Current Research In Head And Neck Cancer

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Current Research in Head and Neck Cancer

Henning Bier
Current Research in Head and Neck Cancer Book PDF

Author : Henning Bier
Publisher : Karger Medical and Scientific Publishers
Page : 215 pages
File Size : 43,9 Mb
Release : 2005-01-01
Category : Medical
ISBN : 9783805577892

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Current Research in Head and Neck Cancer by Henning Bier Pdf

The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors. This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research.

Head and Neck Cancer

Jacques Bernier
Head and Neck Cancer Book PDF

Author : Jacques Bernier
Publisher : Springer
Page : 0 pages
File Size : 50,5 Mb
Release : 2018-06-23
Category : Medical
ISBN : 3319801821

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Head and Neck Cancer by Jacques Bernier Pdf

​This second edition ​provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

Head and Neck Cancer Imaging

Robert Hermans
Head and Neck Cancer Imaging Book PDF

Author : Robert Hermans
Publisher : Springer Science & Business Media
Page : 415 pages
File Size : 47,6 Mb
Release : 2012-01-20
Category : Medical
ISBN : 9783642178689

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Head and Neck Cancer Imaging by Robert Hermans Pdf

Imaging is crucial in the multidisciplinary approach to head and neck cancer management. The rapid technological development of recent years makes it necessary for all members of the multidisciplinary team to understand the potential applications, limitations, and advantages of existing and evolving imaging technologies. It is equally important that the radiologist has sufficient clinical background knowledge to understand the clinical significance of imaging findings. This book provides an overview of the findings obtained using different imaging techniques during the evaluation of head and neck neoplasms, both before and after therapy. All anatomic areas in the head and neck are covered, and the impact of imaging on patient management is discussed in detail. The authors are recognized experts in the field, and numerous high-quality images are included. This second edition provides information on the latest imaging developments in this area, including the application of PET-CT and diffusion-weighted magnetic resonance imaging.

Critical Issues in Head and Neck Oncology

Jan B. Vermorken,Volker Budach,C. René Leemans,Jean-Pascal Machiels,Piero Nicolai,Brian O'Sullivan
Critical Issues in Head and Neck Oncology Book PDF

Author : Jan B. Vermorken,Volker Budach,C. René Leemans,Jean-Pascal Machiels,Piero Nicolai,Brian O'Sullivan
Publisher : Springer Nature
Page : 361 pages
File Size : 53,9 Mb
Release : 2023-03-27
Category : Medical
ISBN : 9783031231759

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Critical Issues in Head and Neck Oncology by Jan B. Vermorken,Volker Budach,C. René Leemans,Jean-Pascal Machiels,Piero Nicolai,Brian O'Sullivan Pdf

This is an open access book. With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up. All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

Multidisciplinary Management of Head and Neck Cancer

Ravi A. Chandra,Ryan J. Li
Multidisciplinary Management of Head and Neck Cancer Book PDF

Author : Ravi A. Chandra,Ryan J. Li
Publisher : Springer Nature
Page : 247 pages
File Size : 51,5 Mb
Release : 2022-09-09
Category : Medical
ISBN : 9783031059735

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Multidisciplinary Management of Head and Neck Cancer by Ravi A. Chandra,Ryan J. Li Pdf

This book is a multidisciplinary guide to head and neck cancer.Head and neck cancer remains one of the most technically complex cancer subsites to manage. This field involves highly specialized, multidisciplinary management and collaboration amongst surgeons, radiation oncologists, medical oncologists, radiologists, pathologists, and other health disciplines. The clinical and research landscape for head and neck oncology continues to evolve at a rapid pace. This multidisciplinary book provides the latest updates in the contemporary understanding and management of these tumors. The text incorporates updates in surgical techniques (minimally invasive and robotic techniques, reconstructive approaches), radiation medicine (new data on dose and fields, oligometastatic/oligoprogressive disease, retreatment), medical oncology (targeted, immunotherapy and molecular agents), in addition to other overarching topics such as side effects, biomarkers/nanotechnology, and epidemiology. Written by experts in their respective fields, chapters include the most up to date scientific and clinical information with perspectives from each relevant subspeciality. These sections are concise and accessible, yet comprehensive. Palliative medicine, pathologic and imaging principles, and health systems/economics considerations are also described. This book is an ideal resource for clinicians, trainees, and researchers dealing with, and interested in, this challenging malignancy.

Head and Neck Cancer

John Frederick Ensley,Silvio Gutkind,John A. Jacobs,Scott Lippman
Head and Neck Cancer Book PDF

Author : John Frederick Ensley,Silvio Gutkind,John A. Jacobs,Scott Lippman
Publisher : Elsevier
Page : 602 pages
File Size : 42,7 Mb
Release : 2003-01-07
Category : Medical
ISBN : 9780080533841

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Head and Neck Cancer by John Frederick Ensley,Silvio Gutkind,John A. Jacobs,Scott Lippman Pdf

By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. Presents a multi-disciplinary perspective from authorities in diverse fields Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field Provides comprehensive yet easily comprehendible source of information

Molecular Determinants of Head and Neck Cancer

Barbara Burtness,Erica A. Golemis
Molecular Determinants of Head and Neck Cancer Book PDF

Author : Barbara Burtness,Erica A. Golemis
Publisher : Springer
Page : 629 pages
File Size : 43,5 Mb
Release : 2018-08-03
Category : Medical
ISBN : 9783319787626

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Molecular Determinants of Head and Neck Cancer by Barbara Burtness,Erica A. Golemis Pdf

Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

Head and Neck Cancer

Bruce Brockstein,Gregory Masters
Head and Neck Cancer Book PDF

Author : Bruce Brockstein,Gregory Masters
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 51,6 Mb
Release : 2006-04-18
Category : Medical
ISBN : 9780306480607

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Head and Neck Cancer by Bruce Brockstein,Gregory Masters Pdf

Exciting advances are occurring in the understanding of the molecular pathogenesis of squamous head and neck cancers. Epidemiology, staging and screening, as well as premalignancy, chemoprevention and the molecular biology of head and neck cancer, lay the groundwork for the understanding of the clinical chapters that follow. Controversial treatments will be compared to the standard management of patient care. Therapy chapters are divided into stage or category specific (resectable advanced, unresectable advanced or metastatic) problems, allowing the reader to review the current standards and options for patient types or specific patients easily. Considerations of supportive care, late toxicities and quality of life, often overlooked are reviewed in detail. This is a comprehensive summary of the current state of the art research and treatment.

Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition

Anonim
Head and Neck Cancer New Insights for the Healthcare Professional 2013 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 425 pages
File Size : 43,7 Mb
Release : 2013-07-22
Category : Medical
ISBN : 9781481652896

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Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf

Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Novel Therapies in Head and Neck Cancer: Beyond the Horizon

Maie A. St. John,No hee Park
Novel Therapies in Head and Neck Cancer Beyond the Horizon Book PDF

Author : Maie A. St. John,No hee Park
Publisher : Academic Press
Page : 268 pages
File Size : 53,7 Mb
Release : 2020-06-29
Category : Science
ISBN : 9780128209295

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Novel Therapies in Head and Neck Cancer: Beyond the Horizon by Maie A. St. John,No hee Park Pdf

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

Head & Neck Cancer: Current Perspectives, Advances, and Challenges

James A. Radosevich
Head Neck Cancer Current Perspectives Advances and Challenges Book PDF

Author : James A. Radosevich
Publisher : Springer Science & Business Media
Page : 1064 pages
File Size : 53,6 Mb
Release : 2013-05-24
Category : Medical
ISBN : 9789400758278

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Head & Neck Cancer: Current Perspectives, Advances, and Challenges by James A. Radosevich Pdf

This is a nearly complete collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals but is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book.

Early Detection and Treatment of Head & Neck Cancers

Rami El Assal,Dyani Gaudilliere,Stephen Thaddeus Connelly
Early Detection and Treatment of Head Neck Cancers Book PDF

Author : Rami El Assal,Dyani Gaudilliere,Stephen Thaddeus Connelly
Publisher : Springer Nature
Page : 233 pages
File Size : 42,7 Mb
Release : 2021-05-07
Category : Medical
ISBN : 9783030698522

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Early Detection and Treatment of Head & Neck Cancers by Rami El Assal,Dyani Gaudilliere,Stephen Thaddeus Connelly Pdf

Head and neck cancer (HNC) is a heterogeneous group of cancers that, if combined, represent one of the most common cancer types. Patients with HNC suffer significant morbidity and mortality due to the importance of the structures involved. Over two-thirds of these patients are diagnosed at a late stage, leading to a poor prognosis. Therefore, advancements in early detection and treatment of HNC are crucial. This second volume provides an up-to-date overview of the theoretical background in the field of head and neck cancer (HNC) as well as of the emerging research that is impacting our understanding of this disease. The book begins with a comprehensive review of the epidemiology, etiology, symptoms, diagnosis, and staging of HNC. Next, it covers the essentials of potentially malignant disorders of the oral cavity, an important variety of HNC. Subsequently, it covers the newly emerging research in the field of HNC. The overall goal is to shift towards precision medicine (discussed in detail in Volume I), which will bring individualized clinical benefit to patients with HNC. This second volume of Early Detection and Treatment of Head & Neck Cancers concludes with the topic of chronic pain associated with HNC, including both the mechanisms of pain and the management strategies, and the emerging oral mucoadhesive drug delivery approach for HNC. All HNC surgeons, scientists, residents, and individuals whose lives have been touched by this disease, will recognize the impact pain has upon a patient’s health and his or her recovery trajectory.

Head and Neck Cancer

Louis B. Harrison,Roy B. Sessions,Waun Ki Hong
Head and Neck Cancer Book PDF

Author : Louis B. Harrison,Roy B. Sessions,Waun Ki Hong
Publisher : Lippincott Williams & Wilkins
Page : 1004 pages
File Size : 47,5 Mb
Release : 2009
Category : Medical
ISBN : 0781771366

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Head and Neck Cancer by Louis B. Harrison,Roy B. Sessions,Waun Ki Hong Pdf

This comprehensive, multidisciplinary text addresses all aspects of head and neck cancer and represents a wide spectrum of specialists, including surgical, radiation, and medical oncologists, dentists, pathologists, radiologists, and nurses. The book focuses on a two-part approach to treatment that maximizes the chance for a cure while maintaining a strong emphasis on quality of life. This Third Edition's updated techniques section includes new radiation techniques such as IMRT and IGRT and new endoscopic and laser surgical techniques. Other highlights include a new chapter on reconstructive techniques; significant updates to all site-specific chapters; updates on chemoprevention and molecular targeting; and discussions of new imaging modalities such as fused PET/CT. A companion Website will offer the fully searchable text with all images.

Head and Neck Cancer

Jacques Bernier
Head and Neck Cancer Book PDF

Author : Jacques Bernier
Publisher : Springer Science & Business Media
Page : 700 pages
File Size : 44,9 Mb
Release : 2011-06-15
Category : Medical
ISBN : 9781441994646

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Head and Neck Cancer by Jacques Bernier Pdf

In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.

Head and Neck Cancer: New Insights for the Healthcare Professional: 2012 Edition

Anonim
Head and Neck Cancer New Insights for the Healthcare Professional 2012 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 185 pages
File Size : 55,7 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464971051

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Head and Neck Cancer: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

Head and Neck Cancer: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Head and Neck Cancer. The editors have built Head and Neck Cancer: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Head and Neck Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Head and Neck Cancer: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.