Current Hypotheses And Research Milestones In Alzheimer S Disease

Author : Ricardo B. Maccioni,George Perry
Publisher : Springer Science & Business Media
Page : 242 pages
File Size : 55,5 Mb
Release : 2009-02-27
Category : Medical
ISBN : 9780387879956

Get Book

Current Hypotheses and Research Milestones in Alzheimer's Disease by Ricardo B. Maccioni,George Perry Pdf

Almost four decades of innovative and intensive research on Alzheimer’s disease (AD) have brought major advances in our understanding of its pathogenesis, improved tools for diagnosis, and strategies for its treatment. This research has helped build a solid foundation of knowledge in the neurosciences and biological basis of AD and AD-related neurological disorders. Scientific background and insightful hypotheses are of major relevance in order to approach to an effective therapy for this devastating disease. Current Hypotheses and Research Milestones in Alzheimer's Disease contains 20 seminal chapters by authors with varying views on the neuroanatomical, neuropathological, neuropsychological, neurological, and molecular aspects of AD. These chapters grew out of “Current Hypothesis on Alzheimer’s Disease”, held in Viña del Mar, Chile, in November of 2007. Participants included the world’s leading Alzheimer’s researchers, whose work has illuminated AD investigations during the past few decades. Students, academics and medical professionals will find this text an invaluable addition to the study of this important subject.

Author : Philip A. Rea,Mark V. Pauly,Lawton R. Burns
Publisher : Cambridge University Press
Page : 557 pages
File Size : 48,6 Mb
Release : 2018-02
Category : Business & Economics
ISBN : 9781107130906

Get Book

Managing Discovery in the Life Sciences by Philip A. Rea,Mark V. Pauly,Lawton R. Burns Pdf

Addresses in roughly equal measure the science and management behind several recent marketable biomedical innovations.

Author : Thomas J. Lewis,Clement L. Trempe
Publisher : Academic Press
Page : 482 pages
File Size : 47,7 Mb
Release : 2017-05-12
Category : Psychology
ISBN : 9780128121139

Get Book

The End of Alzheimer’s by Thomas J. Lewis,Clement L. Trempe Pdf

The End of Alzheimer’s: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer’s outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer’s disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer’s outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer’s, and will hopefully redirect many into new avenues of cellular research and discovery. Comprehensive literature-based summary of the current state of molecular Alzheimer’s disease research Details the shortcomings of the prevailing model and therapeutics in development Reviews blood-based biomarkers for Alzheimer’s and their link to amyloid- and Tau-independent causes outside the brain Describes the tissues outside the brain impacted by Alzheimer’s and the underlying molecular causes Explains the whole-body risks associated with Alzheimer’s, along with concomitant measures to slow or prevent the disease Provides a protocol to properly research, evaluate, measure, diagnose, and potentially treat Alzheimer’s patients

Author : Carlos M. Contreras
Publisher : BoD – Books on Demand
Page : 444 pages
File Size : 54,9 Mb
Release : 2012-03-16
Category : Medical
ISBN : 9789535102076

Get Book

Neuroscience by Carlos M. Contreras Pdf

The Neuronal Doctrine recently reached its 100th year and together with the development of psychopharmacology by the middle of 20th century promoted spectacular developments in the knowledge of the biological bases of behavior. The overwhelming amount of data accumulated, forced the division of neuroscience into several subdisciplines, but this division needs to dissolve in the 21st century and focus on specific processes that involve diverse methodological and theoretical approaches. The chapters contained in this book illustrate that neuroscience converges in the search for sound answers to several questions, including the pathways followed by cells, how individuals communicate with each other, inflammation, learning and memory, the development of drug dependence, and approaches to explaining the processes that underlie two highly incapacitating chronic degenerative illnesses.

Author : Davide Moretti
Publisher : BoD – Books on Demand
Page : 560 pages
File Size : 49,5 Mb
Release : 2016-09-28
Category : Medical
ISBN : 9789535126546

Get Book

Update on Dementia by Davide Moretti Pdf

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Author : Farid Rahimi,Gal Bitan
Publisher : Springer Science & Business Media
Page : 568 pages
File Size : 49,8 Mb
Release : 2012-01-11
Category : Medical
ISBN : 9789400727748

Get Book

Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases by Farid Rahimi,Gal Bitan Pdf

Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, low-order oligomers to spherical, annular, and protofibrillar species. Oligomeric species are believed to mediate various pathogenic mechanisms that lead to cellular dysfunction, cytotoxicity, and cell loss, eventuating in disease-specific degeneration and systemic morbidity. The particular pathologies thus are determined by the afflicted cell types, organs, systems, and the proteins involved. Evidence suggests that the oligomeric species may share structural features and possibly common mechanisms of action. In many cases, the structure–function interrelationships amongst the various protein assemblies described in vitro are still elusive. Deciphering these intricate structure–function correlations will help understanding a complex array of pathogenic mechanisms, some of which may be common across different diseases albeit affecting different cell types and systems.

Author : Joseph Ongrádi
Publisher : BoD – Books on Demand
Page : 273 pages
File Size : 43,9 Mb
Release : 2016-09-07
Category : Medical
ISBN : 9789535126102

Get Book

Herpesviridae by Joseph Ongrádi Pdf

Herpesviruses are unique among viruses as they encode for a complex self-regulatory system, aggressively invade and persist in the host, evade immune defense, alter all regulatory mechanisms of the macroorganism and modify the replication of heterologous viruses. Environmental factors influence these unconventional relationships. Consequently, a single herpesvirus species can be attributed to a wide range of diseases as etiological agents or cofactors. This book is intended to give an overview on selected clinical hot topics: herpes simplex virus encephalitis, persistent infection in the gingiva, thymidine kinase gene expression causing male infertility, and pharmaceutical reactivation of Epstein-Barr virus for oncolysis. Immune evasion mechanisms and new ways to formulate vaccines are exhaustively reviewed. Finally, a surprise: bovine herpesviruses could serve as models to study the pathomechanism of herpesviruses.

Author : Marie T. Banich,Rebecca J. Compton
Publisher : Cambridge University Press
Page : 671 pages
File Size : 44,9 Mb
Release : 2023-09-30
Category : Psychology
ISBN : 9781108831147

Get Book

Cognitive Neuroscience by Marie T. Banich,Rebecca J. Compton Pdf

The fifth edition of this comprehensive text explains the key issues, concepts and clinical applications of cognitive neuroscience.

Author : Arthur James Wells
Publisher : Unknown
Page : 1922 pages
File Size : 55,8 Mb
Release : 2009
Category : Bibliography, National
ISBN : STANFORD:36105211722678

Get Book

The British National Bibliography by Arthur James Wells Pdf

Author : Giuseppe Pignataro
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 50,6 Mb
Release : 2016-07-27
Category : Medicine (General)
ISBN : 9782889199297

Get Book

Mechanisms of Innate Neuroprotection by Giuseppe Pignataro Pdf

As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.

Author : G. Perry,J. Avila,J. Kinoshita
Publisher : IOS Press
Page : 468 pages
File Size : 42,8 Mb
Release : 2006-06-26
Category : Medical
ISBN : 9781607501756

Get Book

Alzheimer's Disease: A Century of Scientific and Clinical Research by G. Perry,J. Avila,J. Kinoshita Pdf

This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.

Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 107 pages
File Size : 42,5 Mb
Release : 2014-02-06
Category : Medical
ISBN : 9780309292498

Get Book

Improving and Accelerating Therapeutic Development for Nervous System Disorders by Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Author : Anonim
Publisher : IOS Press
Page : 3525 pages
File Size : 42,6 Mb
Release : 2024-06-29
Category : Electronic
ISBN : 8210379456XXX

Get Book

by Anonim Pdf

Author : Matthew P. Janicki,Arthur J. Dalton
Publisher : Routledge
Page : 534 pages
File Size : 43,5 Mb
Release : 2014-04-23
Category : Psychology
ISBN : 9781317823810

Get Book

Dementia and Aging Adults with Intellectual Disabilities by Matthew P. Janicki,Arthur J. Dalton Pdf

This definitive handbook assembles the most recent advances in knowledge about dementia, Alzheimer Disease, and related disorders as they affect persons with intellectual disabilities. Diagnosis, assessment, treatment, and management and care practices are detailed in a practical manner making this a useful tool to both students and trained professionals. After an introduction to the subject, the book begins with persoanl accounts of three affected individuals whose signs of dementia are described from clinical, family member, and care-provider perspectives, respectively. The biology and physiology of dementia, as well as the neurological and medical complications associated with it, are then provided in Parts Two, three, and Four. The application and practical perspectives of this handbook are enhanced in Part Five which details the best practices available to meet the needs and challenges involved in care and quality of life issues. The challenge raised by the rapidly growing number of aging individuals with intellectual disabilities forms the basis for the final part of the volume, an analysis and presentation of rarely addressed policy issues. Extensive resource information and a comprehensive glossary contribute to the useful nature of this handbook. Practitioners, service providers, educators and students will benefit from the accessability and practicality if this text as well as the breadth and depth of knowledge of the editors and contributors.

Author : Christian Behl
Publisher : Springer Nature
Page : 661 pages
File Size : 46,7 Mb
Release : 2023-08-14
Category : Medical
ISBN : 9783031315701

Get Book

Alzheimer’s Disease Research by Christian Behl Pdf

This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.