Continuing Assistance To The National Institutes Of Health On Preparation Of Additional Risk Assessments For The Boston University Neidl Phase 3

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL
Publisher : National Academies Press
Page : 22 pages
File Size : 52,7 Mb
Release : 2011-01-01
Category : Science
ISBN : 9780309225472

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Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL, Phase 3 by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL Pdf

In 2003, the Boston University Medical Center (BUMC) was awarded a $128 million grant from the National Institutes of Health (NIH) to build one of two national maximum-containment laboratory facilities for pathogen research. The National Emerging Infectious Diseases Laboratories (NEIDL) are meant to support the National Institute of Allergy and Infectious Diseases' biodefense research agenda, conducting research to develop new approaches to treating, preventing, and diagnosing a variety of bacterial and viral diseases. The facility includes a biosafety level 4 (BSL-4) containment laboratory housed in a 192,000 square foot building. Although the NEIDL BSL-4 laboratory accounts for only 13 percent of the building's total space, it has been the source of virtually all of the community concern surrounding this project. The location of the facility on Albany Street in Boston's South End, which is an environmental justice community, has been controversial, and there have been numerous public meetings over the plans for the facility as well as three legal actions challenging the project. Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL, Phase 3, the fifth in a series of reports about the proposed facility, provides further technical input on the scope and design of any additional studies that may be needed to assess the risks associated with the siting and operation of the NEIDL. This report presents comments and questions on a "90 percent", or penultimate, draft of the revised risk assessment. According to the report, the "90 percent" draft of the risk assessment is a substantial improvement over past documents reviewed. Additionally, the report makes recommendations to improve the version that is ultimately prepared for public comment.

Author : Reynolds M. Salerno,Jennifer Gaudioso
Publisher : CRC Press
Page : 264 pages
File Size : 55,8 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498749749

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Laboratory Biorisk Management by Reynolds M. Salerno,Jennifer Gaudioso Pdf

Over the past two decades bioscience facilities worldwide have experienced multiple safety and security incidents, including many notable incidents at so-called "sophisticated facilities" in North America and Western Europe. This demonstrates that a system based solely on biosafety levels and security regulations may not be sufficient. Setting the stage for a substantively different approach for managing the risks of working with biological agents in laboratories, Laboratory Biorisk Management: Biosafety and Biosecurity introduces the concept of biorisk management—a new paradigm that encompasses both laboratory biosafety and biosecurity. The book also provides laboratory managers and directors with the information and technical tools needed for its implementation. The basis for this new paradigm is a three-pronged, multi-disciplinary model of assessment, mitigation, and performance (the AMP model). The application of the methodologies, criteria, and guidance outlined in the book helps to reduce the risk of laboratories becoming the sources of infectious disease outbreaks. This is a valuable resource for those seeking to embrace and implement biorisk management systems in their facilities and operations, including the biological research, clinical diagnostic, and production/manufacturing communities.

Author : Jeanne Guillemin
Publisher : Macmillan
Page : 337 pages
File Size : 54,7 Mb
Release : 2011-09-13
Category : Political Science
ISBN : 9781429973151

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American Anthrax by Jeanne Guillemin Pdf

From Jeanne Guillemin, one of the world's leading experts on anthrax and bioterrorism, the definitive account of the anthrax investigation It was the most complex case in FBI history. In what became a seven-year investigation that began shortly after 9/11—with America reeling from the terror attacks of al Qaeda—virulent anthrax spores sent through the mail killed Bob Stevens, a Florida tabloid photo editor. His death and, days later, the discovery in New York and Washington, D.C. of letters filled with anthrax sent shock waves through the nation. Federal agencies were blindsided by the attacks, which eventually killed five people. Taken off guard, the FBI struggled to combine on-the-ground criminal investigation with progress in advanced bioforensic analyses of the letters' contents. While the criminal eluded justice, disinformation swirled around the letters, erroneously linking them to Iraq's WMD threat and foreign bioterrorism. Without oversight, billions were lavished on biomedical defenses against anthrax and other exotic diseases. Worst of all, faith in federal justice faltered. American Anthrax is a gripping tale of terror, intrigue, madness, and cover-up.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Institute for Laboratory Animal Research,Board on Earth Sciences and Resources,Board on Health Sciences Policy,Committee on Strengthening the Disaster Resilience of Academic Research Communities
Publisher : National Academies Press
Page : 451 pages
File Size : 52,9 Mb
Release : 2017-10-20
Category : Social Science
ISBN : 9780309462525

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Strengthening the Disaster Resilience of the Academic Biomedical Research Community by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Institute for Laboratory Animal Research,Board on Earth Sciences and Resources,Board on Health Sciences Policy,Committee on Strengthening the Disaster Resilience of Academic Research Communities Pdf

The academic biomedical research community is a hub of employment, economic productivity, and scientific progress. Academic research institutions are drivers of economic development in their local and state economies and, by extension, the national economy. Beyond the economic input that the academic biomedical research community both receives and provides, it generates knowledge that in turn affects society in myriad ways. The United States has experienced and continues to face the threat of disasters, and, like all entities, the academic biomedical research community can be affected. Recent disasters, from hurricanes to cyber-attacks, and their consequences have shown that the investments of the federal government and of the many other entities that sponsor academic research are not uniformly secure. First and foremost, events that damage biomedical laboratories and the institutions that house them can have impacts on the safety and well-being of humans and research animals. Furthermore, disasters can affect career trajectories, scientific progress, and financial stability at the individual and institutional levels. Strengthening the Disaster Resilience of the Academic Biomedical Research Community offers recommendations and guidance to enhance the disaster resilience of the academic biomedical research community, with a special focus on the potential actions researchers, academic research institutions, and research sponsors can take to mitigate the impact of future disasters.

Author : Committee on Anticipating Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories,Board on Life Sciences,Committee on International Security and Arms Control,Division on Earth and Life Studies,Policy and Global Affairs,National Academy of Sciences,National Research Council
Publisher : National Academies Press
Page : 216 pages
File Size : 41,5 Mb
Release : 2012-03-16
Category : Political Science
ISBN : 9780309225762

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Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories by Committee on Anticipating Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories,Board on Life Sciences,Committee on International Security and Arms Control,Division on Earth and Life Studies,Policy and Global Affairs,National Academy of Sciences,National Research Council Pdf

During July 10-13, 2011, 68 participants from 32 countries gathered in Istanbul, Turkey for a workshop organized by the United States National Research Council on Anticipating Biosecurity Challenges of the Global Expansion of High-containment Biological Laboratories. The United States Department of State's Biosecurity Engagement Program sponsored the workshop, which was held in partnership with the Turkish Academy of Sciences. The international workshop examined biosafety and biosecurity issues related to the design, construction, maintenance, and operation of high-containment biological laboratories- equivalent to United States Centers for Disease Control and Prevention biological safety level 3 or 4 labs. Although these laboratories are needed to characterize highly dangerous human and animal pathogens, assist in disease surveillance, and produce vaccines, they are complex systems with inherent risks. Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories summarizes the workshop discussion, which included the following topics: Technological options to meet diagnostic, research, and other goals; Laboratory construction and commissioning; Operational maintenance to provide sustainable capabilities, safety, and security; and Measures for encouraging a culture of responsible conduct. Workshop attendees described the history and current challenges they face in their individual laboratories. Speakers recounted steps they were taking to improve safety and security, from running training programs to implementing a variety of personnel reliability measures. Many also spoke about physical security, access controls, and monitoring pathogen inventories. Workshop participants also identified tensions in the field and suggested possible areas for action.

Author : National Research Council,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology
Publisher : National Academies Press
Page : 164 pages
File Size : 41,8 Mb
Release : 2004-03-02
Category : Technology & Engineering
ISBN : 9780309089777

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Biotechnology Research in an Age of Terrorism by National Research Council,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology Pdf

In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

Author : Frank Gottron
Publisher : DIANE Publishing
Page : 33 pages
File Size : 50,7 Mb
Release : 2009-12
Category : Science
ISBN : 9781437919370

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Oversight of High-Containment Biological Laboratories by Frank Gottron Pdf

The fed. gov¿t. responded to the 9/11 terrorist attacks and the subsequent anthrax attacks with increased focus on and funding for biodefense. High-containment labs. (HCL) play a critical role in the biodefense effort, offering the hope of better responses to an attack and a better understanding of the threat posed by bioterrorism. However, they also could increase the risk of a biological attack by serving as a potential source of materials or training. Policymakers have become increasingly interested in the oversight of these facilities following reports of accidents, regulatory noncompliance, and community resistance. A key task for policymakers is to define their goals for enhancing oversight of HCL. Illustrations

Author : John Timothy Allen
Publisher : Unknown
Page : 50 pages
File Size : 41,9 Mb
Release : 1992
Category : Animal welfare
ISBN : MINN:31951D012384920

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Animal Care and Use Committees by John Timothy Allen Pdf

Author : National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on New and Emerging Models in Biomedical and Behavioral Research
Publisher : National Academies Press
Page : 85 pages
File Size : 48,8 Mb
Release : 1998-02-16
Category : Science
ISBN : 9780309060356

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Biomedical Models and Resources by National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on New and Emerging Models in Biomedical and Behavioral Research Pdf

Printbegrænsninger: Der kan printes 10 sider ad gangen og max. 40 sider pr. session.

Author : Peter Brusilovski,Alfred Kobsa,Wolfgang Nejdl
Publisher : Springer Science & Business Media
Page : 770 pages
File Size : 40,8 Mb
Release : 2007-04-24
Category : Computers
ISBN : 9783540720782

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The Adaptive Web by Peter Brusilovski,Alfred Kobsa,Wolfgang Nejdl Pdf

This state-of-the-art survey provides a systematic overview of the ideas and techniques of the adaptive Web and serves as a central source of information for researchers, practitioners, and students. The volume constitutes a comprehensive and carefully planned collection of chapters that map out the most important areas of the adaptive Web, each solicited from the experts and leaders in the field.

Author : Shabir Ahmad Ganai
Publisher : Springer Nature
Page : 266 pages
File Size : 42,7 Mb
Release : 2020-11-23
Category : Medical
ISBN : 9789811581793

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Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy by Shabir Ahmad Ganai Pdf

This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.

Author : Anonim
Publisher : Unknown
Page : 74 pages
File Size : 42,6 Mb
Release : 2001
Category : Electronic
ISBN : CORNELL:31924071754042

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EPA-100-B. by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 710 pages
File Size : 51,6 Mb
Release : 1967
Category : Refuse and refuse disposal
ISBN : UOM:39015007734091

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Solid Waste Management: Abstracts from the Literature by Anonim Pdf

Author : Cris dos Remedios,Deepak Chhabra
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 54,7 Mb
Release : 2008-01-08
Category : Science
ISBN : 9780387717494

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Actin-Binding Proteins and Disease by Cris dos Remedios,Deepak Chhabra Pdf

There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.

Author : Jerome Groopman,Pamela Hartzband
Publisher : Penguin Books
Page : 322 pages
File Size : 47,9 Mb
Release : 2012-08-28
Category : Health & Fitness
ISBN : 9780143122241

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Your Medical Mind by Jerome Groopman,Pamela Hartzband Pdf

Drs. Groopman and Hartzband reveal a clear path for making the right medical choices. Such factors as authority figures, statistics, other patients' stories, technology, and natural healing are key factors that shape choices.