Current Aspects Of Pathogenesis And Treatment In Diabetic Retinopathy
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Current Aspects of Pathogenesis and Treatment in Diabetic Retinopathy by P. Kroll Pdf
Microvascular complications of diabetes mellitus such as diabetic retinopathy and diabetic maculopathy continue to be the most frequent causes for blindness in working-age adults in industrialized countries. This is only surpassed by age-related macular degeneration in higher age groups. While a few years ago only about 5% of the population suffered from diabetes, a massive increase in the prevalence of up to 16% must be expected. This issue consists of review articles on the pathogenesis of diabetic retinopathy and maculopathy as well as their classification and staging. On that basis up-to-date therapeutic modalities are discussed in detail. Ophthalmologists and diabetes health care professionals as well as internists and pediatrists interested in diabetic eye disease will find a wealth of topical information in this special issue.
Author : Mohammad Shamsul Ola Publisher : BoD – Books on Demand Page : 370 pages File Size : 43,5 Mb Release : 2012-02-24 Category : Medical ISBN : 9789535100447
The aim of this book is to provide a comprehensive overview of current concepts in pathogenesis, diagnosis and treatments of diabetic retinopathy. It provides a collection of topics written by excellent authors, covering discussions on advances in understanding of pathophysiology, immunological factors and emerging concepts, relating to clinical aspects and treatment strategies. The contents of the book will not only provide a resource for our knowledge but also improve diagnosis and treatment options for those patients who suffer vision loss due to diabetic retinopathy.
A well-illustrated and comprehensive analysis of the treatment of diabetic retinopathy, this book covers current treatment options and guidelines, whilst also providing a detailed discussion of emerging therapeutic targets. Existing therapeutic options are covered in depth, with a major focus on anti-vascular endothelial growth factor drugs and sustained release corticosteroids, including a review of trial results supporting current treatment guidelines. The use of agents off-label is also discussed. Controversial topics are discussed in detail with an emphasis on helping the reader make informed decisions, particularly when treating patients for which several treatment approaches may be appropriate because trial data does not clearly define the best option. Emerging therapeutic areas are evaluated, as work continues to identify agents that produce superior morphologic responses and visual acuity gains by targeting other molecules that contribute to diabetic retinopathy. Promising new drugs, targets and delivery systems are identified, and their development analysed.
Retinal Pharmacotherapeutics by Q.D. Nguyen,E.B. Rodrigues,M.E. Farah,W.F. Mieler,D.V. Do Pdf
The use of pharmacotherapeutics in the management of retinal diseases is rapidly evolving, and a favorable therapy for the patient. Today anti-VEGF agents are used for a range of indications from inflammation-related choroidal neovascularization to macular edema secondary to retinal vein occlusion or diabetic retinopathy. Beyond VEGF, there is an array of target areas under investigation – not only for vascular pathologies such as age-related macular degeneration and diabetic eye disease, but also for degenerative, infectious and inflammatory retinal conditions. This publication discusses many aspects from basic research on the retina, to animal models for retinal drug delivery, retinal diseases that are amenable to pharmacotherapy and also drugs and mechanisms in retinal diseases. Anyone concerned with the management of retinal diseases - the general ophthalmologist and the retina specialist alike – will find this book indispensable reading.
Textbook of Vascular Medicine by Rhian M. Touyz,Christian Delles Pdf
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
This book brings together both a review and updates in clinical and research areas. The chapters will be of interest to a wide audience. On one hand, the review and update of clinical practices will interest students and residents, on the other, cutting edge research chapters will be of interest to the researchers in the field. The book is divided into four parts: 1) Review and Updates in Diagnostic Testing, 2) Updates in Anterior Segment Diseases, 3) Updates in Posterior Segment Diseases, and 4) Updates in Research in Ophthalmology, Optometry and Vision Science. The chapters are written by experts and individuals with special interests in topics with a focus on clinical application and translational benefit to eye care.
This book explains how to use intravitreal steroids optimally in the management of patients with intraocular inflammation (uveitis) and macular edema. The rationale for this treatment approach is first explained by examining the pathophysiology of these disease entities, with particular attention to the major role of inflammatory processes. Devices for the delivery of steroids to the eye are discussed, and guidance provided on the role of imaging studies before, during, and after steroid therapy. The value of different steroidal approaches is then considered in detail. Other topics addressed include the use of steroids as a surgical adjunct and within a combination strategy. Uveitis and macular edema are common sight-threatening diseases or complications of diabetes and retinal vein occlusion for which no adequate treatment was available until recently. Both trainees and practitioners will find Intravitreal Steroids to be an invaluable aid in combating these blinding diseases.
Management of Diabetic Retinopathy by F. Bandello,M.A. Zarbin,R. Lattanzio,I. Zucchiatti Pdf
Recently developed diagnostic and therapeutic technologies such as OCT-angiography and small gauge vitrectomy have influenced the modern treatment of diabetic retinopathy. This volume provides a summary of the state-of-the-art evidence-based approach to managing complications that may occur with diabetic retinopathy. It offers the latest information on pathogenesis and diagnosis, and highly experienced clinicians review the results of relevant randomized clinical trials that serve as the basis of current therapy. The book provides not only a summary of data from randomized trials but also an analysis and interpretation by internationally renowned experts. Ophthalmology residents, fellows, and practicing clinicians will find this book to be a useful reference when seeking evidence-based treatment strategies for various complications of diabetic retinopathy. It is also for researchers identifying new avenues of drug developments and for insurance professionals and health care policy administrators who are establishing evidence-based therapy guidelines for therapeutic intervention.
Author : C. Sabanayagam,T.Y. Wong Publisher : Karger Medical and Scientific Publishers Page : 134 pages File Size : 45,6 Mb Release : 2019-06-03 Category : Medical ISBN : 9783318065077
Diabetic Retinopathy and Cardiovascular Disease by C. Sabanayagam,T.Y. Wong Pdf
Diabetic retinopathy (DR), a common microvascular complication, has consistently been shown to be associated with an increased risk of cardiovascular disease (CVD). This book provides complete coverage of DR as a potential marker for CVD in those with diabetes. It succinctly reviews the epidemiological and pathogenic links of DR to various cardiovascular events including stroke, coronary artery disease, chronic kidney disease, heart failure, and mortality. Furthermore, it discusses the usefulness of DR in CVD risk prediction and cardiovascular safety of anti-VEGF therapy in diabetic patients. There are insights from contemporary diabetic trials that demonstrated the enhanced cardiovascular benefit of novel glucose lowering therapy. It also highlights the potential of novel retinal imaging to predict CVD and its risk factors using the state-of-the art artificial intelligence-based deep learning systems. This book will be an invaluable resource for specialists translating research findings into clinical care, including those in cardiology, endocrinology, ophthalmology, and general practitioners. IT will also be of interest to public health practitioners, researchers, graduate students, and biotech companies interested in developing retinal image-based diagnostic and prognostic tools.
Diabetic Foot Ulcers - Pathogenesis, Innovative Treatments and AI Applications by Muhammad E.H. Chowdhury,Susu M. Zughaier,Anwarul Hasan,Rashad Alfkey Pdf
Diabetic Foot Ulcers - Pathogenesis, Innovative Treatments, and AI Applications is a groundbreaking compilation that offers a comprehensive examination of diabetic foot ulcers (DFUs) from multiple perspectives. With contributions from leading experts in the field, this book explores the epidemiology, risk factors, and underlying pathophysiology of DFUs, providing valuable insights into the complexities of this debilitating complication of diabetes. Innovative treatments for DFUs are explored in depth, including the latest advancements in wound care, bioengineered skin substitutes, growth factors, and hyperbaric oxygen therapy. Contributors also discuss the importance of multidisciplinary approaches and patient-centered care in effectively managing DFUs and reducing complications. A highlight of this volume is the exploration of artificial intelligence (AI) applications in DFU management. From machine learning algorithms to deep learning models and computer vision techniques, experts showcase the potential of AI in early detection, risk stratification, and personalized treatment of DFUs, paving the way for more efficient and effective clinical decision-making. With its interdisciplinary approach and cutting-edge insights, Diabetic Foot Ulcers - Pathogenesis, Innovative Treatments, and AI Applications is a valuable resource for researchers, clinicians, students, and healthcare professionals interested in DFU research and management. By sharing knowledge, fostering innovation, and embracing new technologies, this book aims to make significant strides towards preventing and effectively managing DFUs, ultimately improving the health and well-being of individuals affected by this challenging complication of diabetes. Diabetic Foot Ulcers - Pathogenesis, Innovative Treatments, and AI Applications is available now, providing essential reading for anyone seeking to deepen their understanding of DFUs and explore the latest advancements in treatment and care.
Anti-Angiogenic Therapy in Ophthalmology by Andreas Stahl Pdf
This book provides a concise overview over the pathology of retinal angiogenic diseases and explains why anti-angiogenic therapy is effective in so many patients. The reader is guided through the various clinical indications for anti-angiogenic therapy and made aware of its merits as well as current challenges and limitations. It is explained how, since its introduction for the treatment of exudative age-related macular degeneration in 2006, anti-angiogenic therapy has revolutionized the way in which we treat a range of ocular diseases. All of the authors are established experts in their respective fields who share their extensive knowledge and clinical experience with the reader. This book is both a valuable introduction to anti-angiogenic therapy in ophthalmology and a day-to-day companion for all ophthalmologists seeing patients with some of the most prevalent retinal diseases.
Diabetes and Hypertension by Samy I. McFarlane,George L. Bakris Pdf
Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
Diabetes and Ocular Disease by Ingrid Scott,Harry Flynn,William Smiddy Pdf
Diabetes mellitus is a complex, multifactorial disease that is often associated with progressive retinopathy and visual loss. In this book, Drs. Scott, Flynn, and Smiddy have compiled the current basic science and clinical information from leading authorities on diabetic eye disease. They have also included the results of clinical trials in patients with diabetic retinopathy, as well as the guidelines established by collaborative studies and the concepts of disease mechanisms and clinical management that have subsequently evolved from those guidelines. This monograph will provide practitioners with a concise, up-to-date, practical reference for the diagnosis and management of ocular disease in diabetic patients.