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Cushing's Disease by Edward R. Laws Jr,Louise Pace Pdf
Cushing’s Disease: An Often Misdiagnosed and Not So Rare Disorder reviews the epidemiology of Cushing’s, including statistics on the incidence and prevalence of this disease. There are discussions of the signs and symptoms and the most common co-morbidities, such as diabetes mellitus, hypertension, osteoporosis, amenorrhea, and infertility. Surgical, medical, and radiotherapeutic treatments, including indications, results, risks, and complications, are reviewed. Also featured is a chapter on the patient’s perspective, coping with Cushing’s, quality of life, and psychosomatic issues. This book is essential reading for the wide range of physicians who treat patients with Cushing’s disease symptoms, as well as biomedical researchers who investigate the etiology and mechanisms of rare genetic diseases, in particular rare endocrine disorders. Reviews the basics of Cushing’s disease and its interrelation with hormones, the brain, and bodily functions Includes chapters on diagnosis, surgical, medical, and radiotherapeutic treatments, and variations in presentation, including cyclical disease Presents the cognitive and emotional aspects of Cushing’s and the long-term sequelae Offers an important resource for physicians who are accustomed to treating individual symptoms rather than a disease complex Reviews multidisciplinary management, and post-treatment management of Cushing’s, including recommendations for Cushing’s Centers of Excellence
Cushing ́s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing’s syndrome and the differential diagnosis among its diverse etiologies, as well as therapeutic approaches. Additionally, a range of conditions that represent challenges for the diagnosis and treatment--such as renal failure, pediatric age, cyclic hypercortisolism, and pregnancy--are covered in detail. A valuable resource not only for endocrinologists but also internal medicine physicians, gynecologists, pediatricians, , pituitary surgeons and urologists, Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment provides insights by experts that will help all physicians dealing with Cushing ́s syndrome to expand their knowledge about the condition and provide targeted, comprehensive care.
The Cushing's Syndrome Diet is filled with no nonsense recipes that will help control your Cushing's Syndrome symptoms. While there are many treatment options for Cushing's, only one is vital to insuring your overall health: a balanced, nutritional diet, low in salt and fat and high in protein and calcium. This type of diet can slow or prevent the loss of muscle and bone from Cushing's Syndrome. You'll find all of the recipes in this book provide you with maximum nutritional from plant sources-and they are quick and easy to prepare, so you can get back to living your life!
Hyperandrogenism in Women by R. Pasquali,D. Pignatelli Pdf
Hyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding of androgen excess and its impact on several conditions. Topics include development of adipose tissue in females, insulin sensitivity, congenital adrenal hyperplasia, and Cushing’s disease/syndrome. There is also a discussion of PCOS with emphasis on in utero origins and specific genetic and epigenetic factors. This book provides a wealth of relevant information for every endocrinologist and gynecologist who wants to broaden their knowledge of androgens in various conditions.
Cushing's Disease by Brooke Swearingen,Beverly M. K. Biller Pdf
In Cushing’s Disease, leading authorities in the field offer a thorough review of the pathogenesis, diagnostic algorithm and treatment options for this complex disease. Beginning with a fascinating history of Cushing's disease that outlines its historical significance to both endocrinology and neurosurgery, the book goes onto to cover the full range of important issues, including the molecular pathogenesis of Cushing’s, anatomic pathology, the diagnosis of Cushing's syndrome, the differential of pseudo-Cushing's syndromes, hypercortisolemia, surgical removal of the corticotroph adenoma, post-operative management and assessment of remission, radiotherapeutic options, and the exciting developments in medical therapy. In addition, the book also addresses Cushing's disease in the pediatric population, given that its clinical manifestations and impact on growth can be severe; silent corticotroph adenomas as a distinct clinical entity; diagnosis and management of Cushing's disease during pregnancy, bilateral adrenalectomy, and, finally, the long-term psychological manifestations of hypercortisolemia. Comprehensive and an invaluable addition the literature, Cushing’s Disease is an essential reference for enhancing diagnosis and treatment of this debilitating disorder.
Cushing’s Syndrome, An Issue of Endocrinology and Metabolism Clinics of North America E-Book by Adriana G. Ioachimescu Pdf
This issue of Endocrinology and Metabolism Clinics, edited by Adriana G. Ioachimescu, will focus on Cushing’s Syndrome. Topics include--but are not limited to--1. Diagnosis of Cushing’s syndrome in the modern era, Gene mutations in patients with Cushing’s syndrome, Morbidity in Cushing’s syndrome and impact of treatment, Localization of ACTH-dependent Cushing’s syndrome, Prognostic factors of long-term remission after surgical treatment of Cushing’s disease, Outcomes of pituitary radiation for Cushing’s disease, New molecular targets in Cushing’s disease, Recent advances in subclinical Cushing’s syndrome, Adrenal surgery for Cushing’s syndrome, Adrenocortical carcinoma with hypercortisolism, Ectopic Cushing’s syndrome, Medical therapy for Cushing’s syndrome in the 21st century, Pregnancy in patients with Cushing’s syndrome, Mortality in patients with Cushing’s syndrome, and Cushing’s syndrome in children and adolescents.
Author : D. T. Krieger Publisher : Springer Science & Business Media Page : 144 pages File Size : 51,9 Mb Release : 2012-12-06 Category : Medical ISBN : 9783642816598
The unraveling of our knowledge of the functions of the adrenal gland constitutes one exciting development of modern medicine and biochemistry. We owe these advances to the felicitous cooperative efforts of the clinical investigator and the biochemist. Three centuries elapsed between the first recorded anatomical descrip tion of the adrenals and the demonstration by Dr. Addison in the mid-nineteenth century of the fatal results of the destruction of these glands by disease. It became evident from this observation that the adrenals secreted a "factor" or "factors" essential to life. It took approximately 90 years to isolate this elusive vital factor - cortisone - from beef adrenal cortices, independently by both Reichstein and his co-workers in Basle and Kendall and his group in the United States and another 10-15 years before it became more generally available for experimental and clinical use. It is perhaps difficult to believe that as recently as 35-40 years ago, before cortisone and cortisol were clinically available, the surgical removal of a benign adrenal cortical tumor in patients with Cushing's syndrome was associated with a prohibitive postoperative mortality rate. Within 12-36 h after operation, most of such patients developed an intractable state of shock, which was not manifested by significant electrolyte abnormalities or hypoglycemia and was unresponsive to the usual treatment for shock plus the generous use of salt-retaining hormone.
Cushing's Disease in Dogs by Gordon Roberts BVSc MRCVS,Gordon Roberts Pdf
Your Dog and Cushing's Disease provides an insightful and essential guide for every dog owner. The book provides vital support for those with dogs already suffering from the disease, but also helps raise awareness of the condition for those who know little about it. You will be given a walk-through of how Cushing's disease affects a dog's body, the causes, the symptoms, ways of prevention, diagnosis methods, treatment options, general prognosis and tips for dog owners on coping with the disease. You'll also learn the answers to these important questions: - What is Cushing's disease and how does it affect my dog? - What can cause Cushing's and what are the risk factors? - What are the symptoms of the disease? - Are there any ways to prevent the problem and what precautions should I take? - How is Cushing's diagnosed? - How is the condition treated and managed? - What is the prognosis for canine Cushing's disease? - How do I cope having a dog with Cushing's disease? The book is a must-read for anyone living with a dog that has Cushing's disease and will provide you with the valuable insight you need to help your dog live a happier, healthier life with Cushing's.
Author : John A.H. Wass,Paul M. Stewart Publisher : Oxford University Press, USA Page : 2158 pages File Size : 47,9 Mb Release : 2011-07-28 Category : Medical ISBN : 9780199235292
Oxford Textbook of Endocrinology and Diabetes by John A.H. Wass,Paul M. Stewart Pdf
Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.
Cushing’s disease and aggressive pituitary tumours by Daniel Bengtsson Pdf
This thesis focuses on clinical and epidemiological aspects of aggressive pituitary tumours/carcinomas and Cushing’s disease. Pituitary carcinomas account for only 0.1-0.2% of the tumours originating from the anterior pituitary gland and are defined solely by the event of distant metastases, whereas aggressive pituitary tumours are defined by their clinical behaviour of rapid/progressive growth despite optimal treatment with surgery, radiotherapy and medical agents. The prognosis for individuals with aggressive tumours/carcinomas has been poor with few treatment options. However, case reports indicated better outcomes after treatment with the alkylating agent temozolomide. In study I and III, we investigated 24 patients (16 aggressive tumours and 8 carcinomas) given treatment with temozolomide. We found an initial response rate (tumour regression ≥30%) in 10/21 evaluable patients, with complete regression in two carcinomas. Favourable response was associated with low tumour expression of the DNA repair protein MGMT; in responders median 9% (range 5-20%) vs non-responders median 93% (50-100%). Our results also indicated a longer survival in patients with low MGMT. Out of 11 patients with MGMT >10%, nine died with an estimated median survival of 26 months (95% CI 14-38), whereas only 1/6 patients with lower MGMT died from tumour progression during a follow-up of median 83 months (range 12-161). One of the patients in study I and III had a corticotroph pituitary carcinoma and in addition, Lynch syndrome (LS), a hereditary cancer-predisposing syndrome caused by germline mutations in DNA mismatch repair (MMR) genes and primarily associated with colon and endometrial carcinomas. In study II, we investigated the characteristics of the pituitary carcinoma and found loss of MSH2 and MSH6 protein expression, consistent with the patient’s germline mutation in MSH2. This was the first published case of a pituitary tumour associated with LS. In addition, we identified all known Swedish patients with LS (n=910) and searched for diagnostic codes consistent with a pituitary tumour in the Swedish national patient register. We found in total three patients with clinically relevant pituitary tumours, the reported prevalence in the background population is around 1:1000. The last two studies in the thesis focused on Cushing’s disease (CD), i.e. an ACTH-secreting pituitary tumour resulting in excess levels of cortisol. CD is associated with multiple comorbidities and increased mortality. The reversibility of comorbidities and mortality risk after remission of cortisol levels have been under debate. Study IV examined psychiatric consequences of CD, measured by the use of psychotropic drugs. 179 patients with CD and a quadrupled matched control group were followed from diagnosis and at 5- and 10-year follow-up. We found that use of antidepressants remained at around 25% of patients with CD, regardless of remission status, at diagnosis and follow-up, whereas drugs for somatic comorbidities decreased. Use of antidepressants, sleeping pills and anxiolytics was higher in patients with CD compared to controls at diagnosis and 5-year follow-up. A cross-sectional analysis of 76 patients in sustained biochemical remission for median 9.3 years showed that 25% were taking antidepressants, a significantly higher use than controls, OR 2.0 (95% CI 1.1-3.8). In addition, patients with CD had a higher use of psychotropic drugs, already in the 5-year period before diagnosis. Study V investigated mortality and causes of death in 371 patients with CD, compared to a quadrupled matched control group. Follow-up was median 10.6 years (IQR 5.7-18.2) after time of diagnosis. Overall mortality was increased in patients with CD, HR 2.1 (95% CI 1.5-2.8) and remained elevated for patients in remission at last follow-up (n=303), HR 1.5 (1.02-2.2). For patients not in remission (n=31), HR was 5.6 (2.7-11.6). Cardiovascular diseases (32/66) and infections (12/66) were overrepresented causes of death in patients with CD. Main conclusions of the thesis: Temozolomide improves outcome in patients with aggressive pituitary tumours/carcinomas and a low MGMT expression in the tumour predicts a favourable outcome. As additional therapies evolve, MGMT may help to tailor the treatment.Germline mutations in MMR genes may contribute to the development and clinical course of pituitary tumours and may be a novel cause of hereditary pituitary tumours.Patients with Cushing’s disease have a high use of psychotropic drugs that remains elevated despite achievement of biochemical remission, suggesting persisting negative effects on mental health and highlighting the need for long-term monitoring of psychiatric symptoms. In addition, psychiatric symptoms may be early and important signs of CD.Efforts to achieve biochemical remission are crucial to reduce mortality in CD. However, patients in remission still have an increased mortality compared to controls. This underscores the need for life-long monitoring and treatment of associated comorbidities in patients with CD.
Author : Lewis S. Blevins Publisher : Springer Science & Business Media Page : 344 pages File Size : 41,9 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461511038
Cushing's Syndrome provides the reader with an update on the clinical presentation, diagnosis, and treatment of patients with Cushing's syndrome. Molecular mechanisms of pituitary and adrenal causes of Cushing's syndrome are reviewed in detail. Successful diagnostic and treatment strategies that have been employed by readers in the field are recommended and discussed. Numerous advances in the pathophysiology and diagnosis of Cushing's syndrome speak to the timeliness of this volume that has been penned by experts in the field.
Ferri's Clinical Advisor 2019 E-Book by Fred F. Ferri Pdf
Updated annually with the latest developments in diagnosis and treatment recommendations, Ferri’s Clinical Advisor uses the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on more than 900 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all updated by experts in key clinical fields. Updated algorithms and current clinical practice guidelines help you keep pace with the speed of modern medicine. Contains significant updates throughout, with more than 500 new figures, tables, and boxes added to this new edition. Features 17 all-new topics including opioid overdose, obesity-Hypoventilation syndrome, acute pelvic pain in women, new-onset seizures, and eosinophilic esophagitis, among many others. Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. Includes cross-references, outlines, bullets, tables, boxes, and algorithms to help you navigate a wealth of clinical information. Offers access to exclusive online content: more than 90 additional topics; new algorithms, images, and tables; EBM boxes; patient teaching guides, color images, and more.
The Hypothalamus-Pituitary-Adrenal Axis by Anonim Pdf
The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. * Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle. * Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later.