Current Indications For Growth Hormone Therapy

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Current Indications for Growth Hormone Therapy

Peter C. Hindmarsh
Current Indications for Growth Hormone Therapy Book PDF

Author : Peter C. Hindmarsh
Publisher : Karger Medical and Scientific Publishers
Page : 170 pages
File Size : 51,8 Mb
Release : 1999
Category : Medical
ISBN : 9783805567572

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Current Indications for Growth Hormone Therapy by Peter C. Hindmarsh Pdf

Breaking new ground in terms of scientific analysis, this book addresses the question of who benefits most from treatment with recombinant human growth hormone. Outlined at the beginning of this book are the principles of evidence-based medicine along with a critical appraisal of the statistical issues that lie at the center of growth hormone trials. Each chapter reviews the current state of knowledge on the use of growth hormone in conditions ranging from Turner syndrome through other syndromes of intrauterine growth retardation to the short normal child, also highlighting issues that remain to be addressed in further research. Evaluating therapies in terms of efficacy and safety or the health benefit for the individual or society as a whole are rarely approached in pediatric endocrinology and for this reason a special chapter on health economic evaluation is included. This book is of interest and offers practical help to pediatricians and endocrinologists.

Growth Hormone Deficiency in Adults

Jens O. L. Jørgensen,Jens Sandahl Christiansen
Growth Hormone Deficiency in Adults Book PDF

Author : Jens O. L. Jørgensen,Jens Sandahl Christiansen
Publisher : Karger Medical and Scientific Publishers
Page : 241 pages
File Size : 48,5 Mb
Release : 2005-01-01
Category : Science
ISBN : 9783805579926

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Growth Hormone Deficiency in Adults by Jens O. L. Jørgensen,Jens Sandahl Christiansen Pdf

It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Basic and Clinical Aspects of Growth Hormone

Barry D. Bercu
Basic and Clinical Aspects of Growth Hormone Book PDF

Author : Barry D. Bercu
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468455052

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Basic and Clinical Aspects of Growth Hormone by Barry D. Bercu Pdf

In this era of proliferation of synthetic growth hormone in the marketplace, there is a parallel and accentuated interest in growth hormone in the scientific arena. Because many more people can be treated with available growth hormone, clinicians must be prepared to answer hard questions regarding appropriate therapeutic usage and their decisions should be based on substantiated research in growth hormone. In June 1987, an international group of basic and clinical inves tigators gathered in Tampa, Florida, to address these issues and to further explore the very nature of growth hormone. The presentations contained within this book bring together their most current and vital research related to growth hormone. Section I deals with an examination of the molecular and biochemical events which define the growth hormone process. In Section II the neuroregulation of growth hormone secretion is highlighted from contrasting perspectives. The third section emphasizes and defines methods of diagnosis of growth hormone deficiency states. Section IV reviews the physiology, biochemistry and molecular actions of growth hormone and somatomedin. Section V represents an assessment of growth hormone treatment for various disorders, and the sixth section expands current uses of growth hormone therapy as it evolves into the next decade. The symposium upon which this book is based proved to be a dynamic blending of scholarly interaction between basic and clinical scientists. I am indebted to the participants whose worthy contributions are reflected in these pages.

Current Indications for Growth Hormone Therapy

P.C. Hindmarsh
Current Indications for Growth Hormone Therapy Book PDF

Author : P.C. Hindmarsh
Publisher : Karger Medical and Scientific Publishers
Page : 136 pages
File Size : 48,7 Mb
Release : 2010-06-02
Category : Medical
ISBN : 9783805591959

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Current Indications for Growth Hormone Therapy by P.C. Hindmarsh Pdf

Growth hormone (GH) has been used therapeutically for over 50 years. Since the development of a nearly unlimited supply of recombinant human GH in the mid-1980s, children with less severe GH deficiency can also profit from GH replacement therapy. Careful and accurate diagnosis and specific dosing, both essential to ensure normal height development, require the clinician to understand the finer points of clinical trials, to acquire quality evidence and assess the benefits of therapeutic intervention. Furthermore, genetic and environmental factors influencing GH sensitivity and responsiveness need to be taken into account. In this second edition all these aspects are covered in depth. Clinical examination, detailed auxological measurements, bone age assessment, molecular analysis and neuro-radiological evaluation as well as an adaptive strategy of dosing focusing on a patient‘s individual responsiveness are discussed in detail. This volume of Endocrine Development is essential reading for pediatric endocrinologists, pediatricians and clinical nurse specialists involved in GH therapy.

Human Growth Hormone

S. Raiti,R.A. Tolman
Human Growth Hormone Book PDF

Author : S. Raiti,R.A. Tolman
Publisher : Springer Science & Business Media
Page : 642 pages
File Size : 42,9 Mb
Release : 2013-11-09
Category : Medical
ISBN : 9781461572015

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Human Growth Hormone by S. Raiti,R.A. Tolman Pdf

It has been ten years since the National Hormone and Pituitary Program (then called the National Pituitary Agency) sponsored a symposium on human growth hormone (hGH). Numerous advances have occurred during this period. This book does not attempt to summarize past achievements. Rather, it deals with the contemporary issues in hGH research. A discussion of the present state of the art, of necessity, includes a review of the past. Some of the topics herein discussed include the following: 1. Growth hormone releasing factor (GRF). In 1973, the growth hormone inhibitory factor (somatostatin) had recently been discovered. The search for a releasing factor in humans led to its discovery not in the pituitary but in a pancreatic tumor that secreted growth hormone. The advances are discussed in this book. The current hope is that GRF will eventually become an effective therapeutic agent for idiopathic hypopituitarism in childhood and adolescence. 2. Biosynthesis of hGR by recombinant DNA technology. Current advances are discussed. Although hGH is not yet an approved drug, it will eventually become one. This will broaden our horizons in terms of hGH effectiveness in disorders other than hypopituitary dwarfism. The current experience with this type of hGH in both the Vnited States and Europe is reviewed by several authors.

Gigantism and Acromegaly

Constantine A. Stratakis
Gigantism and Acromegaly Book PDF

Author : Constantine A. Stratakis
Publisher : Academic Press
Page : 312 pages
File Size : 41,5 Mb
Release : 2021-06-01
Category : Medical
ISBN : 9780128145388

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Gigantism and Acromegaly by Constantine A. Stratakis Pdf

Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism

New Insights and Controversies in Diagnosis and Treatment of Adult Growth Hormone Deficiency

Antonio Mancini,Luca Persani,Maura Arosio,Ilonka Kreitschmann-Andermahr
New Insights and Controversies in Diagnosis and Treatment of Adult Growth Hormone Deficiency Book PDF

Author : Antonio Mancini,Luca Persani,Maura Arosio,Ilonka Kreitschmann-Andermahr
Publisher : Frontiers Media SA
Page : 123 pages
File Size : 48,9 Mb
Release : 2023-06-19
Category : Medical
ISBN : 9782832525937

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New Insights and Controversies in Diagnosis and Treatment of Adult Growth Hormone Deficiency by Antonio Mancini,Luca Persani,Maura Arosio,Ilonka Kreitschmann-Andermahr Pdf

Adult growth hormone deficiency (aGHD) is the clinical expression of a reduced GH secretion caused by congenital or acquired diseases affecting the hypothalamus-pituitary axis. Once considered a rare clinical disorder, its prevalence is apparently increasing. Nevertheless, due to the subtle clinical manifestations, aGHD could be still underestimated. Thirty years of experience with recombinant GH (rh-GH) clearly indicate the beneficial effects of replacement therapy with amelioration of metabolic and inflammatory parameters, body composition, endothelial function, quality of life, and reduction of cardiovascular risk. Furthermore, the world of GH and aGHD is rapidly enriching: new information on GH physiology, regarding its metabolic role and pleiotropic activities, is spreading, thus even making inappropriate the same name of “growth hormone”. The definition of “functional” and “partial” aGHD is still unclear and debated, although data about partially impaired GH secretion showed alteration of some metabolic and clinical parameters associated with cardiovascular risk. Current guidelines about GHD diagnosis and treatment have been elaborated, but many questions remain debated. New tests for diagnosis have recently been proposed, and non-conventional indications for diagnosis and treatment deserve further investigations. Controlled trials on the beneficial effects on morbidity and mortality are still lacking and new formulations of GH are under investigation. Several questions are related to the age of affected patients (from transition age to ageing) and no indications are available on how long the therapy should be considered. Other concerns are related to a possible pro-oncogenic effect, especially in patients who develop the deficiency after a removal of a hypothalamic-pituitary tumor. The interrelations with other pituitary axes need further clarification since isolate GHD and multiple pituitary deficiencies may have a different spectrum of manifestation. The aim of this Research Topic is to furnish deeper insight to questions related to aGHD: from molecular pathways involved in the pathophysiology to diagnostic tools and replacement therapy.

Growth Hormone Therapy in Pediatrics

Michael B. Ranke,David Anthony Price,Edward O. Reiter
Growth Hormone Therapy in Pediatrics Book PDF

Author : Michael B. Ranke,David Anthony Price,Edward O. Reiter
Publisher : Karger Medical and Scientific Publishers
Page : 534 pages
File Size : 44,5 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9783805582568

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Growth Hormone Therapy in Pediatrics by Michael B. Ranke,David Anthony Price,Edward O. Reiter Pdf

For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.

Prader-Willi Syndrome: New Insights for the Healthcare Professional: 2011 Edition

Anonim
Prader Willi Syndrome New Insights for the Healthcare Professional 2011 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 28 pages
File Size : 47,7 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464910777

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Prader-Willi Syndrome: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf

Prader-Willi Syndrome: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Prader-Willi Syndrome in a compact format. The editors have built Prader-Willi Syndrome: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Prader-Willi Syndrome in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Prader-Willi Syndrome: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Pediatric Endocrinology

Sally Radovick,Margaret H. MacGillivray
Pediatric Endocrinology Book PDF

Author : Sally Radovick,Margaret H. MacGillivray
Publisher : Springer Science & Business Media
Page : 616 pages
File Size : 44,6 Mb
Release : 2013-02-20
Category : Medical
ISBN : 9781607613954

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Pediatric Endocrinology by Sally Radovick,Margaret H. MacGillivray Pdf

A state-of-the-art and concise guide to the clinical management of pediatric endocrine disorders, the second edition of the highly regarded Pediatric Endocrinology: A Practical Clinical Guide covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. This expanded second edition includes new topics being seen more commonly in pediatric endocrinology practices related to obesity and type 2 diabetes mellitus and lipid disorders. Each chapter contains an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Invaluable tables summarize the critical factors in etiology, clinical presentation, diagnosis, and therapeutic dosages. Pediatric Endocrinology: A Practical Clinical Guide, Second Edition, is a comprehensive resource for all clinicians concerned with the myriad endocrinologic disorders seen in children and adolescents.

Growth Disorders 2E

Chris Kelnar,Martin Savage,Paul Saenger,Chris Cowell
Growth Disorders 2E Book PDF

Author : Chris Kelnar,Martin Savage,Paul Saenger,Chris Cowell
Publisher : CRC Press
Page : 728 pages
File Size : 49,6 Mb
Release : 2007-06-29
Category : Medical
ISBN : 9781444113730

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Growth Disorders 2E by Chris Kelnar,Martin Savage,Paul Saenger,Chris Cowell Pdf

Linear growth is a biological process of fundamental importance to the physical and psychological make-up of a child and adolescent but which can be subject to a number of interruptions and disorders. The management and treatment of patients with growth disorders constitues a major, and important, part of practice in clinical paediatrics, while in

Principles of Addictions and the Law

Norman S. Miller
Principles of Addictions and the Law Book PDF

Author : Norman S. Miller
Publisher : Academic Press
Page : 372 pages
File Size : 55,9 Mb
Release : 2010-01-30
Category : Psychology
ISBN : 008092476X

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Principles of Addictions and the Law by Norman S. Miller Pdf

The book includes an examination of sources of law important to addiction and its treatment. The foundations for forensic work in professional legal testimony is explored (e.g., legal system, case law precedent, statutes governing addictions, civil and criminal procedures). The science of addiction is featured including the biology of addiction, addiction as a brain disease, responsibility vs. loss of control, development of addictions, and the role of genetics and environment. Drug testing, its uses with forensic populations, what the tests show and do not show, controversies in using tests in the general population also receives extensive treatment. Addiction and mental illness in forensic populations is highlighted for addiction treatment and continuing care. Case studies and landmark cases illustrate the role of alcohol, drug use, and addictions in legal decisions. Focused primarily on alcohol and drug addictions Case studies and landmark cases are included to illustrate the role of alcohol/drugs in legal decisions (e.g., the Exxon Valdez case) Brief overview of legal system and drug courts will be useful to clinicans, lawyers, administrators, and other professionals

Handbook of Diagnostic Endocrinology

William Winter E,Lori J. Sokoll,Brett Holmquist,Roger L. Bertholf
Handbook of Diagnostic Endocrinology Book PDF

Author : William Winter E,Lori J. Sokoll,Brett Holmquist,Roger L. Bertholf
Publisher : Academic Press
Page : 747 pages
File Size : 49,6 Mb
Release : 2020-10-06
Category : Medical
ISBN : 9780128182789

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Handbook of Diagnostic Endocrinology by William Winter E,Lori J. Sokoll,Brett Holmquist,Roger L. Bertholf Pdf

The clinical laboratory plays a critical role in the diagnosis and management of endocrine and related metabolic disorders, which are leading causes of morbidity and mortality in children and adults. The Handbook of Diagnostic Endocrinology, Third Edition, provides a ready reference for the evaluation, diagnosis, and monitoring of such disorders. This revision incorporates translational medicine, connecting what clinicians need to know with those in research providing a clinical context to which they can relate their molecular findings. This book solves the needs of clinicians and researchers by bringing together in one book endocrinology at the molecular and clinical levels. As the intricacies of intracellular signaling have become better understood, states of hormone resistance are now increasingly recognized. The most common endocrinopathy in westernized countries, the metabolic syndrome, results, to a large extent, from insulin resistance. The complexity of the circulating forms of various hormones are acknowledged in this revision. Each chapter focuses on the biochemical tests that are required, either in the basal state or following provocation or suppression, to assist in the diagnosis of the various disorders Describes proper sample collection and relevant interpretations of laboratory tests Contains essential molecular biology and incorporates it with the clinical information Includes the discovery of new diagnostic and treatment methods

Practical Endocrinology and Diabetes in Children

Joseph E. Raine,Malcolm D. C. Donaldson,John W. Gregory,Martin O. Savage,Raymond L. Hintz
Practical Endocrinology and Diabetes in Children Book PDF

Author : Joseph E. Raine,Malcolm D. C. Donaldson,John W. Gregory,Martin O. Savage,Raymond L. Hintz
Publisher : John Wiley & Sons
Page : 255 pages
File Size : 49,5 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405173131

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Practical Endocrinology and Diabetes in Children by Joseph E. Raine,Malcolm D. C. Donaldson,John W. Gregory,Martin O. Savage,Raymond L. Hintz Pdf

The practical manual for pediatricians andendocrinologists Practical Endocrinology and Diabetes in Children, SecondEdition, continues to provide a very practical overview of managingendocrine problems in children. Coverage of each disorder reflectsits clinical importance. The material is organized in such a waythat it can be referred to at a moment's notice. Helpful overviewsof epidemiology, pathophysiology, investigations, differentialdiagnoses and psychosocial issues support the advice on managementprinciples. New features of this Second Edition include: Completely revised first chapter on diabetes Additional growth charts added to the appendix New Editor, Raymond L. Hintz, MD, Stanford University MedicalCenter, joins the team and brings a North American perspective tothe text New section added to each chapter entitled ‘Potentialpitfalls’ to help you avoid common problems

Pediatric Pharmacotherapy

Wieland Kiess,Matthias Schwab,Johannes van den Anker
Pediatric Pharmacotherapy Book PDF

Author : Wieland Kiess,Matthias Schwab,Johannes van den Anker
Publisher : Springer Nature
Page : 532 pages
File Size : 42,6 Mb
Release : 2020-07-15
Category : Medical
ISBN : 9783030504946

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Pediatric Pharmacotherapy by Wieland Kiess,Matthias Schwab,Johannes van den Anker Pdf

This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.