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Corneal Collagen Cross Linking by Mazen M. Sinjab,Arthur B. Cummings Pdf
This book provides comprehensive coverage of corneal collagen cross-linking (CXL), a major management modality for keratoconus and ectatic corneal disorders. All aspects are covered, including refractive and non-refractive surgery indications, models of application, safety, efficacy, performance, outcome measures, evidence of CXL, complications, contraindications, use in children, and controversies. The discussion reflects the considerable progress that has been made in understanding of the modality since its development in the late 1990s. Detailed attention is paid to new concepts, changing surgical techniques and indications, the latest evidence-based science and research, and the future of CXL. Guidance is also provided on the use of CXL in combination with other modalities, such as LASIK, PRK, intracorneal ring implantation and others. The text is accompanied by numerous high-quality color illustrations. Corneal Collagen Cross Linking will provide the reader with a sound grasp of the technique and its use and will hopefully also serve as a stimulus to further research and advances.
Corneal Collagen Cross Linking by Farhad Hafezi,James Bradley Randleman Pdf
The first of its kind, this comprehensive book, Corneal Collagen Cross-Linking, brings together cross-linking theory, treatment, outcomes, complications and their management. Corneal Collagen Cross-Linking provides a concise yet comprehensive summary of the cross-linking (CXL) process, including the basic science foundations, treatment protocols and outcomes, recognition and management of potential complications, and modifications of the standard protocol for special circumstances. Inside the pages of Corneal Collagen Cross-Linking, Dr. Farhad Hafezi and Dr. J. Bradley Randleman include the latest available information on CXL and additional clinical applications, including CXL for infectious keratitis and corneal edema, CXL combined with other treatments for improved refractive outcomes in patients with keratoconus and ectasia after LASIK, and CXL in the pediatric population. Corneal Collagen Cross-Linking is a perfect resource for a wide range of clinicians and researchers, including general ophthalmologists, refractive surgeons, corneal specialists, pediatric ophthalmologists, and optometrists.
Corneal Collagen Cross-linking and Femtosecond Laser in Refractive and Cataract Surgery by Hui Sun Pdf
The cornea serves as the gateway into the eye for external images. Maintenance of corneal shapes and transparency is critical for refraction. Small changes in the smoothness of the corneal surface or in the total thickness of the cornea can lead to visual distortion. Recently, however, refractive surgery for the transparent cornea has been introduced. In this procedure, the curvature of the cornea is modified either by cutting the stroma or by laser ablation of normal corneal tissue. Given the clinical efficacy of refractive surgery, it is important to understand the anatomical and physiological structure of the cornea such as corneal collagen cross-linking. Multiple commercial femtosecond lasers have been cleared for use by the US Food and Drug Administration for ophthalmic surgery, including use in creating corneal flaps in LASIK surgery. The newest application of femtosecond lasers in ophthalmology is in cataract surgery. In LASIK surgery, all surgery procedures are done in cornea. In cataract surgery, the cornea is also cut with a femtosecond laser. Over the last decade, the field of femtosecond eye surgery has expanded rapidly, supporting the advantages of combined high-ablation precision and minimized collateral tissue effects. One of the most promising applications for femtosecond laser eye surgery has been corneal surgery, namely laser in situ keratomileusis (LASIK) surgery, where the high-pressure laser plasma non-thermally dissociates the dense corneal tissue, thereby enabling lamellar cornea procedures with minimized side effects with the subsequent excimer laser shaping the corneal surface. Millions of people worldwide have been patients for LASIK surgery and have benefited from new forms of technology. LASIK surgery includes three parts: wavefront detection, femtosecond laser flap creation, and excimer laser cornea correction. Some parts of this book focus on femtosecond laser-assisted LASIK surgery, including basic research for femtosecond laser eye surgery and tissue imaging. The newest application of femtosecond lasers in ophthalmology is cataract surgery. Currently, there are a few lasers at or near the point of commercial release, including LenSx (Alcon Laboratories Inc., Fort Worth, Texas), Catalys (Abbott Medical Optics, Santa Ana, California), LensAR (LensAR Inc., Orlando, Florida), Victus (Technolas Perfect Vision and Bausch & Lomb, Rochester, New York), and Femto LDV (Ziemer Ophthalmic Systems AG, Port, Switzerland). All laser systems share a common platformwhich includes an anterior-segment imaging system, patient interface, and femtosecond laser to imageto calculate and deliver the laser pulses. Some parts of this book explain the principle of OCT-guided femtosecond laser cataract surgery. The combination of femtosecond laser surgery and OCT imaging simultaneously guides the development of next generation femtosecond surgical lasers in cataract surgery and explores femtosecond laser surgical strategies.
Controversies in the Management of Keratoconus by Adel Barbara Pdf
This book presents new technologies which are available now for the rehabilitation of visual acuity in patients suffering from keratoconusand for arresting the progression of this frustrating disease. All these current treatment options in differing combinations aim to improve the quality of life of the patients and although successful, they are causing confusion for the ophthalmologists; what procedure to do and when? How to perform? Which combination of treatments to choose? Controversies in the Management of Keratoconusprovidesthe widely used treatment options for keratoconus including collagen corneal cross –linking (CXL) covering all the available techniques, intrastromal corneal ring segments (ICRS) , phakic intra-ocular lenses (IOLs), photorefractive keratectomy (PRK) combined or not with CXL penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty ( DALK). Each treatment is addressed by more than one author with different points of view in order to present the various approaches, the logic behind them and the most relevant clinical data available.A chapter by the editor tries to put some light on how to navigate among these controversies. This book will be of interest to trainees as well as the specialized ophthalmologists.
Corneal Collagen Cross-linking and Femtosecond Laser in Refractive and Cataract Surgery by Hui Sun Pdf
The cornea serves as the gateway into the eye for external images. Maintenance of corneal shapes and transparency is critical for refraction. Small changes in the smoothness of the corneal surface or in the total thickness of the cornea can lead to visual distortion. Recently, however, refractive surgery for the transparent cornea has been introduced. In this procedure, the curvature of the cornea is modified either by cutting the stroma or by laser ablation of normal corneal tissue. Given the clinical efficacy of refractive surgery, it is important to understand the anatomical and physiological structure of the cornea such as corneal collagen cross-linking. Multiple commercial femtosecond lasers have been cleared for use by the US Food and Drug Administration for ophthalmic surgery, including use in creating corneal flaps in LASIK surgery. The newest application of femtosecond lasers in ophthalmology is in cataract surgery. In LASIK surgery, all surgery procedures are done in cornea. In cataract surgery, the cornea is also cut with a femtosecond laser. Over the last decade, the field of femtosecond eye surgery has expanded rapidly, supporting the advantages of combined high-ablation precision and minimized collateral tissue effects. One of the most promising applications for femtosecond laser eye surgery has been corneal surgery, namely laser in situ keratomileusis (LASIK) surgery, where the high-pressure laser plasma non-thermally dissociates the dense corneal tissue, thereby enabling lamellar cornea procedures with minimized side effects with the subsequent excimer laser shaping the corneal surface. Millions of people worldwide have been patients for LASIK surgery and have benefited from new forms of technology. LASIK surgery includes three parts: wavefront detection, femtosecond laser flap creation, and excimer laser cornea correction. Some parts of this book focus on femtosecond laser-assisted LASIK surgery, including basic research for femtosecond laser eye surgery and tissue imaging. The newest application of femtosecond lasers in ophthalmology is cataract surgery. Currently, there are a few lasers at or near the point of commercial release, including LenSx (Alcon Laboratories Inc., Fort Worth, Texas), Catalys (Abbott Medical Optics, Santa Ana, California), LensAR (LensAR Inc., Orlando, Florida), Victus (Technolas Perfect Vision and Bausch & Lomb, Rochester, New York), and Femto LDV (Ziemer Ophthalmic Systems AG, Port, Switzerland). All laser systems share a common platformwhich includes an anterior-segment imaging system, patient interface, and femtosecond laser to imageto calculate and deliver the laser pulses. Some parts of this book explain the principle of OCT-guided femtosecond laser cataract surgery. The combination of femtosecond laser surgery and OCT imaging simultaneously guides the development of next generation femtosecond surgical lasers in cataract surgery and explores femtosecond laser surgical strategies.
This book provides a practical guide to the most recent advances in the diagnostic management of corneal ectasia. Clear, concise chapters address new standardized nomograms of treatment of early progressive ectasia, new epithelium on future crosslinking with and without oxygen supplement, customized protocols, laser assisted corneal regularization protocols and the new femtolaser assisted lamellar corneal transplant. Clinicians and surgeons seeking a go-to guide on the topic of corneal ectasia will find this book to be an essential resource for the latest developments and predicted future trends in the field.
Management of Early Progressive Corneal Ectasia by Cosimo Mazzotta,Frederik Raiskup,Stefano Baiocchi,Giuliano Scarcelli,Marc D. Friedman,Claudio Traversi Pdf
This book provides a rapid overview of crosslinking protocols and the therapeutic guidelines to optimize the application according to patients age and ectasia staging. This book is unique in the field of crosslinking therapy, as it gives the readers a complete guide for their daily practice to understand the modern accelerated crosslinking protocols, indications and customized treatment strategies. Ophthalmic specialists, opticians, optometrists and doctors working in ophthalmic settings, will find this book to be a ‘go-to’ guide for furthering clinical knowledge of this specialized treatment for early progressive corneal ectasia.
Corneal Cross-Linking by Farhad Hafezi,J. Bradley Randleman Pdf
Corneal Cross-Linking, Second Edition represents an innovative approach to treating primary acquired and secondary induced ectatic disorders. In addition, corneal cross-linking (CXL) has promising applications as an alternative in the treatment of corneal infectious and non-infectious melting, as well as conditions such as Fuchs’ endothelial dystrophy. The new and expanded Second Edition of Corneal Cross-Linking by Drs. Farhad Hafezi and J. Bradley Randleman will provide a concise yet comprehensive summary of the CXL process, including the basic science foundations, treatment protocols and outcomes, recognition and management of potential complications, and modification of standard protocol for special circumstances. Given all the changes in this rapidly progressing field, many brief topics from the first edition have now grown into full chapters or sections. These include expanded sections on alternative treatment protocols, corneal imaging and biomechanics, combing cross-linking with other refractive treatments, and a section devoted specifically to the most highly debated controversies in the field today. With each chapter being fully updated plus including over twenty new chapters that covers the latest advances and future directions, Corneal Cross-Linking, Second Edition represents the cutting-edge of CXL research and clinical practice. “Since the publication of the first edition of this book in 2013, our knowledge of corneal cross-linking has again significantly increased, both scientifically and clinically. Today, concise recommendations (guidelines for cross-linking) help the clinician to select the patients, make decisions, and provide optimal treatment” -Eberhard Spoerl, PhD and Theo Seiler, MD, PhD
While lecturing in recent months at a number of prominent institutions, I asked some of the residents and fellows whether and how they might benefit from a book on corneal biomechanics. The typical response was the look of a deer caught in the headlights as they tried to intuit the “appropriate” answer, but had little understanding or insight as to why this would be an important and useful knowledge base for them now, or in the future. I then posed the question differently. “Would a book that explained corneal biomechanical principles and testing devices and their application in detecting eyes at risk for developing keratoconus and post-LASIK ectasia, understanding the biomechanical impact of specific types of keratorefractive surgery and riboflavin UV-A corneal collagen cross-linking, and the impact of corneal biomechanics on the fidelity of intraocular pressure measurement and risk for glaucoma progression be of interest?” Framed in this context, the answer I got was a resounding, “Yes!” Therein lies a fundamental disconnect that highlights both the opportunity and need to educate all ophthalmologists about this nascent field. This comprehensive book is strengthened by the breadth of contributions from leading experts around the world and provides an important resource for ophthalmologists at all levels of training and experience. It gives a panoramic snapshot of our understanding of corneal biomechanics today, bridging the gap between theoretical principles, testing devices that are commercially available and in development as well as current and potential future clinical applications. While there has been a long-held appreciation that all types of keratorefractive surgery have an impact and interdependence on corneal biomechanics and wound healing, the initial finite element analyses that were applied to understand radial keratotomy were limited by incorrect assumptions that the cornea was a linear, elastic, homogenous, isotropic material.1 With the advent of excimer laser vision correction, critical observations indicated that Munnerlyn’s theoretic ablation profiles did not account for either lower or higher order (e.g. spherical aberration) refractive outcomes,2 suggesting that there were important components missing from the equation—e.g., corneal biomechanics and wound healing. In a seminal editorial, Roberts3 pointed out that the cornea is not a piece of plastic, but rather a material with viscoelastic qualities. Since that time, much has been learned about spatial and depth- related patterns of collagen orientation and interweaving, as well as the biomechanical response to different keratorefractive surgeries that sever tension-bearing lamellae, as the cornea responds to and redistributes stress induced by IOP, hydration, eye rubbing, blinking and extraocular muscle forces.3-6 The first reports of post-LASIK ectasia7 highlighted the need to identify a biomechanical signature of early keratoconus as well as corneas at high risk of developing ectasia irrespective of their current topography or tomography. The introduction of two instruments into clinical use—the Ocular Response Analyzer (ORA) and the Corneal Visualization Scheimpflug Technology (Corvis ST)—that allow measurement of various biomechanical metrics further catapulted the field. The availability of these instruments in routine clinical settings allowed the systematic study of the effect of age, collagen disorders, collagen cross-linking, corneal rings, flaps of various depths, contour, sidecut angulation, pockets, and flockets, just to name of few. Future application of biomechanics to the sclera may improve our understanding of the development and prevention of myopia, as well as scleral surgeries and treatments under development for presbyopia. It was appreciated by Goldmann and Schmidt that corneal thickness and curvature would influence the measurement of applanation tonometry. The recent ability to measure some corneal biomechanical metrics have led to IOP measurement that may be more immune both to their influence and the impact of central corneal thickness (CCT). Certain chapters in this book explain how a thin cornea could be stiffer than a thick one and that stiffness is also impacted by IOP, thereby precluding simplistic attempts to adjust IOP measurements using nomograms based upon CCT alone. Also highlighted is how corneal hysteresis, the ability of the cornea to absorb and dissipate energy during the bidirectional applanation response to a linear Gaussian air puff, appears to be an independent risk factor for glaucoma progression and rate of progression.9,10 This comprehensive book starts out with a section devoted to outlining basic biomechanical principles and theories, teaching us the language of what Dupps11 has referred to as “mechanospeak”, thus providing a context and common vocabulary to better comprehend the following chapters. By first defining basic concepts such as stress-strain relationships and creep, this theoretical basis is later applied to explain the pathogenesis of corneal diseases, e.g., explaining how a focal abnormality in corneal biomechanical properties precipitates a cycle of decompensation and localized thinning and steepening, clinically expressed as ectasia progression. These early chapters further detail biomechanical differences between in-vivo and ex-vivo testing, between human and animal corneas and sclera, and between methods of testing. The second section provides a thorough description of two FDA-approved devices to measure corneal biomechanics in the clinic (i.e., the ORA and the Corvis ST), as well as an overview of potential future technologies, including OCT with air puff stimulus, ocular pulse elastography, and Brilloiun microscopy. The third and final section of the book is a thorough treatise on how to interpret the metrics derived from the waveform provided by available clinical devices; their adjunct use in ectasia risk screening; the comparative biomechanical impact of various keratorefractive surgeries and corneal procedures such as PRK, LASIK, SMILE, and corneal collagen cross-linking; the impact of corneal biomechanics on IOP measurement; and potential biomechanical markers of enhanced susceptibility to glaucoma progression. This compendium of our current knowledge of corneal biomechanics, its measurement and application, provides a strong foundation to more fully understand advances in keratorefractive and corneal surgery, diseases, and treatments, all of which are interdependent on and influence inherent corneal biomechanical properties and behavior. Both the robust aspects and limitations of our current understanding are presented, including the challenge of creating accurate and predictive finite element models that incorporate the impact of IOP, corneal thickness, geometry, and scleral properties on corneal biomechanics. This book provides a key allowing clinical ophthalmologists and researchers to grasp the basics and nuances of this exciting field and to shape it as it evolves in the future.
A Practical Guide to Clinical Application of OCT in Ophthalmology by Michele Lanza Pdf
I am very proud and excited to introduce to you this book, which provides many interesting indications on how to better understand and handle the world of opticalcoherence tomography (OCT). Reading the chapters, you will be aware that this device is extremely important not just in the clinical practice of retinal diseases, but is also very useful as a surgical tool. Moreover, application of OCT has crossed the borders of the retina and is currently being applied to corneal diseases and glaucoma. I amconfident you will find enough useful information to improve your practice using OCT and to provide a better quality of care for your patients.
New Frontiers for the Treatment of Keratoconus by César Carriazo,María José Cosentino Pdf
This book updates the reader about the latest bio-mechanical concepts underlying keratoconus diagnosis and the various treatment alternatives: from conventional alternatives with a real cost/benefit description, to some innovative alternatives that have come to the fore in recent years. It discusses the latest software and technology utilized in keratoconus diagnosis as well as the more innovative surgical techniques used to treat keratoconus. New Frontiers for the Treatment of Keratoconus represents an essential book for ophthalmologists and specialists in cornea and refractive surgery who are looking to position themselves at the forefront of the diagnosis and treatment of keratoconus.
The ocular surface refers to the cornea, conjunctiva, lacrimal glands, and lid of the eye. It is composed of the mucosa that lines the globe and palpebrae, the corneoscleral limbus, the corneal epithelium, and the tear film. This book focuses on the tear film, describing its physiology, dynamics, and role in maintaining the health of the ocular surface. It also examines keratoconus, a condition affecting both the preocular tear film and the ocular surface in which the cornea thins and bulges outward, as well as recent possibilities in molecular genetics.
Foundations of Corneal Disease by Kathryn Colby,Reza Dana Pdf
The field of cornea has seen tremendous advances over the last 40 years—this uniquely comprehensive book will discuss the history of these advances, current best practices in important diseases of the cornea and ocular surface, and examine future directions in diagnosis and management. Written by leading experts, many of whom trained under Claes Henrik Dohlman, MD, PhD, whose influence and many invaluable contributions have defined and shaped the field of cornea, each chapter will reflect the state of the art in the various aspects of cornea. Foundations of Corneal Disease: Past, Present, and Future contains six different sections, opening with an introduction which delves into the evolution of subspecialty training in cornea, and provides a historical perspective of our understanding of ocular surface disease. Section Two addresses perspectives on important corneal and external diseases including infectious keratitis, dry eye, and herpes simplex. Section Three and Section Four address surgery and surgical alternatives, and frontiers in corneal research. Section Six closes this book with a discussion of special topics: imaging the cornea, corneal blindness, eye banking, and clinical trials in dry eye, and explores future directions in this fast-paced field. Foundations of Corneal Disease: Past, Present, and Future contains is an ideal guide for corneal specialists, ophthalmology residents and fellows planning to enter cornea, corneal scientists, and to those in ophthalmology and visual science interested in a comprehensive resource on cornea and the history of this field.
Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.
Written by an international team of ophthalmic practitioners, this authoritative book is a vital resource not only for ophthalmic professionals, but for any healthcare professional who cares for patients with eye problems. In the ten years since the first edition was published, practice has moved on, as has the evidence for practice. This second edition draws on the passion and goodwill of the original team of authors, complemented by other colleagues, to fully revise and update the text in line with new findings, new practice and new and exciting treatments. The book is broadly divided into three sections. The first section considers the structure and function of the eye, as well as the basic principles of ophthalmology and eye examination. The second section considers patient care in diverse settings, as well as work-related issues and patient education. It also includes two entirely new chapters on eye banking and global eye health. The third section takes a systematic approach to patient care, working from the front to the back of the eye, discussing some of the common disorders affecting each structure (such as the lens or cornea) or group of structures (such as the eyelids or lacrimal drainage system). The book concludes with a very useful glossary of ophthalmic terms. Some aspects of practice discussed in the text are, of necessity, UK based, but these are clearly indicated and, wherever possible, principles (rather than specifics) are addressed and readers are directed to local policies and interpretations. The first edition of this book became a core text for ophthalmic nursing, in particular, and for the education of ophthalmic nurses across the world. This new edition will provide a comprehensive, up-to-date, evidence-based resource for all ophthalmic healthcare professionals. Contents include: • Physiology of vision • Optics • Pharmacology • Examination of the eye • Visual impairment • Patient education • Work and the eye • Care of the adult ophthalmic patient in an inpatient setting • The care of the child undergoing ophthalmic treatment • Developments in day care surgery for ophthalmic patients • Ophthalmic theatre nursing • The care of patients presenting with acute problems • Eye banking • Global eye health • The eyelids and lacrimal drainage system • The conjunctiva • The cornea • The sclera • The lens • The uveal tract • The angle and aqueous • The retina and vitreous • The orbit and extraocular muscles • Visual and pupillary pathways and neuro-ophthalmology • The eye and systemic disease
