Cytokines In Autoimmunity

Author : Vijay K. Kuchroo,Nora Sarvetnick,David A. Hafler,Lindsay B. Nicholson
Publisher : Springer Science & Business Media
Page : 421 pages
File Size : 48,7 Mb
Release : 2001-11-09
Category : Medical
ISBN : 9781592591299

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Cytokines and Autoimmune Diseases by Vijay K. Kuchroo,Nora Sarvetnick,David A. Hafler,Lindsay B. Nicholson Pdf

Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

Author : Erwan Mortier,Averil Ma,Barbara A. Malynn,Markus Neurath
Publisher : Frontiers Media SA
Page : 202 pages
File Size : 51,6 Mb
Release : 2020-12-11
Category : Medical
ISBN : 9782889662111

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Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer by Erwan Mortier,Averil Ma,Barbara A. Malynn,Markus Neurath Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Pere Santamaria
Publisher : Springer
Page : 320 pages
File Size : 52,7 Mb
Release : 2003-01-31
Category : Medical
ISBN : PURD:32754076903719

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Cytokines and Chemokines in Autoimmune Disease by Pere Santamaria Pdf

This book attempts to capture recent knowledge on the role of cytokines and chemokines in autoimmunity by focusing on some of the most prevalent organ-specific or systemic autoimmune disorders. After beginning chapters on the function and structure of cytokines and chemokines, sections cover their genetics and mechanisms of action in the context of autoimmunity, and the role of different cytokines and chemokines in various autoimmune disorders. Santamaria teaches in the Department of Microbiology and Infectious Diseases at the University of Calgary, Canada.

Author : Wahid Ali Khan
Publisher : Unknown
Page : 218 pages
File Size : 43,8 Mb
Release : 2019-04-24
Category : Microbiology
ISBN : 9781789848526

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Autoantibodies and Cytokines by Wahid Ali Khan Pdf

The mechanism of autoantibodies cannot be explained without the detail knowledge of cytokines and interferon. These active molecules of immunology are very much dependent on each other and their function cannot be completed without their interaction towards each other. Currently, this the most updated book on this subject that helps the readers/students to upgrade their knowledge by going through chapter by chapter. Contribution by the renounced authors across the globe makes this book really unique and consider as one of the most updated textbook on this subject. This book provides a comprehensive guide to the function and types of autoantibodies and cytokines in basic and clinical field.

Author : Valérie Quesniaux,Bernhard Ryffel,Franco Di Padova
Publisher : Springer Science & Business Media
Page : 345 pages
File Size : 55,5 Mb
Release : 2012-12-13
Category : Medical
ISBN : 9783034805223

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IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity by Valérie Quesniaux,Bernhard Ryffel,Franco Di Padova Pdf

The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.

Author : Fionula M. Brennan,Marc Feldmann
Publisher : Landes Bioscience
Page : 286 pages
File Size : 54,5 Mb
Release : 1996
Category : Autoimmune diseases
ISBN : STANFORD:36105018318548

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Cytokines in Autoimmunity by Fionula M. Brennan,Marc Feldmann Pdf

A review of the field of cytokines in autoimmunity written by 22 researchers suggesting diverse applications, and building on the successes of recent rheumatoid arthritis clinical trials. The contributors present and review findings on arthritis, diabetes, multiple sclerosis, thyroid disease, Sjogren's syndrome, Lupus, scleroderma, and psoriasis. The final sections concentrate on laboratory and clinical concerns working with "knockout" mice, transgenic mice, and cytokine therapy. Distributed by Chapman and Hall. CiP shows the title as Role of cytokines..... Annotation copyright by Book News, Inc., Portland, OR

Author : Fionula M. Brennan,Marc Feldmann
Publisher : Unknown
Page : 260 pages
File Size : 41,5 Mb
Release : 1996
Category : Autoimmune diseases
ISBN : 1570593183

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Cytokines in Autoimmunity by Fionula M. Brennan,Marc Feldmann Pdf

Author : Amnon Altman
Publisher : Karger Medical and Scientific Publishers
Page : 206 pages
File Size : 43,9 Mb
Release : 2002
Category : Medical
ISBN : 9783805573085

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Signal Transduction Pathways in Autoimmunity by Amnon Altman Pdf

The chapters included in this volume represent but a few examples of the close link between aberrant signaling pathways and autoimmune diseases. They cover a variety of cells (T, B and myeloid/monocytic cells), receptors (for antigen, Fc and cytokines) and intracellular signaling molecules (kinases, phosphatases, adapters and transcription factors) in the immune system. This book brings together clinical and experimental aspects of autoimmune disease and the fundamental science of intracellular signaling pathways. Therefore, it should be of interest to clinical investigators of autoimmune diseases as wll as to basic immunologists and cell biologists interested in the molecular basis of signal transduction in the immune system.

Author : Payam Behzadi
Publisher : BoD – Books on Demand
Page : 146 pages
File Size : 54,6 Mb
Release : 2021-07-14
Category : Medical
ISBN : 9781839690983

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Interleukins by Payam Behzadi Pdf

The immune system recruits a wide range of molecule groups and categories, each of which has its own function, property, and structure. Among these, interleukins play a pivotal role in supporting the immune and non-immune systems of the human body. Interleukins as effective cytokines participate in different conditions such as homeostasis, infectious diseases, autoimmune diseases, and cancers. This unique property of interleukins makes them invaluable biomarkers that can be used as important biosensors. This book is divided into three sections: “Interleukins’ Classification and Evolutionary Features”, “Autoimmune Diseases and Low Immune System”, and “Cancer and Injuries”. Chapters examine the role of various interleukins in conditions such as leukemia, rheumatoid arthritis, and allergic and autoimmune diseases.

Author : Valérie Quesniaux,Bernhard Ryffel,Franco Di Padova
Publisher : Springer Science & Business Media
Page : 247 pages
File Size : 40,5 Mb
Release : 2009-03-12
Category : Medical
ISBN : 9783764386818

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Th 17 Cells: Role in Inflammation and Autoimmune Disease by Valérie Quesniaux,Bernhard Ryffel,Franco Di Padova Pdf

The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.

Author : Fionula M. Brennan,Marc Feldmann
Publisher : Springer Verlag
Page : 260 pages
File Size : 42,5 Mb
Release : 1996-01-01
Category : Autoimmune diseases
ISBN : 3540606874

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Cytokines in Autoimmunity by Fionula M. Brennan,Marc Feldmann Pdf

This book documents the current state of knowledge concerning cytokines in the pathogenesis of the spectrum of human autoimmune diseases. Where appropriate, animal models of autoimmune diseases are included for comparison. This field has progressed so rapidly that it can no longer be mastered by a single group, hence this multi-authored compendium. Cytokines are now widely acknowledged to be important targets for disease intervention, as demonstrated by the success of anti-TNFa antibody therapy in the treatment of rheumatoid arthritis.

Author : Alberta Hoi
Publisher : Springer Nature
Page : 192 pages
File Size : 47,5 Mb
Release : 2021-11-15
Category : Medical
ISBN : 9783030851613

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Pathogenesis of Systemic Lupus Erythematosus by Alberta Hoi Pdf

The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Author : Maria Florencia Quiroga,María Fernanda Pascutti,Gustavo Javier Martinez
Publisher : Frontiers Media SA
Page : 233 pages
File Size : 46,8 Mb
Release : 2020-05-13
Category : Electronic
ISBN : 9782889636099

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Strategies for Modulating T cell responses in Autoimmunity and Infection by Maria Florencia Quiroga,María Fernanda Pascutti,Gustavo Javier Martinez Pdf

Author : Luciano Adorini
Publisher : Unknown
Page : 200 pages
File Size : 44,9 Mb
Release : 1997
Category : Medical
ISBN : UOM:39015041761035

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Immunointervention in Autoimmunity by Th1/Th2 Regulation by Luciano Adorini Pdf

Author : Carlo Perricone,Yehuda Shoenfeld
Publisher : Academic Press
Page : 728 pages
File Size : 51,8 Mb
Release : 2019-02-15
Category : Medical
ISBN : 9780128143070

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Mosaic of Autoimmunity by Carlo Perricone,Yehuda Shoenfeld Pdf

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications