Cryoem

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cryoEM

Tamir Gonen,Brent L. Nannenga
cryoEM Book PDF

Author : Tamir Gonen,Brent L. Nannenga
Publisher : Humana
Page : 350 pages
File Size : 44,9 Mb
Release : 2021-12-28
Category : Science
ISBN : 1071609688

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cryoEM by Tamir Gonen,Brent L. Nannenga Pdf

This volume details the most up-to-date cryo-EM techniques from leading researchers. Chapters are organized into four parts with emphasis on electron cryotomography, single particle analysis, and the crystal based cryo-EM methods of 2D electron crystallography, and MicroED for the study of 3D crystals. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, CryoEM: Methods and Protocols aims to serve as an excellent resource on cryo-EM and can serve as the foundation for new researchers to this growing field in structural biology.

The Resolution Revolution: Recent Advances In cryoEM

Anonim
The Resolution Revolution Recent Advances In cryoEM Book PDF

Author : Anonim
Publisher : Academic Press
Page : 486 pages
File Size : 54,6 Mb
Release : 2016-08-26
Category : Medical
ISBN : 9780128054352

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The Resolution Revolution: Recent Advances In cryoEM by Anonim Pdf

cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods that determine the structures of biological molecules, a vital step for understanding their function Contains the technical developments underpinning the advances of cryoEM and captures the exciting insights that have resulted

Single-particle Cryo-electron Microscopy

Joachim Frank
Single particle Cryo electron Microscopy Book PDF

Author : Joachim Frank
Publisher : World Scientific Publishing Company
Page : 0 pages
File Size : 48,5 Mb
Release : 2017-12-31
Category : Electron microscopy
ISBN : 9813234857

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Single-particle Cryo-electron Microscopy by Joachim Frank Pdf

The book reproduces 55 of more than 300 articles written by the author, representing milestones in methods development of single-particle cryo-EM as well as important results obtained by this technique in the study of biological macromolecules and their interactions. Importantly, neither symmetries nor ordered arrangements (as in two-dimensional crystals, helical assemblies, icosahedral viruses) are required. Although the biological applications are mainly in the area of ribosome structure and function, the elucidation of membrane channel structures and their activation and gating mechanisms are represented, as well. The book is introduced by a commentary that explains the original development of concepts, describes the contributions of the author's colleagues and students, and shows how challenges were overcome as the technique matured. Along the way, the ribosome served as an example for a macromolecule with intricate structure and conformational dynamics that pose challenges for three-dimensional visualization. Toward the end of the book -- bringing us to the present time -- molecular structures with near-atomic resolution are presented, and a novel type of computational analysis, manifold embedding, is introduced. Single-particle cryo-EM is currently revolutionizing structural biology, presenting a powerful alternative to X-ray crystallography as a means to solve the structure of biological macromolecules. The book presents in one place a number of articles containing key advances in mathematical and computational methods leading up to the present time. Secondly, the development of the technique over the years is reflected by ever-expanding discoveries in the field of ribosome structure and function. Thirdly, as all histories of ideas, the history of concepts pertaining to this new method of visualization is fascinating all in itself.

Single-particle Cryo-EM of Biological Macromolecules

GLAESER,Eva Nogales,Wah Chiu
Single particle Cryo EM of Biological Macromolecules Book PDF

Author : GLAESER,Eva Nogales,Wah Chiu
Publisher : Biophysical Society
Page : 120 pages
File Size : 44,6 Mb
Release : 2021-05-19
Category : Science
ISBN : 0750330376

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Single-particle Cryo-EM of Biological Macromolecules by GLAESER,Eva Nogales,Wah Chiu Pdf

This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. It is especially well suited for larger complexes and molecular machines. This book, provides a comprehensive, accessible and authoritative introduction to the field. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results. Key features Written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM Provides a comprehensive, accessible and authoritative introduction to the field of high-resolution structure analysis by single-article cryo-EM Covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results Authors of individual sections of this book have been recruited from among the most authoritative leaders in each topic

Cryo-EM Part A: Sample Preparation and Data Collection

Anonim
Cryo EM Part A Sample Preparation and Data Collection Book PDF

Author : Anonim
Publisher : Academic Press
Page : 466 pages
File Size : 51,7 Mb
Release : 2010-09-30
Category : Science
ISBN : 9780080956954

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Cryo-EM Part A: Sample Preparation and Data Collection by Anonim Pdf

Cryo-EM Part A: Sample Preparation and Data Collection is dedicated to a description of the instruments, samples, protocols, and analyses that belong to cryo-EM. It emphasizes the relatedness of the ideas, instrumentation, and methods underlying all cryo-EM approaches, which allow practitioners to easily move between them. Within each section, the articles are ordered according to the most common symmetry of the sample to which their methods are applied. Includes time-tested core methods and new innovations applicable to any researcher Methods included are useful to both established researchers and newcomers to the field Relevant background and reference information given for procedures can be used as a guide

Imaging Life

Gary C. Howard,William E. Brown,Manfred Auer
Imaging Life Book PDF

Author : Gary C. Howard,William E. Brown,Manfred Auer
Publisher : Oxford University Press
Page : 480 pages
File Size : 53,5 Mb
Release : 2014-07-30
Category : Science
ISBN : 9780199718177

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Imaging Life by Gary C. Howard,William E. Brown,Manfred Auer Pdf

This volume provides an overview of a variety of approaches to biological image analysis, which allow for the study of living organisms at all levels of complexity and organization. These organisms range from individual macromolecules to subcellular and cellular volumes, tissues and microbial communities. Such a "systems biology" understanding of life requires the combination of a variety of imaging techniques, and with it an in-depth understanding of their respective strengths and limitations, as well as their intersection with other techniques. Howard, Brown, and Auer show us that the integration of these imaging techniques will allow us to overcome the reductionist approach to biology that dominated the twentieth century, which was aimed at examining the physical and chemical properties of life's constituents, one macromolecule at a time. However, while based on the laws of physics and chemistry, life is not simply a set of chemical reactions and physical forces; it features an exquisite spatiotemporal organization that allows an inconceivably large number of chemical processes to coexist, refined by billions of years of evolutionary experimentation. And yet, many fundamental questions remain largely unanswered; Imaging Life argues that we are just now beginning to address the spatiotemporal organizational component of living processes. "Imaging" is needed in order to reveal the spatiotemporal relationships between components, and thus to understand organizational guiding principles of living systems. Only through imaging will we be able to decipher the mechanisms and the marvelous organization that enable and sustain the mystery of life. Imaging Life shows us how biology is beginning to do just that.

Computer Vision – ECCV 2022 Workshops

Leonid Karlinsky,Tomer Michaeli,Ko Nishino
Computer Vision ECCV 2022 Workshops Book PDF

Author : Leonid Karlinsky,Tomer Michaeli,Ko Nishino
Publisher : Springer Nature
Page : 796 pages
File Size : 49,6 Mb
Release : 2023-02-13
Category : Computers
ISBN : 9783031250699

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Computer Vision – ECCV 2022 Workshops by Leonid Karlinsky,Tomer Michaeli,Ko Nishino Pdf

The 8-volume set, comprising the LNCS books 13801 until 13809, constitutes the refereed proceedings of 38 out of the 60 workshops held at the 17th European Conference on Computer Vision, ECCV 2022. The conference took place in Tel Aviv, Israel, during October 23-27, 2022; the workshops were held hybrid or online. The 367 full papers included in this volume set were carefully reviewed and selected for inclusion in the ECCV 2022 workshop proceedings. They were organized in individual parts as follows: Part I: W01 - AI for Space; W02 - Vision for Art; W03 - Adversarial Robustness in the Real World; W04 - Autonomous Vehicle Vision Part II: W05 - Learning With Limited and Imperfect Data; W06 - Advances in Image Manipulation; Part III: W07 - Medical Computer Vision; W08 - Computer Vision for Metaverse; W09 - Self-Supervised Learning: What Is Next?; Part IV: W10 - Self-Supervised Learning for Next-Generation Industry-Level Autonomous Driving; W11 - ISIC Skin Image Analysis; W12 - Cross-Modal Human-Robot Interaction; W13 - Text in Everything; W14 - BioImage Computing; W15 - Visual Object-Oriented Learning Meets Interaction: Discovery, Representations, and Applications; W16 - AI for Creative Video Editing and Understanding; W17 - Visual Inductive Priors for Data-Efficient Deep Learning; W18 - Mobile Intelligent Photography and Imaging; Part V: W19 - People Analysis: From Face, Body and Fashion to 3D Virtual Avatars; W20 - Safe Artificial Intelligence for Automated Driving; W21 - Real-World Surveillance: Applications and Challenges; W22 - Affective Behavior Analysis In-the-Wild; Part VI: W23 - Visual Perception for Navigation in Human Environments: The JackRabbot Human Body Pose Dataset and Benchmark; W24 - Distributed Smart Cameras; W25 - Causality in Vision; W26 - In-Vehicle Sensing and Monitorization; W27 - Assistive Computer Vision and Robotics; W28 - Computational Aspects of Deep Learning; Part VII: W29 - Computer Vision for Civil and Infrastructure Engineering; W30 - AI-Enabled Medical Image Analysis: Digital Pathology and Radiology/COVID19; W31 - Compositional and Multimodal Perception; Part VIII: W32 - Uncertainty Quantification for Computer Vision; W33 - Recovering 6D Object Pose; W34 - Drawings and Abstract Imagery: Representation and Analysis; W35 - Sign Language Understanding; W36 - A Challenge for Out-of-Distribution Generalization in Computer Vision; W37 - Vision With Biased or Scarce Data; W38 - Visual Object Tracking Challenge.

Recent Advances in Electron Cryomicroscopy

Anonim
Recent Advances in Electron Cryomicroscopy Book PDF

Author : Anonim
Publisher : Academic Press
Page : 144 pages
File Size : 48,6 Mb
Release : 2011-04-17
Category : Science
ISBN : 9780123865083

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Recent Advances in Electron Cryomicroscopy by Anonim Pdf

Electron cryomicroscopy is a form of transmission electron microscopy (EM) in which the sample is studied at cryogenic temperatures (generally liquid nitrogen temperatures). Cryo-EM is developing popularity in structural biology. This volume from the Advances in Protein Chemistry and Structural Biology series is Part B and covers essential topics.

Components, Packaging and Manufacturing Technology

Yanwen Wu
Components Packaging and Manufacturing Technology Book PDF

Author : Yanwen Wu
Publisher : Trans Tech Publications Ltd
Page : 870 pages
File Size : 53,7 Mb
Release : 2011-01-20
Category : Technology & Engineering
ISBN : 9783038134800

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Components, Packaging and Manufacturing Technology by Yanwen Wu Pdf

Volume is indexed by Thomson Reuters CPCI-S (WoS). The objective of this special collection is to provide a showcase for researchers, educators, engineers and government officials, involved in the general areas of Components, Packaging and Manufacturing Technology, by which to highlight the latest research results and to exchange views on the future direction of research in these fields. The topics covered include: Advanced Measurement, Test and Information Technology, Components, Packaging and Manufacturing Technology.

The Future of Pharmaceuticals

Sarfaraz K. Niazi
The Future of Pharmaceuticals Book PDF

Author : Sarfaraz K. Niazi
Publisher : CRC Press
Page : 620 pages
File Size : 55,5 Mb
Release : 2022-03-01
Category : Medical
ISBN : 9781000458169

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The Future of Pharmaceuticals by Sarfaraz K. Niazi Pdf

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.

Viral Molecular Machines

Michael G. Rossmann,Venigalla B. Rao
Viral Molecular Machines Book PDF

Author : Michael G. Rossmann,Venigalla B. Rao
Publisher : Springer Science & Business Media
Page : 685 pages
File Size : 40,6 Mb
Release : 2012-02-02
Category : Medical
ISBN : 9781461409809

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Viral Molecular Machines by Michael G. Rossmann,Venigalla B. Rao Pdf

This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chapters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will examine in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion. Each chapter will describe the components of the respective machine in molecular or atomic detail, genetic and biochemical analyses, and mechanism. Topics are carefully selected so that the reader is exposed to systems where there is a substantial infusion of new knowledge in recent years, which greatly elevated the fundamental mechanistic understanding of the respective molecular machine. The authors will be encouraged to simplify the detailed knowledge to basic concepts, include provocative new ideas, as well as design colorful graphics, thus making the cutting-edge information accessible to broad audience.

Handbook of Ion Channels

Jie Zheng,Matthew C. Trudeau
Handbook of Ion Channels Book PDF

Author : Jie Zheng,Matthew C. Trudeau
Publisher : CRC Press
Page : 682 pages
File Size : 49,6 Mb
Release : 2015-02-25
Category : Medical
ISBN : 9781466551428

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Handbook of Ion Channels by Jie Zheng,Matthew C. Trudeau Pdf

The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Prokaryotic Cytoskeletons

Jan Löwe,Linda A. Amos
Prokaryotic Cytoskeletons Book PDF

Author : Jan Löwe,Linda A. Amos
Publisher : Springer
Page : 450 pages
File Size : 47,9 Mb
Release : 2017-05-11
Category : Science
ISBN : 9783319530475

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Prokaryotic Cytoskeletons by Jan Löwe,Linda A. Amos Pdf

This book describes the structures and functions of active protein filaments, found in bacteria and archaea, and now known to perform crucial roles in cell division and intra-cellular motility, as well as being essential for controlling cell shape and growth. These roles are possible because the cytoskeletal and cytomotive filaments provide long range order from small subunits. Studies of these filaments are therefore of central importance to understanding prokaryotic cell biology. The wide variation in subunit and polymer structure and its relationship with the range of functions also provide important insights into cell evolution, including the emergence of eukaryotic cells. Individual chapters, written by leading researchers, review the great advances made in the past 20-25 years, and still ongoing, to discover the architectures, dynamics and roles of filaments found in relevant model organisms. Others describe one of the families of dynamic filaments found in many species. The most common types of filament are deeply related to eukaryotic cytoskeletal proteins, notably actin and tubulin that polymerise and depolymerise under the control of nucleotide hydrolysis. Related systems are found to perform a variety of roles, depending on the organisms. Surprisingly, prokaryotes all lack the molecular motors associated with eukaryotic F-actin and microtubules. Archaea, but not bacteria, also have active filaments related to the eukaryotic ESCRT system. Non-dynamic fibres, including intermediate filament-like structures, are known to occur in some bacteria.. Details of known filament structures are discussed and related to what has been established about their molecular mechanisms, including current controversies. The final chapter covers the use of some of these dynamic filaments in Systems Biology research. The level of information in all chapters is suitable both for active researchers and for advanced students in courses involving bacterial or archaeal physiology, molecular microbiology, structural cell biology, molecular motility or evolution. Chapter 3 of this book is open access under a CC BY 4.0 license.

Structural Biology in Drug Discovery

Jean-Paul Renaud
Structural Biology in Drug Discovery Book PDF

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
Page : 1367 pages
File Size : 42,8 Mb
Release : 2020-01-09
Category : Medical
ISBN : 9781118900505

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Structural Biology in Drug Discovery by Jean-Paul Renaud Pdf

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Structure-based Study of Viral Replication

R. Holland Cheng,Tatsuo Miyamura
Structure based Study of Viral Replication Book PDF

Author : R. Holland Cheng,Tatsuo Miyamura
Publisher : World Scientific
Page : 663 pages
File Size : 47,9 Mb
Release : 2008
Category : Medical
ISBN : 9789812704054

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Structure-based Study of Viral Replication by R. Holland Cheng,Tatsuo Miyamura Pdf

This book addresses the innovative themes in characterizing the cellular membrane platforms and intracellular networking, as well as the architectural aspects of cell compartments mediated by the entry and replication cycles of viruses. The instrumentation of modern molecular and cellular biology provides a potent array of wave packets to image, detect and manipulate major dynamics of macromolecular and subviral assemblies as in the host cellular context.The book includes case studies presented with highly coherent and structured illuminations, including microscopy, spectroscopy and scanning probes. The compilation and integration of the methodology provides time-resolved observations on the reactivity of structures from near-atomic resolution to various molecular or cellular levels of descriptors. The book provides a broad introduction to the various fascinating virus systems and may be used as an advanced textbook by graduate students in biomedicine. It provides adequate background material to explore further the research problems of epidemics in the 21st century.