Control Of Energy Metabolism

Author : Britton Chance,Ronald W. Estabrook,John R. Williamson
Publisher : Academic Press
Page : 454 pages
File Size : 47,5 Mb
Release : 2014-05-12
Category : Science
ISBN : 9781483271668

Get Book

Control of Energy Metabolism by Britton Chance,Ronald W. Estabrook,John R. Williamson Pdf

Control of Energy Metabolism: A Colloquium of the Johnson Research Foundation focuses on the processes, reactions, and approaches involved in the control of energy metabolism. The selection first offers information on the respiratory chain as a model for metabolic control in multi-enzyme systems, dynamics and control in cellular reactions, and computer-based analysis of biochemical data. The text then explores purification and properties of rabbit skeletal muscle phosphofructokinase; multiple forms of heart phosphofructokinase; and mechanisms of inhibition and activation of phosphofructokinase in Novikoff ascites tumor cells. Discussions focus on the properties of purified phosphofructokinase; effect of heart extracts on reactivation of phosphofructokinase; active and inactive forms of phosphofructokinase; and effect of hexose phosphate and adenylic nucleotides on reactivation of phosphofructokinase. The manuscript takes a look at enzyme and metabolite profiles; coordinated stimulation of hexokinase and phosphofructokinase by phosphate in a reconstituted system of glycolysis; control of hexokinase in ascites tumor glycolysis; and cation flux across the mitochondrial membrane as a possible pacemaker of tissue metabolism. The selection is a vital reference for biochemists and researchers interested in the control of energy metabolism.

Author : Britton Chance,John R. Williamson
Publisher : Unknown
Page : 128 pages
File Size : 53,9 Mb
Release : 1967
Category : Energy metabolism
ISBN : OCLC:220625550

Get Book

Control of Energy Metabolism by Britton Chance,John R. Williamson Pdf

Author : Bozzano G Luisa
Publisher : Elsevier
Page : 306 pages
File Size : 40,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323138765

Get Book

Cellular Energy Metabolism and its Regulation by Bozzano G Luisa Pdf

Cellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close analogy with human design, it emphasizes the notion that evolution is a process of functional design, and that the characteristics of an organism, whether morphological or molecular, were selected because of functional advantage to the organism's ancestors. Thus, the study of an enzyme, a reaction, or a sequence can be biologically relevant only if its position in the hierarchy of function is kept in mind. This book deals with some aspects of metabolism from that point of view. The key concepts discussed include the conservation of solvent capacity and energy; functional stoichiometric coupling and metabolic prices; adenylate control and the adenylate energy charge; aspects of enzyme behavior that appear to be related to metabolic control; interactions between metabolic sequences; and the adenylate energy charge in intact cells. This book was designed for graduate students in biochemistry, physiology, microbiology, and related fields. However, it may also be useful to senior undergraduate students and more advanced workers who have a direct or peripheral interest in energy metabolism. It assumes a general familiarity with the material covered in a standard biochemistry textbook as well as some knowledge of such related areas as genetics.

Author : Britton Chance,Ronald Winfield Estabrook,John R. Williamson
Publisher : Unknown
Page : 0 pages
File Size : 51,7 Mb
Release : 1965
Category : Energy transfer
ISBN : OCLC:477073433

Get Book

Control of Energy Metabolism by Britton Chance,Ronald Winfield Estabrook,John R. Williamson Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 52,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Gary D. Lopaschuk,Naranjan S. Dhalla
Publisher : Springer
Page : 301 pages
File Size : 54,6 Mb
Release : 2014-08-22
Category : Science
ISBN : 9781493912278

Get Book

Cardiac Energy Metabolism in Health and Disease by Gary D. Lopaschuk,Naranjan S. Dhalla Pdf

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Author : Myron Mehlman
Publisher : Elsevier
Page : 315 pages
File Size : 51,8 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323141253

Get Book

Energy Metabolism and the Regulation of Metabolic Processes in Mitochondria by Myron Mehlman Pdf

Energy Metabolism and the Regulation of Metabolic Processes in Mitochondria contains papers presented at the 1972 symposium on metabolic regulation, held at the University of Nebraska Medical School in Omaha, Nebraska. The contributors provide alternative views and ideas in some aspects of metabolic regulation directly concerned with mitochondrial function. Separating 16 papers into chapters, this book first discusses the general aspects of control of the biological energy regulation and the kinetic and thermodynamic control of mitochondrial electron transport and energy coupling. It then covers significant topics on citric acid cycle, including its replenishment and depletion; anion transport and regulation; dynamics and substrate compartmentation; and feedback control. Other chapters examine the mechanisms of gluconeogenesis, lipogenesis, redox reaction, and phosphorylation in the mitochondria. Discussions on hormonal regulation of selected enzyme system directly related to mitochondrial function are provided in the concluding chapters. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts of mitochondrial function will find this book of great value.

Author : Wolfgang Meyerhof,Ulrike Beisiegel,Hans-Georg Joost
Publisher : Springer Science & Business Media
Page : 205 pages
File Size : 44,9 Mb
Release : 2010-09-24
Category : Science
ISBN : 9783642144264

Get Book

Sensory and Metabolic Control of Energy Balance by Wolfgang Meyerhof,Ulrike Beisiegel,Hans-Georg Joost Pdf

During the last two decades, the prevalence of obesity has dramatically increased in western and westernized societies. Its devastating health consequences include hypertension, cardiovascular diseases, or diabetes and make obesity the second leading cause of unnecessary deaths in the USA. As a consequence, obesity has a strong negative impact on the public health care systems. Recently emerging scienti?c insight has helped understanding obesity as a complex chronic disease with multiple causes. A multileveled gene–environment interaction appears to involve a substantial number of susceptibility genes, as well as associations with low physical activity levels and intake of high-calorie, low-cost, foods. Unfor- nately, therapeutic options to prevent or cure this disease are extremely limited, posing an extraordinary challenge for today’s biomedical research community. Obesity results from imbalanced energy metabolism leading to lipid storage. Only detailed understanding of the multiple molecular underpinnings of energy metabolism can provide the basis for future therapeutic options. Numerous aspects of obesity are currently studied, including the essential role of neural and endocrine control circuits, adaptive responses of catabolic and anabolic pathways, metabolic fuel sensors, regulation of appetite and satiation, sensory information processing, transcriptional control of metabolic processes, and the endocrine role of adipose tissue. These studies are predominantly fuelled by basic research on mammalian models or clinical studies, but these ?ndings were paralleled by important insights, which have emerged from studying invertebrate models.

Author : Qi Wu,Ruimao Zheng
Publisher : Springer
Page : 233 pages
File Size : 52,7 Mb
Release : 2018-11-02
Category : Medical
ISBN : 9789811312861

Get Book

Neural Regulation of Metabolism by Qi Wu,Ruimao Zheng Pdf

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.

Author : Bruce Spiegelman
Publisher : Springer
Page : 108 pages
File Size : 55,6 Mb
Release : 2018-03-07
Category : Science
ISBN : 9783319727905

Get Book

Hormones, Metabolism and the Benefits of Exercise by Bruce Spiegelman Pdf

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

Author : Kenneth B. Storey
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 42,5 Mb
Release : 2005-02-25
Category : Science
ISBN : 9780471675570

Get Book

Functional Metabolism by Kenneth B. Storey Pdf

Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics. This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields.

Author : Wolfgang Meyerhof,Ulrike Beisiegel,Hans-Georg Joost
Publisher : Springer
Page : 208 pages
File Size : 42,5 Mb
Release : 2010-11-05
Category : Science
ISBN : 3642144276

Get Book

Sensory and Metabolic Control of Energy Balance by Wolfgang Meyerhof,Ulrike Beisiegel,Hans-Georg Joost Pdf

During the last two decades, the prevalence of obesity has dramatically increased in western and westernized societies. Its devastating health consequences include hypertension, cardiovascular diseases, or diabetes and make obesity the second leading cause of unnecessary deaths in the USA. As a consequence, obesity has a strong negative impact on the public health care systems. Recently emerging scienti?c insight has helped understanding obesity as a complex chronic disease with multiple causes. A multileveled gene–environment interaction appears to involve a substantial number of susceptibility genes, as well as associations with low physical activity levels and intake of high-calorie, low-cost, foods. Unfor- nately, therapeutic options to prevent or cure this disease are extremely limited, posing an extraordinary challenge for today’s biomedical research community. Obesity results from imbalanced energy metabolism leading to lipid storage. Only detailed understanding of the multiple molecular underpinnings of energy metabolism can provide the basis for future therapeutic options. Numerous aspects of obesity are currently studied, including the essential role of neural and endocrine control circuits, adaptive responses of catabolic and anabolic pathways, metabolic fuel sensors, regulation of appetite and satiation, sensory information processing, transcriptional control of metabolic processes, and the endocrine role of adipose tissue. These studies are predominantly fuelled by basic research on mammalian models or clinical studies, but these ?ndings were paralleled by important insights, which have emerged from studying invertebrate models.

Author : J. Speakman
Publisher : Springer Science & Business Media
Page : 420 pages
File Size : 54,6 Mb
Release : 1997-09-30
Category : Science
ISBN : 0412637804

Get Book

Doubly Labelled Water by J. Speakman Pdf

Divided into three parts, Doubly Labelled Water presents a clear and accessible account of this technique. Part One presents a general introduction to the study of animal energetics: Part Two discusses the theory behind use of doubled labellled water and Part Three evaluates the practical aspects of its use and the methodlologies required for its application.

Author : Gordon L. Atkins
Publisher : Butterworth-Heinemann
Page : 105 pages
File Size : 50,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483182919

Get Book

An Outline of Energy Metabolism in Man by Gordon L. Atkins Pdf

An Outline of Energy Metabolism in Man provides an overview of the whole energy metabolic process among humans. The book is comprised of seven chapters that are organized according to the lecture series conducted by the author. The text first covers the basic principles of metabolism, and then proceeds to covering catabolism and resynthesis of simple units. Next, the book tackles the storage forms and control mechanisms. The remaining chapters detail the integration of pathways within cells and the metabolism of the body as a whole. The text will be of great use to students of biochemistry and other related fields, such as nutrition and nursing.

Author : William F. Martin,Aloysius G. M. Tielens,Marek Mentel
Publisher : Walter de Gruyter GmbH & Co KG
Page : 269 pages
File Size : 42,8 Mb
Release : 2020-12-07
Category : Science
ISBN : 9783110612417

Get Book

Mitochondria and Anaerobic Energy Metabolism in Eukaryotes by William F. Martin,Aloysius G. M. Tielens,Marek Mentel Pdf

Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.