial agents with various modes of action. The search for remedies derived from medicinal plants for the treatment of malaria is reliant on accurate ethnobotanical and ethnopharmacological information obtained from traditional medical practitioners. Antimalarial Medicinal Plants provides information on bioactive compounds and therapeutic potentials of several antimalarial plant species found around the globe. This book evaluates these plant species with respect to their biology, diversity, distribution, and pharmacological values. A volume in the Exploring Medicinal Plants series, this book highlights trends, technologies, processes, and services important to and necessary for efficient production, use, and understanding of medicinal qualities of antimalarial plants. It critically examines claims made by traditional medical practitioners with scientific validations for safe herbal drug formulation. It is a reference work for researchers of herbal medicine, traditional healers, pharmacists, and students associated with plant sciences and economic botany.

Author : Conference Series
Publisher : ConferenceSeries
Page : 76 pages
File Size : 53,9 Mb
Release : 2019-02-18
Category : Business & Economics
ISBN : 8210379456XXX

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Proceedings Of 20th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems: 2019 by Conference Series Pdf

March 18-20, 2019 Edinburgh, Scotland Bio-Pharmaceutics,Pharmaceutical Chemistry,Drug Targeting and Design,Pharmacokinetics and Pharmacodynamics in Drugs,Pharmaceutical Formulation,Pharmaceutical Manufacturing,Pharmaceutical Nanotechnology,Novel Drug Delivery Systems,Smart Drug Delivery Systems,Nanomedicine and Biomedical Applications,Biomaterials in Drug Delivery,Vaccine Drug Delivery Systems,Medical Devices for Drug Delivery,Biologics & Biosimilars,Pharmaceutical Analysis,Pharmaceutical Process Validation,Pharmaceutical Packaging,Clinical Trials and Clinical Research,Pharmacogenetics and Genomics,Regulatory Affairs and Intellectual Property Rights,Industrial and Physical Pharmacy,Clinical and Hospital Pharmacy,Pharmacovigilance and Drug Safety,Pharmacy Education and Practice,

Author : Tarun Jha
Publisher : CRC Press
Page : 491 pages
File Size : 44,6 Mb
Release : 2023-12-29
Category : Medical
ISBN : 9781003817659

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Modeling Inhibitors of Matrix Metalloproteinases by Tarun Jha Pdf

Matrix metalloproteinases (MMPs) have been established as promising biomolecular targets for novel drug design and discovery against numerous major disease conditions including various cancers, cardiovascular, neurodegenerative, inflammatory diseases, and more. This book covers various modern molecular modeling methodologies particularly related to MMP inhibitors. Included in the text are descriptions of ligand-based drug designing and structure-based drug designing modeling strategies for designing potential and target specific or selective MMPIs. This book will benefit those who are looking for an in-depth text on the design and discovery processes of novel and selective MMPIs. Features Describes modeling strategies applied to MMPs Elaborates on the designing strategies of MMPs specifically Includes in-depth analyses of related case studies Acts as a guide for medicinal chemists, not only from pharmaceutical industries, but also from academia Covers various modern molecular modeling methodologies, particularly related to MMPIs

Author : Anonim
Publisher : Academic Press
Page : 147 pages
File Size : 44,9 Mb
Release : 2015-01-23
Category : Science
ISBN : 9780128029138

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Molecular Basis of Olfaction by Anonim Pdf

The scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths. Comprehensive coverage of molecular processes in olfaction of vertebrates and insects Focus on the emerging field of insect olfaction Contributions by leading research groups in their fields, from a range of countries Discusses fundamental knowledge and also key applications being addressed by the research

Author : Marta Wayne,Benjamin Bolker
Publisher : OUP Oxford
Page : 144 pages
File Size : 46,6 Mb
Release : 2015-06-25
Category : Medical
ISBN : 9780191002823

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Infectious Disease: A Very Short Introduction by Marta Wayne,Benjamin Bolker Pdf

As doctors and biologists have learned, to their dismay, infectious disease is a moving target: new diseases emerge every year, old diseases evolve into new forms, and ecological and socioeconomic upheavals change the transmission pathways by which disease spread. By taking an approach focused on the general evolutionary and ecological dynamics of disease, this Very Short Introduction provides a general conceptual framework for thinking about disease. Ecology and evolution provide the keys to answering the 'where', 'why', 'how', and 'what' questions about any particular infectious disease: where did it come from? How is it transmitted from one person to another, and why are some individuals more susceptible than others? What biochemical, ecological, and evolutionary strategies can be used to combat the disease? Is it more effective to block transmission at the population level, or to block infection at the individual level? Through a series of case studies, Benjamin Bolker and Marta L. Wayne introduce the major ideas of infectious disease in a clear and thoughtful way, emphasising the general principles of infection, the management of outbreaks, and the evolutionary and ecological approaches that are now central to much research about infectious disease. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Author : Anonim
Publisher : Unknown
Page : 1416 pages
File Size : 53,9 Mb
Release : 2024-07-02
Category : Medicine
ISBN : STANFORD:36105119623747

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Research Awards Index by Anonim Pdf

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 1414 pages
File Size : 47,9 Mb
Release : 1970
Category : Medicine
ISBN : IND:30000090423793

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Research Grants Index by National Institutes of Health (U.S.). Division of Research Grants Pdf

Author : Informa Healthcare
Publisher : Unknown
Page : 696 pages
File Size : 43,5 Mb
Release : 1995
Category : Medical
ISBN : 1860670172

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Medical Research Centres by Informa Healthcare Pdf

Focuses on research and development centers in the areas of medical and biomedical sciences including those in anatomy, biochemistry, clinical medicine, dentistry, drugs, genetics, immunology, neoplasms, pharmaceutical technology, and surgery.

Author : World Health Organization
Publisher : World Health Organization
Page : 211 pages
File Size : 50,7 Mb
Release : 2015-08-05
Category : Medical
ISBN : 9789241564861

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Investing to Overcome the Global Impact of Neglected Tropical Diseases by World Health Organization Pdf

"The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.

Author : Vito Colella
Publisher : Mdpi AG
Page : 296 pages
File Size : 45,6 Mb
Release : 2021-12-20
Category : Science
ISBN : 3036526250

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Translational Research for Zoonotic Parasites by Vito Colella Pdf

In this book is reported novel information on diagnosis, treatment, and control of parasites that are naturally transmitted from animal reservoirs to humans. Subjects: Public Health and Healthcare: Prevention; Medicine and Pharmacology: Therapy.

Author : Anonim
Publisher : Unknown
Page : 230 pages
File Size : 49,5 Mb
Release : 1985
Category : Diptera
ISBN : PSU:000014579448

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Biological Control of Mosquitoes by Anonim Pdf

Author : Emily Ying Yang Chan ,Holly Ching Yu Lam
Publisher : MDPI
Page : 294 pages
File Size : 45,9 Mb
Release : 2020-12-29
Category : Medical
ISBN : 9783039363148

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Health-Related Emergency Disaster Risk Management (Health-EDRM) by Emily Ying Yang Chan ,Holly Ching Yu Lam Pdf

Disasters such as earthquakes, cyclones, floods, heat waves, nuclear accidents, and large scale pollution incidents take lives and cause exceptionally large health problems. The majority of large-scale disasters affect the most vulnerable populations, which are often comprised of people of extreme ages, in remote living areas, with endemic poverty, and with low literacy. Health-related emergency disaster risk management (Health-EDRM) [1] refers to the systematic analysis and management of health risks surrounding emergencies and disasters; it plays an important role in reducing hazards and vulnerability along with extending preparedness, response, and recovery measures. This concept encompasses risk analyses and interventions, such as accessible early warning systems, timely deployment of relief workers, and the provision of suitable drugs and medical equipment, to decrease the impact of disaster on people before, during, and after disaster events. Disaster risk profiling and interventions can be at the personal/household, community, and system/political levels; they can be targeted at specific health risks including respiratory issues caused by indoor burning, re-emergence of infectious disease due to low vaccination coverage, and gastrointestinal problems resulting from unregulated waste management. Unfortunately, there has been a major gap in the scientific literature regarding Health-EDRM. The aim of this Special Issue of IJERPH was to present papers describing/reporting the latest disaster and health risk analyses, as well as interventions for health-related disaster risk management, in an effort to address this gap and facilitate major global policies and initiatives for disaster risk reduction.

Author : Branislav Ranković
Publisher : Springer
Page : 260 pages
File Size : 47,5 Mb
Release : 2019-07-26
Category : Science
ISBN : 9783030168148

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Lichen Secondary Metabolites by Branislav Ranković Pdf

This revised and extended edition provides in-depth insights into the benefits and untapped potential of lichen-derived bioactive compounds. The whole spectrum of these compounds’ biological and medical functions, from antibiotic to antiviral and anti-carcinogenic properties, is presented. In addition, a new chapter discusses the anti-neurodegenerative and anti-diabetic activities of lichenic secondary metabolites. Given its scope, the book offers a valuable asset for students and researchers in this field.