Concomitant Continuous Infusion Chemotherapy And Radiation

Author : Marvin Rotman,C. Julian Rosenthal
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642841866

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Concomitant Continuous Infusion Chemotherapy and Radiation by Marvin Rotman,C. Julian Rosenthal Pdf

The administration of chemotherapeutic agents by continuous infusion with concomitant radiation therapy heralds a new approach in the treatment of cancer. This comprehensive book on the subject includes, besides a discussion of its scientific basis, the most promising clinical data on the use of continuous infusion chemotherapy and radiation. Thus, it is an important update for clinical investigators involved in frontline research as well as for practicing physicians participating in the direct care of cancer patients. The contributions include the latest results of this new approach in a number of tumor sites. There is a detailed description of the principles of radiosensitization for malignant tumors and radioprotection for normal tissues; these are the principles which have led to concrete clinical applications. There is also a presentation of the most recent data on the beneficial effects resulting from the administration of commonly used drugs, such as 5-fluorouracil, cisplatinum and adriamycin, with concomitant radiation therapy. Much of the data has never before been published. The wealth of information in this volume makes it a valuable reference; at the same time it gives practicing physicians a detailed presentation of various therapeutic regimens which they could administer in their daily clinical practice. In the future, this innovative cancer treatment may lead to the decreased need for radical surgery and the increased ability to preserve organ function.

Author : C. Julian Rosenthal,Marvin Rotman
Publisher : Springer Science & Business Media
Page : 241 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461321972

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Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy by C. Julian Rosenthal,Marvin Rotman Pdf

The first conference on concomitant infusion chemotherapy and radia tion therapy was organized with the intention of bringing together some of the investigators who have tested, during the last few years, the hypo thesis that continuous infusion chemotherapy could modulate the cytotoxic effect of radiation therapy to the point of having a strongly additive, if not synergistic activity on certain malignant tumors. This volume represents the detailed proceedings of this conference presented in a way that offers the reader a review of the on-going re search in the field. We have stressed a number of subjects from basic biologic research and influence of cell kinetics to the practical methods of drug delivery systems and early clinical experiences. The rationale for this new type of combined modality therapy has been presented by some of its pioneers. Early clinical investigations as well as the preliminary data of many that have not yet completely matured have also been included. The reader should look at these data with some reser vations. Ultimately, these results must be confirmed by larger prospective randomized studies with proper controls before becoming accepted as the treatment of choice in locally advanced tumors.

Author : Gian Gaetano Delaini
Publisher : Springer Science & Business Media
Page : 250 pages
File Size : 50,5 Mb
Release : 2006-01-26
Category : Medical
ISBN : 9788847003439

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Rectal Cancer by Gian Gaetano Delaini Pdf

Despite lifestyle improvements, the incidence of rectal cancer is increasing in industrialised countries. Rapid advances in technology, growing knowledge of the biological history of the disease and closer attention to patients' quality of life after surgery have led to a less invasive approach. In the last 15 years, the surgical approach has shifted from extended resection to sphincter-saving procedures, featuring a multidisciplinary approach and a high level of specialisation. The experienced surgeon can plan and choose the "right treatment for the right patient" only with the support of the radiologist, endoscopist and pathologist (preoperative staging), oncologist and radiotherapist (neoadjuvant therapy), and psychologist and stomatherapist (rehabilitation). In addition, the difficult problems of salvage procedure and the reconstruction of anal sphincter after abdominal resection are explored. The aim of this book is to clarify the rapid advances and to offer guidelines for doctors dealing with rectal cancer. Taking into account indications, contraindications, risks, benefits and controversies, the authors offer clear and practice-oriented answers for a wide range of specialists and experts, as well as those new to the field.

Author : Jürgen Dunst,Rolf Sauer
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 55,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642467943

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Late Sequelae in Oncology by Jürgen Dunst,Rolf Sauer Pdf

Increasing survival figures and the use of more intense combined treatment regimens in modern oncology have raised the problem of late therapeutic sequelae in long-term survivors after cancer. Recent scientific approaches to late sequelae concentrate on the evaluation of subclinical changes with sophisticated functional measurements and experimental investigation of the underlying pathophysiological mechanisms. The objective of the book is to bring together these recent clinical and experimental data from different medical disciplines to give an overview of the most relevant problems of late sequelae. In clinical practice the book may help regarding estimation of risks, selection of diagnostic methods, and estimation of the prognosis of late sequelae.

Author : Daniel Mathieu
Publisher : Springer Science & Business Media
Page : 797 pages
File Size : 42,5 Mb
Release : 2006-08-18
Category : Medical
ISBN : 9781402044489

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Handbook on Hyperbaric Medicine by Daniel Mathieu Pdf

The decade since the first Handbook on Hyperbaric Medicine has seen major advances: studies have clarified the actions of hyperbaric oxygenation; clinical practice is becoming more scientific; various organisational and operational guidelines are now widely accepted. This new Handbook arises from the EU Co-operation in Science and Technology (COST) programme for hyperbaric medicine, COST B14, in combination with the results of a number of recent experimental and clinical studies.

Author : Anonim
Publisher : Unknown
Page : 1850 pages
File Size : 42,9 Mb
Release : 1997
Category : Medicine
ISBN : OSU:32436010520292

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Cumulated Index Medicus by Anonim Pdf

Author : R.K. Oldham
Publisher : Springer Science & Business Media
Page : 512 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400900295

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Principles of Cancer Biotherapy by R.K. Oldham Pdf

At the time of the first edition of Principles of Cancer Biotherapy, this book represented the first comprehensive textbook on biological therapy. Whereas in 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches, it is now generally agreed that biopharmaceuticals are producing major opportunities for new cancer therapies. Cancer biotherapy has truly matured into the fourth modality of cancer treatment. The third edition is now needed as a result of the tremendous progress that has been made in recent years using biologicals in cancer treatment. The book summarizes an evolving science and a rapidly changing medical practice. As we near the millennium, it now becomes possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for patients. Some forms of cancer biotherapy use the strategy of tumour stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this third edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients, for researchers and clinicians to explore and apply these new opportunities in cancer biotherapy.

Author : P. Banzet,J.F. Holland,D. Khayat,M. Weil
Publisher : Springer Science & Business Media
Page : 905 pages
File Size : 41,6 Mb
Release : 2013-12-14
Category : Medical
ISBN : 9782817807652

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Cancer Treatment An Update by P. Banzet,J.F. Holland,D. Khayat,M. Weil Pdf

This book gathers the educational lectures and the texts of the main presenta tions given at the 4th International Congress on Anticancer Chemotherapy which took place in February 1993 in Paris and was attended by 5 000 oncologists from all continents, physicians, students and nurses. This book aspires to give update of the most scientific and clinical aspects of modern oncology. It aims also at showing the prospects that are opened by the rapid progress of cancer biology. The editors are grateful to the authors whose scholarship de fines the quality of the book. Educational lectures The pathogenesis of human cancer metastasis I] Fidler Cancer is a collection of malignancies with each cancer of each organ consist ing of numerous subsets. This biologic and clinical heterogeneity is probably due to the different etiologies, origins, and selection pressures. Despite this heterogeneity, all malignant neoplasms have a uniform characteristic : the ability to invade host tissues and produce metastases. Clinical observations of cancer patients and studies with experimental rodent tumors have revealed that cer tain tumors produce metastasis to specific organs independent of vascular anat omy, rate of blood flow, and number of tumor cells delivered to each organ. The distribution and fate of hematogeneously disseminated, radiolabelled tumor cells in experimental rodent systems amply demonstrate that tumor cells reach the microvasculature of many organs.

Author : M.Heinrich Seegenschmiedt,Peter Fessenden,Clare C. Vernon
Publisher : Springer Science & Business Media
Page : 415 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642609381

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Thermoradiotherapy and Thermochemotherapy by M.Heinrich Seegenschmiedt,Peter Fessenden,Clare C. Vernon Pdf

Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy of ionizing radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Triple modality (thermo-chemo-radiotherapy) or other treatment combinations have not been fully evaluated and may demonstrate extended clinical applications in the future. Problems remain with regard to maximizing the effects of hyperthermia as they are influenced by a variety of external and intrinsic factors including bloodflow, microenvironment etc. While the previous volume has summarized more theoretical aspects of hyper thermia, i.e. biology, physiology and physics, the present volume compiles the current knowledge relative to the clinical applications of hyperthermia in combina tion with radiation therapy and/or chemotherapy, providing a comprehensive over view of its use in cancer management.

Author : Carsten Nieder
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 41,6 Mb
Release : 2003
Category : Medical
ISBN : 3540422315

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Modification of Radiation Response by Carsten Nieder Pdf

This book describes and summarizes the radiation responses of both normal and neoplastic tissues with a focus on rational strategies for the modification of these responses. Emerging data from molecular oncology and radiobiology are reviewed in depth. The book covers not only general principles of radiation-induced reactions but also a large number of preclinical and clinical data that will guide the reader through this complex and dynamic field and will provide valuable information for the development of further research projects.

Author : Stanley E. Order,Sarah S. Donaldson
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 43,6 Mb
Release : 2003-04-09
Category : Medical
ISBN : 3540005757

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Radiation Therapy of Benign Diseases by Stanley E. Order,Sarah S. Donaldson Pdf

This expanded and updated second edition is a practical text to aid radiation oncologists in evaluating and treating benign diseases. An introductory chapter by an eminent malpractice lawyer clarifies the medical-legal implications of the radiation treatment of such diseases, and this is followed by the various benign conditions in alphabetical order. In each case, a brief summary is followed by citations of pertinent literature in both explanatory tables and reference lists. Although a comprehensive review, it remains readily comprehensible and will be recognised as the standard text on the subject.

Author : R.G. Parker,N.A. Janjan,M.T. Selch
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 53,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662052259

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Radiation Oncology for Cure and Palliation by R.G. Parker,N.A. Janjan,M.T. Selch Pdf

Given that treatment with curative intent is possible in only one-half of cancer victims, and that such treatment frequently fails, the majority of patients with cancer will require relief of symptoms and signs caused by their disease. In this book, the specific contribution of radiation therapy to palliation is considered within the context of multidisciplinary management. Individual chapters are devoted to palliative radiation therapy for primary tumours and metastases at different sites. The management of pain is discussed, and chapters are also devoted to end of life care, the management of complications of radiation therapy, and useful medications. This book will prove useful to radiation oncologists and medical students.

Author : Vincent Gregoire,Pierre Scalliet,Kie-Kian Ang
Publisher : Springer Science & Business Media
Page : 253 pages
File Size : 47,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662062708

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Clinical Target Volumes in Conformal and Intensity Modulated Radiation Therapy by Vincent Gregoire,Pierre Scalliet,Kie-Kian Ang Pdf

Conformal radiation therapy represents a new challenge. It offers the prospect of either increasing the radiation dose to target tissues while delivering a similar dose to organs at risk, or reducing the dose to organs at risk while maintaining the dose to target tissues. First, lymph node areas at risk are established using the available data from pathological examination. Then, based on a three-dimensional description of the anatomical regions, guidelines for the delineation of the clinical target volumes are proposed. The data presented should enable the reader to make appropriate decisions regarding the selection and delineation of the target volumes when confronted with the most frequent tumor types and sites.

Author : Paul M. Harari,Nadine P. Connor,Cai Grau
Publisher : Springer Science & Business Media
Page : 323 pages
File Size : 41,6 Mb
Release : 2009-06-12
Category : Medical
ISBN : 9783540732327

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Functional Preservation and Quality of Life in Head and Neck Radiotherapy by Paul M. Harari,Nadine P. Connor,Cai Grau Pdf

The emphasis on cancer management in the past was based primarily on control rates from multidisciplinary input in management. There has always been a recognition that one would like to achieve the best result with the least complication, but never has there been any major emphasis on evidence-based outcome studies, nor on functional preservation and quality of life. The authors of this book have dealt very effectively with the various tumor types in head and neck cancer with the experts in the ? eld of management. The contents range from epidemiology and treatment outcome, treatment techniques with the potential impact on the quality of life such as dysphagia, to the various options relative to high technology radiation therapy programs for mana- ment. The potential for improving form and function through surgical care as an integrated part of the program is dealt with very effectively as well as the potentials for chemotherapy and the use of targeted agents have on quality of life issues. The volume also addresses toxicity, quality of life, and techniques for prevention of adverse effects, as well as the potentials for rehabilitation and supportive care. The authors have clearly done an extraordinarily good job in addressing the mul- plicity of problems that impact upon the functional preservation and quality of life in head and neck radiation therapy. Philadelphia Luther W.

Author : Robert H. Sagerman,W. Alberti
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 52,5 Mb
Release : 2003
Category : Eye
ISBN : 3540673733

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Radiotherapy of Intraocular and Orbital Tumors by Robert H. Sagerman,W. Alberti Pdf

This second edition of Radiotherapy of Intraocular and Orbital Tumors provides up-to-date information on the diagnosis and treatment of cancers of the eye and orbit. Important chapters from the first edition have been revised and thus provide, for example, the most recent data with respect to retinoblastoma, rhabdomyosarcoma, and melanoma. In addition, there are a number of chapters by new contributors, so that this edition has a more broadly based, international character. The volume outlines the presenting signs and symptoms of the various tumors and analyzes the indications for ultrasonography, computed tomography, and magnetic resonance imaging studies. It describes in detail treatment techniques and their results with respect to survival and local tumor control, paying special attention to multimodality therapy. Particle beam irradiation and plaque therapy are reviewed, and chemotherapy and heat treatment are also discussed. Potential complications of radiotherapy are described, and relevant information is provided on the conservative and surgical management of radiation effects. The book emphasizes the need for a holistic approach to the patient that recognizes the wider role of irradiation of the eye now that more careful treatment planning is possible. This revised edition will be a valuable asset to all ophthalmologists, radiation oncologists, pediatricians, endocrinologists, oncologists, and residents in training, as well as to students in these disciplines.