Corticotrophin Acth

Author : Choh Hao Li
Publisher : Elsevier
Page : 212 pages
File Size : 54,8 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323160124

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Corticotrophin (ACTH) by Choh Hao Li Pdf

Hormonal Proteins and Peptides: Corticotrophin (ACTH) is a collection of papers dealing with the chemistry and biology of adrenocorticotropic hormone (ACTH). One paper describes the structure-function studies made on ACTH, with reference to the steroidogenic activity of synthetic ACTH fragments and analogs. The paper also discusses the melanocyte-stimulating hormone (MSH) activity, as well as the behavioral effects among the extraadrenal properties of ACTH. Some problems related to ACTH receptors include the role of extracellular calcium and the characterization of ACTH receptors in fetal and adult human adrenocortical cells. Another paper describes ACTH synthesis in the pituitary and extrapituitary tissues. One paper analyzes the role of ACTH in the regulation process concerning the production of steroid hormones, particularly, on the generation of glucocorticoids. Glucocorticoids are the characteristic products of the zona fasciculata. Another paper shows that the steady-state level of ACTH synthesis and release are due to the effects of stimulatory factors such as CRF and inhibitory hormones (namely, the glucocorticoids on the corticotroph). The maintenance of responsiveness of ACTH-secreting cells (as a response to individual stress in humans) can be a manifestation of an inherent molecular characteristic. This collection will prove valuable to microbiologists, biotechnologists, and academicians connected with the biological sciences.

Author : Derek J. Chadwick,Joan Marsh,Kate Ackrill
Publisher : John Wiley & Sons
Page : 368 pages
File Size : 54,8 Mb
Release : 2008-04-30
Category : Medical
ISBN : 9780470514375

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Corticotropin-Releasing Factor by Derek J. Chadwick,Joan Marsh,Kate Ackrill Pdf

Working on Corticotropin-Releasing Factor in a variety of systems, experts present a coherent depiction of this peptide's role in the control and coordination of the response to stress-inducing situations.

Author : Errol B. De Souza
Publisher : CRC Press
Page : 376 pages
File Size : 42,8 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351087834

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Corticotropin-Releasing Factor by Errol B. De Souza Pdf

This book provides a comprehensive summary of data from basic and clinical studies in support of a role for corticotropin-releasing factor (CRF) as a neurotransmitter in the mammalian central nervous system (CNS). It includes descriptions of the anatomy of CRF and its receptors in the CNS, as well as the characterization of CRF receptors and the second messenger systems mediating effects of CRF in the brain. It discusses the autonomic, behavioral, and electrophysiologic effects of CRF administration in the brain. This work also includes a section which covers the role of brain CRF in the etiology and pathophysiology of a variety of neurologic, psychiatric, and endocrine disorders. Endocrinologists, brain researchers, and neuroendocrinologists are among those who will find this reference both useful and interesting.

Author : National Library of Medicine (U.S.),Marjory Charles Spencer
Publisher : Unknown
Page : 384 pages
File Size : 52,8 Mb
Release : 1950
Category : ACTH
ISBN : SRLF:D0003082567

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The Pituitary-adrenocortical Function by National Library of Medicine (U.S.),Marjory Charles Spencer Pdf

Author : Army Medical Library (U.S.)
Publisher : Unknown
Page : 384 pages
File Size : 40,9 Mb
Release : 1950
Category : ACTH
ISBN : RUTGERS:39030039864568

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The Pituitary-adrenocortical Function by Army Medical Library (U.S.) Pdf

Author : Alan Boulton Myles,John Richard Daly
Publisher : Hodder Education
Page : 240 pages
File Size : 48,8 Mb
Release : 1974
Category : Science
ISBN : UOM:39015003234120

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Corticosteroid and ACTH Treatment by Alan Boulton Myles,John Richard Daly Pdf

Author : Rolf C. Gaillard
Publisher : Springer Science & Business Media
Page : 338 pages
File Size : 55,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461505013

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The Acth Axis: Pathogenesis, Diagnosis and Treatment by Rolf C. Gaillard Pdf

"In this outstanding volume, Dr. Gaillard has assembled a team of international experts who have written one of the most comprehensive treatises on this topic. Ranging from fundamental molecular developmental mechanisms of the corticotroph cell, to the treatment of Cushing's Disease, these chapters provide a cutting edge overview of the pathogenesis, diagnosis and treatment of disordered hypothalamic-pituitary-adrenal function. Especially noteworthy are the inclusion of chapters on appetite control and neuro-immunomodulation, reflecting the recent exciting advances in these fields. The student of Cushing's Disease and the HPA axis will find elucidation of the latest basic scientific advances, coupled with patient friendly guidelines for clinical diagnosis and management of an extremely challenging neuroendocrine disorder. The repute of the authors, highest quality writing, lucid text and comprehensive coverage of the topics, all blend to result in an excellent text."

Author : Nicole Gallo-Payet,Antoine Martinez,André Lacroix
Publisher : Frontiers Media SA
Page : 421 pages
File Size : 49,7 Mb
Release : 2017-07-27
Category : ACTH.
ISBN : 9782889452323

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ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology by Nicole Gallo-Payet,Antoine Martinez,André Lacroix Pdf

By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies.

Author : Dieter K. Lüdecke,George P. Chrousos,George Tolis
Publisher : Lippincott Williams & Wilkins
Page : 344 pages
File Size : 55,7 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015018988892

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ACTH, Cushing's Syndrome, and Other Hypercortisolemic States by Dieter K. Lüdecke,George P. Chrousos,George Tolis Pdf

Author : David de Wied,William Ferrari
Publisher : Springer
Page : 258 pages
File Size : 41,7 Mb
Release : 1986
Category : ACTH
ISBN : UCAL:B4493397

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Central Actions of ACTH and Related Peptides by David de Wied,William Ferrari Pdf

Author : Shlomo Melmed
Publisher : Academic Press
Page : 744 pages
File Size : 46,6 Mb
Release : 2010-12-09
Category : Medical
ISBN : 0123809274

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The Pituitary by Shlomo Melmed Pdf

The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches

Author : Yvette Taché,Catherine Rivier
Publisher : Unknown
Page : 316 pages
File Size : 53,8 Mb
Release : 1993
Category : Medical
ISBN : UVA:X001797679

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Corticotropin-releasing Factor and Cytokines by Yvette Taché,Catherine Rivier Pdf

These 25 papers are taken from the proceedings of a conference sponsored by the Hans Selye Foundation, held on October 10-14, 1992. They cover such issues as CRF mRNA in normal and stress conditions, amygdaloid CRF pathways and neuroendocrine effects of prenatal alcohol exposure.

Author : Gregory Shwartzman
Publisher : Unknown
Page : 224 pages
File Size : 54,7 Mb
Release : 1953
Category : Electronic
ISBN : RUTGERS:39030012532547

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The effect of ACTH and cortisone upon infection and resistance by Gregory Shwartzman Pdf

Author : Gregory Shwartzman
Publisher : Symposia of the Section on Microbiology. The New York Academy of Medicine, 6
Page : 224 pages
File Size : 45,6 Mb
Release : 1953
Category : ACTH.
ISBN : CORNELL:31924003470667

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The Effect of ACTH and Cortisone Upon Infection and Resistance by Gregory Shwartzman Pdf

Outlines the effects of cortisone upon infections such as syphilis and tuberculosis, and the factors that contribute to infection resistance in the human body.

Author : Mortyn T. Jones
Publisher : Unknown
Page : 316 pages
File Size : 50,6 Mb
Release : 1979
Category : Adrenal cortex
ISBN : UOM:39015004402569

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Interaction Within the Brain-pituitary-adrenocortical System by Mortyn T. Jones Pdf